The DOI matches its Crossref record; 123 of the 124 references it cites were found in a registry or an index.
Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style
Open accessAbstract
Biologists have long been intrigued by the possibility that cells can change their identity, a phenomenon known as cellular plasticity. The discovery that terminally differentiated cells can be experimentally coaxed to become pluripotent has invigorated the field, and recent studies have demonstrated that changes in cell identity are not limited to the laboratory. Specifically, certain adult cells retain the capacity to de-differentiate or transdifferentiate under physiological conditions, as part of an organ's normal injury response. Recent studies have highlighted the extent to which cell plasticity contributes to tissue homeostasis, findings that have implications for cell-based therapy.
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“In addition, cell reprogramming often occurs in highly specialized regions of injured tissues.11”
From Kupffer-cell-derived IL-6 is repurposed for hepatocyte dedifferentiation via activating progenitor genes from injury-specific enhancers (2023) · cites this paper as [11]
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1 retracted
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Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors
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Bone Marrow as a Potential Source of Hepatic Oval Cells
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Clements, M., Byrne, E., Guerrero, C., Cattin, A.-L., Zakka, L., Ashraf, A., Burden, J. J., Khadayate, S. P., Lloyd, A. C., Marguerat, S., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.008 · Cited by 328
De novo formation of the biliary system by TGFβ-mediated hepatocyte transdifferentiation
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Metadata
- Authors
- Merrell, A. J., & Stanger, B. Z.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Stanger, Ben Z.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2016-03-16
- Volume
- 17
- Issue
- 7
- Pages
- 413-425
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- PMC
- PMC5818993
- OpenAlex
- W2300048866
- Cited by
- 369
- References
- 124
- Citations by year
- 2026: 21 · 2025: 35 · 2024: 45 · 2023: 42 · 2022: 45 · 2021: 49 · 2020: 40 · 2019: 39 · 2018: 26 · 2017: 19 · 2016: 7
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Funders
- National Cancer Institute (R01CA169123)
- National Institute of Diabetes and Digestive and Kidney Diseases (UC4DK104196)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- cellular plasticity, dedifferentiation, transdifferentiation, terminally differentiated cells, tissue homeostasis, cell therapy, pluripotency
- MeSH terms
- Animals, Cell Transformation, Neoplastic, Humans, Neoplasms, Regeneration, Signal Transduction, Adult Stem Cells, Cell Dedifferentiation, Cell Transdifferentiation
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