Cited by 2,292Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesLipid metabolism and biosynthesis

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Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.

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Guilherme, Adilson, Virbasius, Joseph V., Puri, Vishwajeet, Czech, Michael P.·2008·Nature Reviews Molecular Cell Biology

DOI 10.1038/nrm2391PMC PMC2886982

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Abstract

Acquired resistance to the action of insulin to stimulate glucose transport in skeletal muscle is associated with obesity and promotes the development of type 2 diabetes. In skeletal muscle, insulin resistance can result from high levels of circulating fatty acids that disrupt insulin signalling pathways. However, the severity of insulin resistance varies greatly among obese people. Here we postulate that this variability might reflect differences in levels of lipid-droplet proteins that promote the sequestration of fatty acids within adipocytes in the form of triglycerides, thereby lowering exposure of skeletal muscle to the inhibitory effects of fatty acids.

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Puri, V. et al. Cidea: a novel lipid droplet protein associated with insulin sensitivity in humans. Proc. Natl Acad. Sci. USA (in the press).

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Authors: Guilherme, A., Virbasius, J. V., Puri, V., & Czech, M. P.
Affiliations: University of Massachusetts Chan Medical School (US)
Corresponding author: Czech, Michael P.
ORCID: Virbasius, Joseph V.
Puri, Vishwajeet
Czech, Michael P.
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2008-05
Volume: 9
Issue: 5
Pages: 367-377
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm2391
PMC: PMC2886982
OpenAlex: W2012037560
Cited by: 2,292
References: 144
Citations by year: 2026: 66 · 2025: 104 · 2024: 119 · 2023: 124 · 2022: 137 · 2021: 149 · 2020: 156 · 2019: 144 · 2018: 153 · 2017: 151 · 2016: 174 · 2015: 155 · 2014: 127 · 2013: 117 · 2012: 99
FWCI: 11.29
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK030898, DK 32520, R37DK030898, DK030648, DK030898, P30DK032520, R01DK030648)
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: adipocyte dysfunction, obesity, insulin resistance, type 2 diabetes, fatty acids, lipid droplets, lipid homeostasis, glucose homeostasis, skeletal muscle, insulin signaling, circulating fatty acids
MeSH terms: Adipose Tissue, Animals, Diabetes Mellitus, Type 2, Humans, Inflammation, Insulin, Insulin Resistance, Lipolysis, Mitochondria, Obesity, Triglycerides, Tumor Necrosis Factor-alpha, Signal Transduction, Adipocytes, Muscle, Skeletal, PPAR gamma

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Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.

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