CoChat
Sign Up
Cited by 31Neurogenesis and neuroplasticity mechanismsStress Responses and CortisolNeuroscience and Neuropharmacology Research

Effects of chronic social stress on oligodendrocyte proliferation-maturation and myelin status in prefrontal cortex and amygdala in adult mice

Open access
Poggi, Giulia, Albiez, Jamie, Pryce, Christopher R.·2022·Neurobiology of Stress
DOI 10.1016/j.ynstr.2022.100451PMC PMC9170777
Open this paper in CoChat — free account

Abstract

Stress-related neuropsychiatric disorders present with excessive processing of aversive stimuli. Whilst underlying pathophysiology remains poorly understood, within- and between-regional changes in oligodendrocyte (OL)-myelination status in anterior cingulate cortex and amygdala (ACC-AMY network) could be important. In adult mice, a 15-day chronic social stress (CSS) protocol leads to increased aversion responsiveness, accompanied by increased resting-state functional connectivity between, and reduced oligodendrocyte- and myelin-related transcript expression within, medial prefrontal cortex and amygdala (mPFC-AMY network), the analog of the human ACC-AMY network. In the current study, young-adult male C57BL/6 mice underwent CSS or control handling (CON). To assess OL proliferation-maturation, mice received 5-ethynyl-2′-deoxyuridine via drinking water across CSS/CON and brains were collected on day 16 or 31. In mPFC, CSS decreased the density of proliferative OL precursor cells (OPCs) at days 16 and 31. CSS increased mPFC myelin basic protein (MBP) integrated density at day 31, as well as increasing myelin thickness as determined using transmission electron microscopy, at day 16. In AMY, CSS increased the densities of total CC1+ OLs (day 31) and CC1+/ASPA+ OLs (days 16 and 31), whilst decreasing the density of proliferative OPCs at days 16 and 31. CSS was without effect on AMY MBP content and myelin thickness, at days 16 and 31. Therefore, CSS impacts on the OL lineage in mPFC and AMY and to an extent that, in mPFC at least, leads to increased myelination. This increased myelination could contribute to the excessive aversion learning and memory that occur in CSS mice and, indeed, human stress-related neuropsychiatric disorders.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.ynstr.2022.100451

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The citation lists haven’t been fetched yet

References 92 · Cited by 31

Research works printed but not linked: 72

  1. Adamcyzk I. Kúkeľová D. Just S. Giovannini R. Sigrist H. Amport R. Cuomo-Haymour N. Poggi G. Pryce C.R. Somatostatin receptor 4 agonism normalizes stress-related excessive amygdala glutamate release and Pavlovian aversion learning and memory in rodents Biol. Psychiatry Glob. Open Sci. 2021 10.1016/j.bpsgos.2021.11.006 PMC9616361 36324659 · DOI
  2. Akay L.A. Effenberger A.H. Tsai L.H. Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function Genes Dev. 35 2021 180 198 10.1101/GAD.344218.120 33526585 PMC7849363 · DOI
  3. Azzinnari D. Sigrist H. Staehli S. Palme R. Hildebrandt T. Leparc G. Hengerer B. Seifritz E. Pryce C.R. Mouse social stress induces increased fear conditioning, helplessness and fatigue to physical challenge together with markers of altered immune and dopamine function Neuropharmacology 85 2014 328 341 10.1016/j.neuropharm.2014.05.039 24907589 · DOI
