Cited by 318T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisImmune Response and Inflammation

The DOI matches its Crossref record; 163 of the 163 references it cites were found in a registry or an index.

IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction

Open access

Jabri, Bana, Abadie, Valérie·2015·Nature Reviews Immunology

Open this paper in CoChat — free account

Abstract

In this Opinion article, we discuss the function of tissues as a crucial checkpoint for the regulation of effector T cell responses, and the notion that interleukin-15 (IL-15) functions as a danger molecule that communicates to the immune system that the tissue is under attack and poises it to mediate tissue destruction. More specifically, we propose that expression of IL-15 in tissues promotes T helper 1 cell-mediated immunity and provides co-stimulatory signals to effector cytotoxic T cells to exert their effector functions and drive tissue destruction. Therefore, we think that IL-15 contributes to tissue protection by promoting the elimination of infected cells but that when its expression is chronically dysregulated, it can promote the development of complex T cell-mediated disorders associated with tissue destruction, such as coeliac disease and type 1 diabetes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nri3919

Cites

163 of 163 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
Dong, H., Strome, S. E., Salomao, D. R., Tamura, H., Hirano, F., Flies, D. B., Roche, P. C., Lu, J., Zhu, G., Tamada, K., et al. (2002) · Nature Medicine · doi:10.1038/nm730 · Cited by 5,025
The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer
Zhang, L., Xu, J., Zhang, X., Zhang, Y., Wang, L., Huang, X., & Xu, Z. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479442 · Cited by 4,090
Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA.
Bauer, S., Groh, V., Wu, J., Steinle, A., Phillips, J., Lanier, L., & Spies, T. (1999) · Science · doi:10.1126/science.285.5428.727 · Cited by 3,272
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
Iwai, Y., Ishida, M., Tanaka, Y., Okazaki, T., Honjo, T., & Minato, N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192461099 · Cited by 3,261
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism
Coombes, J. L., Siddiqui, K. R. R., Arancibia-Cárcamo, C. V., Hall, J. A., Sun, C., Belkaid, Y., & Powrie, F. M. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070590 · Cited by 2,708
European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease
Husby, S., Koletzko, S., Korponay‐Szabó, I. R., Mearin, M. L., Phillips, A., Shamir, R., Troncone, R., Giersiepen, K., Branski, D., Catassi, C., et al. (2012) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31821a23d0 · Cited by 2,683
Reciprocal T H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid
Mucida, D., Park, Y., Kim, G., Turovskaya, O., Scott, I., Kronenberg, M., & Cheroutre, H. (2007) · Science · doi:10.1126/science.1145697 · Cited by 1,982
X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
Wildin, R. S., Ramsdell, F., Peake, J., Faravelli, F., Casanova, J., Buist, N. R. M., Levy‐Lahad, E., Mazzella, M., Goulet, O., Perroni, L., et al. (2001) · Nature Genetics · doi:10.1038/83707 · Cited by 1,916
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
Sun, C., Hall, J. A., Blank, R. B., Bouladoux, N. J., Oukka, M., Mora, J. R., & Belkaid, Y. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070602 · Cited by 1,880

