Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673

Identification of stem cells in small intestine and colon by marker gene Lgr5

Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687

Expression of a single transfected cDNA converts fibroblasts to myoblasts

Davis, R. L., Weintraub, H. M., & Lassar, A. B. (1987) · Cell · doi:10.1016/0092-8674(87)90585-x · Cited by 3,388

Direct conversion of fibroblasts to functional neurons by defined factors

Vierbuchen, T., Ostermeier, A., Pang, Z. P., Kokubu, Y., Südhof, T. C., & Wernig, M. (2010) · Nature · doi:10.1038/nature08797 · Cited by 3,017

Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors

Ieda, M., Fu, J.-D., Delgado-Olguin, P., Vedantham, V., Hayashi, Y., Bruneau, B. G., & Srivastava, D. (2010) · Cell · doi:10.1016/j.cell.2010.07.002 · Cited by 2,454

Bone Marrow as a Potential Source of Hepatic Oval Cells

Petersen, B. E., Bowen, W. C., Patrene, K. D., Mars, W. M., Sullivan, A. K., Murase, N., Boggs, S. S., Greenberger, J. S., & Goff, J. P. (1999) · Science · doi:10.1126/science.284.5417.1168 · Cited by 2,377

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J., & Melton, D. A. (2008) · Nature · doi:10.1038/nature07314 · Cited by 2,010

Heart Regeneration in Zebrafish

Poss, K. D., Wilson, L. G., & Keating, M. T. (2002) · Science · doi:10.1126/science.1077857 · Cited by 1,938

Basal cells as stem cells of the mouse trachea and human airway epithelium

Rock, J. R., Onaitis, M. W., Rawlins, E. L., Lu, Y., Clark, C. P., Xue, Y., Randell, S. H., & Hogan, B. L. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906850106 · Cited by 1,591

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

Talchai, C., Xuan, S., Lin, H. V., Sussel, L., & Accili, D. (2012) · Cell · doi:10.1016/j.cell.2012.07.029 · Cited by 1,415

Turning Brain into Blood: A Hematopoietic Fate Adopted by Adult Neural Stem Cells in Vivo

Bjornson, C. R. R., Rietze, R. L., Reynolds, B. A., Magli, M. C., & Vescovi, A. L. (1999) · Science · doi:10.1126/science.283.5401.534 · Cited by 1,412

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

Li, Q., Huang, Y., Spencer, C. I., Foley, A., Vedantham, V., Liu, L., Conway, S. J., Fu, J., & Srivastava, D. (2012) · Nature · doi:10.1038/nature11044 · Cited by 1,376

Incidence of Adenocarcinoma among Patients with Barrett's Esophagus

Hvid‐Jensen, F., Pedersen, L. H., Drewes, A. M., Sørensen, H. T., & Funch-Jensen, P. M. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1103042 · Cited by 1,370

Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation

Jopling, C., Sleep, E., Raya, M., Martí, M., Raya, A., & Belmonte, J. C. I. (2010) · Nature · doi:10.1038/nature08899 · Cited by 1,333

Plasticity of Adult Stem Cells

Wagers, A. J., & Weissman, I. L. (2004) · Cell · doi:10.1016/s0092-8674(04)00208-9 · Cited by 1,268

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

Tian, H., Biehs, B., Warming, S., Leong, K. G., Rangell, L. K., Klein, O. D., & de Sauvage, F. J. (2011) · Nature · doi:10.1038/nature10408 · Cited by 1,244

Heart repair by reprogramming non-myocytes with cardiac transcription factors

Song, K., Nam, Y., Luo, X., Qi, X., Tan, W. H., Huang, G. N., Acharya, A., Smith, C. L., Tallquist, M. D., Neilson, E. G., et al. (2012) · Nature · doi:10.1038/nature11139 · Cited by 1,162

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

Thorel, F., Népote, V., Avril, I., Kohno, K., Desgraz, R., Chera, S., & Herrera, P. L. (2010) · Nature · doi:10.1038/nature08894 · Cited by 1,136

Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes

Kikuchi, K., Holdway, J. E., Werdich, A. A., Anderson, R. M., Fang, Y., Egnaczyk, G. F., Evans, T., MacRae, C. A., Stainier, D. Y. R., & Poss, K. D. (2010) · Nature · doi:10.1038/nature08804 · Cited by 1,084

The Developmental Capacity of Nuclei taken from Intestinal Epithelium Cells of Feeding Tadpoles

Gurdon, J. B. (1962) · Development · doi:10.1242/dev.10.4.622 · Cited by 1,083

Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors

Huang, P., He, Z., Ji, S., Sun, H., Xiang, D., Liu, C., Hu, Y., Wang, X., & Hui, L. (2011) · Nature · doi:10.1038/nature10116 · Cited by 864

Hippo Pathway Activity Influences Liver Cell Fate

Yimlamai, D., Christodoulou, C., Galli, G. G., Yanger, K., Pepe-Mooney, B., Gurung, B., Shrestha, K., Cahan, P., Stanger, B. Z., & Camargo, F. D. (2014) · Cell · doi:10.1016/j.cell.2014.03.060 · Cited by 857

Cells keep a memory of their tissue origin during axolotl limb regeneration

Kragl, M., Knapp, D., Nacu, E., Khattak, S., Maden, M., Epperlein, H. H., & Tanaka, E. M. (2009) · Nature · doi:10.1038/nature08152 · Cited by 854

MyoD1: A Nuclear Phosphoprotein Requiring a Myc Homology Region to Convert Fibroblasts to Myoblasts

Tapscott, S. J., Davis, R. L., Thayer, M. J., Cheng, P.-F., Weintraub, H. M., & Lassar, A. B. (1988) · Science · doi:10.1126/science.3175662 · Cited by 845

Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

van Es, J. H., Sato, T., van de Wetering, M., Lyubimova, A., Nee, A. N. Y., Gregorieff, A., Sasaki, N., Zeinstra, L. M., van den Born, M., Korving, J., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2581 · Cited by 818

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

Zhang, N., Bai, H., David, K. K., Dong, J., Zheng, Y., Cai, J., Giovannini, M., Liu, P., Anders, R. A., & Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.06.015 · Cited by 804

A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration

Greco, V., Chen, T., Rendl, M., Schober, M., Pasolli, H. A., Stokes, N., dela Cruz-Racelis, J., & Fuchs, E. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2008.12.009 · Cited by 800

Intestinal label-retaining cells are secretory precursors expressing Lgr5

Buczacki, S. J. A., Zecchini, H. I., Nicholson, A. M., Russell, R., Vermeulen, L., Kemp, R., & Winton, D. J. (2013) · Nature · doi:10.1038/nature11965 · Cited by 761

Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration

Jopling, C., Boué, S., & Belmonte, J. C. I. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3043 · Cited by 750

Direct conversion of human fibroblasts to dopaminergic neurons

Pfisterer, U., Kirkeby, A., Torper, O., Wood, J. C., Nelander, J., Dufour, A., Björklund, A., Lindvall, O., Jakobsson, J., & Parmar, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105135108 · Cited by 747

Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia

Ferber, S., Halkin, A., Cohen, H., Ber, I., Einav, Y., Goldberg, I., Barshack, I., Seijffers, R., Kopolovic, J., Kaiser, N., et al. (2000) · Nature Medicine · doi:10.1038/75050 · Cited by 745

Risk of Malignant Progression in Barrett's Esophagus Patients: Results from a Large Population-Based Study

Bhat, S., Coleman, H. G., Yousef, F., Johnston, B. T., McManus, D. T., Gavin, A., & Murray, L. (2011) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djr203 · Cited by 737

Epigenetics: A Historical Overview

Holliday, R. (2006) · Epigenetics · doi:10.4161/epi.1.2.2762 · Cited by 712

Stem Cell Self-Renewal Specified by JAK-STAT Activation in Response to a Support Cell Cue

