Macrophage-mediated inflammation in metabolic disease

Chawla, Ajay; Nguyen, Khoa D.; Goh, Y. P. Sharon

doi:10.1038/nri3071

Cited by 1,314Adipokines, Inflammation, and Metabolic DiseasesImmune cells in cancerAdipose Tissue and Metabolism

Macrophage-mediated inflammation in metabolic disease

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Chawla, Ajay, Nguyen, Khoa D., Goh, Y. P. Sharon·2011·Nature reviews. Immunology

DOI 10.1038/nri3071PMC PMC3383854

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Abstract

Metabolism and immunity are two fundamental systems of metazoans. The presence of immune cells, such as macrophages, in metabolic tissues suggests dynamic, ongoing crosstalk between these two regulatory systems. Here, we discuss how changes in the recruitment and activation of macrophages contribute to metabolic homeostasis. In particular, we focus our discussion on the pathogenic and protective functions of classically and alternatively activated macrophages, respectively, in experimental models of obesity and metabolic disease.

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The systemic proinflammatory state in obesity is driven by proinflammatory M1 macrophages and CD4+ Th1-cell infiltrates in adipose tissue.
“which is driven by proinflammatory M1 Mφ and CD4+ Th1-cell infiltrates in adipose tissue (AT) [14]”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [14]
The 'Inflammation and insulin resistance' section describes pro-inflammatory M1 macrophages in obese adipose tissue. Its 'T cell activation in obese adipose tissue' subsection reports accumulation of CD4+ Th1 cells and says their activity amplifies adipose-tissue inflammation. These passages support the local inflammatory mechanism, but do not establish that these infiltrates drive a systemic proinflammatory state. Page numbers are unavailable in our copy. (LLM, conf=0.84)
Experimental — accuracy not yet measured
M1 macrophages secrete TNF-α, IL-1β, IL-6, and chemokines that promote the influx of activated CD4+ Th1 cells.
“M1 macrophages secrete TNF-α, IL-1β, IL-6, and chemokines that promote the influx of activated CD4+ Th1 cells [14,20,239,248].”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [14]
The ‘T cell activation in obese adipose tissue’ section says classically activated macrophages produce TNF-α and IL-1β and interact with CD4+ T cells. It does not identify IL-6 as one of their secretions or say macrophage-secreted chemokines drive Th1-cell influx; instead, it describes Th1-cell IFN-γ as contributing to macrophage activation. The ‘Chemotactic factors’ section discusses chemokine-mediated recruitment of monocytes and macrophages, not Th1 cells (page unavailable in our copy). (LLM, conf=0.86)
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Absence of CC Chemokine Ligand 2 Does Not Limit Obesity-Associated Infiltration of Macrophages Into Adipose Tissue
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Protective and pathogenic functions of macrophage subsets
Murray, P. J., & Wynn, T. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3073 · Cited by 5,269 · see citing works
Macrophage plasticity and polarization in tissue repair and remodelling
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Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes
Hashimoto, D., Chow, A., Noizat, C., Teo, P., Beasley, M. B., Leboeuf, M., Becker, C. D., See, P., Price, J., Lucas, D., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.004 · Cited by 2,311 · see citing works
The metabolic signature of macrophage responses
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Inflammation in obesity, diabetes, and related disorders
Rohm, T. V., Meier, D. T., Olefsky, J. M., & Donath, M. Y. (2022) · Immunity · doi:10.1016/j.immuni.2021.12.013 · Cited by 2,066 · see citing works
Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes
Esser, N., Legrand-Poels, S., Piette, J., Scheen, A. J., & Paquot, N. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2014.04.006 · Cited by 1,981 · see citing works