Flagged first, then by citations

Show all 163 references

Sorted by citations

CD49a Expression Defines Tissue-Resident CD8 + T Cells Poised for Cytotoxic Function in Human Skin
Cheuk, S., Schlums, H., Gallais Sérézal, I., Martini, E., Chiang, S. C., Marquardt, N., Gibbs, A., Detlofsson, E., Introini, A., Forkel, M., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.01.009 · Cited by 678
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531
Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity
Tilg, H., Adolph, T. E., Dudek, M., & Knolle, P. A. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00501-9 · Cited by 539
Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease
Bouziat, R., Hinterleitner, R., Brown, J. J., Stencel-Baerenwald, J., Ikizler, M. R., Mayassi, T., Meisel, M., Kim, S. M., Discepolo, V., Pruijssers, A. J. P., et al. (2017) · Science · doi:10.1126/science.aah5298 · Cited by 451
Self-citation
Inflammatory and Microbiota-Related Regulation of the Intestinal Epithelial Barrier
Barbara, G., Barbaro, M. R., Fuschi, D., Palombo, M., Falangone, F., Cremon, C., Marasco, G., & Stanghellini, V. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.718356 · Cited by 446
CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease
Janelidze, S., Mattsson, N., Stomrud, E., Lindberg, O., Palmqvist, S., Zetterberg, H., Blennow, K., & Hansson, O. (2018) · Neurology · doi:10.1212/wnl.0000000000006082 · Cited by 359
Preinfusion polyfunctional anti-CD19 chimeric antigen receptor T cells are associated with clinical outcomes in NHL
Rossi, J. M., Paczkowski, P., Shen, Y.-W., Morse, K., Flynn, B., Kaiser, A., Ng, C., Gallatin, K., Cain, T., Fan, R., et al. (2018) · Blood · doi:10.1182/blood-2018-01-828343 · Cited by 328
Alopecia areata: a review of disease pathogenesis
Rajabi, F., Drake, L. A., Senna, M. M., & Rezaei, N. (2018) · British Journal of Dermatology · doi:10.1111/bjd.16808 · Cited by 313
Intestinal Epithelial and Intraepithelial T Cell Crosstalk Mediates a Dynamic Response to Infection
van Konijnenburg, D. P. H., Reis, B. S., Pedicord, V. A., Farache, J., Victora, G. D., & Mucida, D. (2017) · Cell · doi:10.1016/j.cell.2017.08.046 · Cited by 279
Rheumatoid arthritis: Recent advances on its etiology, role of cytokines and pharmacotherapy
Alam, J., Jantan, I., & Bukhari, S. N. A. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.05.055 · Cited by 286
Cytokines in CAR T Cell–Associated Neurotoxicity
Gust, J., Ponce, R. A., Liles, W. C., Garden, G. A., & Turtle, C. J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.577027 · Cited by 279
Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19
Bermejo-Martín, J. F., González‐Rivera, M., Almansa, R., Micheloud, D., Tedim, A. P., Domínguez‐Gil, M., Resino, S., Martín-Fernández, M., Ryan, P., Pérez‐García, F., et al. (2020) · Critical Care · doi:10.1186/s13054-020-03398-0 · Cited by 264
Targeting the Janus Kinase Family in Autoimmune Skin Diseases
Howell, M. D., Kuo, F. I., & Smith, P. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02342 · Cited by 253
Tissue adaptation of regulatory and intraepithelial CD4 + T cells controls gut inflammation
Sujino, T., London, M., Hoytema van Konijnenburg, D. P., Rendon, T., Buch, T., Silva, H. M., Lafaille, J. J., Reis, B. S., & Mucida, D. (2016) · Science · doi:10.1126/science.aaf3892 · Cited by 250
IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease
Abadie, V., Kim, S. M., Lejeune, T., Palanski, B. A., Ernest, J. D., Tastet, O., Voisine, J., Discepolo, V., Marietta, E. V., Hawash, M. B. F., et al. (2020) · Nature · doi:10.1038/s41586-020-2003-8 · Cited by 231
Self-citation
T Cells in Celiac Disease
Jabrì, B., & Sollid, L. M. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601693 · Cited by 240
Strategies to Address Chimeric Antigen Receptor Tonic Signaling
Ajina, A., & Maher, J. F. (2018) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-1097 · Cited by 251
Cytokine‐ and chemokine‐induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy
Bhat, A. A., Nisar, S., Singh, M. K., Ashraf, B., Masoodi, T., Prasad, C. P., Sharma, A., Maacha, S., Karedath, T., Hashem, S., et al. (2022) · 癌症：英文版 · doi:10.1002/cac2.12295 · Cited by 251
Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality
Hinks, T., Marchi, E., Jabeen, M., Olshansky, M., Kurioka, A., Pediongco, T. J., Meehan, B. S., Kostenko, L., Turner, S. J., Corbett, A. J., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.039 · Cited by 230
Mucosal immune system of the gastrointestinal tract: maintaining balance between the good and the bad
Ahluwalia, B., Magnusson, M. K., & Öhman, L. (2017) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2017.1349173 · Cited by 242
Cytokine-Induced Modulation of Colorectal Cancer
Mager, L. F., Wasmer, M.-H., Rau, T. T., & Krebs, P. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00096 · Cited by 223
The Immunobiology and Pathogenesis of Celiac Disease
Iversen, R., & Sollid, L. M. (2022) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-031521-032634 · Cited by 222
Recent Advances in Engineered Materials for Immunotherapy‐Involved Combination Cancer Therapy
Liang, J., Luo, G., Chen, W., & Zhang, X. (2021) · Advanced Materials · doi:10.1002/adma.202007630 · Cited by 207
METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells
Song, H., Song, J., Cheng, M., Zheng, M., Wang, T., Tian, S., Flavell, R. A., Zhu, S., Li, H., Ding, C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25803-0 · Cited by 206
Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease
Mayassi, T., Ladell, K., Gudjonson, H., McLaren, J. E., Shaw, D. G., Tran, M. T., Rokicka, J. J., Lawrence, I., Grenier, J., van Unen, V., et al. (2019) · Cell · doi:10.1016/j.cell.2018.12.039 · Cited by 190
Diverse developmental pathways of intestinal intraepithelial lymphocytes
McDonald, B. D., Jabri, B., & Bendelac, A. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0013-7 · Cited by 190
The activation of bystander CD8+ T cells and their roles in viral infection
Kim, T.-S., & Shin, E. (2019) · Experimental and Molecular Medicine · doi:10.1038/s12276-019-0316-1 · Cited by 190
Alarmins: Feel the Stress
Rider, P., Voronov, E., Dinarello, C. A., Apte, R. N., & Cohen, I. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601342 · Cited by 186
Cytokine-Mediated Crosstalk between Immune Cells and Epithelial Cells in the Gut
Mahapatro, M., Erkert, L., & Becker, C. (2021) · Cells · doi:10.3390/cells10010111 · Cited by 184
Unique transcriptional and protein-expression signature in human lung tissue-resident NK cells
Marquardt, N., Kekäläinen, E., Chen, P., Lourda, M., Wilson, J. N., Scharenberg, M., Bergman, P., Al‐Ameri, M., Hård, J., Mold, J. E., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11632-9 · Cited by 154
Tissue-resident CD8 + T cells drive age-associated chronic lung sequelae after viral pneumonia
Goplen, N. P., Wu, Y., Son, Y. M., Li, C., Wang, Z., Cheon, I. S., Jiang, L., Zhu, B., Ayasoufi, K., Chini, E. N., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abc4557 · Cited by 148
Integrative single-cell analysis of human colorectal cancer reveals patient stratification with distinct immune evasion mechanisms
Chu, X., Li, X., Zhang, Y., Dang, G., Miao, Y., Xu, W., Wang, J., Zhang, Z., & Cheng, S. (2024) · Nature Cancer · doi:10.1038/s43018-024-00807-z · Cited by 183
Human intraepithelial lymphocytes
Mayassi, T., & Jabri, B. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0016-5 · Cited by 138
Significance of bystander T cell activation in microbial infection
Lee, H., Jeong, S., & Shin, E.-C. (2022) · Nature Immunology · doi:10.1038/s41590-021-00985-3 · Cited by 134
Interleukin-15 (dys)regulation of lymphoid homeostasis: Implications for therapy of autoimmunity and cancer
Waldmann, T. A., Miljković, M. D., & Conlon, K. C. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20191062 · Cited by 129
A multilayered immune system through the lens of unconventional T cells
Mayassi, T., Barreiro, L. B., Rossjohn, J., & Jabrì, B. (2021) · Nature · doi:10.1038/s41586-021-03578-0 · Cited by 131
Engineering interferons and interleukins for cancer immunotherapy
Holder, P. G., Lim, S. A., Huang, C., Sharma, P. A., Dagdas, Y. S., Bulutoglu, B., & Sockolosky, J. T. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114112 · Cited by 130
