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New insights into the regulation and cellular functions of the ARP2/3 complex

Rotty, Jeremy D., Wu, Congying, Bear, James E.·2013·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm3492
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Abstract

The actin-related protein 2/3 (ARP2/3) complex nucleates branched actin filament networks, but requires nucleation promoting factors (NPFs) to stimulate this activity. NPFs include proteins such as Wiskott-Aldrich syndrome protein (WASP), neural WASP (NWASP), WASP family verprolin-homologous protein (WAVE; also known as SCAR) and the recently identified WASP and SCAR homologue (WASH) complex. The mechanisms underlying NPF-dependent regulation and the cellular functions of ARP2/3 are being unravelled using new chemical and genetic approaches. Of particular interest is the role of the ARP2/3 complex in vesicular trafficking and directional cell motility.

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Metadata

Authors
Rotty, J. D., Wu, C., & Bear, J. E.
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2012-12-05
Volume
14
Issue
1
Pages
7-12
ISSN
  • 1471-0072
  • 1471-0080
DOI
10.1038/nrm3492
Cited by
516
References
1
Language
en
Licence
www.springer.com/tdm (tdm)

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