Basic disturbances in skeletal muscle fatty acid metabolism in obesity and type 2 diabetes mellitus

Blaak, E. E.

doi:10.1079/pns2004361

Cited by 83Adipose Tissue and MetabolismDiabetes, Cardiovascular Risks, and LipoproteinsMuscle metabolism and nutrition

Basic disturbances in skeletal muscle fatty acid metabolism in obesity and type 2 diabetes mellitus

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Blaak, E. E.·2004·Proceedings of the Nutrition Society

DOI 10.1079/pns2004361

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Abstract

The present article addresses the hypothesis that disturbances in skeletal muscle fatty acid handling in abdominal obesity and type 2 diabetes mellitus may play a role in the aetiology of increased adipose tissue stores, increased triacylglycerol storage in skeletal muscle and skeletal muscle insulin resistance. The uptake and/or oxidation of fatty acids have been shown to be impaired during post-absorptive conditions in abdominally-obese subjects and/or subjects with type 2 diabetes. Also, human studies have shown that muscle of subjects that are (abdominally) obese and/or have type 2 diabetes is characterized by an inability to increase fatty acid uptake and/or fatty acid oxidation during β-adrenergic stimulation and exercise. This disturbance in fat oxidation may promote, on one hand, the development of increased adipose tissue stores and obesity. On the other hand, fatty acids that are taken up by muscle and not oxidized may increase triacylglycerol storage in muscle, which has been associated with skeletal-muscle insulin resistance. Disturbances in the capacity to increase fat oxidation during post-absorptive conditions, β-adrenergic stimulation and exercise in subjects who are obese and/or have type 2 diabetes persist after weight reduction, indicating that the diminished fat oxidation may be a primary factor leading to the obese and/or insulin-resistant state rather than an adaptational response. Clearly, the precise sequence of events leading to an increased adiposity and insulin resistance in obesity and type 2 diabetes mellitus is not yet fully understood.

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Cross-sectional studies show that isolated muscle strips, tissue homogenates, or cultured myocytes from severely obese and/or diabetic humans oxidize fat more slowly than specimens from healthy controls.
“cross-sectional studies showing that isolated muscle strips, tissue homogenates or cultured myocytes from severely obese and/or diabetic humans exhibit diminished rates of fat oxidation when compared to specimens derived from healthy control subjects [9,41,46,87].”
From Intramuscular triacylglycerol and insulin resistance: guilty as charged or wrongly accused? (2010) · cites this paper as [9]

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Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance
Tuomilehto, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105033441801 · Cited by 10,873 · cited 2× · see citing works
“programme, addressing diet and exercise, on glucose tolerance and insulin resistance (Tuomilehto et al. 2001; Mensink et al. 2003b).”
Background
Mechanism of free fatty acid-induced insulin resistance in humans.
Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539 · see citing works
Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diab.46.6.983 · Cited by 1,179 · see citing works
Skeletal muscle triglyceride levels are inversely related to insulin action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diabetes.46.6.983 · Cited by 1,179 · see citing works
Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
Kelley, D. E., Goodpaster, B., Wing, R. R., & Simoneau, J.-A. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.6.e1130 · Cited by 1,096 · see citing works
Fuel selection in human skeletal muscle in insulin resistance: a reexamination.
Kelley, D. E., & Mandarino, L. J. (2000) · Diabetes · doi:10.2337/diabetes.49.5.677 · Cited by 1,017 · see citing works
Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats
Aitman, T. J., Glazier, A. M., Wallace, C. A., Cooper, L. D., Norsworthy, P. J., Wahid, F. N., Al-Majali, K., Trembling, P. M., Mann, C. J., Shoulders, C. C., et al. (1999) · Nature Genetics · doi:10.1038/5013 · Cited by 728 · see citing works
Defective Uptake and Utilization of Long Chain Fatty Acids in Muscle and Adipose Tissues of CD36 Knockout Mice
Coburn, C. T., Knapp, F. F., Febbraio, M., Beets, A. L., Silverstein, R. L., & Abumrad, N. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003826200 · Cited by 726 · see citing works
Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ
ZURLO, F., Lillioja, S., Puente, A. E.-D., Nyomba, B. L. G., Raz, I., Saad, M. F., Swinburn, B. A., Knowler, W. C., Bogardus, C., & Ravussin, É. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.259.5.e650 · Cited by 704 · see citing works
Lipid oxidation is reduced in obese human skeletal muscle
Kim, J.-Y., Hickner, R. C., Cortright, R. L., Dohm, G. L., & Houmard, J. A. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.5.e1039 · Cited by 634 · see citing works
Effects of Acute Changes of Plasma Free Fatty Acids on Intramyocellular Fat Content and Insulin Resistance in Healthy Subjects
Boden, G., Lebed, B., Schatz, M., Homko, C., & Lemieux, S. (2001) · Diabetes · doi:10.2337/diabetes.50.7.1612 · Cited by 597 · see citing works
Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss.
