Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

The Hallmarks of Aging

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Resveratrol improves health and survival of mice on a high-calorie diet

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Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

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Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

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Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase

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Nicotinamide Mononucleotide Is Safely Metabolized and Significantly Reduces Blood Triglyceride Levels in Healthy Individuals

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Apprehending the NAD+–ADPr-Dependent Systems in the Virus World

Iyer, L. M., Burroughs, A. M., Anantharaman, V., & Aravind, L. (2022) · Viruses · doi:10.3390/v14091977 · Cited by 20

Exploring the heterogeneous targets of metabolic aging at single-cell resolution

Sun, S., Jiang, M., Ma, S., Ren, J., & Liu, G. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.07.009 · Cited by 20

Interactions between sirtuins and fluorogenic small-molecule substrates offer insights into inhibitor design

Wang, H., Liu, S., Yu, Z., Wu, C., Cheng, L., Wang, Y., Chen, K., Zhou, S. W., Chen, Q., Yu, Y., et al. (2017) · RSC Advances · doi:10.1039/c7ra05824a · Cited by 19

Lipopolysaccharide Induces Gliotoxicity in Hippocampal Astrocytes from Aged Rats: Insights About the Glioprotective Roles of Resveratrol

Bobermin, L. D., Almeida, R. R. D. S., Weber, F. B., Medeiros, L. S., de Medeiros, L. I. P., Wyse, Â. T. D. S., Gonçalves, C., & Quincozes‐Santos, A. (2022) · Molecular Neurobiology · doi:10.1007/s12035-021-02664-8 · Cited by 24

Unlocking the Nexus of Sirtuins: A Comprehensive Review of Their Role in Skeletal Muscle Metabolism, Development, and Disorders

Abdalla, B. A., Xiong, X., Chai, X., Xu, Q., Gong, J., & Xu, J. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.96885 · Cited by 20

ING4 alleviated lipopolysaccharide‐induced inflammation by regulating the NF‐κB pathway via a direct interaction with SIRT1

Yang, Y., Yang, L., He, X. F., Yang, F., Han, S., Qin, A., Wu, G., Liu, M., Li, Z., Wang, J., et al. (2019) · Immunology and Cell Biology · doi:10.1111/imcb.12308 · Cited by 21

Virtual Screening in the Identification of Sirtuins’ Activity Modulators

Abbotto, E., Scarano, N., Piacente, F., Millo, E., Cichero, E., & Bruzzone, S. (2022) · Molecules · doi:10.3390/molecules27175641 · Cited by 18

Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment

Ondracek, C. R., Frappier, V., Ringel, A. E., Wolberger, C., & Guarente, L. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.031 · Cited by 18

A brief history of modern aging research

Zainabadi, K. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.01.018 · Cited by 20

The Interconnections Between Somatic and Ovarian Aging in Murine Models

Schneider, A., Saccon, T. D., Garcia, D. N., Zanini, B. M., Isola, J. V. V., Hense, J. D., Rincón, J. A. A., Cavalcante, M. B., Mason, J. B., Stout, M. B., et al. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa258 · Cited by 18

Sirtuins play critical and diverse roles in acute kidney injury

Peasley, K., Chiba, T., Goetzman, E. S., & Sims‐Lucas, S. (2021) · Pediatric Nephrology · doi:10.1007/s00467-020-04866-z · Cited by 18

Molecular and Cellular Characterization of SIRT1 Allosteric Activators

Schultz, M. B., Rinaldi, C., Lu, Y. R., Amorim, J. A., & Sinclair, D. A. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9434-2_8 · Cited by 18

Acer Truncatum Seed Oil Alleviates Learning and Memory Impairments of Aging Mice

Xiao, L., Li, T., Hong, X., Liu, J., Yang, X. F., & Liu, G. P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.680386 · Cited by 18

1H NMR Profiling of Honey Bee Bodies Revealed Metabolic Differences between Summer and Winter Bees

Lee, S., Kalčic, F., Duarte, I. F., Titěra, D., Kamler, M., Mrna, P., Hyršl, P., Danihlík, J., Dobeš, P., Kunc, M., et al. (2022) · Insects · doi:10.3390/insects13020193 · Cited by 17

Effects of Coffee on Sirtuin-1, Homocysteine, and Cholesterol of Healthy Adults: Does the Coffee Powder Matter?

