Therapeutic Prospects of mRNA-Based Gene Therapy for Glioblastoma
Open accessAbstract
The treatment of glioblastoma has been a big challenge for decades in the oncological field mainly owing to its unique biological characteristics, such as high heterogeneity, diffusing invasiveness, and capacity to resist conventional therapies. The mRNA-based therapeutic modality holds many superior features, including easy manipulation, rapid and transient expression, and adaptive convertibility without mutagenesis, which is suitable for dealing with glioblastoma’s complexity and variability. Synthetic anticancer mRNAs carried by various vehicles act as the ultimate attackers of the tumor across biological barriers. In this modality, specifically targeted glioblastoma treatment can be guaranteed by adding targeting molecules at certain levels. The choice of mRNA-bearing vehicle and administration method is a fully patient-tailored selection. This review covers the advantages and possible limitations of mRNA-based gene therapy, the in vitro synthesis of mRNA, the feasible methods for synthetic mRNA delivery and clinical therapeutic prospects of mRNA-based gene therapy for glioblastoma.
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Specific immune responses against at least one antigen were detected in 63% of patients after treatment, and the frequency of activated IgD+ CD38hi B cells increased by more than two-fold in 60% of evaluated patients.
“Specific immune responses against at least one antigen were detected in 63% of patients after treatment, and the frequency of activated IgD+ CD38hi B cells increased by more than two-fold in 60% of evaluated patients.343,353,354”
From Advances in COVID-19 mRNA vaccine development (2022) · cites this paper as [353]
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- Authors
- Tang, X., Zhang, S., Fu, R., Zhang, L., Huang, K., Peng, H., Dai, L., & Chen, Q.
- Affiliations
- Hubei University of Medicine (CN)
- Renmin Hospital of Wuhan University (CN)
- Corresponding author
- Chen, Qianxue
- Venue
- Frontiers in Oncology
- Publisher
- Frontiers Media SA
- Published
- 2019-11-08
- Volume
- 9
- Pages
- 1208-1208
- ISSN
- 2234-943X (ISSN-L)
- PMC
- PMC6857656
- OpenAlex
- W2988590615
- Cited by
- 69
- References
- 107
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 11 · 2023: 12 · 2022: 18 · 2021: 12 · 2020: 3 · 2019: 1 · 2018: 1
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Oncology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- glioblastoma, synthetic mRNA, tumor heterogeneity
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