Spatial map of human T cell compartmentalization and maintenance over decades of life
Open accessAbstract
Mechanisms for human memory T cell differentiation and maintenance have largely been inferred from studies of peripheral blood, though the majority of T cells are found in lymphoid and mucosal sites. We present here a multidimensional, quantitative analysis of human T cell compartmentalization and maintenance over six decades of life in blood, lymphoid, and mucosal tissues obtained from 56 individual organ donors. Our results reveal that the distribution and tissue residence of naive, central, and effector memory, and terminal effector subsets is contingent on both their differentiation state and tissue localization. Moreover, T cell homeostasis driven by cytokine or TCR-mediated signals is different in CD4+ or CD8+ T cell lineages, varies with their differentiation stage and tissue localization, and cannot be inferred from blood. Our data provide an unprecedented spatial and temporal map of human T cell compartmentalization and maintenance, supporting distinct pathways for human T cell fate determination and homeostasis.
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Both CD8+ and CD4+ Trm have been identified in human skin, lung, intestines, salivary glands, bone marrow, brain, spleen, tonsils, and lymph nodes.
“Both CD8+ and CD4+ Trm have been identified in the human skin, lung, intestines, salivary glands, bone marrow, brain, spleen, tonsils, and lymph nodes [241, 244, 246, 253-259].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [254]
A recent study found approximately equal loss of naive T cell subsets in spleen and selected lymphoid tissues, without preferential CD8+ loss.
“a recent study found an approximately equal loss of naive T cell subsets in spleen and selected lymphoid tissues, without preference for CD8+ T cells”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Thome et al., 2014
These T-cell changes are commonly reported in blood and can also extend to lymphoid tissues and organs such as spleen, lymph nodes, lung and gut in old subjects.
“These cellular changes are commonly reported in the circulation (i.e., the blood) [73], but can also be extended to lymphoid tissues and organs (e.g., spleen, lymph nodes, lung and gut) of old subjects [74].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [74]
Cites
Diversity and Evenness: A Unifying Notation and Its Consequences
Hill, M. O. (1973) · Ecology · doi:10.2307/1934352 · Cited by 6,355 · see citing works
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · see citing works
Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
Sallusto, F., Geginat, J., & Lanzavecchia, A. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104702 · Cited by 3,067 · see citing works
Homeostasis of Naive and Memory T Cells
Surh, C. D., & Sprent, J. (2008) · Immunity · doi:10.1016/j.immuni.2008.11.002 · Cited by 1,193 · see citing works
CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs
Shiow, L. R., Rosen, D. B., Brdičková, N., Xu, Y., An, J., Lanier, L. L., Cyster, J. G., & Matloubian, M. (2006) · Nature · doi:10.1038/nature04606 · Cited by 1,189 · see citing works
Comprehensive assessment of T-cell receptor β-chain diversity in αβ T cells
Robins, H. S., Campregher, P. V., Srivastava, S. K., Wacher, A., Turtle, C. J., Kahsai, O., Riddell, S. R., Warren, E. H., & Carlson, C. S. (2009) · Blood · doi:10.1182/blood-2009-04-217604 · Cited by 1,122 · see citing works
Human memory T cells: generation, compartmentalization and homeostasis
Farber, D. L., Yudanin, N. A., & Restifo, N. P. (2014) · Nature Reviews Immunology · doi:10.1038/nri3567 · Cited by 897 · see citing works
Self-citationDistribution and compartmentalization of human circulating and tissue-resident memory T cell subsets
Sathaliyawala, T., Kubota, M., Yudanin, N., Turner, D., Camp, P., Thome, J. J. C., Bickham, K. L., Lerner, H., Goldstein, M., Sykes, M., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.09.020 · Cited by 848 · see citing works
Self-citationAsymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses
Chang, J. T., Palanivel, V., Kinjyo, I., Schambach, F., Intlekofer, A. M., Banerjee, A., Longworth, S. A., Vinup, K. E., Mrass, P., Oliaro, J., et al. (2007) · Science · doi:10.1126/science.1139393 · Cited by 845 · see citing works
Memory T Cell Subsets, Migration Patterns, and Tissue Residence
Mueller, S. N., Gebhardt, T., Carbone, F., & Heath, W. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095954 · Cited by 842 · see citing works
Skon, C. N., Lee, J.-Y., Anderson, K. G., Masopust, D., Hogquist, K. A., & Jameson, S. C. (2013) · Nature Immunology · doi:10.1038/ni.2745 · Cited by 817 · see citing works
The Vast Majority of CLA+ T Cells Are Resident in Normal Skin
Clark, R. A., Chong, B., Mirchandani, N., Brinster, N. K., Yamanaka, K.-I., Dowgiert, R. K., & Kupper, T. S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.4431 · Cited by 796 · see citing works
Interleukin-7 receptor expression: intelligent design
Mazzucchelli, R. I., & Durum, S. K. (2007) · Nature reviews. Immunology · doi:10.1038/nri2023 · Cited by 649 · see citing works
Casey, K. A., Fraser, K. A., Schenkel, J. M., Moran, A. E., Abt, M. C., Beura, L. K., Lucas, P. J., Artis, D., Wherry, E. J., Hogquist, K. A., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200402 · Cited by 642 · see citing works
Schmidt, D., Goronzy, J. J., & Weyand, C. M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118638 · Cited by 482 · see citing works
Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice.