Sputum autoantibodies in patients with severe eosinophilic asthma
Mukherjee, M., Bulir, D. C., Radford, K., Kjarsgaard, M., Huang, C., Jacobsen, E. A., Ochkur, S. I., Catuneanu, A., Lamothe-Kipnes, H., Mahony, J. B., et al. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.06.033 · Cited by 128
FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity
Mysore, V., Culleré, X., Mears, J., Rosetti, F., Okubo, K., Liew, P. X., Zhang, F., Madera-Salcedo, I. K., Rosenbauer, F., Stone, R. M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24591-x · Cited by 129
Intestinal Barrier Function in Gluten-Related Disorders
da Silva, D. C., Delbue, D., Itzlinger, A., Moerkens, R., Withoff, S., Branchi, F., & Schümann, M. (2019) · Nutrients · doi:10.3390/nu11102325 · Cited by 136
IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection
Younes, S., Freeman, M. L., Mudd, J. C., Shive, C. L., Reynaldi, A., Panigrahi, S., Estes, J. D., Deléage, C., Lucero, C. M., Anderson, J. L., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85996 · Cited by 118
Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Associations, Outcomes, and Pathobiology—Thirty Years of Progress but Still Much to Be Done
Stern, R. S., & Divito, S. J. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.01.003 · Cited by 120
Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies
Gilhar, A., Schrum, A. G., Etzioni, A., Waldmann, H., & Paus, R. (2016) · Autoimmunity Reviews · doi:10.1016/j.autrev.2016.03.008 · Cited by 113
Oxidative stress-induced IL-15 trans-presentation in keratinocytes contributes to CD8+ T cells activation via JAK-STAT pathway in vitiligo
Chen, X., Guo, W., Chang, Y., Chen, J., Kang, P., Yi, X., Cui, T., Guo, S., Xiao, Q., Jian, Z., et al. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.05.011 · Cited by 110
Human enteric viruses autonomously shape inflammatory bowel disease phenotype through divergent innate immunomodulation
Adiliaghdam, F., Amatullah, H., Digumarthi, S., Saunders, T. L., Rahman, R., Wong, L. P., Sadreyev, R. I., Droit, L., Paquette, J., Goyette, P., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abn6660 · Cited by 109
Intestinal epithelium, intraepithelial lymphocytes and the gut microbiota - Key players in the pathogenesis of celiac disease
Cukrowská, B., Sowińska, A., Bierła, J. B., Czarnowska, E., Rybak, A., & Grzybowska‐Chlebowczyk, U. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i42.7505 · Cited by 111
NF-κB/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification
Barruet, E., Morales, B. M., Cain, C. J., Ton, A. N., Wentworth, K. L., Chan, T. V., Moody, T. A., Haks, M. C., Ottenhoff, T. H. M., Hellman, J., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.122958 · Cited by 107
Association Between Inflammatory Bowel Diseases and Celiac Disease: A Systematic Review and Meta-Analysis
Pinto-Sánchez, M. I., Seiler, C., Santesso, N. A., Alaedini, A., Semrad, C. E., Lee, A. R., Berčík, P., Lebwohl, B., Leffler, D. A., Kelly, C. P., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.05.016 · Cited by 100
IL-15 supports the generation of protective lung-resident memory CD4 T cells
Strutt, T. M., Dhume, K., Finn, C. M., Hwang, J. H., Castonguay, C. H., Swain, S. L., & McKinstry, K. K. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.101 · Cited by 97
Understanding Celiac Disease by Genomics
Withoff, S., Li, Y., Jonkers, I. H., & Wijmenga, C. (2016) · Trends in Genetics · doi:10.1016/j.tig.2016.02.003 · Cited by 96
Cytotoxic granzyme C–expressing ILC1s contribute to antitumor immunity and neonatal autoimmunity
Nixon, B. G., Chou, C., Krishna, C., Dadi, S., Michel, A. O., Cornish, A. E., Kansler, E. R., Do, M. H., Wang, X., Capistrano, K. J., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abi8642 · Cited by 101
Transglutaminase 2 in human diseases
Szondy, Z., Korponay-Szabo, I. R., Király, R., Sarang, Z., & Tsay, G. J. (2017) · Biomedicine · doi:10.1051/bmdcn/2017070315 · Cited by 93
Interleukin-15 promotes intestinal dysbiosis with butyrate deficiency associated with increased susceptibility to colitis
