Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation

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Items 201–300 of 834

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6. Genome Editing as a Treatment for the Most Prevalent Causative Genes of Autosomal Dominant Retinitis Pigmentosa
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9. Nanoparticles-mediated CRISPR-Cas9 gene therapy in inherited retinal diseases: applications, challenges, and emerging opportunities
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10. Nanoparticles Based on Poly (β-Amino Ester) and HPV16-Targeting CRISPR/shRNA as Potential Drugs for HPV16-Related Cervical Malignancy
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11. Systematic Evaluation of CRISPRa and CRISPRi Modalities Enables Development of a Multiplexed, Orthogonal Gene Activation and Repression System
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15. Repurposing type I–F CRISPR–Cas system as a transcriptional activation tool in human cells
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16. Noncoding RNAs as therapeutic targets in early stage diabetic kidney disease
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17. Towards quantitative and multiplexed in vivo functional cancer genomics
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18. High-fidelity endonuclease variant HypaCas9 facilitates accurate allele-specific gene modification in mouse zygotes
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19. Repurposing CRISPR System for Transcriptional Activation
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20. Cell Reprogramming With CRISPR/Cas9 Based Transcriptional Regulation Systems
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21. Entry receptors — the gateway to alphavirus infection
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22. An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers
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23. Diagnosis and therapy with CRISPR advanced CRISPR based tools for point of care diagnostics and early therapies
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24. Optogenetic Medicine: Synthetic Therapeutic Solutions Precision-Guided by Light
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25. In situ biomolecule production by bacteria; a synthetic biology approach to medicine
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26. CRISPR activation of endogenous genes reprograms fibroblasts into cardiovascular progenitor cells for myocardial infarction therapy
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27. Recent Advances in Genome-Editing Technology with CRISPR/Cas9 Variants and Stimuli-Responsive Targeting Approaches within Tumor Cells: A Future Perspective of Cancer Management
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28. CRISPR–Mediated Genome Editing and Gene Repression in Scheffersomyces stipitis
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29. CRISPR-based genome editing in primary human pancreatic islet cells
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30. A Review of the Recent Advances in Alzheimer’s Disease Research and the Utilization of Network Biology Approaches for Prioritizing Diagnostics and Therapeutics
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31. Multiplexed sgRNA Expression Allows Versatile Single Nonrepetitive DNA Labeling and Endogenous Gene Regulation
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32. Roads Forward for European GMO Policy—Uncertainties in Wake of ECJ Judgment Have to be Mitigated by Regulatory Reform
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33. Sulfur modification in natural RNA and therapeutic oligonucleotides
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34. Recent advances in tuning the expression and regulation of genes for constructing microbial cell factories
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35. Programmable RNA 5-methylcytosine (m5C) modification of cellular RNAs by dCasRx conjugated methyltransferase and demethylase
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36. Multimode drug inducible CRISPR/Cas9 devices for transcriptional activation and genome editing
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37. CRISPR-Based Genetic Manipulation of Candida Species: Historical Perspectives and Current Approaches
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38. Progress and Perspective of CRISPR‐Cas9 Technology in Translational Medicine
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39. Rewiring Calcium Signaling for Precise Transcriptional Reprogramming
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40. Development of drug-inducible CRISPR-Cas9 systems for large-scale functional screening
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41. Editing the Central Nervous System Through CRISPR/Cas9 Systems
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42. Challenges and opportunities with CRISPR activation in bacteria for data-driven metabolic engineering
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43. MiniCAFE, a CRISPR/Cas9-based compact and potent transcriptional activator, elicits gene expression in vivo
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44. Dual CRISPR interference and activation for targeted reactivation of X-linked endogenous FOXP3 in human breast cancer cells
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45. A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells
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46. Dual-role transcription factors stabilize intermediate expression levels
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47. Microbial CRISPRi and CRISPRa Systems for Metabolic Engineering
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48. Conditional guide RNA through two intermediate hairpins for programmable CRISPR/Cas9 function: building regulatory connections between endogenous RNA expressions
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49. CRISPR–Cas9-mediated functional dissection of 3′-UTRs
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50. Live imaging and tracking of genome regions in CRISPR/dCas9 knock-in mice
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51. Ocular delivery of CRISPR/Cas genome editing components for treatment of eye diseases
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52. Anti‐CRISPRs: The natural inhibitors for CRISPR‐Cas systems
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53. An Improved CRISPR/dCas9 Interference Tool for Neuronal Gene Suppression
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54. Epigenetic principles underlying epileptogenesis and epilepsy syndromes
