The murine dialysis fistula model exhibits a senescence phenotype: pathobiological mechanisms and therapeutic potential
Open accessAbstract
There is no therapy that promotes maturation and functionality of a dialysis arteriovenous fistula (AVF). The search for such therapies largely relies on evaluation of vascular responses and putative therapies in experimental AVFs. We studied an AVF in mice with chronic kidney disease (CKD). We demonstrate numerous stressors in the vein of the AVF-CKD group, including pathological shear, mitogenic, inflammatory, and hypoxia-reoxygenation stress. Because stress promotes premature senescence, we examined whether senescence is induced in the vein of the AVF-CKD model. We demonstrate a senescence phenotype in the AVF-CKD model, as indicated by increased expression of p16 Ink4a, p21 Cip1, and p53 and expected changes for certain senescence-associated microRNAs. RNA-sequencing analysis demonstrated differential expression of ~10,000 genes, including upregulation of proinflammatory and proliferative genes, in the vein of the AVF-CKD group. The vein in the AVF-CKD group exhibited telomere erosion and increased senescence-associated β-galactosidase activity and staining. Senescence was induced in the artery of the AVF-CKD group and in the vein of the AVF without CKD. Finally, given the rapidly rising clinical interest in senolytics, we provide proof of concept of senolytics as a therapeutic approach by demonstrating that senolytics decrease p16 Ink4a expression in the AVF-CKD model. This study introduces a novel concept underlying the basis for maturational and functional failure in human dialysis AVFs and identifies a new target for senolytic therapy.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Cellular senescence is a hallmark of aging and contributes to age-related chronic conditions including Alzheimer's disease.
“Cellular senescence is a hallmark feature of aging and contributes to numerous age-related chronic medical conditions including AD (10–19).”
From Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD): A Pilot Clinical Trial (2022) · cites this paper as [11]
A partial decrease of 35% in NFTs was observed as a disease-modifying effect.
“Moreover, disease-modifying effects were observed with a partial (35%) decrease in NFTs, which was consistent with preclinical studies of senolytic treatment for other models of aging and disease (10–16, 18, 19, 30, 54–56).”
From Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD): A Pilot Clinical Trial (2022) · cites this paper as [11]
In animals, genetic and pharmacologic reduction of senescent cell burden prevents, delays, or alleviates various aging-related diseases and sequelae.
“In animals, genetic and pharmacologic reduction of senescent cell burden results in the prevention, delay, and/or alleviation of a variety of aging-related diseases and sequelae.”
From Reducing Senescent Cell Burden in Aging and Disease (2020) · cites this paper as [6]
In preclinical aging models, senescent cell accumulation is associated with chronic diseases, geriatric syndromes, multimorbidity, and accelerated aging phenotypes.
“In pre-clinical aging models, accumulation of senescent cells is associated with multiple chronic diseases and disorders, geriatric syndromes, multi-morbidity, and accelerated aging phenotypes.”
From Reducing Senescent Cell Burden in Aging and Disease (2020) · cites this paper as [6]
Senolytics have been used to prevent, delay, or alleviate many age-onset diseases and syndromes in preclinical models.
“Senolytics have been used to prevent, delay, or alleviate a plethora of age-onset diseases and syndromes in pre-clinical models.”
From Reducing Senescent Cell Burden in Aging and Disease (2020) · cites this paper as [6]
Senotherapeutic drugs could potentially treat a variety of conditions primarily or secondarily mediated by senescent cell accumulation.
“The use of senotherapeutic drugs could potentially be effective in treating a variety of conditions primarily or secondarily mediated by accumulation of senescent cells [6, 33, 67–87].”
From Reducing Senescent Cell Burden in Aging and Disease (2020) · cites this paper as [6]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364 · see citing works
RSeQC: quality control of RNA-seq experiments
Wang, L., Wang, S., & Li, W. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts356 · Cited by 2,813 · see citing works
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., et al. (2015) · Aging Cell · doi:10.1111/acel.12344 · Cited by 2,562 · cited 1× · see citing works
“In other studies, mice with AVF-CKD were treated with the senolytic agent combination dasatinib (5 mg/kg) and quercetin (50 mg/kg) or vehicle via gavage at 4 and 5 days after AVF creation (24, 29), and p16 protein expression was assessed on day 7.”