Kiger, A. A., Jones, D. L., Schulz, C., Rogers, M. B., & Fuller, M. T. (2001) · Science · doi:10.1126/science.1066707 · Cited by 698

Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma

Kopp, J. L., von Figura, G., Mayes, E., Liu, F.-F., Dubois, C. L., Morris, J. P., Pan, F. C., Akiyama, H., Wright, C. V. E., Jensen, K., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.10.025 · Cited by 697

Dedifferentiation of committed epithelial cells into stem cells in vivo

Tata, P. R., Mou, H., Pardo–Saganta, A., Zhao, R., Prabhu, M., Law, B. M., Vinarsky, V., Cho, J. L., Breton, S., Sahay, A., et al. (2013) · Nature · doi:10.1038/nature12777 · Cited by 679

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

de Lau, W., Peng, W. C., Gros, P., & Clevers, H. (2014) · Genes & Development · doi:10.1101/gad.235473.113 · Cited by 656

Control of Stem Cell Self-Renewal in Drosophila Spermatogenesis by JAK-STAT Signaling

Tulina, N. M., & Matunis, E. L. (2001) · Science · doi:10.1126/science.1066700 · Cited by 653

Dynamics between Stem Cells, Niche, and Progeny in the Hair Follicle

Hsu, Y., Pasolli, H. A., & Fuchs, E. V. (2011) · Cell · doi:10.1016/j.cell.2010.11.049 · Cited by 641

Emerging interactions between skin stem cells and their niches

Hsu, Y., Li, L., & Fuchs, E. V. (2014) · Nature Medicine · doi:10.1038/nm.3643 · Cited by 590

Plasticity of epithelial stem cells in tissue regeneration

Blanpain, C., & Fuchs, E. (2014) · Science · doi:10.1126/science.1242281 · Cited by 589

Replacement of lost Lgr5-positive stem cells through plasticity of their enterocyte-lineage daughters

Tetteh, P. W., Basak, O., Farin, H. F., Wiebrands, K., Kretzschmar, K., Begthel, H., van den Born, M., Korving, J., de Sauvage, F., van Es, J. H., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.01.001 · Cited by 575

The Cellular Basis for Animal Regeneration

Tanaka, E. M., & Reddien, P. W. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.06.016 · Cited by 573

Skin shedding and tissue regeneration in African spiny mice (Acomys)

Seifert, A. W., Kiama, S. G., Seifert, M. G., Goheen, J. R., Palmer, T. M., & Maden, M. (2012) · Nature · doi:10.1038/nature11499 · Cited by 570

Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes

Tarlow, B. D., Pelz, C., Naugler, W. E., Wakefield, L., Wilson, E. M., Finegold, M. J., & Grompe, M. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.09.008 · Cited by 533

Cholangiocarcinomas can originate from hepatocytes in mice

Fan, B., Malato, Y., Calvisi, D. F., Naqvi, S., Razumilava, N., Ribback, S., Gores, G. J., Dombrowski, F., Evert, M., Chen, X., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63212 · Cited by 529

Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium

Stange, D. E., Koo, B., Huch, M., Sibbel, G., Başak, O., Lyubimova, A., Kujala, P., Bartfeld, S., Köster, J., Geahlen, J. H., et al. (2013) · Cell · doi:10.1016/j.cell.2013.09.008 · Cited by 523

Inactivation of specific β cell transcription factors in type 2 diabetes

Guo, S., Dai, C., Guo, M., Taylor, B., Harmon, J. S., Sander, M., Robertson, R. P., Powers, A. C., & Stein, R. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65390 · Cited by 520

Robust cellular reprogramming occurs spontaneously during liver regeneration

Yanger, K., Zong, Y., Maggs, L. R., Shapira, S. N., Maddipati, R., Aiello, N. M., Thung, S. N., Wells, R. G., Greenbaum, L. E., & Stanger, B. Z. (2013) · Genes & Development · doi:10.1101/gad.207803.112 · Cited by 484