  4. Bergamini G. Mechtersheimer J. Azzinnari D. Sigrist H. Buerge M. Dallmann R. Freije R. Kouraki A. Opacka-Juffry J. Seifritz E. Ferger B. Suter T. Pryce C.R. Chronic social stress induces peripheral and central immune activation, blunted mesolimbic dopamine function, and reduced reward-directed behaviour in mice Neurobiol. Stress 8 2018 42 56 10.1016/j.ynstr.2018.01.004 29888303 PMC5991330 · DOI
  5. Bergles D.E. Richardson W.D. Oligodendrocyte development and plasticity Cold Spring Harbor Perspect. Biol. 8 2016 1 27 10.1101/cshperspect.a020453 PMC4743079 26492571 · DOI
  6. Bierer L.M. Ivanov I. Carpenter D.M. Wong E.W. Golier J.A. Tang C.Y. Yehuda R. White matter abnormalities in Gulf War veterans with posttraumatic stress disorder: a pilot study Psychoneuroendocrinology 51 2015 567 576 10.1016/j.psyneuen.2014.11.007 25465169 · DOI
  7. Birey F. Kloc M. Chavali M. Hussein I. Wilson M. Christoffel D.J. Chen T. Frohman M.A. Robinson J.K. Russo S.J. Maffei A. Aguirre A. Genetic and stress-induced loss of NG2 glia triggers emergence of depressive-like behaviors through reduced secretion of FGF2 Neuron 88 2015 941 956 10.1016/j.neuron.2015.10.046 26606998 PMC5354631 · DOI
  8. Bonnefil V. Dietz K. Amatruda M. Wentling M. Aubry A.V. Dupree J.L. Temple G. Park H.-J.J. Burghardt N.S. Casaccia P. Liu J. Region-specific myelin differences define behavioral consequences of chronic social defeat stress in mice Elife 8 2019 1 13 10.7554/eLife.40855 PMC6692108 31407664 · DOI · Paper page
  9. Branzei D. Foiani M. Regulation of DNA repair throughout the cell cycle Nat. Rev. Mol. Cell Biol. 9 2008 297 308 10.1038/nrm2351 18285803 · DOI · Paper page
  10. Cahoy J.D. Emery B. Kaushal A. Foo L.C. Zamanian J.L. Christopherson K.S. Xing Y. Lubischer J.L. Krieg P.A. Krupenko S.A. Thompson W.J. Barres B.A. A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function J. Neurosci. 28 2008 264 278 10.1523/JNEUROSCI.4178-07.2008 18171944 PMC6671143 · DOI · Paper page
  11. Call C.L. Bergles D.E. Cortical neurons exhibit diverse myelination patterns that scale between mouse brain regions and regenerate after demyelination Nat. Commun. 12 2021 10.1038/s41467-021-25035-2 PMC8346564 34362912 · DOI
  12. Cathomas F. Azzinnari D. Bergamini G. Sigrist H. Buerge M. Hoop V. Wicki B. Goetze L. Soares S. Kukelova D. Seifritz E. Goebbels S. Nave K.-A.A. Ghandour M.S. Seoighe C. Hildebrandt T. Leparc G. Klein H. Stupka E. Hengerer B. Pryce C.R. Oligodendrocyte gene expression is reduced by and influences effects of chronic social stress in mice Gene Brain Behav. 18 2019 e12475 10.1111/gbb.12475 29566304 · DOI · Paper page
  13. Chetty S. Friedman A.R. Taravosh-Lahn K. Kirby E.D. Mirescu C. Guo F. Krupik D. Nicholas A. Geraghty A.C. Krishnamurthy A. Tsai M.-K.K. Covarrubias D. Wong A.T. Francis D.D. Sapolsky R.M. Palmer T.D. Pleasure D. Kaufer D. Stress and glucocorticoids promote oligodendrogenesis in the adult hippocampus Mol. Psychiatr. 19 2014 1275 1283 10.1038/mp.2013.190 PMC4128957 24514565 · DOI
  14. Dimou L. Gallo V. NG2-glia and their functions in the central nervous system Glia 63 2015 1429 1451 10.1002/glia.22859 26010717 PMC4470768 · DOI