Simoneau, J., Veerkamp, J. H., Turcotte, L. P., & Kelley, D. E. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.14.2051 · Cited by 491 · see citing works
Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus.
Kelley, D. E., & Simoneau, J. A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117600 · Cited by 487 · see citing works
Skeletal Muscle Triglyceride
Kelley, D. E., & Goodpaster, B. H. (2001) · Diabetes Care · doi:10.2337/diacare.24.5.933 · Cited by 406 · see citing works
Skeletal muscle lipid metabolism with obesity
Hulver, M. W., Berggren, J. R., Cortright, R. N., Dudek, R. W., Thompson, R. P., Pories, W. J., MacDonald, K. G., Cline, G. W., Shulman, G. I., Dohm, G. L., et al. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00514.2002 · Cited by 339 · see citing works
Skeletal muscle utilization of free fatty acids in women with visceral obesity.
Colberg, S. R., Simoneau, J. A., Thaete, F. L., & Kelley, D. E. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117864 · Cited by 320 · see citing works
Contraction-Induced Fatty Acid Translocase/CD36 Translocation in Rat Cardiac Myocytes Is Mediated Through AMP-Activated Protein Kinase Signaling
Luiken, J. J. F. P., Coort, S. L., Willems, J., Coumans, W. A., Bonen, A., Vusse, G. J., & Glatz, J. F. C. (2003) · Diabetes · doi:10.2337/diabetes.52.7.1627 · Cited by 296 · see citing works
Increased Rates of Fatty Acid Uptake and Plasmalemmal Fatty Acid Transporters in Obese Zucker Rats
Luiken, J. J. F. P., Arumugam, Y., Dyck, D. J., Bell, R. C., Pelsers, M. M. L., Turcotte, L. P., Tandon, N. N., Glatz, J. F. C., & Bonen, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100052200 · Cited by 282 · see citing works
Cytoplasmic fatty acid‐binding protein facilitates fatty acid utilization by skeletal muscle
Glatz, J. F. C., Schaap, F. G., Binas, B., Bonen, A., Vusse, G. J., & Luiken, J. J. F. P. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2003.01166.x · Cited by 259 · see citing works
Muscle fibre type and aetiology of obesity
Wade, A. J., Marbut, M. M., & Round, J. M. (1990) · The Lancet · doi:10.1016/0140-6736(90)90933-v · Cited by 245 · see citing works
Free fatty acid oxidation by forearm muscle at rest, and evidence for an intramuscular lipid pool in the human forearm.
Dagenais, G. R., Tancredi, R. G., & Zierler, K. L. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108486 · Cited by 238 · see citing works
Insulin induces the translocation of the fatty acid transporter FAT/CD36 to the plasma membrane
Luiken, J. J. F. P., Dyck, D. J., Han, X.-X., Tandon, N. N., Arumugam, Y., Glatz, J. F. C., & Bonen, A. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00419.2001 · Cited by 230 · see citing works
Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle
Rasmussen, B. B., Holmbäck, U. C., Volpi, E., Morio, B., Paddon‐Jones, D., & Wolfe, R. R. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15715 · Cited by 223 · see citing works
Energy expenditure in obese women before and during weight loss, after refeeding, and in the weight-relapse period
Froidevaux, F., Schutz, Y., Christin, L., & Jéquier, E. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/57.1.35 · Cited by 195 · see citing works
Impaired oxidation of plasma-derived fatty acids in type 2 diabetic subjects during moderate-intensity exercise.