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55. CRISPR/Cas Applications in Myotonic Dystrophy: Expanding Opportunities
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56. CRISPR–Cas12a system in fission yeast for multiplex genomic editing and CRISPR interference
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57. Regulation of Transcription Factors by Reactive Oxygen Species and Nitric Oxide in Vascular Physiology and Pathology
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58. New tools for old drugs: Functional genetic screens to optimize current chemotherapy
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59. Nanotechnology Promotes Genetic and Functional Modifications of Therapeutic T Cells Against Cancer
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60. A genome-scale CRISPR interference guide library enables comprehensive phenotypic profiling in yeast
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61. Therapeutic genome editing in cardiovascular diseases
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62. Exploiting CRISPR Cas9 in Three-Dimensional Stem Cell Cultures to Model Disease
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63. A CRISPR/dCas9-based transcription activated system developed in marine microalga Nannochloropsis oceanica
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64. R-loop formation by dCas9 is mutagenic in Saccharomyces cerevisiae
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65. Photocontrol of CRISPR/Cas9 function by site-specific chemical modification of guide RNA
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66. Human iPSCs and Genome Editing Technologies for Precision Cardiovascular Tissue Engineering
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67. The Future of Multiplexed Eukaryotic Genome Engineering
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68. Tools of pathway reconstruction and production of economically relevant plant secondary metabolites in recombinant microorganisms
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69. Development of an optimized synthetic Notch receptor as an in vivo cell–cell contact sensor
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70. Characterization of the essential role of bone morphogenetic protein 9 (BMP9) in osteogenic differentiation of mesenchymal stem cells (MSCs) through RNA interference
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71. Genome-Wide Association Studies of Endometrial Cancer: Latest Developments and Future Directions
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72. Cas13d-mediated multiplex RNA targeting confers a broad-spectrum resistance against RNA viruses in potato
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73. Roles and regulation of bone morphogenetic protein-7 in kidney development and diseases
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74. Inhibition of CRISPR-Cas systems by mobile genetic elements
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75. Penetration of the blood-brain barrier by peripheral neuropeptides: new approaches to enhancing transport and endogenous expression
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76. One-Pot Visual Detection of African Swine Fever Virus Using CRISPR-Cas12a
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77. The expanding CRISPR toolbox for natural product discovery and engineering in filamentous fungi
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78. CRISPR/Cas9‐mediated 2‐sgRNA cleavage facilitates Pseudorabies virus editing
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79. Mathematical Modeling of RNA-Based Architectures for Closed Loop Control of Gene Expression
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80. CRISPR‐Enabled Tools for Engineering Microbial Genomes and Phenotypes
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81. A CRISPR Interference of CBP and p300 Selectively Induced Synthetic Lethality in Bladder Cancer Cells In Vitro
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82. Integrative analyses of noncoding RNAs reveal the potential mechanisms augmenting tumor malignancy in lung adenocarcinoma
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83. Enhancing site-specific DNA integration by a Cas9 nuclease fused with a DNA donor-binding domain
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84. Development and application of CRISPR-based genetic tools in Bacillus species and Bacillus phages
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85. Induced Pluripotent Stem Cells and Organoids in Advancing Neuropathology Research and Therapies
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86. The expanding footprint of CRISPR/Cas9 in the plant sciences
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87. Optogenetics sheds new light on tissue engineering and regenerative medicine
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88. Novel Prokaryotic CRISPR-Cas12a-Based Tool for Programmable Transcriptional Activation and Repression
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89. CRISPR/Cas9 based genome editing for targeted transcriptional control in triple-negative breast cancer
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90. Characterizing and Learning Equivalence Classes of Causal DAGs under Interventions
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91. Antiviral Defenses in Plants through Genome Editing
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92. Re-engineered RNA-Guided FokI-Nucleases for Improved Genome Editing in Human Cells
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93. Emerging Approaches for Spatiotemporal Control of Targeted Genome with Inducible CRISPR-Cas9
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94. Split Cas9, Not Hairs − Advancing the Therapeutic Index of CRISPR Technology
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95. Mouse medulloblastoma driven by CRISPR activation of cellular Myc
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96. A novel cloning strategy for one-step assembly of multiplex CRISPR vectors
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97. Generation and validation of versatile inducible CRISPRi embryonic stem cell and mouse model
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98. CRISPR-Cas genome editing system: A versatile tool for developing disease resistant crops
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99. Control of Adipogenic Differentiation in Mesenchymal Stem Cells via Endogenous Gene Activation Using CRISPR-Cas9
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100. CRISPR-Cas based targeting of host and viral genes as an antiviral strategy
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