Nox enzymes and new thinking on reactive oxygen: A double-edged sword revisited
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Reactive oxygen species (ROS) are a chemical class of molecules that have generally been conceptualized as deleterious entities, albeit ones whose destructive properties could be harnessed as antimicrobial effector functions to benefit the whole organism. This appealingly simplistic notion has been turned on its head in recent years with the discovery of the NADPH oxidases, or Noxes, a family of enzymes dedicated to the production of ROS in a variety of cells and tissues. The Nox-dependent, physiological generation of ROS is highly conserved across virtually all multicellular life, often as a generalized response to microbes and/or other exogenous stressors. This review discusses the current knowledge of the role of physiologically generated ROS and the enzymes that form them in both normal biology and disease.
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The Nox enzyme family and the respiratory electron transport chain of mitochondria are the two major sources of ROS in many eukaryotic cells.
“The enzyme family of NADPH oxidases (Nox) [13,83] and the respiratory electron transport chain (ETC) of mitochondria [84,85,86] are the two major sources of ROS in many eukaryotic cells.”
From Functions of ROS in Macrophages and Antimicrobial Immunity (2021) · cites this paper as [13]
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- Authors
- Lambeth, J. D., & Neish, A. S.
- Affiliations
- Emory University (US)
- ORCID
- Neish, Andrew S.
- Venue
- Annual Review of Pathology: Mechanisms of Disease
- Publisher
- Annual Reviews
- Published
- 2014-01-24
- Volume
- 9
- Issue
- 1
- Pages
- 119-145
- ISSN
- 1553-4006 (ISSN-L)
- 1553-4014
- OpenAlex
- W2106453911
- Cited by
- 495
- References
- 155
- Citations by year
- 2026: 26 · 2025: 34 · 2024: 43 · 2023: 32 · 2022: 45 · 2021: 44 · 2020: 45 · 2019: 42 · 2018: 32 · 2017: 59 · 2016: 50 · 2015: 26 · 2014: 15 · 2013: 2
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Pathology Mechanisms of Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R33AI102197, R01AI064462)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- reactive oxygen species, NADPH oxidase, antimicrobial defense, host-pathogen interaction, oxidative stress, pathogenesis
- MeSH terms
- Animals, Humans, Reactive Oxygen Species, NADPH Oxidases
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