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The SCF ubiquitin ligase: insights into a molecular machine
Abstract
Ubiquitin ligases are well suited to regulate molecular networks that operate on a post-translational timescale. The F-box family of proteins - which are the substrate-recognition components of the Skp1-Cul1-F-box-protein (SCF) ubiquitin ligase - are important players in many mammalian functions. Here we explore a unifying and structurally detailed view of SCF-mediated proteolytic control of cellular processes that has been revealed by recent studies.
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“The phosphorylation of both serines in the degron sequence is needed to allow recognition by βTRCP [69].”
From Control Mechanisms of the Tumor Suppressor PDCD4: Expression and Functions (2019) · cites this paper as [69]
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Metadata
- Authors
- Cardozo, T., & Pagano, M.
- Affiliations
- NYU Langone Health (US)
- Corresponding author
- Pagano, Michele
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2004-09-01
- Volume
- 5
- Issue
- 9
- Pages
- 739-751
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2061156149
- Cited by
- 1,114
- References
- 131
- Citations by year
- 2026: 29 · 2025: 33 · 2024: 31 · 2023: 50 · 2022: 39 · 2021: 44 · 2020: 43 · 2019: 34 · 2018: 38 · 2017: 54 · 2016: 35 · 2015: 61 · 2014: 64 · 2013: 73 · 2012: 74
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- SCF ubiquitin ligase, F-box protein, substrate recognition, ubiquitination, proteolytic regulation, post-translational regulation, protein degradation, molecular machines
- MeSH terms
- Animals, Cell Cycle, Humans, Models, Molecular, Drug Design, Protein Structure, Tertiary, Cyclin-Dependent Kinases, Evolution, Molecular, F-Box Proteins, SKP Cullin F-Box Protein Ligases
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