Blaak, E. E., van Aggel-Leijssen, D. P., Wagenmakers, A. J., Saris, W. H., & van Baak, M. A. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2102 · Cited by 178 · see citing works
Self-citation
Defective Fatty Acid Uptake in the Spontaneously Hypertensive Rat Is a Primary Determinant of Altered Glucose Metabolism, Hyperinsulinemia, and Myocardial Hypertrophy
Hajri, T., Ibrahimi, A., Coburn, C. T., Knapp, F. F., Kurtz, T., Pravenec, M., & Abumrad, N. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100942200 · Cited by 175 · see citing works
Glucose and insulin-induced inhibition of fatty acid oxidation: the glucose-fatty acid cycle reversed
Sidossis, L. S., & Wolfe, R. R. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.4.e733 · Cited by 165 · see citing works
Expression of hormone-sensitive lipase and its regulation by adrenaline in skeletal muscle
Langfort, J., Ploug, T., Ihlemann, J., Saldo, M., Holm, C., & Galbo, H. (1999) · Biochemical Journal · doi:10.1042/bj3400459 · Cited by 157 · see citing works
The Effect of a 3-Month Low-Intensity Endurance Training Program on Fat Oxidation and Acetyl-CoA Carboxylase-2 Expression
Schrauwen, P., van Aggel‐Leijssen, D. P., Hul, G. B. J., Wagenmakers, A. J. M., Vidal, H., Saris, W. H. M., & van Baak, M. A. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2220 · Cited by 141 · see citing works
Plasma FFA utilization and fatty acid-binding protein content are diminished in type 2 diabetic muscle
Blaak, E. E., Wagenmakers, A. J. M., Glatz, J. F. C., Wolffenbuttel, B. H. R., Kemerink, G. J., Langenberg, C. J. M., Heidendal, G. A. K., & Saris, W. H. M. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.1.e146 · Cited by 140 · see citing works
Self-citation
Plasma Free Fatty Acid Uptake and Oxidation Are Already Diminished in Subjects at High Risk for Developing Type 2 Diabetes
Mensink, M., Blaak, E. E., van Baak, M. A., Wagenmakers, A. J. M., & Saris, W. H. M. (2001) · Diabetes · doi:10.2337/diabetes.50.11.2548 · Cited by 128 · see citing works
Self-citation
Changes in fatty acid transport and transporters are related to the severity of insulin deficiency
Luiken, J. J. F. P., Arumugam, Y., Bell, R. C., Calles-Escandón, J., Tandon, N. N., Glatz, J. F. C., & Bonen, A. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00011.2002 · Cited by 126 · see citing works
Malonyl-CoA regulation in skeletal muscle: its link to cell citrate and the glucose-fatty acid cycle
Saha, A. K., Vavvas, D. G., Kurowski, T. G., Apazidis, A., Witters, L. A., Shafrir, E., & Ruderman, N. B. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.272.4.e641 · Cited by 124 · see citing works
Fat metabolism in formerly obese women
Ranneries, C., Bülow, J., Buemann, B., Christensen, N. J., Madsen, J., & Astrup, A. V. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.1.e155 · Cited by 91 · see citing works
Oxidation of nonplasma fatty acids during exercise is increased in women with abdominal obesity
Horowitz, J. F., & Klein, S. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.6.2276 · Cited by 85 · see citing works
Interaction of carbohydrate and fat fuels in human skeletal muscle: impact of obesity and NIDDM
Mandarino, L. J., Consoli, A., Jain, A., & Kelley, D. E. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.3.e463 · Cited by 83 · see citing works
Interrelationships between muscle fibre type, substrate oxidation and body fat
Helge, J. W., Fraser, A., Kriketos, A. D., Jenkins, A. B., Calvert, G. D., Ayre, K. J., & Storlien, L. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0801030 · Cited by 79 · see citing works
Involvement of Membrane-Associated Proteins in the Acute Regulation of Cellular Fatty Acid Uptake
Glatz, J. F. C., Luiken, J. J. F. P., & Bonen, A. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:16:2-3:123 · Cited by 78 · see citing works
Critical steps in cellular fatty acid uptake and utilization
Vusse, G. J., van Bilsen, M., Glatz, J. F. C., Hasselbaink, D. M., & Luiken, J. J. F. P. (2002) · Springer eBooks · doi:10.1007/978-1-4419-9270-3_2 · Cited by 77 · see citing works
Study on lifestyle-intervention and impaired glucose tolerance Maastricht (SLIM): design and screening results
Mensink, M., Corpeleijn, E., Feskens, E. J. M., Kruijshoop, M., Saris, W. H. M., de Bruin, T. W., & Blaak, E. E. (2003) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(03)00067-6 · Cited by 74 · see citing works
Self-citation
Thiazolidinediones upregulate impaired fatty acid uptake in skeletal muscle of type 2 diabetic subjects
Wilmsen, H. M., Ciaraldi, T. P., Carter, L., Reehman, N., Mudaliar, S. R. D., & Henry, R. R. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00491.2001 · Cited by 74 · see citing works
Long- and medium-chain fatty acid oxidation is increased in exercise-trained human skeletal muscle
Jong-Yeon, K., Hickner, R. C., Dohm, G. L., & Houmard, J. A. (2002) · Metabolism · doi:10.1053/meta.2002.31326 · Cited by 66 · see citing works
Impaired free fatty acid uptake in skeletal muscle but not in myocardium in patients with impaired glucose tolerance: studies with PET and 14(R,S)-[18F]fluoro-6-thia-heptadecanoic acid.
