Cited by 318T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisImmune Response and Inflammation

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IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction

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Jabri, Bana, Abadie, Valérie·2015·Nature Reviews Immunology

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Abstract

In this Opinion article, we discuss the function of tissues as a crucial checkpoint for the regulation of effector T cell responses, and the notion that interleukin-15 (IL-15) functions as a danger molecule that communicates to the immune system that the tissue is under attack and poises it to mediate tissue destruction. More specifically, we propose that expression of IL-15 in tissues promotes T helper 1 cell-mediated immunity and provides co-stimulatory signals to effector cytotoxic T cells to exert their effector functions and drive tissue destruction. Therefore, we think that IL-15 contributes to tissue protection by promoting the elimination of infected cells but that when its expression is chronically dysregulated, it can promote the development of complex T cell-mediated disorders associated with tissue destruction, such as coeliac disease and type 1 diabetes.

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Authors: Jabri, B., & Abadie, V.
Affiliations: CHU Sainte-Justine Research Center (CA)
Corresponding author: Abadie, Valérie
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2015-11-16
Volume: 15
Issue: 12
Pages: 771-783
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri3919
PMC: PMC5079184
OpenAlex: W2189537077
Cited by: 315
References: 163
Citations by year: 2026: 11 · 2025: 34 · 2024: 44 · 2023: 20 · 2022: 32 · 2021: 48 · 2020: 29 · 2019: 30 · 2018: 25 · 2017: 31 · 2016: 11
FWCI: 2.14
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: University of Chicago
Hospital for Sick Children
National Institute of Diabetes and Digestive and Kidney Diseases (R01_DK67180, R01DK098435, R01DK067180, DK42086, P30DK042086)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: IL-15, damage-associated molecular patterns, tissue-resident T cells, tissue destruction, sterile inflammation, T cell-mediated autoimmunity, Th1 cells, cytotoxic T lymphocytes, costimulation, tissue protection, celiac disease, type 1 diabetes
MeSH terms: Bacterial Infections, Celiac Disease, Diabetes Mellitus, Type 1, Humans, Immunity, Cellular, Killer Cells, Natural, Protein Binding, T-Lymphocytes, Signal Transduction, CD8-Positive T-Lymphocytes, Th1 Cells, Models, Immunological, Interleukin-15, Interleukin-15 Receptor alpha Subunit

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IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction

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