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Preventing re-replication of chromosomal DNA
Open accessAbstract
To ensure its duplication, chromosomal DNA must be precisely duplicated in each cell cycle, with no sections left unreplicated, and no sections replicated more than once. Eukaryotic cells achieve this by dividing replication into two non-overlapping phases. During late mitosis and G1, replication origins are 'licensed' for replication by loading the minichromosome maintenance (Mcm) 2–7 proteins to form a pre-replicative complex. Mcm2–7 proteins are then essential for initiating and elongating replication forks during S phase. Recent data have provided biochemical and structural insight into the process of replication licensing and the mechanisms that regulate it during the cell cycle.
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Cited by
Jin, J., Arias, E. E., Chen, J., Harper, J. W., & Walter, J. C. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.08.010 · Cited by 632
Galanos, P., Vougas, K., Walter, D., Polyzos, A., Maya-Mendoza, A., Haagensen, E. J., Kokkalis, A., Roumelioti, F.-M., Gagos, S., Tzetis, M., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3378 · Cited by 308
Self-citationPersistent Telomere Damage Induces Bypass of Mitosis and Tetraploidy
Davoli, T., Denchi, E. L., & de Lange, T. (2010) · Cell · doi:10.1016/j.cell.2010.01.031 · Cited by 298
The structural determinants of checkpoint activation
MacDougall, C. A., Byun, T. S., Van, C., Yee, M.-C., & Cimprich, K. A. (2007) · Genes & Development · doi:10.1101/gad.1522607 · Cited by 240
Mechanism of Genomic Instability in Cells Infected with the High-Risk Human Papillomaviruses
Kadaja, M., Isok-Paas, H., Laos, T., Ustav, E., & Ustav, M. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000397 · Cited by 173
Metadata
- Authors
- Blow, J. J., & Dutta, A.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2005-06
- Volume
- 6
- Issue
- 6
- Pages
- 476-486
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2057896961
- Cited by
- 660
- References
- 0
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- green
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