Gonçalinho, G. H. F., Nascimento, J. R. D. O., Mioto, B. M., Amato, R. V., Moretti, M. A., Strunz, C. M. C., César, L. A. M., & Mansur, A. D. P. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11112985 · Cited by 22

The NAD salvage pathway in mesenchymal cells is indispensable for skeletal development in mice

Warren, A. D., Porter, R. M., Reyes‐Castro, O., Ali, M. M., Marques-Carvalho, A., Kim, H., Gatrell, L. B., Schipani, E., Nookaew, I., O’Brien, C. A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39392-7 · Cited by 20

Tapping lipid droplets: A rich fat diet of intracellular bacterial pathogens

Hüsler, D., Stauffer, P., & Hilbi, H. (2023) · Molecular Microbiology · doi:10.1111/mmi.15120 · Cited by 17

Recent Advances in the Discovery of SIRT1/2 Inhibitors via Computational Methods: A Perspective

Scarano, N., Brullo, C., Musumeci, F., Millo, E., Bruzzone, S., Schenone, S., & Cichero, E. (2024) · Pharmaceuticals · doi:10.3390/ph17050601 · Cited by 18

Hydrogen sulfide mitigates mitochondrial dysfunction and cellular senescence in diabetic patients: Potential therapeutic applications

Chen, T., Bai, D., Gong, C., Cao, Y. J., Yan, X., & Peng, R. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116556 · Cited by 18

The interplay of NAD and hypoxic stress and its relevance for ageing

Burtscher, J., Denti, V., Gostner, J. M., Weiss, A. K., Strasser, B., Hüfner, K., Burtscher, M., Paglia, G., Kopp, M., & Dünnwald, T. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102646 · Cited by 18

Hsp90 Stabilizes SIRT1 Orthologs in Mammalian Cells and C. elegans

Nguyễn, M. T., Somogyvári, M., & Sőti, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113661 · Cited by 17

Reduction of senescence‐associated beta‐galactosidase activity by vitamin E in human fibroblasts depends on subjects’ age and cell passage number

Ricciarelli, R., Azzi, A., & Zingg, J.-M. A. (2020) · BioFactors · doi:10.1002/biof.1636 · Cited by 17

COVID-19: A Challenge to Physiology of Aging

Golubev, A. G. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.584248 · Cited by 18

Circulating NAD+ Metabolism-Derived Genes Unveils Prognostic and Peripheral Immune Infiltration in Amyotrophic Lateral Sclerosis

Li, C., Zhu, Y., Chen, W., Li, M.-H., Yang, M., Shen, Z., Zhou, Y., Wang, L., Wang, H., Li, S., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.831273 · Cited by 17

Discovery of 5-(4-methylpiperazin-1-yl)-2-nitroaniline derivatives as a new class of SIRT6 inhibitors

Sun, W., Chen, X., Huang, S., Li, W., Tian, C., Yang, S., & Li, L. (2020) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2020.127215 · Cited by 17

The Nuclear Lamina: Protein Accumulation and Disease

Almendáriz-Palacios, C., Gillespie, Z. E., Janzen, M., Martinez, V., Bridger, J. M., Harkness, T. A. A., Mousseau, D. D., & Eskiw, C. H. (2020) · Biomedicines · doi:10.3390/biomedicines8070188 · Cited by 22

REV-ERBα regulates brain NAD+ levels and tauopathy via an NFIL3–CD38 axis

Lee, J., Kang, R., Park, S., Saliu, I. O., Son, M., Voorhees, J. R., Dimitry, J. M., Quillin, E. I., Woodie, L. N., Lananna, B. V., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00950-x · Cited by 20

Resveratrol potentiates BCG-induced trained immunity in human monocytes

Bulut, O. P., Baydemir, İ., Kılıç, G., Domínguez‐Andrés, J., & Netea, M. G. (2024) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiae241 · Cited by 16

The Variable Role of SIRT1 in the Maintenance and Differentiation of Mesenchymal Stem Cells