The role of estrogens in control of energy balance and glucose homeostasis
Mauvais-Jarvis, F., Clegg, D. J., & Hevener, A. L. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1055 · Cited by 1,329 · see citing works
Regulation and function of mTOR signalling in T cell fate decisions
Chi, H. (2012) · Nature Reviews Immunology · doi:10.1038/nri3198 · Cited by 1,035 · see citing works
Western Diet and the Immune System: An Inflammatory Connection
Christ, A., Lauterbach, M., & Latz, E. (2019) · Immunity · doi:10.1016/j.immuni.2019.09.020 · Cited by 907 · see citing works
Microglia: Scapegoat, saboteur, or something else?
Aguzzi, A., Barres, B. A., & Bennett, M. L. (2013) · Science · doi:10.1126/science.1227901 · Cited by 836 · see citing works
Skeletal muscle inflammation and insulin resistance in obesity
Wu, H., & Ballantyne, C. M. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88880 · Cited by 695 · see citing works
Chronic Low Grade Inflammation in Pathogenesis of PCOS
Rudnicka, E., Suchta, K., Grymowicz, M., Calik-Ksepka, A., Smolarczyk, K., Duszewska, A. M., Smolarczyk, R., & Meczekalski, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073789 · Cited by 680 · see citing works
The reactive oxygen species in macrophage polarization: reflecting its dual role in progression and treatment of human diseases
Tan, H.-Y., Wang, N., Li, S., Hong, M., Wang, X., & Feng, Y. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2795090 · Cited by 657 · see citing works
Exosomes From Adipose-Derived Stem Cells Attenuate Adipose Inflammation and Obesity Through Polarizing M2 Macrophages and Beiging in White Adipose Tissue
Zhao, H., Shang, Q., Pan, Z., Bai, Y., Li, Z., Zhang, H., Zhang, Q., Guo, C., Zhang, L., & Wang, Q. (2018) · Diabetes · doi:10.2337/db17-0356 · Cited by 657 · see citing works
Mechanisms Linking Inflammation to Insulin Resistance
Chen, L., Chen, R., Wang, H., & Liang, F. (2015) · International Journal of Endocrinology · doi:10.1155/2015/508409 · Cited by 644 · see citing works
Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis
Odegaard, J. I., & Chawla, A. (2013) · Science · doi:10.1126/science.1230721 · Cited by 643 · see citing works
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Kupffer cells in the liver
Dixon, L. J., Barnes, M., Tang, H., Pritchard, M. T., & Nagy, L. E. (2013) · Comprehensive Physiology · doi:10.1002/cphy.c120026 · Cited by 628 · see citing works
Anti-inflammatory effects of exercise: role in diabetes and cardiovascular disease
Pedersen, B. K. (2017) · European Journal of Clinical Investigation · doi:10.1111/eci.12781 · Cited by 617 · see citing works
The inflammation highway: metabolism accelerates inflammatory traffic in obesity
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The macrophage switch in obesity development
Castoldi, A., Naffah de Souza, C., Câmara, N. O. S., & Moraes-Vieira, P. M. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00637 · Cited by 575 · see citing works
Tissue Tregs
Panduro, M., Benoist, C., & Mathis, D. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095948 · Cited by 536 · see citing works
Macrophage Polarization in Chronic Inflammatory Diseases: Killers or Builders?
Parisi, L., Gini, E., Baci, D., Tremolati, M., Fanuli, M., Bassani, B., Farronato, G., Bruno, A., & Mortara, L. (2018) · Journal of Immunology Research · doi:10.1155/2018/8917804 · Cited by 508 · see citing works
Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver
Satapati, S., Sunny, N. E., Kucejova, B., Fu, X., He, T. T., Méndez-Lucas, A., Shelton, J. M., Perales, J. C., Browning, J. D., & Burgess, S. C. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m023382 · Cited by 407 · see citing works
Functional roles of p38 mitogen-activated protein kinase in macrophage-mediated inflammatory responses
Yang, Y., Kim, S. C., Yu, T., Yi, Y.-S., Rhee, M. H., Sung, G.-H., Yoo, B. C., & Cho, J. Y. (2014) · Mediators of Inflammation · doi:10.1155/2014/352371 · Cited by 406 · see citing works
HIF1 α -Induced Glycolysis Metabolism Is Essential to the Activation of Inflammatory Macrophages