Meisel, M., Mayassi, T., Fehlner-Peach, H., Koval, J., O'Brien, S. L., Hinterleitner, R., Lesko, K., Kim, S. M., Bouziat, R., Chen, L., et al. (2016) · The ISME Journal · doi:10.1038/ismej.2016.114 · Cited by 95
PD-1 blockade-unresponsive human tumor-infiltrating CD8+ T cells are marked by loss of CD28 expression and rescued by IL-15
Kim, K. H., Kim, H. K., Kim, H., Kim, C. G., Lee, H., Han, J. W., Choi, S. J., Jeong, S., Jeon, M., Kim, H., et al. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-0427-6 · Cited by 90
Intraepithelial Lymphocytes of the Intestine
Lockhart, A. A. K., Mucida, D., & Bilate, A. M. B. (2024) · Annual Review of Immunology · doi:10.1146/annurev-immunol-090222-100246 · Cited by 92
The NKG2D/NKG2DL Axis in the Crosstalk Between Lymphoid and Myeloid Cells in Health and Disease
Stojanovic, A., Correia, M. P., & Cerwenka, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00827 · Cited by 92
Interleukin-15 in autoimmunity
Allard‐Chamard, H., Mishra, H. K., Nandi, M., Mayhue, M., Menéndez, A., Ilangumaran, S., & Ramanathan, S. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155258 · Cited by 84
Tissue-resident memory T cell maintenance during antigen persistence requires both cognate antigen and interleukin-15
Tieu, R., Zeng, Q., Zhao, D., Zhang, G., Feizi, N., Manandhar, P., Williams, A. L., Popp, B. A., Wood, M. A., Demetris, A. J., et al. (2023) · Science Immunology · doi:10.1126/sciimmunol.add8454 · Cited by 88
Intestinal immune compartmentalization: implications of tissue specific determinants in health and disease
Brown, H. M., & Esterházy, D. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00420-8 · Cited by 88
Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells
Mahadevan, K. K., LeBleu, V. S., Ramirez, E. V., Chen, Y., Li, B., Sockwell, A. M., Gagea, M., Sugimoto, H., Sthanam, L. K., Tampe, D., et al. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.07.025 · Cited by 76
A human autoimmune organoid model reveals IL-7 function in coeliac disease
Santos, A. J. M., van Unen, V., Lin, Z., Chirieleison, S. M., Ha, N., Batish, A., Chan, J. E., Cedano, J., Zhang, E., Mu, Q., et al. (2024) · Nature · doi:10.1038/s41586-024-07716-2 · Cited by 79
CD137 (4-1BB) Engagement Fine-Tunes Synergistic IL-15– and IL-21–Driven NK Cell Proliferation
Vidard, L., Dureuil, C., Baudhuin, J., Vescovi, L., Durand, L., Sierra, V., & Parmantier, E. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801137 · Cited by 73
The Cytokine Network in Colorectal Cancer: Implications for New Treatment Strategies
Braumüller, H., Mauerer, B., Andris, J., Berlin, C., Wieder, T., & Kesselring, R. (2022) · Cells · doi:10.3390/cells12010138 · Cited by 81
Increased Serum Levels of IFN-γ, IL-1β, and IL-6 in Patients with Alopecia Areata and Nonsegmental Vitiligo
Tomaszewska, K. A., Kozłowska, M., Kaszuba, A., Lesiak, A., Narbutt, J., & Zalewska-Janowska, A. M. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/5693572 · Cited by 73
IL-15 in T-Cell Responses and Immunopathogenesis
Lee, H., Park, S., & Shin, E. (2024) · Immune Network · doi:10.4110/in.2024.24.e11 · Cited by 76
New Insights on Genes, Gluten, and Immunopathogenesis of Celiac Disease
Abadie, V., Han, A. S., Jabrì, B., & Sollid, L. M. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.03.042 · Cited by 75
Self-citation
Distinct human circulating NKp30 + FcεRIγ + CD8 + T cell population exhibiting high natural killer-like antitumor potential
Correia, M. P., Stojanovic, A., Bauer, K., Juraeva, D., Tykocinski, L., Lorenz, H., Brors, B., & Cerwenka, A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720564115 · Cited by 69
Interplay Between Gluten, HLA, Innate and Adaptive Immunity Orchestrates the Development of Coeliac Disease
Voisine, J., & Abadie, V. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.674313 · Cited by 78
Self-citation
Tissue adaptation: Implications for gut immunity and tolerance
Faria, A. M. C., Reis, B. S., & Mucida, D. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20162014 · Cited by 69
STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+ T cell dysregulation and accumulation