Zainabadi, K. (2018) · Regenerative Medicine · doi:10.2217/rme-2017-0128 · Cited by 18

Sonication-assisted Layer-by-Layer self-assembly nanoparticles for resveratrol delivery

Paiva‐Santos, A. C., Sequeira, J. A. D., Pereira, I., Cabral, C., Collado-González, M., Ribeiro, C., Ribeiro, A. J., LVOV, Y. M., & Veiga, F. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110022 · Cited by 16

Novel multifunctional iron chelators of the aroyl nicotinoyl hydrazone class that markedly enhance cellular NAD+/NADH ratios

Wu, Z., Palanimuthu, D., Braidy, N., Salikin, N. H., Egan, S., Huang, M., & Richardson, D. R. (2020) · British Journal of Pharmacology · doi:10.1111/bph.14963 · Cited by 14

Melatonin Alleviates the Toxicity of High Nicotinamide Concentrations in Oocytes: Potential Interaction with Nicotinamide Methylation Signaling

El-Sheikh, M., Mesalam, A. A., Song, S., Ko, J., & Kong, I. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5573357 · Cited by 16

Sevoflurane ameliorates LPS-induced inflammatory injury of HK-2 cells through Sirtuin1/NF-κB pathway

Wang, P., Wang, P., Yin, M., & Wang, S. (2022) · Allergologia et Immunopathologia · doi:10.15586/aei.v50i4.623 · Cited by 16

NAD+‐Boosters Improve Mitochondria Quality Control In Parkinson's Disease Models Via Mitochondrial UPR

Zhou, S., Xiong, X., Hou, J., Duan, Q., Zheng, Y., Jiang, T., Huang, J., He, H., Xu, J., Chen, K., et al. (2025) · Advanced Science · doi:10.1002/advs.202408503 · Cited by 15

Assays for NAD+-Dependent Reactions and NAD+ Metabolites

Schultz, M. B., Lu, Y. R., Braidy, N., & Sinclair, D. A. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8588-3_6 · Cited by 15

Energy Metabolism Focused Analysis of Sexual Dimorphism in Biological Aging and Hypothesized Sex-specificity in Sirtuin Dependency

Salekeen, R., Diaconeasa, A. G., Billah, M. M., & Islam, K. M. D. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.07.007 · Cited by 16

The role of structural biology in the design of sirtuin activators

Fiorentino, F., Mai, A., & Rotili, D. (2023) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2023.102666 · Cited by 15

SIRT1 maintains bone homeostasis by regulating osteoblast glycolysis through GOT1

Jin, X., Sun, X.-L., Ma, X., Qin, Z., Gao, X., Kang, X., Li, H., & Sun, H. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-05043-9 · Cited by 16

Targeting senescent cells in atherosclerosis: Pathways to novel therapies

Tian, Y., Shao, S., Feng, H., Zeng, R., Li, S., & Zhang, Q. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102502 · Cited by 15

Rodent diet aids and the fallacy of caloric restriction

Wolf, A. M. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111584 · Cited by 15

Resveratrol in animal models of pancreatitis and pancreatic cancer: A systematic review with machine learning

Cai, W., Li, Z., Wang, W., Liu, S., Li, Y., Sun, X., Sutton, R., Deng, L., Liu, T., Xia, Q., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156538 · Cited by 15

SIRT1: The first key to unlocking the mystery of cardiovascular diseases

Dinislam, K., Khoso, M. A., Kataev, V. A., Meshcheryakova, S. M., Liu, H., Liu, L., Guo, M., Wang, S., Lou, H., Zhang, Y., et al. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1668718 · Cited by 16

Aging: Epigenetic modifications

Mishra, S., Raval, M., Kachhawaha, A. S., Tiwari, B. S., & Tiwari, A. K. (2023) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2023.02.002 · Cited by 14

Sanpian decoction ameliorates cerebral ischemia-reperfusion injury by regulating SIRT1/ERK/HIF-1α pathway through in silico analysis and experimental validation

Yang, T., Liu, X., Zhou, Y., Du, L., Fu, Y., Luo, Y., Zhang, W., Feng, Z., Ge, J., & Mei, Z. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116898 · Cited by 14