Functional Hierarchy and Reversibility Within the Murine Spermatogenic Stem Cell Compartment

Nakagawa, T., Sharma, M., Nabeshima, Y., Braun, R. E., & Yoshida, S. (2010) · Science · doi:10.1126/science.1182868 · Cited by 473

Notch signaling controls liver development by regulating biliary differentiation

Zong, Y., Panikkar, A., Xu, J., Antoniou, A., Raynaud, P., Lemaigre, F. P., & Stanger, B. Z. (2009) · Development · doi:10.1242/dev.029140 · Cited by 443

Pdx1 Maintains β Cell Identity and Function by Repressing an α Cell Program

Gao, T., McKenna, B. D., Li, C., Reichert, M., Nguyen, J., Singh, T., Yang, C., Pannikar, A., Doliba, N. M., Zhang, T., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.002 · Cited by 431

Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers

Chera, S., Baronnier, D., Ghila, L., Cigliola, V., Jensen, J. N., Gu, G., Furuyama, K., Thorel, F., Gribble, F. M., Reimann, F., et al. (2014) · Nature · doi:10.1038/nature13633 · Cited by 410

Spatial organization within a niche as a determinant of stem-cell fate

Rompolas, P., Mesa, K. R., & Greco, V. (2013) · Nature · doi:10.1038/nature12602 · Cited by 409

How cells change their phenotype

Tosh, D., & Slack, J. M. W. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm761 · Cited by 404

Regeneration of Male Germline Stem Cells by Spermatogonial Dedifferentiation in Vivo

Brawley, C. M., & Matunis, E. L. (2004) · Science · doi:10.1126/science.1097676 · Cited by 402

Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia

Jean–Paul De La, O., Emerson, L. L., Goodman, J. L., Froebe, S. C., Illum, B. E., Curtis, A. B., & Murtaugh, L. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810111105 · Cited by 396

In vivo differentiation potential of tracheal basal cells: evidence for multipotent and unipotent subpopulations

Hong, K. U., Reynolds, S. D., Watkins, S. C., Fuchs, E. V., & Stripp, B. R. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00155.2003 · Cited by 375

Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes

Sekiya, S., & Suzuki, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63065 · Cited by 348

Differentiating germ cells can revert into functional stem cells in Drosophila melanogaster ovaries

Kai, T., & Spradling, A. C. (2004) · Nature · doi:10.1038/nature02436 · Cited by 344

Experimental Conversion of Liver to Pancreas

Horb, M. E., Shen, C., Tosh, D., & Slack, J. M. W. (2003) · Current Biology · doi:10.1016/s0960-9822(02)01434-3 · Cited by 325

Fundamental Differences in Dedifferentiation and Stem Cell Recruitment during Skeletal Muscle Regeneration in Two Salamander Species

Sandoval‐Guzmán, T., Wang, H., Khattak, S., Schuez, M., Roensch, K., Nacu, E., Tazaki, A., Joven, A., Tanaka, E. M., & Simon, A. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.11.007 · Cited by 321

The Epidermis Comprises Autonomous Compartments Maintained by Distinct Stem Cell Populations

Page, M. E., Lombard, P., Ng, F., Göttgens, B., & Jensen, K. B. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.07.010 · Cited by 320

Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury†

Michalopoulos, G. K., Barua, L., & Bowen, W. C. (2005) · Hepatology · doi:10.1002/hep.20600 · Cited by 319

Notch Signaling Is Activated in Human Hepatocellular Carcinoma and Induces Tumor Formation in Mice

Villanueva, A., Alsinet, C., Yanger, K., Hoshida, Y., Zong, Y., Toffanin, S., Rodríguez‐Carunchio, L., Solé, M., Thung, S. N., Stanger, B. Z., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.09.002 · Cited by 317

Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung

Jain, R., Barkauskas, C. E., Takeda, N., Bowie, E. J., Aghajanian, H., Wang, Q., Padmanabhan, A., Manderfield, L. J., Gupta, M., Li, D., et al. (2015) · Nature Communications · doi:10.1038/ncomms7727 · Cited by 303

Barrett's oesophagus

Shaheen, N. J., & Richter, J. E. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60487-6 · Cited by 299

Adult Stem Cell Plasticity: Fact or Artifact?