Turpeinen, A., Takala, T., Nuutila, P., Axelin, T., Luotolahti, M., Haaparanta‐Solin, M., Bergman, J. R., Hämäläinen, H., Iida, H., Mäki, M. T., et al. (1999) · Diabetes · doi:10.2337/diabetes.48.6.1245 · Cited by 65 · see citing works
Critical steps in cellular fatty acid uptake and utilization
Vusse, G. J., van Bilsen, M., Glatz, J. F. C., Hasselbaink, D. M., & Luiken, J. J. F. P. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1020538119691 · Cited by 64 · see citing works
Suppression of Systemic, Intramuscular, and Subcutaneous Adipose Tissue Lipolysis by Insulin in Humans <sup>1</sup>
Stumvoll, M., Jacob, S., Wahl, H. G., Hauer, B., Löblein, K., Grauer, P., Becker, R., Nielsen, M., Renn, W., & Häring, H. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.10.6898 · Cited by 63 · see citing works
beta-Adrenergic stimulation of skeletal muscle metabolism in relation to weight reduction in obese men
Blaak, E. E., van Baak, M. A., Kemerink, G. J., Pakbiers, M. T. W., Heidendal, G. A. K., & Saris, W. H. M. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.267.2.e316 · Cited by 60 · see citing works
Self-citation
Hormone-Sensitive Lipase (HSL) Expression and Regulation in Skeletal Muscle
Langfort, J., Ploug, T., Ihlemann, J., Enevoldsen, L. H., Stallknecht, B. M., Saldo, M., Kjær, M., Holm, C., & Galbo, H. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-1928-1_20 · Cited by 59 · see citing works
The Fate of [U-13C]Palmitate Extracted by Skeletal Muscle in Subjects With Type 2 Diabetes and Control Subjects
Blaak, E. E., & Wagenmakers, A. J. M. (2002) · Diabetes · doi:10.2337/diabetes.51.3.784 · Cited by 51 · see citing works
Self-citation
Effects of Plasma Adrenaline on Hormone‐Sensitive Lipase at Rest and during Moderate Exercise in Human Skeletal Muscle
Watt, M. J., Stellingwerff, T., Heigenhauser, G. J. F., & Spriet, L. L. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.043133 · Cited by 50 · see citing works
Weight Reduction and the Impaired Plasma-Derived Free Fatty Acid Oxidation in Type 2 Diabetic Subjects1
Blaak, E. E., Wolffenbuttel, B. H. R., Saris, W. H. M., Pelsers, M. M. A. L., & Wagenmakers, A. J. M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.4.7397 · Cited by 46 · see citing works
Self-citation
Evidence for a Major Role of Skeletal Muscle Lipolysis in the Regulation of Lipid Oxidation During Caloric Restriction In Vivo
Toft, E., Thörne, A., Reynisdottir, S., Moberg, E., Rössner, S., Bolinder, J., & Arner, P. (2001) · Diabetes · doi:10.2337/diabetes.50.7.1604 · Cited by 46 · see citing works
Suppression of Systemic, Intramuscular, and Subcutaneous Adipose Tissue Lipolysis by Insulin in Humans
Stümvoll, M. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.10.3740 · Cited by 43 · see citing works
Lifestyle changes and lipid metabolism gene expression and protein content in skeletal muscle of subjects with impaired glucose tolerance
Mensink, M., Blaak, E. E., Vidal, H., de Bruin, T. W., Glatz, J. F. C., & Saris, W. H. M. (2003) · Diabetologia · doi:10.1007/s00125-003-1152-2 · Cited by 39 · see citing works
Self-citation
Weight Reduction and the Impaired Plasma-Derived Free Fatty Acid Oxidation in Type 2 Diabetic Subjects
Blaak, E. E. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.4.1638 · Cited by 38 · see citing works
Self-citation
Substrate oxidation and availability during acute exercise in non‐obese, obese, and post‐obese sedentary females
Ezell, D. M., Geiselman, P. J., Anderson, A., Dowdy, M. L., Womble, L. G., Greenway, F., & Zachwieja, J. J. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0801037 · Cited by 36 · see citing works
Fatness in relation to substrate oxidation during exercise.