Wang, T., Liu, H., Lian, G., Zhang, S.-Y., Wang, X., & Jiang, C. (2017) · Mediators of Inflammation · doi:10.1155/2017/9029327 · Cited by 371 · see citing works
Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair
Yang, W., Tao, Y., Wu, Y., Zhao, X., Ye, W., Zhao, D., Fu, L., Tian, C., Yang, J., He, F., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09046-8 · Cited by 367 · see citing works
Adipose tissue-resident immune cells: key players in immunometabolism
Schipper, H. S., Prakken, B., Kalkhoven, E., & Boes, M. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.05.011 · Cited by 342 · see citing works
Regulation of inflammation by interleukin-4: a review of "alternatives"
Luzina, I. G., Keegan, A. D., Heller, N. M., Rook, G. A. W., Shea-Donohue, T., & Atamas, S. P. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0412214 · Cited by 351 · see citing works
The Roles of Adipokines, Proinflammatory Cytokines, and Adipose Tissue Macrophages in Obesity-Associated Insulin Resistance in Modest Obesity and Early Metabolic Dysfunction
Kang, Y. E., Kim, J. M., Joung, K. H., Lee, J. H., You, B. R., Choi, M. J., Ryu, M. J., Ko, Y. B., Lee, M. A., Lee, J., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0154003 · Cited by 306 · see citing works
Cytokines and abnormal glucose and lipid metabolism
Shi, J., Fan, J., Su, Q., & Yang, Z. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00703 · Cited by 282 · see citing works
The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review
Gonzalez-Gil, A. M., & Elizondo-Montemayor, L. (2020) · Nutrients · doi:10.3390/nu12061899 · Cited by 278 · see citing works
“IL-10 Ob: ↓ [9]+ AE: ↑ (Healthy; aerobic or HIIT, duration-dependent [250]+) CE: ↑ (T2DM; aerobic, resistance, and combined [253]+) ↑: IL-6 [74], adiponectin [230]+ ↓: TNF-α and IL-1β [9,238]+; IL-6 and IL-8 [261]+ Systemic: anti-inflammatory (↓IFN-γ by Th1, ↓ TNF-α by M1 Mφ, ↑IL-10 by Tregs) [14]+; ↑insulin sensitivi…”
BackgroundInfluential
Macrophages in age-related chronic inflammatory diseases
Oishi, Y., & Manabe, I. (2016) · npj Aging and Mechanisms of Disease · doi:10.1038/npjamd.2016.18 · Cited by 262 · see citing works
Gastric bypass and banding equally improve insulin sensitivity and β cell function
Bradley, D., Conte, C., Mittendorfer, B., Eagon, J. C., Varela, J. E., Fabbrini, E., Gastaldelli, A., Chambers, K. T., Su, X., Okunade, A., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64895 · Cited by 244 · see citing works
Interplay between the immune system and adipose tissue in obesity
Exley, M. A., Hand, L., O'Shea, D., & Lynch, L. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0516 · Cited by 242 · see citing works
The Differential Roles of T Cells in Non-alcoholic Fatty Liver Disease and Obesity
Van Herck, M. A., Weyler, J., Kwanten, W. J., Dirinck, E. L., De Winter, B. Y., Francque, S. M., & Vonghia, L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00082 · Cited by 238 · see citing works
Adipose tissue macrophages function as antigen-presenting cells and regulate adipose tissue CD4+ T cells in mice
Morris, D. L., Cho, K. W., DelProposto, J. L., Oatmen, K. E., Geletka, L. M., Martinez-Santibanez, G., Singer, K., & Lumeng, C. N. (2013) · Diabetes · doi:10.2337/db12-1404 · Cited by 217 · see citing works
Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine–driven inflammation and fibrosis
Vannella, K. M., Ramalingam, T. R., Borthwick, L. A., Barron, L., Hart, K. M., Thompson, R. W., Kindrachuk, K. N., Cheever, A. W., White, S., Budelsky, A. L., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf1938 · Cited by 188 · see citing works
Inhibiting microglia expansion prevents diet-induced hypothalamic and peripheral inflammation
André, C., Guzman-Quevedo, O., Rey, C., Rémus-Borel, J., Clark, S., Castellanos-Jankiewicz, A., Ladeveze, E., Leste-Lasserre, T., Nadjar, A., Abrous, D. N., et al. (2017) · Diabetes · doi:10.2337/db16-0586 · Cited by 182 · see citing works
Source and Amount of Carbohydrate in the Diet and Inflammation in Women with Polycystic Ovary Syndrome