RAFF, M. C. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111301.143037 · Cited by 296

Diminished Schwann Cell Repair Responses Underlie Age-Associated Impaired Axonal Regeneration

Painter, M. W., Lutz, A. B., Cheng, Y.-C., Latrémolière, A., Duong, K., Miller, C. M., Posada, S., Cobos, E. J., Zhang, A., Wagers, A. J., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.06.016 · Cited by 291

Pancreatic β Cell Identity Is Maintained by DNA Methylation-Mediated Repression of Arx

Dhawan, S., Georgia, S. K., Tschen, S.-I., Fan, G., & Bhushan, A. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.03.012 · Cited by 268

The stem cell niche: lessons from the Drosophila testis

de Cuevas, M., & Matunis, E. L. (2011) · Development · doi:10.1242/dev.056242 · Cited by 263

Cellular Homeostasis and Repair in the Mammalian Liver

Stanger, B. Z. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170255 · Cited by 248

Metaplasia and transdifferentiation: from pure biology to the clinic

Slack, J. M. W. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2146 · Cited by 245

Novel signals controlling embryonic Schwann cell development, myelination and dedifferentiation

Mirsky, R., Woodhoo, A., Parkinson, D. B., Arthur‐Farraj, P., Bhaskaran, A., & Jessen, K. R. (2008) · Journal of the Peripheral Nervous System · doi:10.1111/j.1529-8027.2008.00168.x · Cited by 229

Yap Tunes Airway Epithelial Size and Architecture by Regulating the Identity, Maintenance, and Self-Renewal of Stem Cells

Zhao, R., Fallon, T. R., Saladi, S. V., Pardo–Saganta, A., Villoria, J., Mou, H., Vinarský, V., Gonzalez-Celeiro, M., Nunna, N., Hariri, L. P., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.06.004 · Cited by 219

Adrenocortical Zonation Results from Lineage Conversion of Differentiated Zona Glomerulosa Cells

Freedman, B. D., Kempná, P., Carlone, D. L., Shah, M. S., Guagliardo, N. A., Barrett, P. Q., Gómez-Sánchez, C. E., Majzoub, J. A., & Breault, D. T. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.07.016 · Cited by 216

Acinar Cells Contribute to the Molecular Heterogeneity of Pancreatic Intraepithelial Neoplasia

Zhu, L., Shi, G., Schmidt, C. M., Hruban, R. H., & Konieczny, S. F. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.061176 · Cited by 213

Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic mice.

Grippo, P. J., Nowlin, P. S., Demeure, M. J., Longnecker, D. S., & Sandgren, E. P. (2003) · PubMed · Cited by 207

Transient Inactivation of Rb and ARF Yields Regenerative Cells from Postmitotic Mammalian Muscle

Pajcini, K. V., Corbel, S. Y., Sage, J., Pomerantz, J. H., & Blau, H. M. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.05.022 · Cited by 193

Sensitivity of the cervical transformation zone to estrogen-induced squamous carcinogenesis.

