Cited by 466Nanoparticle-Based Drug DeliveryRNA Interference and Gene DeliveryAdvanced Drug Delivery Systems

Multifunctional polymeric micelles for delivery of drugs and siRNA

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Jhaveri, Aditi M., Torchilin, Vladimir P.·2014·Frontiers in Pharmacology

Abstract

Polymeric micelles, self-assembling nano-constructs of amphiphilic copolymers with a core-shell structure have been used as versatile carriers for delivery of drugs as well as nucleic acids. They have gained immense popularity owing to a host of favorable properties including their capacity to effectively solubilize a variety of poorly soluble pharmaceutical agents, biocompatibility, longevity, high stability in vitro and in vivo and the ability to accumulate in pathological areas with compromised vasculature. Moreover, additional functions can be imparted to these micelles by engineering their surface with various ligands and cell-penetrating moieties to allow for specific targeting and intracellular accumulation, respectively, to load them with contrast agents to confer imaging capabilities, and incorporating stimuli-sensitive groups that allow drug release in response to small changes in the environment. Recently, there has been an increasing trend toward designing polymeric micelles which integrate a number of the above functions into a single carrier to give rise to "smart," multifunctional polymeric micelles. Such multifunctional micelles can be envisaged as key to improving the efficacy of current treatments which have seen a steady increase not only in hydrophobic small molecules, but also in biologics including therapeutic genes, antibodies and small interfering RNA (siRNA). The purpose of this review is to highlight recent advances in the development of multifunctional polymeric micelles specifically for delivery of drugs and siRNA. In spite of the tremendous potential of siRNA, its translation into clinics has been a significant challenge because of physiological barriers to its effective delivery and the lack of safe, effective and clinically suitable vehicles. To that end, we also discuss the potential and suitability of multifunctional polymeric micelles, including lipid-based micelles, as promising vehicles for both siRNA and drugs.

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Crossref · 10.3389/fphar.2014.00077

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  1. Matsumoto S. Christie R. J. Nishiyama N. Miyata K. Ishii A. Oba M. (2009). Environment-responsive block copolymer micelles with a disulfide cross-linked core for enhanced siRNA delivery. Biomacromolecules 10, 119– 127 10.1021/bm800985e 19061333 · DOI

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Authors
Jhaveri, A. M., & Torchilin, V. P.
Affiliations
Northeastern University (US)
Corresponding author
Torchilin, Vladimir P.
Venue
Frontiers in Pharmacology
Published
2014-04-25
Volume
5
Pages
77-77
ISSN
1663-9812 (ISSN-L)
OpenAlex
W1983964788
Cited by
466
References
265
Citations by year
2026: 18 · 2025: 26 · 2024: 40 · 2023: 60 · 2022: 53 · 2021: 57 · 2020: 42 · 2019: 29 · 2018: 32 · 2017: 33 · 2016: 30 · 2015: 34 · 2014: 12
FWCI
2.48
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Pharmacology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
polymeric micelles, siRNA delivery, drug delivery, amphiphilic copolymers, core-shell nanostructures, targeted drug delivery, stimuli-responsive drug release, contrast media, nucleic acid delivery, intracellular accumulation

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