MethodSelf-citationCellular senescence and the senescent secretory phenotype: therapeutic opportunities
Tchkonia, T., Zhu, Y., van Deursen, J., Campisi, J., & Kirkland, J. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64098 · Cited by 1,774 · see citing works
Self-citationCellular senescence mediates fibrotic pulmonary disease
Schafer, M. J., White, T. A., Iijima, K., Haak, A. J., Ligresti, G., Atkinson, E. J., Oberg, A. L., Birch, J., Salmonowicz, H., Zhu, Y., et al. (2017) · Nature Communications · doi:10.1038/ncomms14532 · Cited by 1,613 · see citing works
Self-citationHofstra, L., Tordoir, J. H. M., Kitslaar, P. J. E. H. M., Hoeks, A. P. G., & Daemen, M. J. A. P. (1996) · PubMed · doi:10.1161/01.cir.94.6.1283 · Cited by 1,603 · see citing works
Cellular senescence drives age-dependent hepatic steatosis
Ogrodnik, M., Miwa, S., Tchkonia, T., Tiniakos, D., Wilson, C. L., Lahat, A., Day, C. P., Burt, A., Palmer, A., Anstee, Q. M., et al. (2017) · Nature Communications · doi:10.1038/ncomms15691 · Cited by 1,044 · see citing works
Self-citationCellular senescence: a translational perspective
Kirkland, J. L., & Tchkonia, T. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.04.013 · Cited by 1,013 · see citing works
Self-citationVascular heterogeneity and specialization in development and disease
Potente, M., & Mäkinen, T. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.36 · Cited by 653 · see citing works
Hemodialysis Vascular Access Dysfunction
Roy‐Chaudhury, P., Sukhatme, V. P., & Cheung, A. K. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005050615 · Cited by 584 · see citing works
The Clinical potential of Senolytic Drugs
Kirkland, J. L., Tchkonia, T., Zhu, Y., Niedernhofer, L. J., & Robbins, P. D. (2017) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14969 · Cited by 539 · see citing works
Self-citationHowe, E., Sinha, R., Schlauch, D., & Quackenbush, J. F. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr490 · Cited by 514 · see citing works
MAP-RSeq: Mayo Analysis Pipeline for RNA sequencing
Kalari, K. R., Nair, A., Bhavsar, J., O’Brien, D. R., Davila, J. I., Bockol, M. A., Nie, J. J., Tang, X., Baheti, S., Doughty, J. B., et al. (2014) · BMC Bioinformatics · doi:10.1186/1471-2105-15-224 · Cited by 415 · see citing works
Self-citationCumulative Patency of Contemporary Fistulas versus Grafts (2000–2010)
Lok, C. E., Sontrop, J. M., TOMLINSON, G. A., Rajan, D. K., Cattral, M. S., Oreopoulos, G. D., Harris, J., & MOIST, L. M. (2013) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.00730112 · Cited by 240 · see citing works
MicroRNAs linking inflamm-aging, cellular senescence and cancer
Olivieri, F., Rippo, M. R., Monsurrò, V., Salvioli, S., Capri, M., Procopio, A. D., & Franceschi, C. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.05.001 · Cited by 203 · see citing works
Vascular access in haemodialysis: strengthening the Achilles' heel
RIELLA, M. C., & Roy‐Chaudhury, P. (2013) · Nature Reviews Nephrology · doi:10.1038/nrneph.2013.76 · Cited by 164 · see citing works
MCP-1 Contributes to Arteriovenous Fistula Failure
Juncos, J. P., Grande, J. P., Lu, K., Ackerman, A. W., Croatt, A. J., Katušić, Z. S., & Nath, K. A. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010040373 · Cited by 97 · see citing works
Self-citationViecelli, A. K., Mori, T. A., Roy‐Chaudhury, P., Polkinghorne, K. R., Hawley, C. M., Johnson, D. W., Pascoe, E. M., & Irish, A. B. (2017) · Seminars in Dialysis · doi:10.1111/sdi.12658 · Cited by 94 · see citing works
Nath, K. A., Kanakiriya, S., Grande, J. P., Croatt, A. J., & Katušić, Z. S. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64339-8 · Cited by 74 · see citing works
Self-citationJuncos, J. P., Tracz, M. J., Croatt, A. J., Grande, J. P., Ackerman, A. W., Katušić, Z. S., & Nath, K. A. (2008) · Kidney International · doi:10.1038/ki.2008.110 · Cited by 64 · see citing works
Self-citationCharacterization of a Model of an Arteriovenous Fistula in the Rat