Elson, D. A., Riley, R. R., Lacey, A., Thórdarson, G., Talamantes, F. J., & Arbeit, J. M. (2000) · PubMed · Cited by 187

Mouse differentiating spermatogonia can generate germinal stem cells in vivo

Barroca, V., Lassalle, B., Coureuil, M., Louis, J. P., Page, F. L., Testart, J., Allemand, I., Riou, L., & Fouchet, P. (2008) · Nature Cell Biology · doi:10.1038/ncb1826 · Cited by 183

Somatic stem cell heterogeneity: diversity in the blood, skin and intestinal stem cell compartments

Goodell, M. A., Nguyen, H., & Shroyer, N. F. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3980 · Cited by 182

Eye regeneration at the molecular age

Rio‐Tsonis, K. D., & Tsonis, P. A. (2003) · Developmental Dynamics · doi:10.1002/dvdy.10224 · Cited by 182

Hydra, a fruitful model system for 270 years

Galliot, B. (2012) · The International Journal of Developmental Biology · doi:10.1387/ijdb.120086bg · Cited by 178

CELLULAR AND MOLECULAR CHARACTERISTICS OF BASAL CELLS IN AIRWAY EPITHELIUM

Evans, M. J., Winkle, L. S. V., Fanucchi, M. V., & Plopper, C. G. (2001) · Experimental Lung Research · doi:10.1080/019021401300317125 · Cited by 176

A subset of mouse tracheal epithelial basal cells generates large colonies in vitro.

Schoch, K., Lori, A., Burns, K., Eldred, T., Olsen, J., & Randell, S. (2004) · American Journal of Physiology - Lung cellular and Molecular Physiology · doi:10.1152/ajplung.00112.2003 · Cited by 174

The planarian neoblast: the rambling history of its origin and some current black boxes

Baguñ, J. (2012) · The International Journal of Developmental Biology · doi:10.1387/ijdb.113463jb · Cited by 173

De Novo Formation of Insulin-Producing “Neo-β Cell Islets” from Intestinal Crypts

Chen, Y.-J., Finkbeiner, S. R., Weinblatt, D., Emmett, M. J., Tameire, F., Yousefi, M., Yang, C., Maehr, R., Zhou, Q., Shemer, R., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.02.013 · Cited by 172

Deregulation of Hippo kinase signalling in Human hepatic malignancies

Li, H., Wolfe, A. R., Septer, S. S., Edwards, G., Zhong, X., Abdulkarim, A. B., Ranganathan, S., & Apte, U. M. (2011) · Liver International · doi:10.1111/j.1478-3231.2011.02646.x · Cited by 168

The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma

Krah, N. M., De La O, J.-P., Swift, G. H., Hoang, C. Q., Willet, S. G., Chen Pan, F., Cash, G. M., Bronner, M. P., Wright, C. V., MacDonald, R. J., et al. (2015) · eLife · doi:10.7554/elife.07125 · Cited by 166

Control of Cell Identity in Pancreas Development and Regeneration

Stanger, B. Z., & Hebrok, M. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.074 · Cited by 158

Dedifferentiating Spermatogonia Outcompete Somatic Stem Cells for Niche Occupancy in the Drosophila Testis

Sheng, X., Brawley, C. M., & Matunis, E. L. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.05.024 · Cited by 149

The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia

Carrière, C., Seeley, E. S., Goetze, T., Longnecker, D. S., & Korc, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701117104 · Cited by 138

Expression of stem cell pluripotency factors during regeneration in newts

Maki, N., Suetsugu‐Maki, R., Tarui, H., Agata, K., Rio‐Tsonis, K. D., & Tsonis, P. A. (2009) · Developmental Dynamics · doi:10.1002/dvdy.21959 · Cited by 130

Regeneration and Transdetermination in Drosophila Imaginal Discs

Worley, M. I., Setiawan, L., & Hariharan, I. K. (2012) · Annual Review of Genetics · doi:10.1146/annurev-genet-110711-155637 · Cited by 126

Stability of chondrocyte differentiation and contribution of muscle to cartilage during limb regeneration in the axolotl (Siredon mexicanum)

Steen, T. P. (1968) · Journal of Experimental Zoology · doi:10.1002/jez.1401670105 · Cited by 118

A Caenorhabditis elegans model for epithelial–neuronal transdifferentiation

Jarriault, S., Schwab, Y., & Greenwald, I. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712159105 · Cited by 114

