MAPKAP kinases — MKs — two's company, three's a crowd

The protein kinase complement of the human genome

Manning, G., Whyte, D. B., Martinez, R., Hunter, T., & Sudarsanam, S. (2002) · Science · doi:10.1126/science.1075762 · Cited by 8,145 · see citing works

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

Shaw, G. D., & Kamen, R. (1986) · Cell · doi:10.1016/0092-8674(86)90341-7 · Cited by 3,946 · see citing works

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

Lee, J. C., Laydon, J. T., McDonnell, P., Gallagher, T. F., Kumar, S., Green, D., McNulty, D. E., Blumenthal, M. J., Keys, J., vatter, S. W. L., et al. (1994) · Nature · doi:10.1038/372739a0 · Cited by 3,266 · see citing works

AU-rich elements: characterization and importance in mRNA degradation

Chen, C.-Y. A., & Shyu, A.-B. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89102-1 · Cited by 1,948 · see citing works

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

Rouse, J. W., Cohen, P., Trigon, S., Morange, M., Alonso‐Llamazares, A., Zamanillo, D., Hunt, T., & Nebreda, Á. R. (1994) · Cell · doi:10.1016/0092-8674(94)90277-1 · Cited by 1,674 · see citing works

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.

Lessard, J., & Sauvageau, G. (2003) · Nature · doi:10.1038/nature01572 · Cited by 1,452 · see citing works

Small heat shock proteins are molecular chaperones.

Jakob, U., Gaestel, M., Engel, K., & Büchner, J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53882-5 · Cited by 1,377 · see citing works

Feedback Inhibition of Macrophage Tumor Necrosis Factor-α Production by Tristetraprolin

Carballo, E., Lai, W. S., & Blackshear, P. J. (1998) · Science · doi:10.1126/science.281.5379.1001 · Cited by 1,162 · see citing works

Evolution of protein kinase signaling from yeast to man

Manning, G., Plowman, G. D., Hunter, T. R., & Sudarsanam, S. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02179-5 · Cited by 986 · see citing works

Mitogen‐activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

Waskiewicz, A. J., Flynn, A., Proud, C. G., & Cooper, J. A. (1997) · The EMBO Journal · doi:10.1093/emboj/16.8.1909 · Cited by 951 · see citing works

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27

Freshney, N. W., Rawlinson, L. M., Guesdon, F., Jones, E., Cowley, S. A., Hsuan, J. J., & Saklatvala, J. (1994) · Cell · doi:10.1016/0092-8674(94)90278-x · Cited by 865 · see citing works

A conserved docking motif in MAP kinases common to substrates, activators and regulators

Tanoue, T., Adachi, M., Moriguchi, T., & Nishida, E. (2000) · Nature Cell Biology · doi:10.1038/35000065 · Cited by 816 · see citing works

Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.Preprint

van der Lugt, N. M. T., Domen, J., Linders, K., van ROON, M. A., Robanus-Maandag, E. C., Riele, H. T., van der Valk, M., Deschamps, J., Sofroniew, M. V., & van Lohuizen, M. (1994) · Genes & Development · doi:10.1101/gad.8.7.757 · Cited by 781 · see citing works

The p38 MAP kinase pathway signals for cytokine‐induced mRNA stabilization via MAP kinase‐activated protein kinase 2 and an AU‐rich region‐targeted mechanism

Winzen, R., Kracht, M., Ritter, B., Wilhelm, A., Chen, C. A., Shyu, A., Müller, M., Gaestel, M., Resch, K., & Holtmann, H. (1999) · The EMBO Journal · doi:10.1093/emboj/18.18.4969 · Cited by 770 · see citing works

MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis

Kotlyarov, A., Neininger, A., Schubert, C., Eckert, R., Birchmeier, C., Volk, H.-D., & Gaestel, M. (1999) · Nature Cell Biology · doi:10.1038/10061 · Cited by 763 · see citing works

Binding of non‐native protein to Hsp25 during heat shock creates a reservoir of folding intermediates for reactivation