Bj, G., Ms, A., Pr, M., Gr, G., Harding, M., & Prentice, A. M. (1994) · PubMed · Cited by 28 · see citing works
Session 1 Roundtable Discussion (An International Workshop): Fatty Acid Uptake by and Transport in the Brain
A, N. A. N. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:16:2-3:151 · Cited by 4 · see citing works
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Randle (1998) · doi:10.1002/(sici)1099-0895(199812)14:4

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Pearen, M. A., Eriksson, N. A., Fitzsimmons, R. L., Goode, J. M., Martel, N., Andrikopoulos, S., & Muscat, G. E. O. (2012) · Molecular Endocrinology · doi:10.1210/me.2011-1274 · Cited by 94 · see citing works
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Stephens, F. B., Constantin‐Teodosiu, D., Laithwaite, D., Simpson, E. J., & Greenhaff, P. L. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1584 · Cited by 91 · see citing works
Time‐dependent effects of fatty acids on skeletal muscle metabolism
Hirabara, S. M., Silveira, L. R., Abdulkader, F., Carvalho, C. R. D. O., Procópio, J., & Curi, R. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20811 · Cited by 80 · see citing works
Individual Responses to Completion of Short-Term and Chronic Interval Training: A Retrospective Study
Astorino, T. A., & Schubert, M. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097638 · Cited by 75 · see citing works
Skeletal Muscle Fatty Acid Handling in Insulin Resistant Men
van Hees, A. M. J., Jans, A., Hul, G. B. J., Roche, H. M., Saris, W. H. M., & Blaak, E. E. (2011) · Obesity · doi:10.1038/oby.2011.10 · Cited by 71 · see citing works
Self-citation
Transgenic Muscle-Specific Nor-1 Expression Regulates Multiple Pathways That Effect Adiposity, Metabolism, and Endurance
Pearen, M. A., Goode, J. M., Fitzsimmons, R. L., Eriksson, N. A., Thomas, G. P., Cowin, G., Wang, S.-C., Tuong, Z. K., & Muscat, G. E. O. (2013) · Molecular Endocrinology · doi:10.1210/me.2013-1205 · Cited by 63 · see citing works
Individuals with Metabolically Healthy Overweight/Obesity Have Higher Fat Utilization than Metabolically Unhealthy Individuals
Pujia, A., Gazzaruso, C., Ferro, Y., Mazza, E., Maurotti, S., Russo, C., Lazzaro, V., Romeo, S., & Montalcini, T. (2016) · Nutrients · doi:10.3390/nu8010002 · Cited by 63 · see citing works
Diet, obesity and diabetes: a current update
Walker, C. G., Zariwala, M. G., Holness, M. J., & Sugden, M. C. (2006) · Clinical Science · doi:10.1042/cs20060150 · Cited by 62 · see citing works
Maximal lipid oxidation during exercise (Lipoxmax): From physiological measurements to clinical applications. Facts and uncertainties
Brun, J.-F., Romain, A.-J., & Mercier, J. (2011) · Science & Sports · doi:10.1016/j.scispo.2011.02.001 · Cited by 60 · see citing works
Metabolic fluxes in skeletal muscle in relation to obesity and insulin resistance
Blaak, E. E. (2005) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2005.04.001 · Cited by 57 · see citing works
Self-citation
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van Can, J. G. P., IJzerman, T. H., van Loon, L. J. C., Brouns, F. J. P. H., & Blaak, E. E. (2009) · British Journal Of Nutrition · doi:10.1017/s000711450999050x · Cited by 55 · see citing works
Self-citation
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van Can, J. G. P., IJzerman, T. H., van Loon, L. J. C., Brouns, F. J. P. H., & Blaak, E. E. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509990687 · Cited by 47 · see citing works
Self-citation
Mid-arm muscle circumference as a significant predictor of all-cause mortality in male individuals
Wu, L., Lin, Y.-Y., Kao, T., Lin, C., Liaw, F., Wang, C., Peng, T., & Chen, W. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171707 · Cited by 45 · see citing works
Hormone-Sensitive Lipase Serine Phosphorylation and Glycerol Exchange Across Skeletal Muscle in Lean and Obese Subjects
Jocken, J. W. E., Roepstorff, C., Goossens, G. H., van der Baan, P., van Baak, M. A., Saris, W. H. M., Kiens, B., & Blaak, E. E. (2008) · Diabetes · doi:10.2337/db07-0857 · Cited by 43 · see citing works