Nicotine induces senescence in spermatogonia stem cells by disrupting homeostasis between circadian oscillation and rhythmic mitochondrial dynamics via the SIRT6/Bmal1 pathway

Zhang, Z., Jiang, Z., Cheng, J., Price, C. A., Yang, L., & Li, Q. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122860 · Cited by 14

Exploring nicotinamide adenine dinucleotide precursors across biosynthesis pathways: Unraveling their role in the ovary

Ren, C., Shuang, Z., Chen, Y., Deng, K., Kuang, M., Gong, Z., Zhang, K., Wang, P., Huang, P., Zhou, Z., et al. (2024) · The FASEB Journal · doi:10.1096/fj.202400453r · Cited by 14

Stem Cells and Progenitors in Human Peripheral Blood Get Activated by Extremely Active Resveratrol (XAR™)

Tripathi, V., Chhabria, S., Jadhav, V., Bhartiya, D., & Tripathi, A. (2017) · Stem Cell Reviews and Reports · doi:10.1007/s12015-017-9784-7 · Cited by 14

Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence

Gu, C., Zhang, Q., Ni, D., Xiao, Q., Cao, L., Fei, C.-Y., Ying, Y., Li, N., & Feng, T. (2020) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.1080/15412555.2020.1797657 · Cited by 14

Precursor comparisons for the upregulation of nicotinamide adenine dinucleotide. Novel approaches for better aging

Palmer, R. D., Elnashar, M. M. M., & Vaccarezza, M. (2021) · Aging Medicine · doi:10.1002/agm2.12170 · Cited by 13

In silico insights into potential gut microbial modulation of NAD+ metabolism and longevity

Salekeen, R., Siam, M. H. B., Sharif, D. I., Lustgarten, M. S., Billah, M. M., & Islam, K. M. D. (2021) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22925 · Cited by 14

Geroprotective interventions in the 3xTg mouse model of Alzheimer’s disease

Sonsalla, M. M., & Lamming, D. W. (2023) · GeroScience · doi:10.1007/s11357-023-00782-w · Cited by 17

Investigating the role of Sirtuins in cell reprogramming

Shin, J., Kim, J., Park, H., & Kim, J. (2018) · BMB Reports · doi:10.5483/bmbrep.2018.51.10.172 · Cited by 14

Cost‐efficient nanoscopy reveals nanoscale architecture of liver cells and platelets

Mao, H., Diekmann, R., Liang, H., Cogger, V. C., Couteur, D. G. L., Lockwood, G. P., Hunt, N. J., Schüttpelz, M., Huser, T. R., Chen, V. M. Y., et al. (2018) · Nanophotonics · doi:10.1515/nanoph-2019-0066 · Cited by 14

Structural Insights into Phosphite Dehydrogenase Variants Favoring a Non-natural Redox Cofactor

Liu, Y., Feng, Y., Wang, L., Guo, X., Liu, W., Li, Q., Wang, X., Xue, S., & Zhao, Z. K. (2019) · ACS Catalysis · doi:10.2210/pdb6ih8/pdb · Cited by 14

Sirtuin1 in vascular endothelial function, an overview

Kumar, J., & Kumar, S. (2021) · Epigenetics · doi:10.1080/15592294.2021.1975936 · Cited by 14

Combining Metabolomics and Experimental Evolution Reveals Key Mechanisms Underlying Longevity Differences in Laboratory Evolved Drosophila melanogaster Populations

Phillips, M., Arnold, K. R., Vue, Z., Beasley, H. K., Lopez, E. G., Marshall, A. G., Morton, D. J., McReynolds, M. R., Barter, T. T., & Hinton, A. O., Jr. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031067 · Cited by 15

Peroxisome proliferator-activated receptor γ coactivator 1α maintains NAD+ bioavailability protecting against steatohepatitis

Shen, W., Wan, X., Hou, J., Liu, Z., Mao, G., Xu, X., Yu, C., Zhu, X., & Ju, Z. (2022) · Life Medicine · doi:10.1093/lifemedi/lnac031 · Cited by 14