Ehrnsperger, M., Gräber, S., Gaestel, M., & Büchner, J. (1997) · The EMBO Journal · doi:10.1093/emboj/16.2.221 · Cited by 755 · see citing works

Stem Cells and Cancer

Valk-Lingbeek, M. E., Bruggeman, S. W. M., & van Lohuizen, M. (2004) · Cell · doi:10.1016/j.cell.2004.08.005 · Cited by 743 · see citing works

Regulation of Hsp27 Oligomerization, Chaperone Function, and Protective Activity against Oxidative Stress/Tumor Necrosis Factor α by Phosphorylation

Rogalla, T., Ehrnsperger, M., Préville, X., Kotlyarov, A., Lutsch, G., Ducasse, C., Paul, C., Wieske, M., Arrigo, A., Büchner, J., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.27.18947 · Cited by 742 · see citing works

Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27

Guay, J., Lambert, H., Gingras-Breton, G., Lavoie, J. N., Huot, J., & Landry, J. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.3.357 · Cited by 705 · see citing works

Phosphorylation of human p53 by p38 kinase coordinates N‐terminal phosphorylation and apoptosis in response to UV radiation

Bulavin, D. V., Saito, S., Hollander, M. C., Sakaguchi, K., Anderson, C. W., Appella, E., & Fornace, A. J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.23.6845 · Cited by 704 · see citing works

MNK1, a new MAP kinase‐activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

Fukunaga, R., & Hunter, T. (1997) · The EMBO Journal · doi:10.1093/emboj/16.8.1921 · Cited by 666 · see citing works

Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins

Stokoe, D., Engel, K., Campbell, D. G., Cohen, P., & Gaestel, M. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)81216-9 · Cited by 569 · see citing works

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

Bulavin, D. V., Higashimoto, Y., Popoff, I., Gaarde, W. A., Basrur, V., Potapova, O., Appella, E., & Fornace, A. J. (2001) · Nature · doi:10.1038/35075107 · Cited by 531 · see citing works

MK2‐induced tristetraprolin:14‐3‐3 complexes prevent stress granule association and ARE‐mRNA decay

Stoecklin, G., Stubbs, T., Kedersha, N., Wax, S. D., Rigby, W. F. C., Blackwell, T. K., & Anderson, P. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600163 · Cited by 518 · see citing works

MSK2 and MSK1 mediate the mitogen‐ and stress‐induced phosphorylation of histone H3 and HMG‐14

Soloaga, A., Thomson, S., Wiggin, G. R., Rampersaud, N., Dyson, M. H., Hazzalin, C. A., Mahadevan, L. C., & Arthur, J. S. C. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg273 · Cited by 508 · see citing works

Phosphorylation and supramolecular organization of murine small heat shock protein HSP25 abolish its actin polymerization-inhibiting activity.

Benndorf, R., Hayeß, K., Ryazantsev, S., Wieske, M., Behlke, J., & Lutsch, G. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32060-4 · Cited by 486 · see citing works

MAPKAP kinase‐2; a novel protein kinase activated by mitogen‐activated protein kinase.

Stokoe, D., Campbell, D. G., Nakielny, S., Hidaka, H., Leevers, S. J., Marshall, C. J., & Cohen, P. T. W. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05492.x · Cited by 467 · see citing works

MAPKAP Kinase-2 Is a Cell Cycle Checkpoint Kinase that Regulates the G2/M Transition and S Phase Progression in Response to UV Irradiation

Manke, I. A., Nguyen, A., Lim, D., Stewart, M. Q., Elia, A. E. H., & Yaffe, M. B. (2005) · Molecular Cell · doi:10.1016/j.molcel.2004.11.021 · Cited by 416 · see citing works

Regulation of Cyclooxygenase 2 mRNA Stability by the Mitogen-Activated Protein Kinase p38 Signaling Cascade

Lasa, M., Mahtani, K. R., Finch, A. J., Brewer, G., Saklatvala, J., & Clark, A. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.12.4265-4274.2000 · Cited by 413 · see citing works

Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction.Preprint

Beals, C. R., Clipstone, N. A., Ho, S. N., & Crabtree, G. R. (1997) · Genes & Development · doi:10.1101/gad.11.7.824 · Cited by 402 · see citing works

A Role for p38MAPK/HSP27 Pathway in Smooth Muscle Cell Migration

Hedges, J. C., Dechert, M. A., Yamboliev, I. A., Martin, J. W., Hickey, E. D., Weber, L. A., & Gerthoffer, W. T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.24211 · Cited by 396 · see citing works

MK2 Targets AU-rich Elements and Regulates Biosynthesis of Tumor Necrosis Factor and Interleukin-6 Independently at Different Post-transcriptional Levels

Neininger, A., Kontoyiannis, D. L., Kotlyarov, A., Winzen, R., Eckert, R., Volk, H., Holtmann, H., Kollias, G. A., & Gaestel, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c100685200 · Cited by 394 · see citing works

Activation of the tumour suppressor kinase LKB1 by the STE20‐like pseudokinase STRAD

Baas, A. F., Boudeau, J., Sapkota, G. P., Smit, L., Medema, R. H., Morrice, N. A., Alessi, D. R., & Clevers, H. C. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg292 · Cited by 385 · see citing works

Genome-wide survey of protein kinases required for cell cycle progression

Bettencourt‐Dias, M., Giet, R., Sinka, R., Mazumdar, A., Lock, W. G., Balloux, F., Zafiropoulos, P. J., Yamaguchi, S., Winter, S. L., Carthew, R. W., et al. (2004) · Nature · doi:10.1038/nature03160 · Cited by 345 · see citing works

Identification of Mitogen-activated Protein (MAP) Kinase-activated Protein Kinase-3, a Novel Substrate of CSBP p38 MAP Kinase

McLaughlin, M. M., Kumar, S., McDonnell, P., Horn, S. V., Lee, J. C., Livi, G. P., & Young, P. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.14.8488 · Cited by 342 · see citing works

Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2

Ben-Levy, R., Hooper, S., Wilson, R., Paterson, H. F., & Marshall, C. J. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70442-7 · Cited by 338 · see citing works

PRAK, a novel protein kinase regulated by the p38 MAP kinase

New, L., Jiang, Y., Zhao, M., Liu, K., Zhu, W., Flood, L. J., Kato, Y., Parry, G. C. N., & Han, J. (1998) · The EMBO Journal · doi:10.1093/emboj/17.12.3372 · Cited by 319 · see citing works

The mouse kinome: Discovery and comparative genomics of all mouse protein kinases

Caenepeel, S. R., Charydczak, G., Sudarsanam, S., Hunter, T. R., & Manning, G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306880101 · Cited by 309 · see citing works

In vivo binding pattern of a trans-regulator of homoeotic genes in Drosophila melanogaster

Zink, B., & Paro, R. (1989) · Nature · doi:10.1038/337468a0 · Cited by 304 · see citing works

Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun.

Cano, E., Hazzalin, C. A., & Mahadevan, L. C. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.11.7352 · Cited by 297 · see citing works

p38 Mitogen-Activated Protein Kinase-Dependent and -Independent Signaling of mRNA Stability of AU-Rich Element-Containing Transcripts

Frevel, M. A. E., Bakheet, T. M., Silva, A. M., Hissong, J. G., Khabar, K. S. A., & Williams, B. R. G. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.23.2.425-436.2003 · Cited by 288 · see citing works

Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions

Tanoue, T., Maeda, R., Adachi, M., & Nishida, E. (2001) · The EMBO Journal · doi:10.1093/emboj/20.3.466 · Cited by 285 · see citing works

MAPKAP Kinase 2 Phosphorylates Tristetraprolin on in Vivo Sites Including Ser178, a Site Required for 14-3-3 Binding

Chrestensen, C. A., Schroeder, M. J., Shabanowitz, J., Hunt, D. F., Pelo, J. W., Worthington, M., & Sturgill, T. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310486200 · Cited by 273 · see citing works