Dynamics of Lgr6 + Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis

Füllgrabe, A., Joost, S., Are, A., Jacob, T., Sivan, U., Haegebarth, A., Linnarsson, S., Simons, B. D., Clevers, H. C., Toftgård, R., et al. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.09.013 · Cited by 98

Keratinising Squamous Metaplasia of the Bladder: Natural History and Rationalization of Management Based on Review of 54 Years Experience

Khan, M. S., Thornhill, J. A., Gaffney, E. F., Loftus, B. M., & Butler, M. R. (2002) · European Urology · doi:10.1016/s0302-2838(02)00358-5 · Cited by 96

Growth and regeneration in Planaria lugubris

Morgan, T. H. (1901) · Development Genes and Evolution · doi:10.1007/bf02161982 · Cited by 92

Epidemiology of Premalignant Gastric Lesions: Implications for the Development of Screening and Surveillance Strategies

de Vries, A. C., & Kuipers, E. J. (2007) · Helicobacter · doi:10.1111/j.1523-5378.2007.00562.x · Cited by 88

Schwann Cell Dedifferentiation Is Independent of Mitogenic Signaling and Uncoupled to Proliferation

Monje, P. V., Soto, J., Bacallao, K., & Wood, P. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.116970 · Cited by 81

Sequential histone-modifying activities determine the robustness of transdifferentiation

Zuryn, S., Ahier, A., Portoso, M., White, E. R., Morin, M.-C., Margueron, R., & Jarriault, S. (2014) · Science · doi:10.1126/science.1255885 · Cited by 80

Ectopic PDX-1 expression in liver ameliorates type 1 diabetes

Keren Shternhall-ron, A., Quintana, F. J., Perl, S., Meivar‐Levy, I., Barshack, I., Cohen, I. R., & Ferber, S. (2007) · Journal of Autoimmunity · doi:10.1016/j.jaut.2007.02.010 · Cited by 74

Stimulation of lens regeneration from the newt dorsal iris when implanted into the blastema of the regenerating limb

Reyer, R. W., Woolfitt, R. A., & Lt, W. (1973) · Developmental Biology · doi:10.1016/0012-1606(73)90240-6 · Cited by 72

Epigenetic reprogramming during tissue regeneration

Katsuyama, T., & Paro, R. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.010 · Cited by 61

Paracrine Interactions Within Islets of Langerhans

Koh, D., Cho, J.-H., & Chen, L. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9752-2 · Cited by 60

Lens formation by pigmented epithelial cell reaggregate from dorsal iris implanted into limb blastema in the adult newt

Ito, M., Hayashi, T., Kuroiwa, A., & Okamoto, M. (1999) · Development Growth & Differentiation · doi:10.1046/j.1440-169x.1999.00447.x · Cited by 54

Turning terminally differentiated skeletal muscle cells into regenerative progenitors

Wang, H., Lööf, S., Borg, P., Nader, G. A., Blau, H. M., & Simon, A. (2015) · Nature Communications · doi:10.1038/ncomms8916 · Cited by 53

Oocyte‐type linker histone B4 is required for transdifferentiation of somatic cells in vivo

Maki, N., Suetsugu‐Maki, R., Sano, S., Nakamura, K., Nishimura, O., Tarui, H., Rio‐Tsonis, K. D., Ohsumi, K., Agata, K., & Tsonis, P. A. (2010) · The FASEB Journal · doi:10.1096/fj.10-159285 · Cited by 43

Physiological cellular reprogramming and cancer

Abollo‐Jiménez, F., Jiménez, R., & Cobaleda, C. (2010) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2010.02.002 · Cited by 42

Transdifferentiation and remodeling of post-embryonic C. elegans cells by a single transcription factor

Riddle, M. R., Weintraub, A. S., Nguyen, K. C. Q., Hall, D. H., & Rothman, J. H. (2013) · Development · doi:10.1242/dev.103010 · Cited by 41

Stem cells to insulin secreting cells: two steps forward and now a time to pause?