Croatt, A. J., Grande, J. P., Hernandez, M. C., Ackerman, A. W., Katušić, Z. S., & Nath, K. A. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090649 · Cited by 60 · see citing works
Self-citationCardiomyopathy and Worsened Ischemic Heart Failure in SM22-α Cre-Mediated Neuropilin-1 Null Mice
Wang, Y., Cao, Y., Yamada, S., Thirunavukkarasu, M., Nin, V., Joshi, M., Rishi, M. T., Bhattacharya, S., Camacho-Pereira, J., Sharma, A. K., et al. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305566 · Cited by 54 · see citing works
Self-citationLu, K., Grande, J. P., Hillestad, M. L., Croatt, A. J., Barry, M. A., Katušić, Z. S., & Nath, K. A. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00288.2015 · Cited by 39 · see citing works
Self-citationAnatomic configuration affects the flow rate and diameter of porcine arteriovenous fistulae
Krishnamoorthy, M. K., Banerjee, R. K., Wang, Y., Choe, A. K., Rigger, D., & Roy‐Chaudhury, P. (2012) · Kidney International · doi:10.1038/ki.2011.468 · Cited by 28 · see citing works
Experimental reduction of miR-92a mimics arterial aging
Hazra, S., Henson, G. D., Morgan, R. G., Breevoort, S. R., Ives, S. J., Richardson, R. S., Donato, A. J., & Lesniewski, L. A. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.08.007 · Cited by 27 · see citing works
Lu, K., Hillestad, M. L., Grande, J. P., Croatt, A. J., Barry, M. A., Farrugia, G., Katušić, Z. S., & Nath, K. A. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00882.2014 · Cited by 19 · see citing works
Self-citationVascular Access for Hemodialysis and Value-Based Purchasing for ESRD
Mehrotra, R., Cheung, A. K., Meyer, T. W., & Nath, K. A. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016070769 · Cited by 11 · see citing works
Self-citationChallenges in Developing New Therapies for Vascular Access Dysfunction
Nath, K. A., & Allon, M. (2017) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.06650617 · Cited by 8 · see citing works
Self-citationPredicting the Functionality and Form of a Dialysis Fistula
Nath, K. A., & Katušić, Z. S. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016050569 · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Hickson, L. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.08.069 · Cited by 1,383 · see citing works
Self-citationSenolytic drugs: from discovery to translation
Kirkland, J. L., & Tchkonia, T. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13141 · Cited by 1,227 · see citing works
Self-citationCellular senescence and senolytics: the path to the clinic
Chaib, S., Tchkonia, T., & Kirkland, J. L. (2022) · Nature Medicine · doi:10.1038/s41591-022-01923-y · Cited by 1,105 · see citing works
Self-citationThe role of cellular senescence in ageing and endocrine disease
Khosla, S., Farr, J. N., Tchkonia, T., & Kirkland, J. L. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0335-y · Cited by 523 · see citing works
Self-citationTherapy-Induced Senescence: An “Old” Friend Becomes the Enemy
Saleh, T., Bloukh, S., Carpenter, V. J., Alwohoush, E., Bakeer, J., Darwish, S., Azab, B., & Gewirtz, D. A. (2020) · Cancers · doi:10.3390/cancers12040822 · Cited by 289 · see citing works
Gonzales, M. M., Garbarino, V. R., Marques Zilli, E., Petersen, R. C., Kirkland, J. L., Tchkonia, T., Musi, N., Seshadri, S., Craft, S., & Orr, M. E. (2022) · The Journal of Prevention of Alzheimer's Disease · doi:10.14283/jpad.2021.62 · Cited by 203 · see citing works
Self-citationReducing Senescent Cell Burden in Aging and Disease
Pignolo, R. J., Passos, J. F., Khosla, S., Tchkonia, T., & Kirkland, J. L. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.03.005 · Cited by 177 · see citing works
Self-citationCellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies
Lucas, V., Cavadas, C., & Aveleira, C. A. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000622 · Cited by 169 · see citing works
Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities
Song, S., Tchkonia, T., Jiang, J., Kirkland, J. L., & Sun, Y. (2020) · Advanced Science · doi:10.1002/advs.202002611 · Cited by 129 · see citing works
Self-citationSenolytics for Cancer Therapy: Is All that Glitters Really Gold?