Self-citation
THE MUSCLE STRENGTH AND SIZE RESPONSE TO UPPER ARM,UNILATERAL RESISTANCE TRAINING AMONG ADULTS WHO ARE OVERWEIGHT AND OBESE
Pescatello, L. S., Kelsey, B. K., Price, T. B., Seip, R. L., Angelopoulos, T. J., Clarkson, P. M., Gordon, P. M., Moyna, N. M., Visich, P. S., Zoeller, R. F., et al. (2007) · The Journal of Strength and Conditioning Research · doi:10.1519/r-22236.1 · Cited by 43 · see citing works
Urinary F2‐Isoprostanes Are Not Associated with Increased Risk of Type 2 Diabetes
Il’yasova, D., Morrow, J. D., & Wagenknecht, L. E. (2005) · Obesity Research · doi:10.1038/oby.2005.201 · Cited by 40 · see citing works
The effect of diet and exercise on lipid droplet dynamics in human muscle tissue
Daemen, S., van Polanen, N., & Hesselink, M. K. C. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.167015 · Cited by 36 · see citing works
Oxidation of intramyocellular lipids is dependent on mitochondrial function and the availability of extracellular fatty acids
Corpeleijn, E., Hessvik, N. P., Bakke, S. S., Levin, K., Blaak, E. E., Thoresen, G. H., Gaster, M., & Rustan, A. C. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00187.2010 · Cited by 35 · see citing works
Self-citation
Glucometabolic consequences of acute and prolonged inhibition of fatty acid oxidation
Lundsgaard, A., Fritzen, A. M., Nicolaisen, T. S., Carl, C. S., Sjøberg, K. A., Raun, S. H., Klein, A. B., Sanchez-Quant, E., Langer, J., Ørskov, C., et al. (2019) · Journal of Lipid Research · doi:10.1194/jlr.ra119000177 · Cited by 33 · see citing works
A combination of probiotics and whey proteins enhances anti-obesity effects of calcium and dairy products during nutritional energy restriction in aP2-agouti transgenic mice
Yoda, K., Sun, X., Kawase, M., Kubota, A., Miyazawa, K., Harata, G., Hosoda, M., Hiramatsu, M., He, F., & Zemel, M. B. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515000914 · Cited by 33 · see citing works
Diabetes and Stem Cell Function
Fujimaki, S., Wakabayashi, T., Takemasa, T., Asashima, M., & Kuwabara, T. (2015) · BioMed Research International · doi:10.1155/2015/592915 · Cited by 32 · see citing works
Stable Isotope- and Mass Spectrometry-based Metabolomics as Tools in Drug Metabolism: A Study Expanding Tempol Pharmacology
Li, F., Pang, X., Krausz, K. W., Jiang, C., Chen, C., Cook, J. A., Krishna, M. C., Mitchell, J. B., Gonzalez, F. J., & Patterson, A. D. (2013) · Journal of Proteome Research · doi:10.1021/pr301023x · Cited by 31 · see citing works
Effects of dietary fat modification on skeletal muscle fatty acid handling in the metabolic syndrome
van Hees, A. M. J., Saris, W. H. M., Hul, G. B. J., Schaper, N. C., Timmerman, B. E., Lovegrove, J. A., Roche, H. M., & Blaak, E. E. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.6 · Cited by 26 · see citing works
Self-citation
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Guillerm-Regost, C., Louveau, I., Sebert, S. P., Damon, M., Champ, M. M. J., & Gondret, F. (2006) · Obesity · doi:10.1038/oby.2006.195 · Cited by 26 · see citing works
Fighting obesity: When muscle meets fat
Yang, X., Bi, P., & Kuang, S. (2014) · Adipocyte · doi:10.4161/21623945.2014.964075 · Cited by 25 · see citing works
Exercise-induced improvements in cardiorespiratory fitness and heart rate response to exercise are impaired in overweight/obese postmenopausal women
Ciolac, E. G., & Greve, J. M. D. (2011) · Clinics · doi:10.1590/s1807-59322011000400011 · Cited by 25 · see citing works
The Effects of Palmitic Acid on Nitric Oxide Production by Rat Skeletal Muscle: Mechanism via Superoxide and iNOS Activation
Lambertucci, R. H., Leandro, C. G., Vinolo, M. A. R., Nachbar, R. T., Silveira, L. R., Hirabara, S. M., Curi, R., & Pithon‐Curi, T. C. (2012) · Cellular Physiology and Biochemistry · doi:10.1159/000343307 · Cited by 25 · see citing works
Peroxisome Proliferator-Activated Receptor γ Decouples Fatty Acid Uptake from Lipid Inhibition of Insulin Signaling in Skeletal Muscle