  15. Drevets W.C. Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders Curr. Opin. Neurobiol. 11 2001 240 249 10.1016/S0959-4388(00)00203-8 11301246 · DOI · Paper page
  16. Fields R.D. A new mechanism of nervous system plasticity: activity-dependent myelination Nat. Rev. Neurosci. 16 2015 756 767 10.1038/nrn4023 26585800 PMC6310485 · DOI · Paper page
  17. Fields R.D. White matter in learning, cognition and psychiatric disorders Trends Neurosci. 31 2008 361 370 10.1016/j.tins.2008.04.001 18538868 PMC2486416 · DOI · Paper page
  18. Fleshner M. Frank M. Maier S.F. Danger signals and inflammasomes: stress-evoked sterile inflammation in mood disorders Neuropsychopharmacology 42 2017 36 45 10.1038/npp.2016.125 27412959 PMC5143484 · DOI · Paper page
  19. Friedman M.J. Resick P.A. Bryant R.A. Strain J. Horowitz M. Spiegel D. Classification of trauma and stressor-related disorders in DSM-5 Depress. Anxiety 28 2011 737 749 10.1002/da.20845 21681870 · DOI
  20. Gibson E.M. Purger D. Mount C.W. Goldstein A.K. Lin G.L. Wood L.S. Inema I. Miller S.E. Bieri G. Zuchero J.B. Barres B. a Woo P.J. Vogel H. Monje M. Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain Science 344 2014 1252304 10.1126/science.1252304 24727982 PMC4096908 · DOI · Paper page
  21. Grandjean J. Azzinnari D. Seuwen A. Sigrist H. Seifritz E. Pryce C.R. Rudin M. Chronic psychosocial stress in mice leads to changes in brain functional connectivity and metabolite levels comparable to human depression Neuroimage 142 2016 544 552 10.1016/j.neuroimage.2016.08.013 27520750 · DOI
  22. Guadagno A. Kang M.S. Devenyi G.A. Mathieu A.P. Rosa-Neto P. Chakravarty M. Walker C.D. Reduced resting-state functional connectivity of the basolateral amygdala to the medial prefrontal cortex in preweaning rats exposed to chronic early-life stress Brain Struct. Funct. 223 2018 3711 3729 10.1007/s00429-018-1720-3 30032360 · DOI
  23. Guilloux J.P. Douillard-Guilloux G. Kota R. Wang X. Gardier A.M. Martinowich K. Tseng G.C. Lewis D.A. Sibille E. Molecular evidence for BDNF-and GABA-related dysfunctions in the amygdala of female subjects with major depression Mol. Psychiatr. 17 2012 1130 1142 10.1038/mp.2011.113 PMC3237836 21912391 · DOI · Paper page
  24. Harrison P.J. The neuropathology of primary mood disorder Brain 125 2002 1428 1449 10.1093/brain/awf149 12076995 · DOI
  25. Hemanth Kumar B.S. Mishra S.K. Trivedi R. Singh S. Rana P. Khushu S. Demyelinating evidences in CMS rat model of depression: a DTI study at 7T Neuroscience 275 2014 12 21 10.1016/j.neuroscience.2014.05.037 24881571 · DOI
  26. Hill R.A. Nishiyama A. NG2 cells (polydendrocytes): listeners to the neural network with diverse properties Glia 62 2014 1195 1210 10.1002/glia.22664 24753030 PMC4282324 · DOI
  27. Hirrlinger J. Nave K.A. Adapting brain metabolism to myelination and long-range signal transduction Glia 62 2014 1749 1761 10.1002/glia.22737 25130164 · DOI · Paper page
  28. Huang P. Dong Z. Huang W. Zhou C. Zhong W. Hu P. Wen G. Sun X. Hua H. Cao H. Gao L. Lv Z. Voluntary wheel running ameliorates depression-like behaviors and brain blood oxygen level-dependent signals in chronic unpredictable mild stress mice Behav. Brain Res. 330 2017 17 24 10.1016/j.bbr.2017.05.032 28527694 · DOI · Paper page