PRDX6 Promotes Fatty Acid Oxidation via PLA2-Dependent PPARα Activation in Rats Fed High-Fat Diet

Shen, W., Yang, L. S., Yang, Y., Wang, P., Tao, X., Shen, Y., Wang, S., & Shen, Y. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0065 · Cited by 13

The Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis

Yang, C., Chen, L., Guo, X., Sun, H., & Miao, D. (2025) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2024.10.011 · Cited by 13

Resveratrol and SIRT1 Activators for the Treatment of Aging and Age-Related Diseases

Stacchiotti, A., Favero, G., & Rezzani, R. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.78977 · Cited by 16

Sirtuin-1 regulates organismal growth by altering feeding behavior and intestinal morphology in planarians

Ziman, B., Karabinis, P., Barghouth, P. G., & Oviedo, N. J. (2020) · Journal of Cell Science · doi:10.1242/jcs.239467 · Cited by 14

The eroding chromatin landscape of aging stem cells

Shi, C., Wang, L., & Sen, P. (2020) · Translational Medicine of Aging · doi:10.1016/j.tma.2020.08.002 · Cited by 14

Ameliorative effects of chickpea flavonoids on redox imbalance and mitochondrial complex I dysfunction in type 2 diabetic rats

Ying-hua, F., Li, Z., Xiao, S., Zhao, C., Zhou, K., & Cao, S. (2022) · Food & Function · doi:10.1039/d2fo00753c · Cited by 13

The Effects of Nutrient Signaling Regulators in Combination with Phytocannabinoids on the Senescence-Associated Phenotype in Human Dermal Fibroblasts

Gerasymchuk, M., Robinson, G. I., Kovalchuk, O., & Kovalchuk, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158804 · Cited by 13

The use of Nicotinamide and Nicotinamide riboside as an adjunct therapy in the treatment of glaucoma

Silva, S. G. N. E., Occhiutto, M. L., & Costa, V. P. (2023) · European Journal of Ophthalmology · doi:10.1177/11206721231161101 · Cited by 14

From Sarcopenia to Frailty: The Pathophysiological Basis and Potential Target Molecules of Intervention

Yu, Z., Ruan, Q., D’Onofrio, G., & Greco, A. (2017) · InTech eBooks · doi:10.5772/intechopen.69639 · Cited by 15

Chemical Probes in Sirtuin Research

Hu, X., & Zheng, W. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.11.014 · Cited by 13

SIRT2 gene has a classic SRE element, is a downstream target of serum response factor and is likely activated during serum stimulation

Zhang, X., Azhar, G., & Wei, J. Y. (2017) · PLoS ONE · doi:10.1371/journal.pone.0190011 · Cited by 15

Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis

Brandl, L., Zhang, Y., Kirstein, N., Sendelhofert, A., Boos, S. L., Jung, P., Greten, F. R., Rad, R., & Menssen, A. (2019) · Neoplasia · doi:10.1016/j.neo.2019.07.009 · Cited by 15

Calorie Restriction and Intermittent Fasting: Impact on Glycemic Control in People With Diabetes

Ganesan, K., Habboush, Y. Y., & Dagogo-Jack, S. E. (2020) · Diabetes Spectrum · doi:10.2337/ds19-0064 · Cited by 15

Hypothesis and Theory: Characterizing Abnormalities of Energy Metabolism Using a Cellular Platform as a Personalized Medicine Approach for Alzheimer’s Disease

Ryu, W., Cohen, B. M., & Sonntag, K. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.697578 · Cited by 14

Metabolic pathways at the crossroads of diabetes and inborn errors

Goetzman, E. S., Gong, Z., Schiff, M., Wang, Y., & Muzumdar, R. H. (2017) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-017-0091-x · Cited by 16

Marine phycocompound screening reveals a potential source of novel senotherapeutics

Salekeen, R., Barua, J., Shaha, P. R., Islam, K. M. D., Islam, M. E., Billah, M. M., & Rahman, S. M. M. (2021) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2021.1877822 · Cited by 12

Posttranslational modifications of keratins and their associated proteins as therapeutic targets in keratin diseases