Hu, S., Yao, J., Howe, A. A., Menke, B. M., Sivitz, W. I., Spector, A. A., & Norris, A. W. (2012) · Molecular Endocrinology · doi:10.1210/me.2011-1253 · Cited by 25 · see citing works
A threshold exists for the stimulatory effect of insulin on plasma<scp>l</scp>-carnitine clearance in humans
Stephens, F. B., Constantin-Teodosiu, D., Laithwaite, D., Simpson, E. J., & Greenhaff, P. L. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00508.2006 · Cited by 23 · see citing works
Twenty-Four Hour Total and Dietary Fat Oxidation in Lean, Obese and Reduced-Obese Adults with and without a Bout of Exercise
Bergouignan, A., Kealey, E. H., Schmidt, S. L., Jackman, M. R., & Bessesen, D. H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094181 · Cited by 23 · see citing works
Transcriptional Metabolic Inflexibility in Skeletal Muscle Among Individuals With Increasing Insulin Resistance
Jans, A., Sparks, L. M., van Hees, A. M. J., Gjelstad, I. M. F., Tierney, A. C., Risérus, U., Drevon, C. A., Roche, H. M., Schrauwen, P., & Blaak, E. E. (2011) · Obesity · doi:10.1038/oby.2011.149 · Cited by 21 · see citing works
Self-citation
Effect of exercise on lipolysis in adipose tissue
Polak, J., Bajzová, M., & Štich, V. (2008) · Future Lipidology · doi:10.2217/17460875.3.5.557 · Cited by 20 · see citing works
Measurement and Physiological Relevance of the Maximal Lipid Oxidation Rate During Exercise (LIPOXmax)
Brun, J.-F., Varlet-Marie, E., Jrme, A., & Mercier, J. (2012) · An International Perspective on Topics in Sports Medicine and Sports Injury · doi:10.5772/25451 · Cited by 19 · see citing works
Correlation between skeletal muscle acetylcarnitine and phosphocreatine metabolism during submaximal exercise and recovery: interleaved 1H/31P MRS 7 T study
Klepochová, R., Niess, F., Meyerspeer, M., Sluková, D., Just, I., Trattnig, S., Ukropec, J., Ukropcová, B., Kautzky‐Willer, A., Leutner, M., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-53221-x · Cited by 16 · see citing works
Insulin management in overweight or obese type 2 diabetes patients: the role of insulin glargine
Davies, M. J., & Khunti, K. (2008) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2008.00844.x · Cited by 16 · see citing works
Congenital and Environmental Factors Associated with Adipocyte Dysregulation as Defects of Insulin Resistance
Wang, C.-P., Chung, F., Shin, S., & Lee, Y. (2007) · The Review of Diabetic Studies · doi:10.1900/rds.2007.4.77 · Cited by 14 · see citing works
Human genome comparison of paretic and nonparetic vastus lateralis muscle in patients with hemiparetic stroke
McKenzie, M. J. (2008) · The Journal of Rehabilitation Research and Development · doi:10.1682/jrrd.2007.02.0036 · Cited by 14 · see citing works
Skeletal muscle proteins involved in fatty acid transport influence fatty acid oxidation rates observed during exercise
Maunder, E., Rothschild, J. A., Fritzen, A. M., Jordy, A. B., Kiens, B., Brick, M. J., Leigh, W. B., Chang, W., & Kilding, A. E. (2023) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-023-02843-7 · Cited by 13 · see citing works
Retinoblastoma Protein Knockdown Favors Oxidative Metabolism and Glucose and Fatty Acid Disposal in Muscle Cells
Petrov, P., Ribot, J., López‐Mejía, I. C., Fajas, L., Palou, A., & Bonet, M. L. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25121 · Cited by 11 · see citing works
Intramuscular adipocyte and fatty acid differences between high‐fat and control rabbit groups subject to a restricted diet
Li, Y., Gan, M., Tang, T., Shao, J., Lai, T., Ma, Y., Elzo, M. A., Jia, X., Hu, S., Wang, J., et al. (2021) · Veterinary Medicine and Science · doi:10.1002/vms3.576 · Cited by 11 · see citing works
In vivo multi‐tissue efficacy of peroxisome proliferator‐activated receptor‐γ therapy on glucose and fatty acid metabolism in obese type 2 diabetic rats
Nemanich, S. T., Rani, S. D., & Shoghi, K. I. (2013) · Obesity · doi:10.1002/oby.20378 · Cited by 10 · see citing works
« Calories » et obésité : quantité ou qualité ?
