The RSK family of kinases: emerging roles in cellular signalling

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7. Chapter 2 Cell Signaling in Protein Synthesis
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8. Oxidized LDL induces FAK-dependent RSK signaling to drive NF-κB activation and VCAM-1 expression
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11. Phosphoproteomics Reveals MAPK Inhibitors Enhance MET- and EGFR-Driven AKT Signaling in KRAS -Mutant Lung Cancer
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14. Selective Targeting of RSK Isoforms in Cancer
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15. Targeting p90 Ribosomal S6 Kinase Eliminates Tumor-Initiating Cells by Inactivating Y-Box Binding Protein-1 in Triple-Negative Breast Cancers
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16. WT1 and kidney progenitor cells
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17. The transcriptional induction of PIK3CA in tumor cells is dependent on the oncoprotein Y-box binding protein-1
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18. Phosphorylation of Eukaryotic Translation Initiation Factor 4B (EIF4B) by Open Reading Frame 45/p90 Ribosomal S6 Kinase (ORF45/RSK) Signaling Axis Facilitates Protein Translation during Kaposi Sarcoma-associated Herpesvirus (KSHV) Lytic Replication
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19. Fibroblast Growth Factor Receptor 1–Transformed Mammary Epithelial Cells Are Dependent on RSK Activity for Growth and Survival
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20. Ribosomal S6 protein kinase 4 promotes radioresistance in esophageal squamous cell carcinoma
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21. The role of the ERK signaling pathway in promoting angiogenesis for treating ischemic diseases
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22. S6K2: The Neglected S6 Kinase Family Member
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23. EphA2 is a key effector of the MEK/ERK/RSK pathway regulating glioblastoma cell proliferation
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24. A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade
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25. LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer
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26. mTOR Hyperactivation in Down Syndrome Hippocampus Appears Early During Development
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28. EGF-induced MAPK Signaling Inhibits Hemidesmosome Formation through Phosphorylation of the Integrin β4
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29. Actomyosin bundles serve as a tension sensor and a platform for ERK activation
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30. The mTOR pathway is activated in glial cells in mesial temporal sclerosis
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31. Erk1/2 activation and modulation of STAT3 signaling in oral cancer
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32. Targeting MAPK (Ras/ERK) and PI3K/Akt pathways in pituitary tumorigenesis
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33. Loss of transcriptional plasticity but sustained adaptive capacity after adaptation to global change conditions in a marine copepod
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34. Histamine may induce airway remodeling through release of epidermal growth factor receptor ligands from bronchial epithelial cells
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35. Identification of Naturally Occurring Fatty Acids of the Myelin Sheath That Resolve Neuroinflammation
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36. Alcohol impairs skeletal muscle protein synthesis and mTOR signaling in a time-dependent manner following electrically stimulated muscle contraction
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37. Yersinia Virulence Factor YopM Induces Sustained RSK Activation by Interfering with Dephosphorylation
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38. ERK/Ribosomal S6 Kinase (RSK) Signaling Positively Regulates Death Receptor 5 Expression through Co-activation of CHOP and Elk1
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39. MicroRNA 543 suppresses breast cancer cell proliferation, blocks cell cycle and induces cell apoptosis via direct targeting of ERK/MAPK
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40. Mitogen-activated protein kinase p38 and MK2, MK3 and MK5: Ménage à trois or ménage à quatre?
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41. RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth
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42. The Basis of Distinctive IL-2– and IL-15–Dependent Signaling: Weak CD122-Dependent Signaling Favors CD8+ T Central-Memory Cell Survival but Not T Effector-Memory Cell Development
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43. MAPK/ERK-Dependent Translation Factor Hyperactivation and Dysregulated Laminin γ2 Expression in Oral Dysplasia and Squamous Cell Carcinoma
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44. RETRACTED: Epac1‐induced cellular proliferation in prostate cancer cells is mediated by B‐Raf/ERK and mTOR signaling cascades
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45. The Scaffold Protein Muscle A-Kinase Anchoring Protein β Orchestrates Cardiac Myocyte Hypertrophic Signaling Required for the Development of Heart Failure
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46. The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of cytoprotection by the microenvironment
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49. Alternative Mammalian Target of Rapamycin (mTOR) Signal Activation in Sorafenib-resistant Hepatocellular Carcinoma Cells Revealed by Array-based Pathway Profiling
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50. TLR and TNF-R1 activation of the MKK3/MKK6–p38α axis in macrophages is mediated by TPL-2 kinase
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51. Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway
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52. Mechanism of Sustained Activation of Ribosomal S6 Kinase (RSK) and ERK by Kaposi Sarcoma-associated Herpesvirus ORF45
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53. Two PTP receptors mediate CSPG inhibition by convergent and divergent signaling pathways in neurons
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54. Key role of the ERK1/2 MAPK pathway in the transcriptional regulation of the Stearoyl-CoA Desaturase (SCD1) gene expression in response to leptin
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55. PAUF functions in the metastasis of human pancreatic cancer cells and upregulates CXCR4 expression
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56. Proteinase-activated Receptor 2 (PAR2) Decreases Apoptosis in Colonic Epithelial Cells
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57. Anchored p90 Ribosomal S6 Kinase 3 Is Required for Cardiac Myocyte Hypertrophy