Li, P., Rietscher, K., Jopp, H., Magin, T. M., & Omary, M. B. (2023) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2023.102264 · Cited by 12

Heavy-chain antibody targeting of CD38 NAD+ hydrolase ectoenzyme to prevent fibrosis in multiple organs

Shi, B., Amin, A., Dalvi, P., Wang, W., Lukacs, N. W., Kai, L., Cheresh, P., Peclat, T., Chini, C. C. S., Chini, E. N., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-49450-1 · Cited by 12

Perfluorooctanoic acid triggers premature ovarian insufficiency by impairing NAD+ synthesis and mitochondrial function in adult zebrafish

Xu, H. G., Mao, X., Zhang, S., Ren, J., Jiang, S., Cai, L., Miao, X., Tao, Y., Peng, C., Lv, M., et al. (2024) · Toxicological Sciences · doi:10.1093/toxsci/kfae071 · Cited by 12

Shikonin Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis to Attenuate Renal Ischemia/Reperfusion Injury by Activating the Sirt1/Nrf2/HO-1 Pathway

Huang, Q., Shi, Z., Zheng, D., Chen, H., & Huang, Q. (2024) · Kidney & Blood Pressure Research · doi:10.1159/000542417 · Cited by 12

Opening the Selectivity Pocket in the Human Lysine Deacetylase Sirtuin2 – New Opportunities, New Questions

Robaa, D., Monaldi, D., Wössner, N., Kudo, N., Rumpf, T., Schiedel, M., Yoshida, M., & Jung, M. (2018) · The Chemical Record · doi:10.1002/tcr.201800044 · Cited by 12

Recent efforts in drug discovery on vascular inflammation and consequent atherosclerosis

Martelli, A., Citi, V., & Calderone, V. (2020) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2021.1850688 · Cited by 12

Nutritional interventions for spinal cord injury: preclinical efficacy and molecular mechanisms

Campos, J., Silva, N. A., & Salgado, A. J. (2021) · Nutrition Reviews · doi:10.1093/nutrit/nuab068 · Cited by 12

Cellular senescence and abdominal aortic aneurysm: From pathogenesis to therapeutics

Wang, D., Hao, X., Jia, L., Jing, Y., Jiang, B., & Xin, S. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.999465 · Cited by 14

The Pursuit of Enzyme Activation: A Snapshot of the Gold Rush

Teng, M., Young, D. W., & Tan, Z. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01291 · Cited by 12

Proteomics of Long‐Lived Mammals

Tombline, G., Gigas, J., Macoretta, N., Zacher, M., Emmrich, S., Zhao, Y., Seluanov, A., & Gorbunova, V. A. (2019) · PROTEOMICS · doi:10.1002/pmic.201800416 · Cited by 12

Sleeve gastrectomy ameliorated high-fat diet (HFD)-induced non-alcoholic fatty liver disease and upregulated the nicotinamide adenine dinucleotide +/ Sirtuin-1 pathway in mice

Hua, R., Wang, G., Shen, Q., Yang, Y., Wang, M., Wu, M., Shao, Y., He, M., Zang, Y., Yao, Q., et al. (2020) · Asian Journal of Surgery · doi:10.1016/j.asjsur.2020.05.030 · Cited by 11

Rejuvenation Through Oxygen, More or Less

Kamat, S., Mendelsohn, A. R., & Larrick, J. W. (2021) · Rejuvenation Research · doi:10.1089/rej.2021.0014 · Cited by 13

An Inflammatory Clock Predicts Multi-morbidity, Immunosenescence and Cardiovascular Aging in HumansPreprint

Sayed, N., Gao, T., Tibshirani, R. J., Hastie, T. J., Cui, L., Kuznetsova, T., Rosenberg‐Hasson, Y., Ostan, R., Monti, D., Lehallier, B., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/840363 · Cited by 12

Mitochondria‑derived peptides: Promising microproteins in cardiovascular diseases (Review)

Ran, Y., Guo, Z.-L., Zhang, L., Li, H., Zhang, X.-Y., Guan, X.-M., Cui, X.-D., Chen, H., & Cheng, M. (2025) · Molecular Medicine Reports · doi:10.3892/mmr.2025.13492 · Cited by 11

