Transcriptional responses to DNA damage
Open accessAbstract
In response to the threat of DNA damage, cells exhibit a dramatic and multi-factorial response spanning from transcriptional changes to protein modifications, collectively known as the DNA damage response (DDR). Here, we review the literature surrounding the transcriptional response to DNA damage. We review differences in observed transcriptional responses as a function of cell cycle stage and emphasize the importance of experimental design in these transcriptional response studies. We additionally consider topics including structural challenges in the transcriptional response to DNA damage as well as the connection between transcription and protein abundance.
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Genotoxic stressors mimicking synovial microenvironment modulate B cell fate in RA-FLS co-culture
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“Notably, the absence of transcriptional modulation in several other DNA damage and effector genes might suggest a limited breadth of early response, with only a subset of sensors and mediators activated under acute stress (29).”
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- Authors
- Silva, E., & Ideker, T.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Silva, Erica
- Venue
- DNA repair
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 79
- Pages
- 40-49
- ISSN
- 1568-7856 (ISSN-L)
- 1568-7864
- PMC
- PMC6570417
- OpenAlex
- W2944350703
- Cited by
- 31
- References
- 139
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 7 · 2023: 6 · 2022: 4 · 2021: 2 · 2020: 1
- FWCI
- 0.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- DNA repair (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Environmental Health Sciences
- National Cancer Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- DNA damage response, transcriptional response, DNA damage, cell cycle phases, transcriptional regulation, protein abundance, experimental design
- MeSH terms
- Animals, Cell Cycle, DNA Damage, Humans, Stress, Physiological, Transcription, Genetic, Yeasts
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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