  29. Hughes E.G. Orthmann-Murphy J.L. Langseth A.J. Bergles D.E. Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex Nat. Neurosci. 21 2018 696 706 10.1038/s41593-018-0121-5 29556025 PMC5920726 · DOI · Paper page
  30. Just S. Chenard B.L. Ceci A. Strassmaier T. Chong J.A. Blair N.T. Gallaschun R.J. Del Camino D. Cantin S. D'Amours M. Eickmeier C. Fanger C.M. Hecker C. Hessler D.P. Hengerer B. Kroker K.S. Malekiani S. Mihalek R. McLaughlin J. Rast G. Witek J. Sauer A. Pryce C.R. Moran M.M. Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice PLoS One 13 2018 e0191225 10.1371/journal.pone.0191225 PMC5791972 29385160 · DOI
  31. Kato D. Wake H. Myelin plasticity modulates neural circuitry required for learning and behavior Neurosci. Res. 2021 10.1016/j.neures.2020.12.005 33417972 · DOI
  32. Laine M.A. Sokolowska E. Dudek M. Callan S.A. Hyytiä P. Hovatta I. Brain activation induced by chronic psychosocial stress in mice Sci. Rep. 7 2017 1 11 10.1038/s41598-017-15422-5 29118417 PMC5678090 · DOI
  33. Laine M.A. Trontti K. Misiewicz Z. Sokolowska E. Kulesskaya N. Heikkinen A. Saarnio S. Balcells I. Ameslon P. Greco D. Mattila P. Ellonen P. Paulin L. Auvinen P. Jokitalo E. Hovatta I. Genetic control of myelin plasticity after chronic psychosocial stress eneuro 5 2018 10.1523/ENEURO.0166-18.2018 2018, ENEURO.0166-18 PMC6071195 30073192 · DOI
  34. Laubach M. Amarante L.M. Swanson K. White S.R. What, if anything, is rodent prefrontal cortex? eneuro 5 2018 10.1523/ENEURO.0315-18.2018 2018, ENEURO.0315-18 PMC6220587 30406193 · DOI
  35. Liu J. Dietz K. DeLoyht J.M. Pedre X. Kelkar D. Kaur J. Vialou V. Lobo M.K. Dietz D.M. Nestler E.J. Dupree J. Casaccia P. Impaired adult myelination in the prefrontal cortex of socially isolated mice Nat. Neurosci. 15 2012 1621 1623 10.1038/nn.3263 23143512 PMC3729624 · DOI · Paper page
  36. Lloyd A.F. Davies C.L. Miron V.E. Microglia: origins, homeostasis, and roles in myelin repair Curr. Opin. Neurobiol. 47 2017 113 120 10.1016/j.conb.2017.10.001 29073528 · DOI
  37. Luo Y. Xiao Q. Wang J. Jiang L. Hu M. Jiang Y. Tang J. Liang X. Qi Y. Dou X. Zhang Y. Huang C. Chen L. Tang Y. Running exercise protects oligodendrocytes in the medial prefrontal cortex in chronic unpredictable stress rat model Transl. Psychiatry 9 2019 322 10.1038/s41398-019-0662-8 31780641 PMC6882819 · DOI
  38. Lupien S.J. McEwen B.S. Gunnar M.R. Heim C. Effects of stress throughout the lifespan on the brain, behaviour and cognition Nat. Rev. Neurosci. 10 2009 434 445 10.1038/nrn2639 19401723 · DOI · Paper page
  39. Lutz P.E. Tanti A. Gasecka A. Barnett-Burns S. Kim J.J. Zhou Y. Chen G.G. Wakid M. Shaw M. Almeida D. Chay M.A. Yang J. Larivière V. M'Boutchou M.N. Van Kempen L.C. Yerko V. Prud'Homme J. Davoli M.A. Vaillancourt K. Théroux J.F. Bramoullé A. Zhang T.Y. Meaney M.J. Ernst C. Côté D. Mechawar N. Turecki G. Association of a history of child abuse with impaired myelination in the anterior cingulate cortex: convergent epigenetic, transcriptional, and morphological evidence Am. J. Psychiatr. 174 2017 1185 1194 10.1176/appi.ajp.2017.16111286 28750583 · DOI · Paper page
  40. Madhavarao C.N. Moffett J.R. Moore R.A. Viola R.E. Namboodiri M.A.A. Jacobowitz D.M. Immunohistochemical localization of aspartoacylase in the rat central nervous system J. Comp. Neurol. 472 2004 318 329 10.1002/cne.20080 15065127 · DOI