Carpenter, V. J., Saleh, T., & Gewirtz, D. A. (2021) · Cancers · doi:10.3390/cancers13040723 · Cited by 124 · see citing works
“associated hepatic steatosis [71], arteriovenous fistulation in chronic kidney disease [72], Alzheimer’s disease [73,74], hyperoxia-induced airway dysfunction [75], obesity-associated anxiety [76], obesity-induced metabolic dysfunction [77], osteoarthritis [78], radiationinduced bone degeneration [79] and radiation-in…”
BackgroundSenescent Cells: A Therapeutic Target in Cardiovascular Diseases
Suda, M., Paul, K. H., Minamino, T., Miller, J. D., Lerman, A., Ellison, G. M., Tchkonia, T., & Kirkland, J. L. (2023) · Cells · doi:10.3390/cells12091296 · Cited by 116 · see citing works
“D+Q has been shown to decrease senescent cell burden in arteriovenous fistulae allowing hemodialysis in chronic kidney disease model mice [284].”
BackgroundSelf-citationOrally-active, clinically-translatable senolytics restore α-Klotho in mice and humans
Zhu, Y., Prata, L. G. P. L., Gerdes, E. O. W., Netto, J. M. E., Pirtskhalava, T., Giorgadze, N., Tripathi, U., Inman, C. L., Johnson, K. O., Xue, A., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.103912 · Cited by 96 · see citing works
Self-citationImpact of Geroscience on Therapeutic Strategies for Older Adults With Cardiovascular Disease
Forman, D. E., Kuchel, G. A., Newman, J. C., Kirkland, J. L., Volpi, E., Taffet, G. E., Barzilai, N., Pandey, A., Kitzman, D. W., Libby, P., et al. (2023) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.05.038 · Cited by 63 · see citing works
Self-citationTranslating the Biology of Aging into New Therapeutics for Alzheimer's Disease: Senolytics
Rießland, M., & Orr, M. E. (2023) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2023.104 · Cited by 55 · see citing works
Potential Clinical Implications of Senotherapies for Cardiovascular Disease
Suda, M., Katsuumi, G., Tchkonia, T., Kirkland, J. L., & Minamino, T. (2023) · Circulation Journal · doi:10.1253/circj.cj-23-0657 · Cited by 37 · see citing works
Self-citationWalker, J., Richards, S., Belghasem, M., Arinze, N. V., Yoo, S. B., Tashjian, J. Y., Whelan, S. A., Lee, N., Kolachalama, V. B., Francis, J. M., et al. (2019) · Kidney International · doi:10.1016/j.kint.2019.09.029 · Cited by 35 · see citing works
Targeting senescent cells for the treatment of age-associated diseases
Suda, M., Tchkonia, T., Kirkland, J. L., & Minamino, T. (2024) · The Journal of Biochemistry · doi:10.1093/jb/mvae091 · Cited by 34 · see citing works
Self-citationMixing old and young: enhancing rejuvenation and accelerating aging
Lau, A., Kennedy, B. K., Kirkland, J. L., & Tullius, S. G. (2019) · Journal of Clinical Investigation · doi:10.1172/jci123946 · Cited by 29 · see citing works
Self-citationVascular access animal models used in research
Kokozidou, M., Katsargyris, Α., Verhoeven, E. L. G., & Schulze-Tanzil, G. G. (2019) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2019.06.002 · Cited by 28 · see citing works
Čubro, H., Nath, K. A., Suvakov, S. R., Valencia, O. A. G., Parashuram, S., White, W., Weissgerber, T. L., Nath, M. C., Milic, N. M., Sontag, F., et al. (2020) · Kidney International · doi:10.1016/j.kint.2020.09.034 · Cited by 23 · see citing works
Self-citationPotential Use of Senolytics for Pharmacological Targeting of Precancerous Lesions
Saleh, T., & Carpenter, V. J. (2021) · Molecular Pharmacology · doi:10.1124/molpharm.121.000361 · Cited by 17 · see citing works
“…appears to contribute to their pathogenesis such as myocardial infarction and ischemia-reperfusion injury (Walaszczyk et al., 2019; Dookun et al., 2020), chronic kidney disease (Nath et al., 2018), pulmonary fi brosis (Pan et al., 2017), and bone degeneration (Kim et al., 2017; Yao et al., 2020).”
