Cited by 369Pluripotent Stem Cells ResearchMesenchymal stem cell researchCongenital heart defects research

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Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style

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Merrell, Allyson J., Stanger, Ben Z.·2016·Nature Reviews Molecular Cell Biology

DOI 10.1038/nrm.2016.24PMC PMC5818993

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Abstract

Biologists have long been intrigued by the possibility that cells can change their identity, a phenomenon known as cellular plasticity. The discovery that terminally differentiated cells can be experimentally coaxed to become pluripotent has invigorated the field, and recent studies have demonstrated that changes in cell identity are not limited to the laboratory. Specifically, certain adult cells retain the capacity to de-differentiate or transdifferentiate under physiological conditions, as part of an organ's normal injury response. Recent studies have highlighted the extent to which cell plasticity contributes to tissue homeostasis, findings that have implications for cell-based therapy.

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Authors: Merrell, A. J., & Stanger, B. Z.
Affiliations: University of Pennsylvania (US)
Corresponding author: Stanger, Ben Z.
ORCID: Merrell, Allyson J.
Stanger, Ben Z.
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2016-03-16
Volume: 17
Issue: 7
Pages: 413-425
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm.2016.24
PMC: PMC5818993
OpenAlex: W2300048866
Cited by: 369
References: 124
Citations by year: 2026: 21 · 2025: 35 · 2024: 45 · 2023: 42 · 2022: 45 · 2021: 49 · 2020: 40 · 2019: 39 · 2018: 26 · 2017: 19 · 2016: 7
FWCI: 2.75
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
Funders: National Cancer Institute (R01CA169123)
National Institute of Diabetes and Digestive and Kidney Diseases (UC4DK104196)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords: cellular plasticity, dedifferentiation, transdifferentiation, terminally differentiated cells, tissue homeostasis, cell therapy, pluripotency
MeSH terms: Animals, Cell Transformation, Neoplastic, Humans, Neoplasms, Regeneration, Signal Transduction, Adult Stem Cells, Cell Dedifferentiation, Cell Transdifferentiation

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Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style

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