Mitochondrial function and mitochondrial DNA maintenance with advancing age

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works

How mitochondria produce reactive oxygen species

Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207 · see citing works

The DNA-damage response in human biology and disease

Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092 · see citing works

Instability and decay of the primary structure of DNA

Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679 · see citing works

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057 · see citing works

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy · doi:10.4161/auto.19496 · Cited by 3,996 · cited 6× · see citing works

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works

Mitochondrial Fission, Fusion, and Stress

Youle, R. J., & van der Bliek, A. M. (2012) · Science · doi:10.1126/science.1219855 · Cited by 3,674 · see citing works

A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Wallace, D. C. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.110304.095751 · Cited by 3,185 · see citing works

Premature ageing in mice expressing defective mitochondrial DNA polymerase

Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734 · see citing works

Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production

Powers, S. K., & Jackson, M. J. (2008) · Physiological Reviews · doi:10.1152/physrev.00031.2007 · Cited by 2,459 · see citing works

Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression

Zelko, I. N., Mariani, T. J., & Folz, R. J. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00905-x · Cited by 2,212 · see citing works

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

Kujoth, G. C., Hiona, A., Pugh, T. D., Someya, S., Panzer, K., Wohlgemuth, S. E., Hofer, T., Seo, A. Y., Sullivan, R., Jobling, W. A., et al. (2005) · Science · doi:10.1126/science.1112125 · Cited by 2,165 · see citing works

Autophagy and Aging

Rubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107 · see citing works

Mitochondrial fusion and fission in cell life and death

Westermann, B. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3013 · Cited by 2,002 · see citing works

A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology

Pagliarini, D. J., Calvo, S. E., Chang, B., Sheth, S. A., Vafai, S. B., Ong, S.-E., Walford, G. A., Sugiana, C., Boneh, A., Chen, W. K., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.016 · Cited by 1,994 · see citing works

The Biologic Clock: The Mitochondria?

Harman, D. (1972) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1972.tb00787.x · Cited by 1,991 · see citing works

The aging process

Harman, D. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.11.7124 · Cited by 1,915 · see citing works

The pathways of mitophagy for quality control and clearance of mitochondria

Ashrafi, G., & Schwarz, T. L. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2012.81 · Cited by 1,900 · see citing works

Mitochondrial DNA mutations in human disease

Taylor, R. W., & Turnbull, D. M. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1606 · Cited by 1,866 · see citing works

Endonuclease G is an apoptotic DNase when released from mitochondria

Li, L. Y., Luo, X., & Wang, X. (2001) · Nature · doi:10.1038/35083620 · Cited by 1,787 · see citing works

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

Richter, C., Park, J. W., & Ames, B. N. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.17.6465 · Cited by 1,730 · see citing works

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

Ravikumar, B., Sarkar, S., Davies, J. E., Futter, M., Garcı́a-Arencibia, M., Green-Thompson, Z. W., Jiménez-Sánchez, M., Korolchuk, V. I., Lichtenberg, M., Luo, S., et al. (2010) · Physiological Reviews · doi:10.1152/physrev.00030.2009 · Cited by 1,726 · see citing works

mTOR is a key modulator of ageing and age-related disease

Johnson, S. C., Rabinovitch, P. S., & Kaeberlein, M. (2013) · Nature · doi:10.1038/nature11861 · Cited by 1,676 · see citing works

Transcriptional paradigms in mammalian mitochondrial biogenesis and function

Scarpulla, R. C. (2008) · Physiological Reviews · doi:10.1152/physrev.00025.2007 · Cited by 1,666 · see citing works

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

Vives-Bauza, C., Zhou, C., Huang, Y., Cui, M., de Vries, R. L. A., Kim, J., May, J., Tocilescu, M. A., Liu, W., Ko, H. S., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911187107 · Cited by 1,616 · see citing works

Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury

Azzam, E. I., Jay‐Gerin, J., & Pain, D. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.12.012 · Cited by 1,611 · see citing works