Schön, M. P., Arya, A., Murphy, E. A., Adams, C. M., Strauch, U., Agace, W. W., Marsal, J., Donohue, J. P., Her, H., Beier, D. R., et al. (1999) · PubMed · Cited by 424 · see citing works
Lung niches for the generation and maintenance of tissue-resident memory T cells
Turner, D., Bickham, K. L., Thome, J. J. C., Kim, C. Y., D’Ovidio, F., Wherry, E. J., & Färber, D. L. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.67 · Cited by 399 · see citing works
Self-citationMucosal T Lymphocyte Numbers Are Selectively Reduced in Integrin αE (CD103)-Deficient Mice
Schön, M. P., Arya, A., Murphy, E. A., Adams, C. M., Strauch, U., Agace, W. W., Marsal, J., Donohue, J. P., Her, H., Beier, D. R., et al. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.11.6641 · Cited by 399 · see citing works
Saule, P., Trauet, J., Dutriez, V., Lekeux, V., Dessaint, J., & Labalette, M. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.11.001 · Cited by 369 · see citing works
Cutting Edge: Gut Microenvironment Promotes Differentiation of a Unique Memory CD8 T Cell Population
Masopust, D., Vezys, V., Wherry, E. J., Barber, D. L., & Ahmed, R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.4.2079 · Cited by 357 · see citing works
CCR7 Expression and Memory T Cell Diversity in Humans
Campbell, J. J., Murphy, K. E., Kunkel, E. J., Brightling, C. E., Soler, D., Shen, Z., Boisvert, J., Greenberg, H. B., Vierra, M. A., Goodman, S. B., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.2.877 · Cited by 335 · see citing works
Campbell, J. J., Bowman, E. P., Murphy, K. E., Youngman, K. R., Siani, M. A., Thompson, D. A., Wu, L., Zlotnik, A., & Butcher, E. C. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.4.1053 · Cited by 316 · see citing works
Bankovich, A. J., Shiow, L. R., & Cyster, J. G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.123299 · Cited by 310 · see citing works
Skin-resident T cells: the ups and downs of on site immunity
Clark, R. A. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.247 · Cited by 298 · see citing works
Expansion of unusual CD4+ T cells in severe rheumatoid arthritis
Martens, P. B., Goronzy, J. J., Schaid, D. J., & Weyand, C. M. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400615 · Cited by 290 · see citing works
Purwar, R., Campbell, J. J., Murphy, G. F., Richards, W. G., Clark, R. A., & Kupper, T. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016245 · Cited by 286 · see citing works
Quantifying T lymphocyte turnover
de Boer, R. J., & Perelson, A. S. (2013) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2012.12.025 · Cited by 241 · see citing works
Antiviral CD4+ memory T cells are IL-15 dependent
Purton, J. F., Tan, J. T., Rubinstein, M. P., Kim, D. M., Sprent, J., & Surh, C. D. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061805 · Cited by 235 · see citing works
Lineage relationship of effector and memory T cells
Restifo, N. P., & Gattinoni, L. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.09.003 · Cited by 230 · see citing works
Vallejo, A. N., Brandes, J. C., Weyand, C. M., & Goronzy, J. J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.11.6572 · Cited by 209 · see citing works
The precursors of memory: models and controversies
Ahmed, R., Bevan, M. J., Reiner, S. L., & Fearon, D. T. (2009) · Nature reviews. Immunology · doi:10.1038/nri2619 · Cited by 202 · see citing works
Immunosequencing: applications of immune repertoire deep sequencing
Robins, H. S. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.09.017 · Cited by 199 · see citing works
Rapid Turnover of Effector–Memory CD4+ T Cells in Healthy Humans
Macallan, D. C., Wallace, D. L., Zhang, Y., de Lara, C., Worth, A. T., Ghattas, H., Griffin, G. E., Beverley, P. C. L., & Tough, D. F. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040341 · Cited by 193 · see citing works
Réthi, B., Fluur, C., Atlas, A., Krzyżowska, M., Mowafi, F., Grützmeier, S., Milito, A. D., Bellocco, R., Falk, K. I., Rajnavölgyi, É., et al. (2005) · AIDS · doi:10.1097/01.aids.0000189848.75699.0f · Cited by 138 · see citing works