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58. Long-term High Fat Ketogenic Diet Promotes Renal Tumor Growth in a Rat Model of Tuberous Sclerosis
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59. Chronic Inflammation and Cancer: Key Pathways and Targeted Therapies
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60. Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer
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61. Down-regulation of CMTM8 Induces Epithelial-to-Mesenchymal Transition-like Changes via c-MET/Extracellular Signal-regulated Kinase (ERK) Signaling
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62. LRP-1: Functions, Signaling and Implications in Kidney and Other Diseases
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63. RSK2-inactivating mutations potentiate MAPK signaling and support cholesterol metabolism in hepatocellular carcinoma
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64. Synergistic combinations of signaling pathway inhibitors: Mechanisms for improved cancer therapy
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65. Effective response of doxorubicin-sensitive and -resistant breast cancer cells to combinational siRNA therapy
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66. RSK2 Protein Suppresses Integrin Activation and Fibronectin Matrix Assembly and Promotes Cell Migration
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67. A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development
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68. Triple-negative breast cancer: investigating potential molecular therapeutic target
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69. Cotranslational cis -phosphorylation of the COOH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase
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70. Resveratrol directly targets DDX5 resulting in suppression of the mTORC1 pathway in prostate cancer
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71. Elevated Activation of ERK1 and ERK2 Accompany Enhanced Liver Injury Following Alcohol Binge in Chronically Ethanol‐Fed Rats
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72. The Prometastatic Ribosomal S6 Kinase 2-cAMP Response Element-binding Protein (RSK2-CREB) Signaling Pathway Up-regulates the Actin-binding Protein Fascin-1 to Promote Tumor Metastasis
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73. Periplocin Inhibits Growth of Lung Cancer in vitro and in vivo by Blocking AKT/ERK Signaling Pathways
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74. Importance of ERK1/2 in Regulation of Protein Translation during Oocyte Meiosis
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75. Mek/<scp>ERK1</scp>/<scp>2‐MAPK</scp> and <scp>PI3K</scp>/Akt/<scp>mTOR</scp> signaling plays both independent and cooperative roles in Schwann cell differentiation, myelination and dysmyelination
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76. P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation
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77. Phosphorylation of KIBRA by the extracellular signal-regulated kinase (ERK)–ribosomal S6 kinase (RSK) cascade modulates cell proliferation and migration
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78. RSK Promotes Prostate Cancer Progression in Bone through ING3, CKAP2, and PTK6-Mediated Cell Survival
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79. Fisetin targets YB-1/RSK axis independent of its effect on ERK signaling: insights from in vitro and in vivo melanoma models
    Mario Sechi, Rahul Kumar Lall, Saheed Olanrewaju Afolabi, Anant Kumar Singh, Dinesh Chandra Joshi, Shing Yan Chiu, Hasan Mukhtar, Deeba N. Syed · 2018 · Scientific Reports
80. Kartogenin hydrolysis product 4-aminobiphenyl distributes to cartilage and mediates cartilage regeneration
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81. The costimulatory activity of Tim-3 requires Akt and MAPK signaling and its recruitment to the immune synapse
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82. Novel Changes in NF-κB Activity during Progression and Regression Phases of Hyperplasia
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83. The Genetic Basis of Rapidly Evolving Male Genital Morphology inDrosophila
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84. Ribosomal Protein S6 Kinase (RSK)-2 as a central effector molecule in RON receptor tyrosine kinase mediated epithelial to mesenchymal transition induced by macrophage-stimulating protein
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85. EGFR is required for FOS‐dependent bone tumor development via RSK2/CREB signaling
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86. Activation of extracellular signal-regulated kinases during dehydration in the African clawed frog, Xenopus laevis
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87. Acquired Resistance to the Hsp90 Inhibitor, Ganetespib, in KRAS- Mutant NSCLC Is Mediated via Reactivation of the ERK–p90RSK–mTOR Signaling Network
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88. Phosphoproteomic Analysis of KSHV-Infected Cells Reveals Roles of ORF45-Activated RSK during Lytic Replication
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89. Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylation
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90. Different downstream signalling of CCK1receptors regulates distinct functions of CCK in pancreatic beta cells
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91. mAKAP—A Master Scaffold for Cardiac Remodeling
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92. Isoform-selective activity-based profiling of ERK signaling
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93. Myricetin exerts anti-proliferative, anti-invasive, and pro-apoptotic effects on esophageal carcinoma EC9706 and KYSE30 cells via RSK2
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94. Novel Role for p90 Ribosomal S6 Kinase in the Regulation of Cardiac Myofilament Phosphorylation
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95. Rsk‐mediated phosphorylation and 14‐3‐3ε binding of Apaf‐1 suppresses cytochrome c‐induced apoptosis
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96. Male hormones activate EphA2 to facilitate Kaposi’s sarcoma-associated herpesvirus infection: Implications for gender disparity in Kaposi’s sarcoma
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97. Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling
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98. DAMPs Released From Injured Renal Tubular Epithelial Cells Activate Innate Immune Signals in Healthy Renal Tubular Epithelial Cells
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99. Suppression of nuclear GSK3 signaling promotes serine/one-carbon metabolism and confers metabolic vulnerability in lung cancer cells
    Long He, Jennifer E. Endress, Sungyun Cho, Zhongchi Li, Yuxiang Zheng, John M. Asara, John Blenis · 2022 · Science Advances
100. Biliverdin reductase: a target for cancer therapy?
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