  41. McEwen B.S. Bowles N.P. Gray J.D. Hill M.N. Hunter R.G. Karatsoreos I.N. Nasca C. Mechanisms of stress in the brain Nat. Neurosci. 18 2015 1353 1363 10.1038/nn.4086 26404710 PMC4933289 · DOI · Paper page
  42. Miguel-Hidalgo J.J. Moulana M. Deloach P.H. Rajkowska G. Chronic unpredictable stress reduces immunostaining for connexins 43 and 30 and myelin basic protein in the rat prelimbic and orbitofrontal cortices Chronic Stress 2 2018 10.1177/2470547018814186 PMC6375503 30775650 · DOI
  43. Milic M. Schmitt U. Lutz B. Müller M.B. Individual baseline behavioral traits predict the resilience phenotype after chronic social defeat Neurobiol. Stress 14 2021 100290 10.1016/j.ynstr.2020.100290 PMC7797906 33457472 · DOI
  44. Miller A.H. Maletic V. Raison C.L. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression Biol. Psychiatr. 65 2009 732 741 10.1016/j.biopsych.2008.11.029 PMC2680424 19150053 · DOI · Paper page
  45. Miyata S. Taniguchi M. Koyama Y. Shimizu S. Tanaka T. Yasuno F. Yamamoto A. Iida H. Kudo T. Katayama T. Tohyama M. Association between chronic stress-induced structural abnormalities in Ranvier nodes and reduced oligodendrocyte activity in major depression Sci. Rep. 6 2016 23084 10.1038/srep23084 26976207 PMC4791682 · DOI
  46. Mosebach J. Keilhoff G. Gos T. Schiltz K. Schoeneck L. Dobrowolny H. Mawrin C. Müller S. Schroeter M.L. Bernstein H.G. Bogerts B. Steiner J. Increased nuclear Olig1-expression in the pregenual anterior cingulate white matter of patients with major depression: a regenerative attempt to compensate oligodendrocyte loss? J. Psychiatr. Res. 47 2013 1069 1079 10.1016/j.jpsychires.2013.03.018 23615187 · DOI
  47. Nave K.-A. Myelination and support of axonal integrity by glia Nature 468 2010 244 252 10.1038/nature09614 21068833 · DOI · Paper page
  48. Nishiyama A. Komitova M. Suzuki R. Zhu X. Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity Nat. Rev. Neurosci. 10 2009 9 22 10.1038/nrn2495 19096367 · DOI · Paper page
  49. Pan S. Mayoral S.R. Choi H.S. Chan J.R. Kheirbek M.A. Preservation of a remote fear memory requires new myelin formation Nat. Neurosci. 23 2020 487 499 10.1038/s41593-019-0582-1 32042175 PMC7213814 · DOI
  50. Poggi G. Boretius S. Wiebke M. Moschny N. Ruhwedel T. Hassouna I. Wieser G.L. Werner H.B. Goebbels S. Nave K.A. Ehrenreich H. Möbius W. Moschny N. Baudewig J. Ruhwedel T. Hassouna I. Wieser G.L. Werner H.B. Goebbels S. Nave K.A. Ehrenreich H. Cortical network dysfunction caused by a subtle defect of myelination Glia 64 2016 2025 2040 10.1002/glia.23039 27470661 PMC5129527 · DOI
  51. Pryce C.R. Fuchs E. Chronic psychosocial stressors in adulthood: studies in mice, rats and tree shrews Neurobiol. Stress 6 2017 94 103 10.1016/j.ynstr.2016.10.001 28229112 PMC5314423 · DOI
  52. Rajkowska G. Mahajan G. Maciag D. Sathyanesan M. Iyo A.H. Moulana M. Kyle P.B. Woolverton W.L. Miguel-Hidalgo J.J. Stockmeier C.A. Newton S.S. Oligodendrocyte morphometry and expression of myelin - related mRNA in ventral prefrontal white matter in major depressive disorder J. Psychiatr. Res. 65 2015 53 62 10.1016/j.jpsychires.2015.04.010 25930075 PMC4836860 · DOI
  53. Rohleder N. Stimulation of systemic low-grade inflammation by psychosocial stress Psychosom. Med. 76 2014 181 189 10.1097/PSY.0000000000000049 24608036 · DOI · Paper page
