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A nucleator arms race: cellular control of actin assembly
Open accessAbstract
For over a decade, the actin-related protein 2/3 (ARP2/3) complex, a handful of nucleation-promoting factors and formins were the only molecules known to directly nucleate actin filament formation de novo. However, the past several years have seen a surge in the discovery of mammalian proteins with roles in actin nucleation and dynamics. Newly recognized nucleation-promoting factors, such as WASP and SCAR homologue (WASH), WASP homologue associated with actin, membranes and microtubules (WHAMM), and junction-mediating regulatory protein (JMY), stimulate ARP2/3 activity at distinct cellular locations. Formin nucleators with additional biochemical and cellular activities have also been uncovered. Finally, the Spire, cordon-bleu and leiomodin nucleators have revealed new ways of overcoming the kinetic barriers to actin polymerization.
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Metadata
- Authors
- Campellone, K. G., & Welch, M. D.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2010-03-18
- Volume
- 11
- Issue
- 4
- Pages
- 237-251
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W1991549216
- Cited by
- 928
- References
- 2
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- green
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