Shiu, Y.-T. E., Northrup, H. M., Huang, Y., Cho, M. E., & Bunsawat, K. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00010.2025 · Cited by 16 · see citing works
Translating cellular senescence research into clinical practice for metabolic disease
Chaib, S., Palmer, A. K., Wyles, S. P., Musi, N., Kirkland, J. L., & Tchkonia, T. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01187-9 · Cited by 14 · see citing works
Self-citationGonzález, I., & Maldonado‐Agurto, R. (2025) · The Journal of Physiology · doi:10.1113/jp287387 · Cited by 9 · see citing works
“Considering that in AVFs there are also regions exposed to disturbed flow like those observed in atherosclerotic regions prone to accumulating senescent cells, it is reasonable to suggest that a similar phenomenon occurs in AVFs.”
InfluentialBioinformatics identifies predictors of arteriovenous fistula maturation
Liu, J., Zhang, D., Brahmandam, A., Matsubara, Y., Gao, M., Tian, J., Liu, B., Shu, C., & Dardik, A. (2022) · The Journal of Vascular Access · doi:10.1177/11297298221102298 · Cited by 9 · see citing works
Kim, K., Anderson, E., Martin, A. J., Hu, Q., Cort, T. A., Harland, K. C., O’Malley, K. A., Lu, G., Berceli, S. A., RYAN, T. E., et al. (2021) · JVS Vascular Science · doi:10.1016/j.jvssci.2021.09.022 · Cited by 8 · see citing works
Nath, K. A., Singh, R. D., Croatt, A. J., Ackerman, A. W., Grande, J. P., O’Brien, D. R., Garovic, V. D., Adams, C. M., Tchkonia, T., & Kirkland, J. L. (2024) · Kidney360 · doi:10.34067/kid.0000000000000395 · Cited by 6 · see citing works
Self-citationThe Occurrence of Senescence in the Arteriovenous Fistula in the Rat
Nath, K. A., Juncos, L. A., Singh, R. D., Grande, J. P., Croatt, A. J., Ackerman, A. W., Kanamori, K. S., Adams, C. M., Tchkonia, T., Kirkland, J. L., et al. (2024) · Kidney360 · doi:10.34067/kid.0000000605 · Cited by 6 · see citing works
Self-citationHe, Y., Zheng, G., & Zhou, D. (2020) · Healthy ageing and longevity · doi:10.1007/978-3-030-44903-2_1 · Cited by 6 · see citing works
The potential for senotherapy as a novel approach to extend life quality in veterinary medicine
Williams, Z. J., Chow, L., Dow, S., & Pezzanite, L. M. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1369153 · Cited by 5 · see citing works
Mauro, R., Rocchi, C., Vasuri, F., Pini, A., Chiocchini, A. L. C., Ciavarella, C., Manna, G. L., Pasquinelli, G., Faggioli, G., & Gargiulo, M. (2021) · The Journal of Vascular Access · doi:10.1177/11297298211015495 · Cited by 4 · see citing works
A Murine Model of Hemodialysis Access-Related Hand Dysfunction
Kim, K., Anderson, E., Fazzone, B. J., O’Malley, K. A., Berceli, S. A., RYAN, T. E., & Scali, S. T. (2022) · Journal of Visualized Experiments · doi:10.3791/63892 · Cited by 4 · see citing works
A Modified Technique for Arteriovenous Fistula Construction in Rabbits
Liu, Z., Hou, G., Xiaohe, W., Jingfang, H., Jie, L., & Minggang, W. (2023) · Journal of Visualized Experiments · doi:10.3791/64352 · Cited by 3 · see citing works
Does the Primacy of the Fistula Still Prevail in an Aging Hemodialysis Population?
Nath, K. A. (2023) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000000000000183 · Cited by 2 · see citing works
Self-citationCell senescence in pulmonary hypertension
Born, E., Lipskaia, L., Abid, S., Houssaini, A., Breau, M., Beaulieu, D., Marcos, É., & Adnot, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822514-1.00003-1 · Cited by 1 · see citing works
Interventions that target fundamental aging mechanisms: myths and realities
Gerdes, E. O. W., Zhu, Y. Z., Tchkonia, T., & Kirkland, J. L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823761-8.00009-4
Self-citationVázquez-Padrón, R. I., & Shiu, Y.-T. E. (2025) · Kidney360 · doi:10.34067/kid.0000000684
Senolytic Changes in Murine Arteriovenous Fistulas with CKD
Kane, J., Kilari, S., Lemieux, A., Singh, P. G., Anderson, N., Saul, D., Tchkonia, T., Kirkland, J. L., & Misra, S. (2026) · Kidney360 · doi:10.34067/kid.0000001104
Self-citationArteriovenous fistula creation results in cardiac dysfunction and remodeling in a uremic pig model
Kane, J., Singh, P. G., Kilari, S., Baranwal, G., Roy-Chowdhury, S., Naskar, A., Montonye, D., Lutgens, E., Wang, Y., Negm, A., et al. (2026) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00227.2025
Mechanism of Quercetin in Treatment of Vascular Calcification in Chronic Kidney Disease
Yin, X., Guo, X., Gao, W., Dong, X., & Liu, S. (2026) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2026.151717
- Authors
- Nath, K. A., O’Brien, D. R., Croatt, A. J., Grande, J. P., Ackerman, A. W., Nath, M. C., Yamada, S., Terzic, A., Tchkonia, T., Kirkland, J. L., & Katusic, Z. S.
- Affiliations
- Mayo Clinic (US)
- Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota
- Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota
- Departments of Anesthesiology and Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota
- Corresponding author
- Nath, Karl A.
- ORCID
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 2018-11-01
- Volume
- 315
- Issue
- 5
- Pages
- F1493-F1499
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- PMC
- PMC6293292
- OpenAlex
- W2883574935
- Cited by
- 40
- References
- 29
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 4
- FWCI
- 6.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Physiology-Renal Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (DK70124, DK47060)
- HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI) (HL134664)
- HHS | NIH | National Institute on Aging (U.S. National Institute on Aging) (AG13925)
- Russ and Kathy Van Cleve Foundation
- Connor Group Foundation
- Robert J. and Theresa W. Ryan Foundation
- Ted Nash Long Life Foundation
- Noaber Foundation
- Topics
- Health Sciences › Health Professions › Emergency Medical Services › Central Venous Catheters and Hemodialysis
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Keywords
- arteriovenous fistula, hemodialysis vascular access, premature senescence, chronic kidney disease, senolytics, p16INK4a, p21, p53, telomere shortening, senescence-associated β-galactosidase, inflammation, mouse model
- MeSH terms
- Dasatinib, Animals, Arteriovenous Shunt, Surgical, Blood Flow Velocity, Disease Models, Animal, Gene Expression Regulation, Renal Dialysis, Mice, Inbred C57BL, Phenotype, Postoperative Complications, Quercetin, Regional Blood Flow, Stress, Mechanical, Tail, Vascular Patency, Veins, Cellular Senescence, MicroRNAs, Mice, Renal Insufficiency, Chronic, Vascular Remodeling
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