Antioxidants prevent health-promoting effects of physical exercise in humans

Ristow, M., Zarse, K., Oberbach, A., Klöting, N., Birringer, M., Kiehntopf, M., Stumvoll, M., Kahn, C. R., & Blüher, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903485106 · Cited by 1,582 · see citing works

High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

Bender, A., Krishnan, K. J., Morris, C. M., Taylor, G. A., Reeve, A. K., Perry, R. H., Jaros, E., Hersheson, J. S., Betts, J., Klopstock, T., et al. (2006) · Nature Genetics · doi:10.1038/ng1769 · Cited by 1,570 · see citing works

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

Lee, I. H., Cao, L., Mostoslavsky, R., Lombard, D. B., Liu, J., Bruns, N. E., Tsokos, M., Alt, F. W., & Finkel, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712145105 · Cited by 1,473 · see citing works

Oxidative DNA damage and disease: induction, repair and significance

Evans, M. D., Dizdaroglu, M., & Cooke, M. S. (2004) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2003.11.001 · Cited by 1,372 · see citing works

Selective Mitochondrial Autophagy, or Mitophagy, as a Targeted Defense Against Oxidative Stress, Mitochondrial Dysfunction, and Aging

Lemasters, J. J. (2005) · Rejuvenation Research · doi:10.1089/rej.2005.8.3 · Cited by 1,342 · see citing works

Decline in skeletal muscle mitochondrial function with aging in humans

Short, K. R., Bigelow, M. L., Kahl, J., Singh, R., Coenen-Schimke, J., Raghavakaimal, S., & Nair, K. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501559102 · Cited by 1,333 · see citing works

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

Chen, Y., & Dorn, G. W. (2013) · Science · doi:10.1126/science.1231031 · Cited by 1,323 · see citing works

Mitochondria and the Autophagy–Inflammation–Cell Death Axis in Organismal Aging

Green, D. R., Galluzzi, L., & Kroemer, G. (2011) · Science · doi:10.1126/science.1201940 · Cited by 1,245 · see citing works

Fusion and fission: interlinked processes critical for mitochondrial health

Chan, D. C. (2012) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132529 · Cited by 1,196 · see citing works

Mitochondrial transfer between cells can rescue aerobic respiration

Spees, J. L., Olson, S. D., Whitney, M. J., & Prockop, D. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510511103 · Cited by 1,134 · see citing works

The antioxidant function of the p53 tumor suppressor

Sablina, A. A., Budanov, A. V., Ilyinskaya, G. V., Agapova, L. S., Kravchenko, J. E., & Chumakov, P. M. (2005) · Nature Medicine · doi:10.1038/nm1320 · Cited by 1,110 · see citing works

Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS

Nisoli, E., Tonello, C., Cardile, A., Cozzi, V., Bracale, R., Tedesco, L., Falcone, S., Valerio, A., Cantoni, O., Clementi, E., et al. (2005) · Science · doi:10.1126/science.1117728 · Cited by 1,107 · see citing works

Peroxisome Proliferator-Activated Receptor γ Coactivator 1 Coactivators, Energy Homeostasis, and Metabolism

Handschin, C., & Spiegelman, B. M. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0037 · Cited by 1,090 · see citing works

The role of mitochondria in aging

Bratic, A., & Larsson, N.-G. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64125 · Cited by 1,087 · see citing works

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

Chu, C. T., Ji, J., Dagda, R. K., Jiang, J. F., Tyurina, Y. Y., Kapralov, A. A., Tyurin, V. A., Yanamala, N., Shrivastava, I. H., Mohammadyani, D., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2837 · Cited by 1,083 · see citing works

MITOCHONDRIAL DNA MAINTENANCE IN VERTEBRATES

Shadel, G. S., & Clayton, D. A. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.409 · Cited by 1,059 · see citing works

Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases

Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007176.pub2 · Cited by 924 · see citing works

Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress

Tao, R., Coleman, M. C., Pennington, J. D., Ozden, O., Park, S.-H., Jiang, H., Kim, H.-S., Flynn, C. R., Hill, S., Hayes McDonald, W., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.12.013 · Cited by 899 · see citing works

Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons

Kraytsberg, Y., Kudryavtseva, E., McKee, A. C., Geula, C., Kowall, N. W., & Khrapko, K. (2006) · Nature Genetics · doi:10.1038/ng1778 · Cited by 884 · see citing works

Mitochondria-Anchored Receptor Atg32 Mediates Degradation of Mitochondria via Selective Autophagy

Okamoto, K., Kondo‐Okamoto, N., & Ohsumi, Y. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.013 · Cited by 867 · see citing works

Unraveling the biological roles of reactive oxygen species

Murphy, M. P., Holmgren, A., Larsson, N.-G., Halliwell, B., Chang, C. J., Kalyanaraman, B., Rhee, S. G., Thornalley, P. J., Partridge, L., Gems, D., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.010 · Cited by 836 · see citing works

Mitochondrial threshold effects

Rossignol, R., Faustin, B., Rocher, C., Malgat, M., Mazat, J., & Letellier, T. (2003) · Biochemical Journal · doi:10.1042/bj20021594 · Cited by 802 · see citing works

Atg32 Is a Mitochondrial Protein that Confers Selectivity during Mitophagy

Kanki, T., Wang, K., Cao, Y., Baba, M., & Klionsky, D. J. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.014 · Cited by 798 · see citing works

Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans

Civitarese, A. E., Carling, S., Heilbronn, L. K., Hulver, M. H., Ukropcova, B., Deutsch, W. A., Smith, S. R., & Ravussin, E. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040076 · Cited by 790 · see citing works

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

Ristow, M., & Zarse, K. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.03.014 · Cited by 789 · see citing works

Repair and Genetic Consequences of Endogenous DNA Base Damage in Mammalian Cells

Barnes, D. E., & Lindahl, T. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.092448 · Cited by 753 · see citing works

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

Van Remmen, H., Ikeno, Y., Hamilton, M., Pahlavani, M., Wolf, N., Thorpe, S. R., Alderson, N. L., Baynes, J. W., Epstein, C. J., Huang, T.-T., et al. (2003) · Physiological Genomics · doi:10.1152/physiolgenomics.00122.2003 · Cited by 734 · see citing works

On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1Preprint

Luo, X., & Kraus, W. L. (2012) · Genes & Development · doi:10.1101/gad.183509.111 · Cited by 725 · see citing works

Extending life span by increasing oxidative stress

Ristow, M., & Schmeisser, S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.010 · Cited by 718 · see citing works

DNA replication and transcription in mammalian mitochondria.

Falkenberg, M., Larsson, N., & Gustafsson, C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.060305.152028 · Cited by 686 · see citing works

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer’s disease

Lipinski, M. M., Zheng, B., Lu, T., Yan, Z., Py, B. F., Ng, A., Xavier, R. J., Li, C., Yankner, B. A., Scherzer, C. R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009485107 · Cited by 680 · see citing works

Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress

Lee, H., & Wei, Y. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.09.010 · Cited by 660 · see citing works

The mitochondrial pathways of apoptosis

Estaquier, J., Vallette, F., Vayssiere, J.-L., & Mignotte, B. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-2869-1_7 · Cited by 637 · see citing works

Transcriptional Control of Mitochondrial Biogenesis and Function

Hock, M. B., & Kralli, A. (2009) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163119 · Cited by 616 · see citing works

Is the oxidative stress theory of aging dead?

Pérez, V. I., Bokov, A., Remmen, H. V., Mele, J., Ran, Q., Ikeno, Y., & Richardson, A. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.06.003 · Cited by 604 · see citing works

The Mitochondrial Proteome and Human Disease

Calvo, S. E., & Mootha, V. K. (2010) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-082509-141720 · Cited by 590 · see citing works

X-ray induced DNA double strand break production and repair in mammalian cells as measured by neutral filter elution

Bradley, M. O., & Kohn, K. W. (1979) · Nucleic Acids Research · doi:10.1093/nar/7.3.793 · Cited by 565 · see citing works