Deficiency of the Stress Kinase P38α Results in Embryonic Lethality

Allen, M. R., Svensson, L., Roach, M. L., Hambor, J., McNeish, J. D., & Gabel, C. A. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.5.859 · Cited by 268 · see citing works

Leptomycin B‐sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation

Engel, K., Kotlyarov, A., & Gaestel, M. (1998) · The EMBO Journal · doi:10.1093/emboj/17.12.3363 · Cited by 267 · see citing works

Genetic Dissection of the Cellular Pathways and Signaling Mechanisms in Modeled Tumor Necrosis Factor–induced Crohn's-like Inflammatory Bowel Disease

Kontoyiannis, D. L., Boulougouris, G., Manoloukos, M., et al. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020281 · Cited by 267 · see citing works

Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)

Anderson, D. R., Hegde, S. G., Reinhard, E. J., et al. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.01.067 · Cited by 266 · see citing works

Posttranslational Regulation of Tristetraprolin Subcellular Localization and Protein Stability by p38 Mitogen-Activated Protein Kinase and Extracellular Signal-Regulated Kinase Pathways

Brook, M., Tchen, C. R., Santalucı́a, T., McIlrath, J. M., Arthur, J. S. C., Saklatvala, J., & Clark, A. R. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.6.2408-2418.2006 · Cited by 250 · see citing works

The Kaposin B Protein of KSHV Activates the p38/MK2 Pathway and Stabilizes Cytokine mRNAs

McCormick, C., & Ganem, D. (2005) · Science · doi:10.1126/science.1105779 · Cited by 242 · see citing works

Distinct Cellular Functions of MK2

Kotlyarov, A., Yannoni, Y. M., Fritz, S., Laaß, K., Telliez, J., Pitman, D., Lin, L., & Gaestel, M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.13.4827-4835.2002 · Cited by 230 · see citing works

Division of labor in Polycomb group repression

Levine, S. S., King, I. F. G., & Kingston, R. E. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.07.007 · Cited by 219 · see citing works

Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP‐K2 and its interaction with cytokine mRNAs

Rousseau, S., Morrice, N., Peggie, M., Campbell, D. G., Gaestel, M., & Cohen, P. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf639 · Cited by 219 · see citing works

Stabilization of Urokinase and Urokinase Receptor mRNAs by HuR Is Linked to Its Cytoplasmic Accumulation Induced by Activated Mitogen-Activated Protein Kinase-Activated Protein Kinase 2

Tran, H., Maurer, F., & Nagamine, Y. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.20.7177-7188.2003 · Cited by 217 · see citing works

5-Lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases

Werz, O., Klemm, J., Samuelsson, B. O., & Rådmark, O. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050588997 · Cited by 216 · see citing works

The Mnks Are Novel Components in the Control of TNFα Biosynthesis and Phosphorylate and Regulate hnRNP A1

Buxadé, M., Parra-Palau, J. L., Rousseau, S., Shpiro, N., Márquez, R., MORRICE, N. A., Bain, J., Espel, E., & Proud, C. G. (2005) · Immunity · doi:10.1016/j.immuni.2005.06.009 · Cited by 215 · see citing works

Identification of novel phosphorylation sites required for activation of MAPKAP kinase‐2.

Ben-Levy, R., Leighton, I. A., Doza, Y. N., Attwood, P. V., MORRICE, N. A., Marshall, C. J., & Cohen, P. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00280.x · Cited by 198 · see citing works

The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2

Stokoe, D., Caudwell, B., Cohen, P., & Cohen, P. T. W. (1993) · Biochemical Journal · doi:10.1042/bj2960843 · Cited by 190 · see citing works

3pK, a Novel Mitogen-Activated Protein (MAP) Kinase-Activated Protein Kinase, Is Targeted by Three MAP Kinase Pathways

Ludwig, S., Engel, K., Hoffmeyer, A., Sithanandam, G., Neufeld, B., Palm, D., Gaestel, M., & Rapp, U. R. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.12.6687 · Cited by 177 · see citing works

