Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

The Hallmarks of Aging

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Hallmarks of aging: An expanding universe

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From discoveries in ageing research to therapeutics for healthy ageing

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Functions and mechanisms of non-histone protein acetylation

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Why does COVID-19 disproportionately affect older people?

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Modulation of cellular processes by histone and non-histone protein acetylation

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Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

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NAD+ in Brain Aging and Neurodegenerative Disorders

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Regulation of SIRT1 and Its Roles in Inflammation

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The metabolic roots of senescence: mechanisms and opportunities for intervention

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Epigenetic regulation of aging: implications for interventions of aging and diseases

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Quantitative Analysis of NAD Synthesis-Breakdown Fluxes

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Meta-hallmarks of aging and cancer

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NAD+ metabolism, stemness, the immune response, and cancer

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Immunosenescence: a key player in cancer development

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NAD(+) in aging: molecular mechanisms and translational implications

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Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation

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Sirtuins and NAD + in the Development and Treatment of Metabolic and Cardiovascular Diseases

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NAD + supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

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Sirtuins, a promising target in slowing down the ageing process

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Sirtuin activators and inhibitors: Promises, achievements, and challenges

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Sirtuin signaling in cellular senescence and aging

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The landscape of aging

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Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury

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Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

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DNA damage and repair in age-related inflammation

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De novo NAD+ biosynthetic impairment in acute kidney injury in humans

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Mitophagy in neurodegeneration and aging

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Mitochondria and Epigenetics – Crosstalk in Homeostasis and Stress

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The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy

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Sirtuins in Renal Health and Disease

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Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow

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SIRT2 Acts as a Cardioprotective Deacetylase in Pathological Cardiac Hypertrophy

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Repairing mitochondrial dysfunction in disease

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Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes

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Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles

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NAD+ homeostasis in renal health and disease

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Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics

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Drosophila as a model for ageing

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SIRT6: Novel Mechanisms and Links to Aging and Disease

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Plant Polyphenols, More than Just Simple Natural Antioxidants: Oxidative Stress, Aging and Age-Related Diseases

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The role of nutrition in inflammaging

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Mitochondrial sirtuins, metabolism, and aging

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The multifaceted benefits of walking for healthy aging: from Blue Zones to molecular mechanisms

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NLRP3 inflammasome activation in inflammaging

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New insight into dyslipidemia‐induced cellular senescence in atherosclerosis

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Sirtuins and intervertebral disc degeneration: Roles in inflammation, oxidative stress, and mitochondrial function

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SIRT6 in Aging, Metabolism, Inflammation and Cardiovascular Diseases

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The crosstalk between Sirt1 and Keap1/Nrf2/ARE anti-oxidative pathway forms a positive feedback loop to inhibit FN and TGF-β1 expressions in rat glomerular mesangial cells

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SIRT1 activation attenuates cardiac fibrosis by endothelial-to-mesenchymal transition

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Mitochondria initiate and regulate sarcopenia

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Aging and Caloric Restriction Research: A Biological Perspective with Translational Potential

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Mechanisms and disease implications of sirtuin-mediated autophagic regulation

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Immunosenescence: signaling pathways, diseases and therapeutic targets

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AMP-Activated Protein Kinase Regulation of the NLRP3 Inflammasome during Aging

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The landscape of transcription errors in eukaryotic cells

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Sirtuins and Insulin Resistance

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Semisynthetic biosensors for mapping cellular concentrations of nicotinamide adenine dinucleotides

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Targeting Mitochondrial Impairment in Parkinson's Disease: Challenges and Opportunities

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Sirtuins and FoxOs in osteoporosis and osteoarthritis

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