Masle‐Farquhar, E., Jackson, K., Peters, T. J., Al‐Eryani, G., Singh, M., Payne, K. J., Rao, G., Avery, D. T., Apps, G., Kingham, J., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.11.001 · Cited by 68
CD4 T-cell cytokines synergize to induce proliferation of malignant and nonmalignant innate intraepithelial lymphocytes
Kooy–Winkelaar, Y., Bouwer, D., Janssen, G. M. C., Thompson, A., Brugman, M. H., Schmitz, F., de Ru, A. H., Gils, T. V., Bouma, G., van Rood, J. J., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620036114 · Cited by 61
The elusive case of human intraepithelial T cells in gut homeostasis and inflammation
Lutter, L., van Konijnenburg, D. P. H., Brand, E. C., Oldenburg, B., & van Wijk, F. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0039-0 · Cited by 59
The Ugly Duckling Turned to Swan: A Change in Perception of Bystander-Activated Memory CD8 T Cells
Maurice, N. J., Taber, A. K., & Prlic, M. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2000937 · Cited by 57
Antigen-Presenting Human γδ T Cells Promote Intestinal CD4+ T Cell Expression of IL-22 and Mucosal Release of Calprotectin
Tyler, C. J., McCarthy, N. E., Lindsay, J. O., Stagg, A. J., Moser, B., & Eberl, M. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700003 · Cited by 59
Emerging role of Tissue Resident Memory T cells in vitiligo: From pathogenesis to therapeutics
Shah, F., Patel, S., Begum, R., & Dwivedi, M. (2021) · Autoimmunity Reviews · doi:10.1016/j.autrev.2021.102868 · Cited by 62
Deciphering the Complex Immunopathogenesis of Alopecia Areata
Udović, I. Š., Hlača, N., Massari, L. P., Brajac, I., Kaštelan, M., & Vičić, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115652 · Cited by 58
A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease
Villella, V. R., Venerando, A., Cozza, G., Esposito, S., Ferrari, E., Monzani, R., Spinella, M. C., Oikonomou, V., Renga, G., Tosco, A., et al. (2018) · The EMBO Journal · doi:10.15252/embj.2018100101 · Cited by 58
TGF-β Controls the Formation of Kidney-Resident T Cells via Promoting Effector T Cell Extravasation
Ma, C., Mishra, S., Demel, E. L., Liu, Y., & Zhang, N. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1601500 · Cited by 55
Epithelial IL-15 Is a Critical Regulator of γδ Intraepithelial Lymphocyte Motility within the Intestinal Mucosa
Hu, M. D., Ethridge, A. D., Lipstein, R., Kumar, S., Wang, Y., Jabrì, B., Turner, J. R., & Edelblum, K. L. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701603 · Cited by 54
Role of the Innate Immunity Signaling Pathway in the Pathogenesis of Sjögren’s Syndrome
Shimizu, T., Nakamura, H., & Kawakami, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063090 · Cited by 63
Longevity, clonal relationship, and transcriptional program of celiac disease–specific plasma cells
Lindeman, I., Zhou, C., Eggesbø, L. M., Miao, Z., Polak, J., Lundin, K. E. A., Jahnsen, J., Qiao, S., Iversen, R., & Sollid, L. M. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20200852 · Cited by 53
miR-34a as hub of T cell regulation networks
Hart, M., Walch‐Rückheim, B., Krammes, L., Kehl, T., Rheinheimer, S., Tänzer, T., Glombitza, B., Sester, M., Lenhof, H., Keller, A., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0670-5 · Cited by 49
IL‐15 is a biomarker involved in the development of rapidly progressive interstitial lung disease complicated with polymyositis/dermatomyositis
Shimizu, T., Koga, T., Furukawa, K., Horai, Y., Fujikawa, K., Okada, A., Okamoto, M., Endo, Y., Tsuji, S., Takatani, A., et al. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13154 · Cited by 50
Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis
Vicari, A. P., Schoepfer, A. M., Meresse, B., Goffin, L., Léger, O. J. P., Josserand, S., Guégan, N., Yousefi, S., Straumann, A., Cerf–Bensussan, N., et al. (2017) · mAbs · doi:10.1080/19420862.2017.1332553 · Cited by 48
Programming cytomegalovirus as an HIV vaccine
Picker, L. J., Lifson, J. D., Gale, M., Hansen, S. G., & Früh, K. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.02.001 · Cited by 46
The potential role of m6A modifications on immune cells and immunotherapy
Gan, L., Zhao, Y., Fu, Y., & Chen, Q. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114343 · Cited by 40