Kushner, J., Macdonald, P., & Atkinson, M. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.10.012 · Cited by 39

In vitro transdifferentiation of adult hematopoietic stem cells: An alternative source of engraftable hepatocytes

Khurana, S., & Mukhopadhyay, A. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.05.019 · Cited by 39

Recent Advances in Cell Replacement Therapies for the Treatment of Type 1 Diabetes

Cogger, K. F., & Nostro, M. C. (2014) · Endocrinology · doi:10.1210/en.2014-1691 · Cited by 37

Expression of crystallin genes in embryonic and regenerating newt lenses

Mizuno, N., Agata, K., Sawada, K., Mochii, M., & Eguchi, G. (2002) · Development Growth & Differentiation · doi:10.1046/j.1440-169x.2002.00639.x · Cited by 36

Kinetics of Compensatory Growth

Goss, R. J. (1965) · The Quarterly Review of Biology · doi:10.1086/404538 · Cited by 33

Cochlear supporting cell transdifferentiation and integration into hair cell layers by inhibition of ephrin-B2 signalling

Defourny, J., Sánchez, S. M., Schoonaert, L., Robberecht, W., Davy, A., Nguyen, L., & Malgrange, B. (2015) · Nature Communications · doi:10.1038/ncomms8017 · Cited by 30

Myofibroblasts in Fibrotic Kidneys

Nakagawa, N., & Duffield, J. S. (2013) · Current Pathobiology Reports · doi:10.1007/s40139-013-0025-8 · Cited by 30

Detection and minimally invasive treatment of early squamous lung cancer

Daniels, J. M. A., & Sutedja, T. G. (2013) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758834013482345 · Cited by 23

Conversion of one cell type into another: implications for understanding organ development, pathogenesis of cancer and generating cells for therapy

Corbett, J., & Tosh, D. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140058 · Cited by 15

Liver cell reprogramming

Yanger, K., & Stanger, B. Z. (2014) · Cell Cycle · doi:10.4161/cc.28381 · Cited by 9

Hallmarks of Cancer: New Dimensions

Hanahan, D. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-1059 · Cited by 9,887

Cellular Plasticity in Cancer

Yuan, S., Norgard, R. J., & Stanger, B. Z. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0015 · Cited by 491

Resolution of organ fibrosis

Jun, J.-I., & Lau, L. F. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93563 · Cited by 358

The Wound Microenvironment Reprograms Schwann Cells to Invasive Mesenchymal-like Cells to Drive Peripheral Nerve Regeneration

Clements, M., Byrne, E., Guerrero, C., Cattin, A.-L., Zakka, L., Ashraf, A., Burden, J. J., Khadayate, S. P., Lloyd, A. C., Marguerat, S., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.008 · Cited by 328

De novo formation of the biliary system by TGFβ-mediated hepatocyte transdifferentiation

Schaub, J. R., Huppert, K. A., Kurial, S. N. T., Hsu, B. Y., Cast, A. E., Donnelly, B., Karns, R. A., Chen, F., Rezvani, M., Luu, H. Y., et al. (2018) · Nature · doi:10.1038/s41586-018-0075-5 · Cited by 289

Transdifferentiation In Neuroscience: Lights And Shadows

Mollinari, C. (2020) · Stem Cells Research Development & Therapy · doi:10.24966/srdt-2060/100056

Cellular plasticity: 1712 to the present day

Tata, P. R., & Rajagopal, J. (2016) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2016.07.005 · Cited by 93

Transdifferentiation of adult stem cells and its possible mechanisms

Chen, J. (2004) · Guoji shengwu yixue gongcheng zazhi

Plasticity of adult stem cells

Zhao, H., YueMao, Z., Cao, H., Ye-fei, W., & Yong, Z. (2005) · Xibei Nong-Lin Keji Daxue xuebao. Ziran kexue ban

The progress of studies on plasticity of adult stem cell

Huang, H. L. (2003)