The AU-Rich Transcriptome: More Than Interferons and Cytokines, and Its Role in Disease

Khabar, K. S. A. (2005) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2005.25.1 · Cited by 174 · see citing works

MAPKAP Kinase 2 Phosphorylates Serum Response Factor in Vitro and in Vivo

Heidenreich, O. T., Neininger, A., Schratt, G. M., Zinck, R., Cahill, M. A., Engel, K., Kotlyarov, A., Kraft, R., Kostka, S., Gaestel, M., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.20.14434 · Cited by 170 · see citing works

MAPKAP Kinase 3pK Phosphorylates and Regulates Chromatin Association of the Polycomb Group Protein Bmi1

Voncken, J. W., Niessen, H. E. C., Neufeld, B., Rennefahrt, U. E. E., Dahlmans, V. E. H., Kubben, N., Holzer, B., Ludwig, S., & Rapp, U. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407155200 · Cited by 166 · see citing works

The p38 and MK2 Kinase Cascade Phosphorylates Tuberin, the Tuberous Sclerosis 2 Gene Product, and Enhances Its Interaction with 14-3-3

Li, Y., Inoki, K., Vacratsis, P. O., & Guan, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300862200 · Cited by 163 · see citing works

LSP1 Is the Major Substrate for Mitogen-activated Protein Kinase-activated Protein Kinase 2 in Human Neutrophils

Huang, C., Zhan, L., Ai, Y., & Jongstra, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.1.17 · Cited by 161 · see citing works

Chromatin-association of the Polycomb group protein BMI1 is cell cycle-regulated and correlates with its phosphorylation status

Voncken, J. W., Schweizer, D., Aagaard, L., Sattler, L., Jantsch, M. F., & van Lohuizen, M. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.24.4627 · Cited by 153 · see citing works

A comparison of the substrate specificity of MAPKAP kinase‐2 and MAPKAP kinase‐3 and their activation by cytokines and cellular stress

Clifton, A. D., Young, P. R., & Cohen, P. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00816-2 · Cited by 141 · see citing works

Rapid Turnover of Extracellular Signal-Regulated Kinase 3 by the Ubiquitin-Proteasome Pathway Defines a Novel Paradigm of Mitogen-Activated Protein Kinase Regulation during Cellular Differentiation

Coulombe, P., Rodier, G., Pelletier, S. W., Pellerin, J., & Meloche, S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.13.4542-4558.2003 · Cited by 133 · see citing works

Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway

Seternes, O. M., Mikalsen, T., Johansen, B., Michaelsen, E., Armstrong, C. G., MORRICE, N. A., Turgeon, B., Meloche, S., Moens, U. L., & Keyse, S. M. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600489 · Cited by 132 · see citing works

Proteomic Identification of 14-3-3ζ as a Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Substrate: Role in Dimer Formation and Ligand Binding

Powell, D. W., Rane, M. J., Joughin, B. A., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5376-5387.2003 · Cited by 131 · see citing works

Phosphorylation of αB-crystallin in Mitotic Cells and Identification of Enzymatic Activities Responsible for Phosphorylation

Kato, K., Ito, H., Kamei, K., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.43.28346 · Cited by 129 · see citing works

Structure of Mitogen-activated Protein Kinase-activated Protein (MAPKAP) Kinase 2 Suggests a Bifunctional Switch That Couples Kinase Activation with Nuclear Export

Meng, W., Swenson, L. L., Fitzgibbon, M. J., Hayakawa, K., ter Haar, E., Behrens, A. E., Fulghum, J. R., & Lippke, J. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200418200 · Cited by 128 · see citing works

Scaffolding by ERK3 regulates MK5 in development

Schumacher, S., Laaß, K., Kant, S., Shi, Y., Visel, A., Gruber, A. D., Kotlyarov, A., & Gaestel, M. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600467 · Cited by 121 · see citing works

