Cited by 1,114Ubiquitin and proteasome pathwaysProtein Degradation and InhibitorsCancer-related Molecular Pathways

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The SCF ubiquitin ligase: insights into a molecular machine

Cardozo, Timothy, Pagano, Michele·2004·Nature Reviews Molecular Cell Biology

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Abstract

Ubiquitin ligases are well suited to regulate molecular networks that operate on a post-translational timescale. The F-box family of proteins - which are the substrate-recognition components of the Skp1-Cul1-F-box-protein (SCF) ubiquitin ligase - are important players in many mammalian functions. Here we explore a unifying and structurally detailed view of SCF-mediated proteolytic control of cellular processes that has been revealed by recent studies.

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THE UBIQUITIN SYSTEM
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Authors: Cardozo, T., & Pagano, M.
Affiliations: NYU Langone Health (US)
Corresponding author: Pagano, Michele
ORCID: Cardozo, Timothy
Pagano, Michele
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2004-09-01
Volume: 5
Issue: 9
Pages: 739-751
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm1471
OpenAlex: W2061156149
Cited by: 1,114
References: 131
Citations by year: 2026: 29 · 2025: 33 · 2024: 31 · 2023: 50 · 2022: 39 · 2021: 44 · 2020: 43 · 2019: 34 · 2018: 38 · 2017: 54 · 2016: 35 · 2015: 61 · 2014: 64 · 2013: 73 · 2012: 74
FWCI: 4.21
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: SCF ubiquitin ligase, F-box protein, substrate recognition, ubiquitination, proteolytic regulation, post-translational regulation, protein degradation, molecular machines
MeSH terms: Animals, Cell Cycle, Humans, Models, Molecular, Drug Design, Protein Structure, Tertiary, Cyclin-Dependent Kinases, Evolution, Molecular, F-Box Proteins, SKP Cullin F-Box Protein Ligases

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The SCF ubiquitin ligase: insights into a molecular machine

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