Bergouignan, A., Blanc, S., & Simon, C. (2010) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2010.04.003 · Cited by 8 · see citing works
The Gut Microbiota and Effects on Metabolism
Hussey, S. E., & Bergman, M. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-386456-7.02009-8 · Cited by 8 · see citing works
Effects of different low-intensity exercise types on duration, energy expenditure and perceived exertion in Obese individuals
Khanfir, M. A., Awicha, H. B., Masmoudi, L., Hmadou, F. B., Dardouri, W., Alardan, S., Nouira, S., & Zouch, M. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19084893 · Cited by 6 · see citing works
Énergétique de l'obésité
Bergouignan, A., & Blanc, S. (2006) · Journal de la Société de Biologie · doi:10.1051/jbio:2006004 · Cited by 6 · see citing works
Metabolic Mechanisms of Muscle Insulin Resistance
Muoio, D. M., Koves, T. R., An, J., & Newgard, C. B. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-043-4_3 · Cited by 4 · see citing works
Physical activity and health, novel concepts and new targets: report from the 12th Conference of the International Research Group on the Biochemistry of Exercise
Hesselink, M. K. C., & van Baak, M. A. (2004) · Proceedings of The Nutrition Society · doi:10.1079/pns2004353 · Cited by 4 · see citing works
Diacylglycerol levels modulate the cellular distribution of the nicotinic acetylcholine receptor
Kamerbeek, C. B., Mateos, M. V., Vallés, A. S., Pediconi, M. F., Barrantes, F. J., & Borroni, V. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.02.010 · Cited by 3 · see citing works
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Fatouros, I. G., & Mitrakou, A. (2012) · CRC Press eBooks · doi:10.1201/b12085-16 · Cited by 2 · see citing works
The nutritional supplement FFD-002 attenuates streptozotocin-induced diabetes and decelerates diabetes-related tissue injury
Kumar, B. P., Azeemuddin, M. M., Rao, R. P., Rafiq, M., Ashok, B. K., Thippeswamy, A. H. M., Jagadeesh, M., Verma, P., Anturlikar, S. D., Azher, M., et al. (2017) · Journal of Food Biochemistry · doi:10.1111/jfbc.12486 · Cited by 1 · see citing works
RNA‐Seq Analysis of the Liver Transcriptome Reveals the Networks Regulating Treatment of Sitagliptin Phosphate plus Fuzhujiangtang Granule in the Zucker Diabetic Fatty Rats
Guo, X., Sun, W., Xu, G., Hou, D., Zhang, Z., Wu, L., & Liu, T. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/8463858 · Cited by 1 · see citing works
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Singh, B. P. (2013) · doi:10.17077/etd.0f00qet8 · Cited by 1 · see citing works
Fatty acid metabolism in the metabolic syndrome : effects of dietary fat quantity and quality
van Hees, A. M. J. (2011) · doi:10.26481/dis.20111111ah
Fatty acid metabolism, impaired glucose tolerance and the effects of lifestyle
Corpeleijn, E. (2006) · doi:10.26481/dis.20061110ec
THE ROLE OF LONG-CHAIN ACYL-COENZYME A SYNTHETASE 1 (ACSL-1) IN LIPID METABOLISM IN HUMAN SKELETAL MUSCLE PRIMARY MYOTUBES.
Ellis, R. J. (2011) · The Scholarship East Carolina University's Institutional Repository (East Carolina University)
Skeletal muscle fatty acid handling in insulin resistance : the effect of dietary fatty acids
Jans, A. (2012) · doi:10.26481/dis.20120427aj
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Levine, T. B., & Levine, A. B. (2012) · Wiley eBooks · doi:10.1002/9781118480045.ch15
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Mathews, A. E. W. (2008) · D-Scholarship@Pitt (University of Pittsburgh)
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Tao, Y. (2009) · Jyväskylä University Digital Archive (University of Jyväskylä)
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Fjørkenstad, A. (2008) · NORA - Norwegian Open Research Archives
Effects of intermittent normobaric hypoxia on substrate utilization and metabolic rate in sedentary males
Workman, C. (2013) · Memorial University Research Repository (Memorial University)
Fatty acid metabolism in the metabolic syndrome
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Blaak (2007) · doi:10.26481/spe.20071005eb
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van Can, J. G. P. (2012) · doi:10.26481/dis.20121031jc
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Pierre-Jerome, C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13328-2.00002-7
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Authors: Blaak, E. E.
Affiliations: Maastricht University (NL)
Corresponding author: Blaak, E. E.
ORCID: Blaak, E. E.
Venue: Proceedings of the Nutrition Society
Publisher: Cambridge University Press (CUP)
Published: 2004-05
Volume: 63
Issue: 2
Pages: 323-330
ISSN: 0029-6651 (ISSN-L)
1475-2719
DOI: 10.1079/pns2004361
OpenAlex: W2154525024
Cited by: 83
References: 63
Citations by year: 2026: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 5 · 2012: 9
FWCI: 0.77
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified, 1038 d)
Locations: Proceedings of The Nutrition Society (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion, other-oa)
Research Publications (Maastricht University) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords: abdominal obesity, type 2 diabetes, fatty acid oxidation, fatty acid uptake, triacylglycerol storage, skeletal muscle insulin resistance, beta-adrenergic stimulation, physical activity, weight loss
MeSH terms: Diabetes Mellitus, Type 2, Fatty Acids, Humans, Insulin Resistance, Lipolysis, Obesity, Muscle, Skeletal

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Basic disturbances in skeletal muscle fatty acid metabolism in obesity and type 2 diabetes mellitus

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