The DOI matches its Crossref record; 144 of the 144 references it cites were found in a registry or an index.
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.
Open accessAbstract
Acquired resistance to the action of insulin to stimulate glucose transport in skeletal muscle is associated with obesity and promotes the development of type 2 diabetes. In skeletal muscle, insulin resistance can result from high levels of circulating fatty acids that disrupt insulin signalling pathways. However, the severity of insulin resistance varies greatly among obese people. Here we postulate that this variability might reflect differences in levels of lipid-droplet proteins that promote the sequestration of fatty acids within adipocytes in the form of triglycerides, thereby lowering exposure of skeletal muscle to the inhibitory effects of fatty acids.
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In the citing paper
“TNF-α inhibits both the insulin and the catecholamine signaling pathways in adipocytes, resulting in decreased metabolic flexibility”
From Effect of Exercise Training on Fat Loss—Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution (2021) · cites this paper as Guilherme et al., 2008
In the citing paper
“Studies indicate that weight gain and loss correlate with decreasing and increasing insulin sensitivity, respectively.10”
From Changes in lean body mass with glucagon‐like peptide ‐1‐based therapies and mitigation strategies (2024) · cites this paper as [10]
In the citing paper
“These events cause insulin resistance in adipocytes, exacerbation of the inflammatory state, and systemic insulin resistance ([59](#B59), [147](#B147))”
From Mitochondrial fatty acid oxidation in obesity (2013) · cites this paper as [59]
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Cites
1 retracted
Tsukumo, D. M. L., Carvalho-Filho, M. A., Carvalheira, J. B. C., Prada, P. O., Hirabara, S. M., Schenka, A. A., Araújo, E. P., Vassallo, J., Curi, R., Velloso, L. A., et al. (2007) · Diabetes · doi:10.2337/db06-1595 · Cited by 826
RetractedMootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Adipose Tissue as an Endocrine Organ
Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522
Economic Costs of Diabetes in the U.S. in 2002
American Diabetes Association (2003) · Diabetes Care · doi:10.2337/diacare.26.3.917 · Cited by 4,147
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
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A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
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Research works printed but not linked: 1
- Puri, V. et al. Cidea: a novel lipid droplet protein associated with insulin sensitivity in humans. Proc. Natl Acad. Sci. USA (in the press).
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Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754
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Guo, H., Callaway, J. B., & Ting, J. P.-Y. (2015) · Nature Medicine · doi:10.1038/nm.3893 · Cited by 3,340
The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)
Buzzetti, E., Pinzani, M., & Tsochatzis, E. A. (2016) · Metabolism · doi:10.1016/j.metabol.2015.12.012 · Cited by 3,119
Mechanisms of Insulin Action and Insulin Resistance
Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028
DeFronzo, R. A., Ferrannini, E., Groop, L., Henry, R. R., Herman, W. H., Holst, J. J., Hu, F. B., Kahn, C. R., Raz, I., Shulman, G. I., et al. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.19 · Cited by 2,611
Metadata
- Authors
- Guilherme, A., Virbasius, J. V., Puri, V., & Czech, M. P.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- Czech, Michael P.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2008-05
- Volume
- 9
- Issue
- 5
- Pages
- 367-377
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- PMC
- PMC2886982
- OpenAlex
- W2012037560
- Cited by
- 2,292
- References
- 144
- Citations by year
- 2026: 66 · 2025: 104 · 2024: 119 · 2023: 124 · 2022: 137 · 2021: 149 · 2020: 156 · 2019: 144 · 2018: 153 · 2017: 151 · 2016: 174 · 2015: 155 · 2014: 127 · 2013: 117 · 2012: 99
- FWCI
- 11.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK030898, DK 32520, R37DK030898, DK030648, DK030898, P30DK032520, R01DK030648)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- adipocyte dysfunction, obesity, insulin resistance, type 2 diabetes, fatty acids, lipid droplets, lipid homeostasis, glucose homeostasis, skeletal muscle, insulin signaling, circulating fatty acids
- MeSH terms
- Adipose Tissue, Animals, Diabetes Mellitus, Type 2, Humans, Inflammation, Insulin, Insulin Resistance, Lipolysis, Mitochondria, Obesity, Triglycerides, Tumor Necrosis Factor-alpha, Signal Transduction, Adipocytes, Muscle, Skeletal, PPAR gamma
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