Selective Targeting of Human Alloresponsive CD8+ Effector Memory T Cells Based on CD2 Expression
Lo, D. J., Weaver, T. A., Stempora, L., Mehta, A. K., Ford, M. L., Larsen, C. P., & Kirk, A. D. (2010) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2010.03317.x · Cited by 134 · see citing works
CD28 loss in senescent CD4+ T cells: reversal by interleukin-12 stimulation
Warrington, K. J., Vallejo, A. N., Weyand, C. M., & Goronzy, J. J. (2003) · Blood · doi:10.1182/blood-2002-08-2574 · Cited by 132 · see citing works
Cognate antigen directs CD8+ T cell migration to vascularized transplants
Walch, J., Zeng, Q., Li, Q., Oberbarnscheidt, M. H., Hoffman, R. A., Williams, A. L., Rothstein, D. M., Shlomchik, W. D., Kim, J. V., Camirand, G., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66722 · Cited by 118 · see citing works
Wang, X. Z., Stepp, S. E., Brehm, M. A., Chen, H. D., Selin, L. K., & Welsh, R. M. (2003) · Immunity · doi:10.1016/s1074-7613(03)00116-x · Cited by 81 · see citing works
Strauch, U., Mueller, R. C., Li, X. Y., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.5.3506 · Cited by 73 · see citing works
Regulation of CD103 Expression by CD8+ T Cells Responding to Renal Allografts
Wang, D., Yuan, R., Feng, Y., El-Asady, R. S., Färber, D. L., Gress, R. E., Lucas, P. J., & Hadley, G. A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.1.214 · Cited by 67 · see citing works
Do most lymphocytes in humans really reside in the gut?
Ganusov, V., & de Boer, R. D. (2007) · Trends in immunology · doi:10.1016/j.it.2007.08.009 · Cited by 60 · see citing works
Tissue‐resident T cells, in situ immunity and transplantation
Turner, D., Gordon, C. L., & Färber, D. L. (2014) · Immunological Reviews · doi:10.1111/imr.12149 · Cited by 56 · see citing works
Loss of CD127 expression links immune activation and CD4+ T cell loss in HIV infection
Kiazyk, S. A. K., & Fowke, K. R. (2008) · Trends in Microbiology · doi:10.1016/j.tim.2008.08.011 · Cited by 49 · see citing works
CCR7 Plays No Appreciable Role in Trafficking of Central Memory CD4 T Cells to Lymph Nodes
Lugt, B. V., Tubo, N., Nizza, S. T., Boes, M., Malissen, B., Fuhlbrigge, R., Kupper, T., & Campbell, J. (2013) · Journal of Immunology · doi:10.4049/jimmunol.1200938 · Cited by 40 · see citing works
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Kumar, B. V., Ma, W., Miron, M., Granot, T., Guyer, R. S., Carpenter, D. J., Senda, T., Sun, X., Ho, S.-H., Lerner, H., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.078 · Cited by 1,068 · see citing works
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- Authors
- Thome, J. J. C., Yudanin, N., Ohmura, Y., Kubota, M., Grinshpun, B., Sathaliyawala, T., Kato, T., Lerner, H., Shen, Y., & Farber, D. L.
- Affiliations
- Columbia University Irving Medical Center (US)
- Columbia University (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 159
- Issue
- 4
- Pages
- 814-828
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2006192795
- Cited by
- 587
- References
- 44
- Citations by year
- 2026: 39 · 2025: 40 · 2024: 37 · 2023: 40 · 2022: 56 · 2021: 84 · 2020: 66 · 2019: 61 · 2018: 60 · 2017: 36 · 2016: 43 · 2015: 24 · 2013: 1
- FWCI
- 15.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (F31AG047003)
- National Institute of Allergy and Infectious Diseases (P01AI106697, P01AI06697, RC1AI086164)
- National Center for Research Resources (S10RR027050)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- T cell compartmentalization, memory T cells, T cell homeostasis, lymphoid tissue, mucosal tissues, naive T cells, central memory T cells, effector memory T cells, CD4+ T cells, CD8+ T cells, T cell differentiation, T cell fate determination, T cell senescence, organ donors
- MeSH terms
- Adolescent, Adult, Aged, Aging, Cell Differentiation, Child, Child, Preschool, Humans, Lymphoid Tissue, Middle Aged, Mucous Membrane, Receptors, Antigen, T-Cell, T-Lymphocytes, Tissue Donors, T-Lymphocyte Subsets, CD28 Antigens, Interleukin-7 Receptor alpha Subunit, Young Adult
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