Targeting pathogenic CD8+ tissue-resident T cells with chimeric antigen receptor therapy in murine autoimmune cholangitis
Zhu, H., Yang, S.-H., Gao, C., Bian, Z.-H., Chen, X.-M., Huang, R., Meng, Q.-L., Li, X., Jin, H., Tsuneyama, K., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46654-5 · Cited by 43
The Interleukins Orchestrate Mucosal Immune Responses to Salmonella Infection in the Intestine
Huang, F. (2021) · Cells · doi:10.3390/cells10123492 · Cited by 42
Human Gastric Cancer Mesenchymal Stem Cell-Derived IL15 Contributes to Tumor Cell Epithelial-Mesenchymal Transition via Upregulation Tregs Ratio and PD-1 Expression in CD4 + T Cell
Sun, L., Wang, Q., Chen, B., Zhao, Y., Shen, B., Wang, X., Zhu, M., Li, Z., Zhao, X., Xu, C., et al. (2018) · Stem Cells and Development · doi:10.1089/scd.2018.0043 · Cited by 41
Common gamma chain cytokines and CD8 T cells in cancer
Shourian, M., Beltra, J., Bourdin, B., & Decaluwe, H. (2019) · Seminars in Immunology · doi:10.1016/j.smim.2019.101307 · Cited by 43
Intestinal tissue-resident T cell activation depends on metabolite availability
Konjar, Š., Ferreira, C., Carvalho, F. S., Figueiredo‐Campos, P., Fanczal, J., Ribeiro, S., Morais, V. A., & Veldhoen, M. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2202144119 · Cited by 41
Identification of a γc Receptor Antagonist That Prevents Reprogramming of Human Tissue-resident Cytotoxic T Cells by IL15 and IL21
Ciszewski, C., Discepolo, V., Pacis, A., Doerr, N., Tastet, O., Mayassi, T., Maglio, M., Basheer, A., Al‐Mawsawi, L. Q., Green, P. H. R., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.10.006 · Cited by 41
Gluten-Dependent Activation of CD4+ T Cells by MHC Class II–Expressing Epithelium
Rahmani, S., Galipeau, H. J., Clarizio, A. V., Wang, X., Hann, A., Rueda, G. H., Kirtikar, U., Constante, M., Wulczynski, M., Su, H., et al. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.07.008 · Cited by 41
Injury-induced myosin-specific tissue-resident memory T cells drive immune checkpoint inhibitor myocarditis
Kalinoski, H. M., Daoud, A. R., Rusinkevich, V., Jurčová, I., Talor, M. V., Welsh, R. A., Hughes, D., Zemanová, K., Stříž, I., Hooper, J. E., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2323052121 · Cited by 40
CD4 effector T cell differentiation is controlled by IL-15 that is expressed and presented in trans
Waickman, A. T., Ligons, D. L., Hwang, S., Park, J., Lazarevic, V., Sato, N., Hong, C., & Park, J. (2017) · Cytokine · doi:10.1016/j.cyto.2017.08.004 · Cited by 36
Comparative analysis of inflammatory signature profiles in eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyposis
Yao, Y., Yang, C., Yi, X., Xie, S., & Sun, H. (2020) · Bioscience Reports · doi:10.1042/bsr20193101 · Cited by 37
Cytomegalovirus Coinfection Is Associated with Increased Vascular-Homing CD57+ CD4 T Cells in HIV Infection
Chen, B., Morris, S. R., Panigrahi, S., Michaelson, G. M., Wyrick, J. M., Komissarov, A. A., Potashnikova, D. M., Lebedeva, А., Younes, S., Harth, K. C., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1900734 · Cited by 37
Rapid Depletion of Intratumoral Regulatory T Cells Induces Synchronized CD8 T- and NK-cell Activation and IFNγ-Dependent Tumor Vessel Regression
Kurebayashi, Y., Olkowski, C. P., Lane, K. C., Vasalatiy, O. V., Xu, B., Okada, R., Furusawa, A., Choyke, P. L., Kobayashi, H., & Sato, N. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-2673 · Cited by 38
Mammary intraepithelial lymphocytes promote lactogenesis and offspring fitness
Corral, D., Ansaldo, E., Delaleu, J., Pichler, A., Kabát, J., Oguz, C., Teijeiro, A., Yong, D., Abid, M., Rivera, C. A., et al. (2025) · Cell · doi:10.1016/j.cell.2025.01.028 · Cited by 37
Cytokines (IL-15, IL-21, and IFN-γ) in rheumatoid arthritis: association with positivity to autoantibodies (RF, anti-CCP, anti-MCV, and anti-PADI4) and clinical activity
Reyes‐Pérez, I. V., Sánchez‐Hernández, P. E., Muñóz-Valle, J. F., Martínez-Bonilla, G., García‐Iglesias, T., González-Díaz, V., García‐Arellano, S., Cerpa‐Cruz, S., Polanco-Cruz, J., & Ramírez‐Dueñas, M. G. (2019) · Clinical Rheumatology · doi:10.1007/s10067-019-04681-4 · Cited by 35