NAD+ boosting increases atherosclerotic plaques and inflammation in Apoe knockout mice

Wang, Y.-J., Gaul, D. S., Gorica, E., Pahla, J., Wang, Z., Mohammed, S. A., Dahlby, T., Dietrich, E., Osto, E., Gariani, K., et al. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.119188 · Cited by 13

Elevated plasma Sirtuin2 level predicts heart failure after acute myocardial infarction

Zheng, M., Du, X.-P., Zhao, L., Sun, H., Chen, M., & Yang, X. (2021) · Journal of Thoracic Disease · doi:10.21037/jtd-20-2234 · Cited by 11

Promising drug discovery strategies for sirtuin modulators: what lessons have we learnt?

Garg, G., Singh, A. K., Singh, S., & Rizvi, S. I. (2021) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2021.1915980 · Cited by 11

NAD + , Senolytics, or Pyruvate for Healthy Aging?

Zhou, F. (2021) · Nutrition and Metabolic Insights · doi:10.1177/11786388211053407 · Cited by 12

Antibiotic heliomycin and its water-soluble 4-aminomethylated derivative provoke cell death in T24 bladder cancer cells by targeting sirtuin 1 (SIRT1).

Lin, M. H., Islam, A., Liu, Y.-H., Weng, C.-W., Zhan, J.-H., Liang, R.-H., Tikhomirov, A. S., Shchekotikhin, A. E., & Chueh, P. J. (2022) · PubMed Central · Cited by 11

Vitamin D induces SIRT1 activation through K610 deacetylation in colon cancer

García-Martínez, J. M., Chocarro‐Calvo, A., Martínez‐Useros, J., Fernández‐Aceñero, M. J., Fiuza, C., Cáceres-Rentero, J., la Vieja, A. D., Barbáchano, A., Múñoz, A., Larriba, M. J., et al. (2023) · eLife · doi:10.7554/elife.86913 · Cited by 26

DNA methylation extends lifespan in the bumblebee Bombus terrestris

Renard, T., Martinet, B., Araujo, N. D. S., & Aron, S. (2023) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2023.2093 · Cited by 11

The potential of aging rejuvenation

O’Loghlen, A. (2022) · Cell Cycle · doi:10.1080/15384101.2021.2013612 · Cited by 11

Unraveling the nexus of NAD+ metabolism and diabetic kidney disease: insights from murine models and human data

Yang, S., Gong, W., Wang, Y., Hao, C., & Guan, Y. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1384953 · Cited by 10

Piceatannol enhances hyaluronic acid synthesis through SIRT1-Mediated HAS2 upregulation in human dermal fibroblasts

Yoshihara, M., Kawakami, S., Matsui, Y., & Kawama, T. (2024) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2024.101746 · Cited by 11

Phytochemicals targeting mitophagy: Therapeutic opportunities and prospects for treating Alzheimer’s disease

Yang, J., Zhao, H., & Qu, S. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117144 · Cited by 11

Alcohol, aging, and the gut microbiome: Intersections of immunity, barrier dysfunction, and disease

Melamed, E., Rungratanawanich, W., Liangpunsakul, S., Maki, K. A., McCullough, R. L., & Llorente, C. (2025) · Alcohol · doi:10.1016/j.alcohol.2025.07.001 · Cited by 13

Sirtuin Activators

Kane, A. E., & Sinclair, D. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.62135-9

Sirtuin Activation by Small Molecules

Massudi, H., Wu, L. E., & Sinclair, D. A. (2016) · Springer eBooks · doi:10.1007/978-94-024-0962-8_12 · Cited by 4

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

Hubbard, B. P., & Sinclair, D. A. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.12.004 · Cited by 588

Antiaging Strategies Based on Sirtuin Activation

Garg, G., & Singh, S. (2023) · Springer eBooks · doi:10.1007/978-981-19-7443-4_14 · Cited by 1

The Role of Mammalian Sirtuins in the Regulation of Metabolism, Aging, and Longevity

Satoh, A., Stein, L. R., & Imai, S. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-21631-2_7 · Cited by 175