Cited by 2,002Mitochondrial Function and PathologyAutophagy in Disease and TherapyCell death mechanisms and regulation

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Mitochondrial fusion and fission in cell life and death

Westermann, Benedikt·2010·Nature Reviews Molecular Cell Biology

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Abstract

Mitochondria are dynamic organelles that constantly fuse and divide. These processes (collectively termed mitochondrial dynamics) are important for mitochondrial inheritance and for the maintenance of mitochondrial functions. The core components of the evolutionarily conserved fusion and fission machineries have now been identified, and mechanistic studies have revealed the first secrets of the complex processes that govern fusion and fission of a double membrane-bound organelle. Mitochondrial dynamics was recently recognized as an important constituent of cellular quality control. Defects have detrimental consequences on bioenergetic supply and contribute to the pathogenesis of neurodegenerative diseases. These findings open exciting new directions to explore mitochondrial biology.

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Authors: Westermann, B.
Affiliations: University of Bayreuth (DE)
Corresponding author: Westermann, Benedikt
ORCID: Westermann, Benedikt
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2010-11-23
Volume: 11
Issue: 12
Pages: 872-884
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm3013
OpenAlex: W2032234589
Cited by: 2,002
References: 135
Citations by year: 2026: 91 · 2025: 109 · 2024: 158 · 2023: 135 · 2022: 134 · 2021: 192 · 2020: 184 · 2019: 125 · 2018: 113 · 2017: 141 · 2016: 117 · 2015: 119 · 2014: 107 · 2013: 95 · 2012: 118
FWCI: 7.67
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
ERef Bayreuth (University of Bayreuth) (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: mitochondrial fusion, mitochondrial fission, mitochondrial dynamics, mitochondrial inheritance, mitochondrial quality control, mitochondrial bioenergetics, neurodegenerative diseases
MeSH terms: Animals, Humans, Membrane Fusion, Mitochondria, Models, Biological, Cell Death, Cytokinesis, Cell Proliferation, Genes, Mitochondrial, Mitochondrial Membranes

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Mitochondrial fusion and fission in cell life and death

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