Barrea, L., Marzullo, P., Muscogiuri, G., Di Somma, C., Scacchi, M., Orio, F., Aimaretti, G., Colao, A., & Savastano, S. (2018) · Nutrition Research Reviews · doi:10.1017/s0954422418000136 · Cited by 171 · see citing works
Hypoxia-inducible factors: key regulators of myeloid cells during inflammation
Lin, N., & Simon, M. C. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84426 · Cited by 170 · see citing works
The physiology of optimizing health with a focus on exercise as medicine
Pedersen, B. K. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114339 · Cited by 163 · see citing works
Brain trauma elicits non-canonical macrophage activation states
Kim, C. C., Nakamura, M. C., & Hsieh, C. L. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0581-z · Cited by 149 · see citing works
β-aminoisobutyric acid attenuates LPS-induced inflammation and insulin resistance in adipocytes through AMPK-mediated pathway
Jung, T. W., Park, H. S., Choi, G. H., Kim, D., & Lee, T. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0431-7 · Cited by 137 · see citing works
Is interleukin-1β a culprit in macrophage-adipocyte crosstalk in obesity?
Bing, C. (2015) · Adipocyte · doi:10.4161/21623945.2014.979661 · Cited by 127 · see citing works
A dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity
Kim, D., Xiao, Z., Kwon, S., Sun, X., Ryerson, D., Tkac, D., Ma, P., Wu, S., Chiang, C., Zhou, E., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201489527 · Cited by 126 · see citing works
G Protein–Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus
Riddy, D. M., Delerive, P., Summers, R. J., Sexton, P. M., & Langmead, C. J. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014373 · Cited by 108 · see citing works
B‐1a lymphocytes attenuate insulin resistance
Shen, L., Chng, M. H. Y., Alonso, M. N., Yuan, R., Winer, D. A., & Engleman, E. G. (2015) · Diabetes · doi:10.2337/db14-0554 · Cited by 109 · see citing works
Long-Acting Glucose-Dependent Insulinotropic Polypeptide Ameliorates Obesity-Induced Adipose Tissue Inflammation
Varol, C., Zvibel, I., Spektor, L., Mantelmacher, F. D., Vugman, M., Thurm, T., Khatib, M., Elmaliah, E., Halpern, Z., & Fishman, S. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401149 · Cited by 89 · see citing works
Circulating NOD1 activators and hematopoietic NOD1 contribute to metabolic inflammation and insulin resistance
Chan, K. L., Tam, T. H., Boroumand, P., Prescott, D., Costford, S. R., Escalante, N. K., Fine, N., Tu, Y., Robertson, S. J., Prabaharan, D., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.027 · Cited by 88 · see citing works
Nlrp3 Inflammasome Activation in Type 2 Diabetes: Is It Clinically Relevant?
Dixit, V. D. (2013) · Diabetes · doi:10.2337/db12-1115 · Cited by 85 · see citing works
Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages
Yamazaki, H., Kushiyama, A., Sakoda, H., Fujishiro, M., Yamamotoya, T., Nakatsu, Y., Kikuchi, T., Kaneko, S., Tanaka, H., & Asano, T. (2018) · Mediators of Inflammation · doi:10.1155/2018/3062319 · Cited by 86 · see citing works
Interleukin 4 modulates microglia homeostasis and attenuates the early slowly progressive phase of amyotrophic lateral sclerosis
Rossi, C., Cusimano, M., Zambito, M., Finardi, A., Capotondo, A., Garcia-Manteiga, J. M., Comi, G., Furlan, R., Martino, G., & Muzio, L. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-0288-4 · Cited by 77 · see citing works
Beneficial Effects of Intermittent Fasting: A Narrative Review
Song, D.-K., & Kim, Y.-W. (2023) · Journal of Yeungnam Medical Science · doi:10.12701/jyms.2022.00010 · Cited by 69 · see citing works
Vaspin suppresses cytokine-induced inflammation in 3T3-L1 adipocytes via inhibition of NFκB pathway
Zieger, K., Weiner, J., Krause, K., Schwarz, M., Kohn, M., Stumvoll, M., Blüher, M., & Heiker, J. T. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.07.022 · Cited by 65 · see citing works
Fish oil ameliorates trimethylamine N-oxide-exacerbated glucose intolerance in high-fat diet-fed mice