Authors: Jabri, B., & Abadie, V.
Affiliations: CHU Sainte-Justine Research Center (CA)
Corresponding author: Abadie, Valérie
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2015-11-16
Volume: 15
Issue: 12
Pages: 771-783
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri3919
PMC: PMC5079184
OpenAlex: W2189537077
Cited by: 315
References: 163
Citations by year: 2026: 11 · 2025: 34 · 2024: 44 · 2023: 20 · 2022: 32 · 2021: 48 · 2020: 29 · 2019: 30 · 2018: 25 · 2017: 31 · 2016: 11
FWCI: 2.14
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: University of Chicago
Hospital for Sick Children
National Institute of Diabetes and Digestive and Kidney Diseases (R01_DK67180, R01DK098435, R01DK067180, DK42086, P30DK042086)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: IL-15, damage-associated molecular patterns, tissue-resident T cells, tissue destruction, sterile inflammation, T cell-mediated autoimmunity, Th1 cells, cytotoxic T lymphocytes, costimulation, tissue protection, celiac disease, type 1 diabetes
MeSH terms: Bacterial Infections, Celiac Disease, Diabetes Mellitus, Type 1, Humans, Immunity, Cellular, Killer Cells, Natural, Protein Binding, T-Lymphocytes, Signal Transduction, CD8-Positive T-Lymphocytes, Th1 Cells, Models, Immunological, Interleukin-15, Interleukin-15 Receptor alpha Subunit

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks