The SCF ubiquitin ligase: insights into a molecular machine

THE UBIQUITIN SYSTEM

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SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif, the F-Box

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Comprehensive Proteome Analysis of an Apc Mouse Model Uncovers Proteins Associated with Intestinal Tumorigenesis

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E3 Ligase Subunit Fbxo15 and PINK1 Kinase Regulate Cardiolipin Synthase 1 Stability and Mitochondrial Function in Pneumonia

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Experimental Validation of the Docking Orientation of Cdc25 with Its Cdk2−CycA Protein Substrate

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Accelerated Neuronal Cell Recovery from Botulinum Neurotoxin Intoxication by Targeted Ubiquitination

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Ubiquitination involved enzymes and cancer

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Loss of peptide: N -glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase

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Smad3 Protein Levels Are Modulated by Ras Activity and during the Cell Cycle to Dictate Transforming Growth Factor-β Responses

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Isolation and Characterization ofcul1-7, a Recessive Allele ofCULLIN1That Disrupts SCF Function at the C Terminus of CUL1 inArabidopsis thaliana

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The FBXL10/KDM2B Scaffolding Protein Associates with Novel Polycomb Repressive Complex-1 to Regulate Adipogenesis

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Origin and Evolution of GALA-LRR, a New Member of the CC-LRR Subfamily: From Plants to Bacteria?

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Ter94 ATPase Complex Targets K11-Linked Ubiquitinated Ci to Proteasomes for Partial Degradation

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Roles of F-box Proteins in Plant Hormone Responses

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SCFβ-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration

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A broad view of scaffolding suggests that scaffolding proteins can actively control regulation and signaling of multienzyme complexes through allostery

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F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7

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Structural Basis of Dimerization-dependent Ubiquitination by the SCFFbx4 Ubiquitin Ligase

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Twists and turns in ubiquitin‐like protein conjugation cascades

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A Transcriptional Activator Is Part of an SCF Ubiquitin Ligase to Control Degradation of Its Cofactors

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LPS Impairs Phospholipid Synthesis by Triggering β-Transducin Repeat-containing Protein (β-TrCP)-mediated Polyubiquitination and Degradation of the Surfactant Enzyme Acyl-CoA:Lysophosphatidylcholine Acyltransferase I (LPCAT1)

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Identification of Key Regulatory Genes and Pathways in Prefrontal Cortex of Alzheimer’s Disease

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The Novel F-Box Protein Mfb1p Regulates Mitochondrial Connectivity and Exhibits Asymmetric Localization in Yeast

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Ectromelia Virus Encodes a Novel Family of F-Box Proteins That Interact with the SCF Complex

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Gln40 deamidation blocks structural reconfiguration and activation of SCF ubiquitin ligase complex by Nedd8

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Targeting SCF E3 Ligases for Cancer Therapies

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FBXL2 is a ubiquitin E3 ligase subunit that triggers mitotic arrest

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Zoledronic acid induces S-phase arrest via a DNA damage response in normal human oral keratinocytes

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CRL Ubiquitin Ligases and DNA Damage Response

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USP18 and ISG15 coordinately impact on SKP2 and cell cycle progression

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Identification and selectivity profiling of small-molecule degraders via multi-omics approaches

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Cardiomyocyte proliferation and protection against post-myocardial infarction heart failure by cyclin D1 and Skp2 ubiquitin ligase

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The Emerging Role of the Ubiquitin Proteasome in Pulmonary Biology and Disease

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The tumor-suppressor gene Nkx2.8 suppresses bladder cancer proliferation through upregulation of FOXO3a and inhibition of the MEK/ERK signaling pathway

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Post-Translational Modifications in Oocyte Maturation and Embryo Development

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Mechanisms of pseudosubstrate inhibition of the anaphase promoting complex by Acm1

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Novel functions for the anaphase-promoting complex in neurobiology

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SCFSLF-mediated cytosolic degradation of S-RNase is required for cross-pollen compatibility in S-RNase-based self-incompatibility in Petunia hybrida

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SmKFB5 protein regulates phenolic acid biosynthesis by controlling the degradation of phenylalanine ammonia-lyase inSalvia miltiorrhiza

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A new ubiquitin ligase involved in p57KIP2 proteolysis regulates osteoblast cell differentiation

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SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination

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Poxvirus Exploitation of the Ubiquitin-Proteasome System

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Nonstructural protein P7-2 encoded by Rice black-streaked dwarf virus interacts with SKP1, a core subunit of SCF ubiquitin ligase

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SMALL LEAF AND BUSHY1 controls organ size and lateral branching by modulating the stability of BIG SEEDS1 in Medicago truncatula

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Lineage-Specific Variation in Intensity of Natural Selection in Mammals

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States of G0 and the proliferation-quiescence decision in cells, tissues and during development

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SCFJFK is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancerPreprint

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Wrenches in the works: drug discovery targeting the SCF ubiquitin ligase and APC/C complexes

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Control of Epithelial Cell Migration and Invasion by the IKKβ- and CK1α-Mediated Degradation of RAPGEF2

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FBXL5-mediated degradation of single-stranded DNA-binding protein hSSB1 controls DNA damage response

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Roles of ubiquitination in pattern-recognition receptors and type I interferon receptor signaling

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PI3K-dependent phosphorylation of Fbw7 modulates substrate degradation and activity

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Molecular Dynamics Reveal the Essential Role of Linker Motions in the Function of Cullin–RING E3 Ligases

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Discovery of candidate KEN-box motifs using Cell Cycle keyword enrichment combined with native disorder prediction and motif conservation

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Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2

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FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system

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FBX8 degrades GSTP1 through ubiquitination to suppress colorectal cancer progression

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Ubiquitination of BST-2 Protein by HIV-1 Vpu Protein Does Not Require Lysine, Serine, or Threonine Residues within the BST-2 Cytoplasmic Domain

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Signal-Induced Disassembly of the SCF Ubiquitin Ligase Complex by Cdc48/p97

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A Neural-specific F-box Protein Fbs1 Functions as a Chaperone Suppressing Glycoprotein Aggregation

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MIF coordinates the cell cycle with DNA damage checkpoints. Lessons from knockout mouse models

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The ETS Protein MEF Is Regulated by Phosphorylation-Dependent Proteolysis via the Protein-Ubiquitin Ligase SCFSkp2

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Ubiquitin E3 ligase atrogin-1 (Fbox-32) in Atlantic salmon (Salmo salar): Sequence analysis, genomic structure and modulation of expression

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The adenovirus E4orf6 E3 ubiquitin ligase complex assembles in a novel fashion

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The SKP1-Like Gene Family of Arabidopsis Exhibits a High Degree of Differential Gene Expression and Gene Product Interaction during Development

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Cytoplasmic Skp2 Expression Is Increased in Human Melanoma and Correlated with Patient Survival

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Skp1 stabilizes the conformation of F-box proteins

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Induction of Gsk3β-β-TrCP Interaction Is Required for Late Phase Stabilization of β-Catenin in Canonical Wnt Signaling

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Molecular characterization of axonemal proteins and signaling molecules responsible for chemoattractant‐induced sperm activation in Ciona intestinalis

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The oncoprotein hepatitis B X-interacting protein promotes the migration of ovarian cancer cells through the upregulation of S-phase kinase-associated protein 2 by Sp1

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Regulating Fbw7 on the road to cancer

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A genome-scale CRISPR-Cas9 screening method for protein stability reveals novel regulators of Cdc25A

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The application of targeted mass spectrometry‐based strategies to the detection and localization of post‐translational modifications

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The highly conserved orthopoxvirus 68k ankyrin-like protein is part of a cellular SCF ubiquitin ligase complex

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Ring structure amino acids affect the suppressor activity of melon aphid-borne yellows virus P0 protein

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Skp1: Implications in cancer and SCF-oriented anti-cancer drug discovery

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SCF Cdc4 -mediated Degradation of the Hac1p Transcription Factor Regulates the Unfolded Protein Response in Saccharomyces cerevisiae

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The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction

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The Biology of F-box Proteins: The SCF Family of E3 Ubiquitin Ligases

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F-box protein substrate recognition

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Identification of novel F-box proteins in Xenopus laevis

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A family of mammalian F-box proteins

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