  54. Sampaio-Baptista C. Khrapitchev A. a Foxley S. Schlagheck T. Scholz J. Jbabdi S. DeLuca G.C. Miller K.L. Taylor A. Thomas N. Kleim J. Sibson N.R. Bannerman D. Johansen-Berg H. Motor skill learning induces changes in white matter microstructure and myelination J. Neurosci. 33 2013 19499 19503 10.1523/JNEUROSCI.3048-13.2013 24336716 PMC3858622 · DOI · Paper page
  55. Schindelin J. Arganda-Carreras I. Frise E. Kaynig V. Longair M. Pietzsch T. Preibisch S. Rueden C. Saalfeld S. Schmid B. Tinevez J.Y. White D.J. Hartenstein V. Eliceiri K. Tomancak P. Cardona A. Fiji: an open-source platform for biological-image analysis Nat. Methods 9 2012 676 682 10.1038/nmeth.2019 22743772 PMC3855844 · DOI · Paper page
  56. Seney M.L. Huo Z. Cahill K. French L. Puralewski R. Zhang J. Logan R.W. Tseng G. Lewis D.A. Sibille E. Opposite molecular signatures of depression in men and women Biol. Psychiatr. 84 2018 18 27 10.1016/j.biopsych.2018.01.017 PMC6014892 29548746 · DOI · Paper page
  57. Sibille E. Wang Y. Joeyen-Waldorf J. Gaiteri C. Surget A. Oh S. Belzung C. Tseng G.C. Lewis D.A. A molecular signature of depression in the amygdala Am. J. Psychiatr. 166 2009 1011 1024 10.1176/appi.ajp.2009.08121760 19605536 PMC2882057 · DOI
  58. Stadelmann C. Timmler S. Barrantes-Freer A. Simons M. Myelin in the central nervous system: structure, function, and pathology Physiol. Rev. 99 2019 1381 1431 10.1152/physrev.00031.2018 31066630 · DOI
  59. Steadman P.E. Xia F. Ahmed M. Mocle A.J. Penning A.R.A. Geraghty A.C. Steenland H.W. Monje M. Josselyn S.A. Frankland P.W. Disruption of oligodendrogenesis impairs memory consolidation in adult mice Neuron 105 2020 150 164 10.1016/j.neuron.2019.10.013 e6 31753579 PMC7579726 · DOI · Paper page
  60. Süß P. Hoffmann A. Rothe T. Ouyang Z. Baum W. Staszewski O. Schett G. Prinz M. Krönke G. Glass C.K. Winkler J. Schlachetzki J.C.M. Chronic peripheral inflammation causes a region-specific myeloid response in the central nervous system Cell Rep. 30 2020 4082 4095 10.1016/j.celrep.2020.02.109 e6 32209470 · DOI
  61. Tanti A. Lutz P.E. Kim J. O'Leary L. Théroux J.F. Turecki G. Mechawar N. Evidence of decreased gap junction coupling between astrocytes and oligodendrocytes in the anterior cingulate cortex of depressed suicides Neuropsychopharmacology 44 2019 2099 2111 10.1038/s41386-019-0471-z 31374562 PMC6897926 · DOI
  62. Teissier A. Le Magueresse C. Olusakin J. Andrade da Costa B.L.S. De Stasi A.M. Bacci A. Imamura Kawasawa Y. Vaidya V.A. Gaspar P. Early-life stress impairs postnatal oligodendrogenesis and adult emotional behaviour through activity-dependent mechanisms Mol. Psychiatr. 25 2020 1159 1174 10.1038/s41380-019-0493-2 PMC7244403 31439936 · DOI
  63. Treccani G. Yigit H. Lingner T. Schleubner V. Mey F. van der Kooij M.A. Wennström M. Herzog D.P. Linke M. Fricke M. Schmeisser M.J. Wegener G. Mittmann T. Trotter J. Müller M.B. Early life adversity targets the transcriptional signature of hippocampal NG2+ glia and affects voltage gated sodium (Nav) channels properties Neurobiol. Stress 15 2021 10.1016/j.ynstr.2021.100338 PMC8164094 34095364 · DOI
  64. Uranova N.a. Vikhreva O.V. Rachmanova V.I. Orlovskaya D.D. Ultrastructural alterations of myelinated fibers and oligodendrocytes in the prefrontal cortex in schizophrenia: a postmortem morphometric study Schizophr. Res. Treat. 2011 1 13 10.1155/2011/325789 2011 PMC3420756 22937264 · DOI