Constitutive Activation of Mitogen-activated Protein Kinase-activated Protein Kinase 2 by Mutation of Phosphorylation Sites and an A-helix Motif

Engel, K., Schultz, H. S., Martin, F., Kotlyarov, A., Plath, K., Hahn, M. G., Heinemann, U., & Gaestel, M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.27213 · Cited by 114 · see citing works

MAPKAPK5, a Novel Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinase, Is a Substrate of the Extracellular-Regulated Kinase (ERK) and p38 Kinase

Ni, H., Wang, X. S., Diener, K., & Yao, Z. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8135 · Cited by 108 · see citing works

Transducible heat shock protein 20 (HSP20) phosphopeptide alters cytoskeletal dynamics

Dreiza, C. M., Brophy, C. M., Komalavilas, P., et al. (2004) · The FASEB Journal · doi:10.1096/fj.04-2911fje · Cited by 108 · see citing works

Discovery and Characterization of a Substrate Selective p38α Inhibitor

Davidson, W. C., Frego, L., Peet, G. W., Kroe‐Barrett, R., Labadia, M. E., Lukas, S., Snow, R. J., Jakes, S., Grygon, C. A., Pargellis, C., et al. (2004) · Biochemistry · doi:10.1021/bi0495073 · Cited by 107 · see citing works

Inactivation of the Cdc25 Phosphatase by the Stress-Activated Srk1 Kinase in Fission Yeast

López‐Avilés, S., Grande, M., González, M., Helgesen, A.-L., Alemany, V., Sánchez‐Piris, M., Bachs, O., Millar, J. B. A., & Aligué, R. (2005) · Molecular Cell · doi:10.1016/j.molcel.2004.11.043 · Cited by 104 · see citing works

The cAMP-dependent Protein Kinase Site (Ser312) Enhances Dorsal Nuclear Import through Facilitating Nuclear Localization Sequence/Importin Interaction*

Briggs, L. J., Stein, D., Goltz, J. S., Corrigan, V. C., Efthymiadis, A., Hübner, S., & Jans, D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.35.22745 · Cited by 98 · see citing works

3pK, a New Mitogen-Activated Protein Kinase-Activated Protein Kinase Located in the Small Cell Lung Cancer Tumor Suppressor Gene Region

Sithanandam, G., Latif, F., Duh, F.-M. C., Bernal, R. A., Smola, U., Li, H., Kuzmin, I., Wixler, V., Geil, L., Shrestha, S., et al. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.868 · Cited by 89 · see citing works

Elimination of Protein Kinase MK5/PRAK Activity by Targeted Homologous Recombination

Shi, Y., Kotlyarov, A., Laaß, K., Gruber, A. D., Butt, E., Marcus, K., Meyer, H. E., Friedrich, A., Volk, H., & Gaestel, M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.21.7732-7741.2003 · Cited by 86 · see citing works

Rac1-MKK3-p38-MAPKAPK2 Pathway Promotes Urokinase Plasminogen Activator mRNA Stability in Invasive Breast Cancer Cells

Han, Q., Leng, J., Bian, D., Mahanivong, C., Carpenter, K. A., Pan, Z. K., Han, J., & Huang, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209542200 · Cited by 86 · see citing works

Herpes Simplex Virus 1 Induces Cytoplasmic Accumulation of TIA-1/TIAR and both Synthesis and Cytoplasmic Accumulation of Tristetraprolin, Two Cellular Proteins That Bind and Destabilize AU-Rich RNAs

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A dominant mutation in<i>MAPKAPK3</i>, an actor of p38 signaling pathway, causes a new retinal dystrophy involving Bruch's membrane and retinal pigment epithelium

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Supplemental Figure 6: UAB30 did not alter expression or phosphorylation of kinases. from Preclinical Evaluation of UAB30 in Pediatric Renal and Hepatic Malignancies

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Supplemental Figure 6: UAB30 did not alter expression or phosphorylation of kinases. from Preclinical Evaluation of UAB30 in Pediatric Renal and Hepatic Malignancies

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