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Preventing re-replication of chromosomal DNA
Open accessAbstract
To ensure its duplication, chromosomal DNA must be precisely duplicated in each cell cycle, with no sections left unreplicated, and no sections replicated more than once. Eukaryotic cells achieve this by dividing replication into two non-overlapping phases. During late mitosis and G1, replication origins are 'licensed' for replication by loading the minichromosome maintenance (Mcm) 2–7 proteins to form a pre-replicative complex. Mcm2–7 proteins are then essential for initiating and elongating replication forks during S phase. Recent data have provided biochemical and structural insight into the process of replication licensing and the mechanisms that regulate it during the cell cycle.
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Cited by
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The structural determinants of checkpoint activation
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Srinivasan, S. V., Mayhew, C. N., Schwemberger, S., Zagorski, W., & Knudsen, E. S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700542200 · Cited by 42
The protein phosphatase 2A regulatory subunit PR70 is a gonosomal melanoma tumor suppressor gene
van Kempen, L. C. L., Redpath, M., Elchebly, M., Klein, K. O., Papadakis, A. I., Wilmott, J. S., Scolyer, R. A., Edqvist, P.-H., Pontén, F., Schadendorf, D., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aai9188 · Cited by 29
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Metadata
- Authors
- Blow, J. J., & Dutta, A.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2005-06
- Volume
- 6
- Issue
- 6
- Pages
- 476-486
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2057896961
- Cited by
- 660
- References
- 0
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- green
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