Oxidative stress induces degradation of mitochondrial DNA

Shokolenko, I. N., Venediktova, N. I., Bochkareva, A., Wilson, G. L., & ALEXEYEV, M. F. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp100 · Cited by 556 · see citing works

Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis

Reznick, R. M., Zong, H., Li, J., Morino, K., Moore, I. K., Yu, H. J., Liu, Z.-X., Dong, J., Mustard, K. J., Hawley, S. A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.008 · Cited by 555 · see citing works

Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA

Kukat, C., Wurm, C., Spåhr, H., Falkenberg, M., Larsson, N., & Jakobs, S. (2011) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1109263108 · Cited by 551 · see citing works

Somatic Mitochondrial DNA Mutations in Mammalian Aging

Larsson, N. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060408-093701 · Cited by 543 · see citing works

Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals

Barja, G., & Herrero, A. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.2.312 · Cited by 540 · see citing works

The Absence of a Pyrimidine Dimer Repair Mechanism in Mammalian Mitochondria

Clayton, D. A., Doda, J. N., & Friedberg, E. C. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.7.2777 · Cited by 531 · see citing works

Rapalogs and mTOR inhibitors as anti-aging therapeutics

Lamming, D. W., Ye, L., Sabatini, D. M., & Baur, J. A. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64099 · Cited by 531 · see citing works

Autophagy and aging: keeping that old broom working

Cuervo, A. M. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.10.002 · Cited by 527 · see citing works

New insights into the role of mitochondria in aging: mitochondrial dynamics and more

Seo, A. Y., Joseph, A.-M., Dutta, D., Hwang, J. C. Y., Aris, J. P., & Leeuwenburgh, C. (2010) · Journal of Cell Science · doi:10.1242/jcs.070490 · Cited by 522 · cited 2× · see citing works

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

Zhang, C., & Cuervo, A. M. (2008) · Nature Medicine · doi:10.1038/nm.1851 · Cited by 520 · see citing works

Number matters: control of mammalian mitochondrial DNA copy number

Montier, L., Deng, J., & Bai, Y. (2009) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/s1673-8527(08)60099-5 · Cited by 513 · see citing works

Energetics, epigenetics, mitochondrial genetics

Wallace, D. C., & Fan, W. (2009) · Mitochondrion · doi:10.1016/j.mito.2009.09.006 · Cited by 507 · see citing works

Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging

Terman, A., Kurz, T., Navratil, M., Arriaga, E. A., & Brunk, U. T. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2598 · Cited by 490 · see citing works

Image-based genome-wide siRNA screen identifies selective autophagy factors

Orvedahl, A., Sumpter, R., Xiao, G., Ng, A., Zou, Z., Tang, Y., Narimatsu, M., Gilpin, C. J., Sun, Q., Roth, M. G., et al. (2011) · Nature · doi:10.1038/nature10546 · Cited by 486 · see citing works

The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo

Vincow, E. S., Merrihew, G., Thomas, R. E., Shulman, N. J., Beyer, R. P., MacCoss, M. J., & Pallanck, L. J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221132110 · Cited by 478 · see citing works

Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos)

Wang, Y., Kim, N. S., Haince, J.-F., Kang, H. C., David, K. K., Andrabi, S. A., Poirier, G. G., Dawson, V. L., & Dawson, T. M. (2011) · Science Signaling · doi:10.1126/scisignal.2000902 · Cited by 476 · see citing works

New insights into the function and regulation of mitochondrial fission

Otera, H., Ishihara, N., & Mihara, K. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.02.002 · Cited by 476 · see citing works

Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner

Frank, M., Duvezin-Caubet, S., Koob, S., Occhipinti, A., Jagasia, R., Petcherski, A., Ruonala, M. O., Priault, M., Salin, B., & Reichert, A. S. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.08.007 · Cited by 468 · see citing works

Mitochondrial transcription factor A regulates mitochondrial transcription initiation, DNA packaging, and genome copy number

Campbell, C. T., Kolesar, J. E., & Kaufman, B. A. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2012.03.002 · Cited by 458 · see citing works

SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage.