Gao, X., Xu, J., Jiang, C., Zhang, Y., Xue, Y., Li, Z., Wang, J., Xue, C., & Wang, Y. (2015) · Food & Function · doi:10.1039/c5fo00007f · Cited by 60 · see citing works
Sympathetic Nerve Activity Maintains an Anti-Inflammatory State in Adipose Tissue in Male Mice by Inhibiting TNF-α Gene Expression in Macrophages
Tang, L., Okamoto, S., Shiuchi, T., Toda, C., Takagi, K., Sato, T., Saito, K., Yokota, S., & Minokoshi, Y. (2015) · Endocrinology · doi:10.1210/en.2015-1096 · Cited by 55 · see citing works
LECT2 promotes inflammation and insulin resistance in adipocytes via P38 pathways
Jung, T. W., Chung, Y. H., Kim, H.-C., Abd El-Aty, A. M., & Jeong, J. H. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-17-0267 · Cited by 53 · see citing works
Inflammation and the depot-specific secretome of human preadipocytes
Zhu, Y., Tchkonia, T., Stout, M. B., Giorgadze, N., Wang, L., Li, P. W., Heppelmann, C. J., Bouloumié, A., Jensen, M. D., Bergen, H. R., et al. (2015) · Obesity · doi:10.1002/oby.21053 · Cited by 42 · see citing works
Targeting inflammation through a physical active lifestyle and pharmaceuticals for the treatment of type 2 diabetes
Knudsen, S. H., & Pedersen, B. K. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0642-1 · Cited by 41 · see citing works
Comparison of sirtuin 3 levels in ALS and Huntington's disease-differential effects in human tissue samples vs. transgenic mouse models
Buck, E., Bayer, H., Lindenberg, K. S., Hanselmann, J., Pasquarelli, N., Ludolph, A. C., Weydt, P., & Witting, A. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00156 · Cited by 36 · see citing works
Dynamic changes in chromatin accessibility, altered adipogenic gene expression, and total versus de novo fatty acid synthesis in subcutaneous adipose stem cells of normal-weight polycystic ovary syndrome (PCOS) women during adipogenesis: evidence of cellular programming
Leung, K. L., Sanchita, S., Pham, C. T., Davis, B. A., Okhovat, M., Ding, X., Dumesic, P., Grogan, T. R., Williams, K. J., Morselli, M., et al. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00970-x · Cited by 33 · see citing works
MKP-1 coordinates ordered macrophage-phenotype transitions essential for stem cell-dependent tissue repair
Perdiguero, E., Kharraz, Y., Serrano, A. L., & Muñoz-Cánoves, P. (2012) · Cell Cycle · doi:10.4161/cc.11.5.19374 · Cited by 30 · see citing works
Calorie restriction prevents diet‐induced insulin resistance independently of PGC‐1‐driven mitochondrial biogenesis in white adipose tissue
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Authors: Chawla, A., Nguyen, K. D., & Goh, Y. P. S.
Affiliations: University of California, San Francisco (US)
Corresponding author: Chawla, Ajay
ORCID: Chawla, Ajay
Nguyen, Khoa D.
Venue: Nature reviews. Immunology
Publisher: Springer Science and Business Media LLC
Published: 2011-10-10
Volume: 11
Issue: 11
Pages: 738-749
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri3071
PMC: PMC3383854
OpenAlex: W2040153748
Cited by: 1,314
References: 101
Citations by year: 2026: 35 · 2025: 58 · 2024: 60 · 2023: 63 · 2022: 101 · 2021: 108 · 2020: 103 · 2019: 113 · 2018: 99 · 2017: 120 · 2016: 111 · 2015: 101 · 2014: 97 · 2013: 84 · 2012: 58
FWCI: 9.02
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Larry L. Hillblom Foundation
National Institutes of Health (DP1OD006415)
National Heart, Lung, and Blood Institute (HL076746, R01HL076746)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK081405, DK076760, R01DK076760, R01DK094641)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (DP1AR064158)
Topics: Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords: adipose tissue macrophages, macrophage polarization, M1/M2 macrophages, insulin resistance, obesity, metabolic disorders, inflammation, metabolic homeostasis, immune-metabolic crosstalk, macrophage recruitment
MeSH terms: Animals, Homeostasis, Humans, Insulin Resistance, Macrophage Activation, Macrophages, Obesity, Cytokines, Models, Immunological, Inflammation Mediators

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