  65. Uranova N. a Vostrikov V.M. Vikhreva O.V. Zimina I.S. Kolomeets N.S. Orlovskaya D.D. The role of oligodendrocyte pathology in schizophrenia Int. J. Neuropsychopharmacol. 10 2007 537 545 10.1017/S1461145707007626 17313698 · DOI · Paper page
  66. Uranova N. Orlovskaya D. Vikhreva O. Zimina I. Kolomeets N. Vostrikov V. Rachmanova V. Electron microscopy of oligodendroglia in severe mental illness Brain Res. Bull. 55 2001 597 610 10.1016/S0361-9230(01)00528-7 11576756 · DOI · Paper page
  67. Urbán N. Guillemot F. Neurogenesis in the embryonic and adult brain: same regulators, different roles Front. Cell. Neurosci. 8 2014 1 19 10.3389/fncel.2014.00396 25505873 PMC4245909 · DOI · Paper page
  68. Willner P. Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation Psychopharmacology (Berl) 134 1997 319 329 10.1007/s002130050456 9452163 · DOI · Paper page
  69. Wohleb E.S. Fenn A.M. Pacenta A.M. Powell N.D. Sheridan J.F. Godbout J.P. Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice Psychoneuroendocrinology 37 2012 1491 1505 10.1016/j.psyneuen.2012.02.003 22386198 PMC3368999 · DOI · Paper page
  70. Wohleb E.S. McKim D.B. Shea D.T. Powell N.D. Tarr A.J. Sheridan J.F. Godbout J.P. Re-establishment of anxiety in stress-sensitized mice is caused by monocyte trafficking from the spleen to the brain Biol. Psychiatr. 75 2014 970 981 10.1016/j.biopsych.2013.11.029 PMC4084643 24439304 · DOI · Paper page
  71. Yang S.M. Michel K. Jokhi V. Nedivi E. Arlotta P. Neuron class-specific responses govern adaptive myelin remodeling in the neocortex Science 80 2021 370 10.1126/science.abd2109 PMC7931669 33335032 · DOI
  72. Yang Y. Zhang Y. Luo F. Li B. Chronic stress regulates NG2+ cell maturation and myelination in the prefrontal cortex through induction of death receptor 6 Exp. Neurol. 277 2016 202 214 10.1016/j.expneurol.2016.01.003 26772637 · DOI

Authors
Poggi, G., Albiez, J., & Pryce, C. R.
Affiliations
University of Zurich (CH)
Corresponding author
  • Poggi, Giulia
  • Pryce, Christopher R.
ORCID
Venue
Neurobiology of Stress
Publisher
Elsevier BV
Published
2022-05
Volume
18
Pages
100451
ISSN
2352-2895 (ISSN-L)
DOI
10.1016/j.ynstr.2022.100451
PMC
PMC9170777
OpenAlex
W4224305129
Cited by
31
References
92
Citations by year
2026: 5 · 2025: 9 · 2024: 6 · 2023: 9 · 2022: 2
FWCI
2.39
Type
journal article
Language
en
Open access
Licence
Locations
  • Neurobiology of Stress (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by-nc-nd)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by-nc-nd)
  • ETH Zürich Research Collection
  • Zurich Open Repository and Archive (University of Zurich)
Funders
  • National Science Foundation
  • McGill University
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (189481)
  • Universität Zürich
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
chronic social stress, oligodendrocyte proliferation, oligodendrocyte maturation, myelination, myelin basic protein, oligodendrocyte precursor cells, medial prefrontal cortex, amygdala, aversion learning, stress-related neuropsychiatric disorders, resting-state functional connectivity, CC1, aspartoacylase

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review