Tseng, A. H., Shieh, S., & Wang, D. (2013) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2013.05.002 · Cited by 445 · see citing works

Mitochondrial DNA–Deletion Mutations Accumulate Intracellularly to Detrimental Levels in Aged Human Skeletal Muscle Fibers

Bua, E., Johnson, J., Herbst, A., Delong, B., McKenzie, D., Salamat, S., & Aiken, J. M. (2006) · The American Journal of Human Genetics · doi:10.1086/507132 · Cited by 442 · see citing works

The Mitochondrial Transcription Factor TFAM Coordinates the Assembly of Multiple DNA Molecules into Nucleoid-like Structures

Kaufman, B. A., Durisic, N., Mativetsky, J. M., Costantino, S., Hancock, M. A., Grütter, P., & Shoubridge, E. A. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-05-0404 · Cited by 431 · see citing works

Can autophagy promote longevity?

Madeo, F., Tavernarakis, N., & Kroemer, G. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-842 · Cited by 429 · see citing works

Mitochondrial homeostasis: The interplay between mitophagy and mitochondrial biogenesis

Palikaras, K., & Tavernarakis, N. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.01.021 · Cited by 428 · see citing works

Mitochondrial Regulation of Cell Cycle and Proliferation

Arciuch, V. G. A., Elguero, M. E., Poderoso, J. J., & Carreras, M. C. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4085 · Cited by 428 · see citing works

Mitochondrial endonuclease G is important for apoptosis in C. elegans

Parrish, J., Li, L., Klotz, K., Ledwich, D., Wang, X., & Xue, D. (2001) · Nature · doi:10.1038/35083608 · Cited by 427 · see citing works

Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission–fusion proteins

Wu, S., Zhou, F., Zhang, Z., & Xing, D. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08010.x · Cited by 420 · see citing works

Uth1p Is Involved in the Autophagic Degradation of Mitochondria

Bhatia‐Kiššová, I., Deffieu, M. S., Manon, S., & Camougrand, N. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406960200 · Cited by 418 · see citing works

Minimizing the damage: repair pathways keep mitochondrial DNA intact

Kazak, L., Reyes, A., & Holt, I. J. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3439 · Cited by 412 · see citing works

DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice

Vermulst, M., Wanagat, J., Kujoth, G. C., Bielas, J. H., Rabinovitch, P. S., Prolla, T. A., & Loeb, L. A. (2008) · Nature Genetics · doi:10.1038/ng.95 · Cited by 411 · see citing works

Mitochondrial point mutations do not limit the natural lifespan of mice

Vermulst, M., Bielas, J. H., Kujoth, G. C., Ladiges, W. C., Rabinovitch, P. S., Prolla, T. A., & Loeb, L. A. (2007) · Nature Genetics · doi:10.1038/ng1988 · Cited by 404 · see citing works

Effects of exercise on mitochondrial content and function in aging human skeletal muscle

Menshikova, E. V., Ritov, V. B., Fairfull, L., Ferrell, R. E., Kelley, D. E., & Goodpaster, B. H. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.6.534 · Cited by 398 · see citing works

Universal heteroplasmy of human mitochondrial DNA

Payne, B. A. I., Wilson, I., Yu‐Wai‐Man, P., Coxhead, J., Deehan, D. J., Horváth, R., Taylor, R. W., Samuels, D. C., Santibanez‐Koref, M., & Chinnery, P. F. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds435 · Cited by 396 · see citing works

The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals

Joseph, A., Adhihetty, P. J., Buford, T. W., Wohlgemuth, S. E., Lees, H. A., Nguyen, L. M. ‐., Aranda, J. M., Sandesara, B. D., Pahor, M., Manini, T. M., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00844.x · Cited by 395 · see citing works

Mitochondrial genetics

Chinnery, P. F., & Hudson, G. (2013) · British Medical Bulletin · doi:10.1093/bmb/ldt017 · Cited by 395 · see citing works

Parkin and PINK1: much more than mitophagy

Scarffe, L. A., Stevens, D. A., Dawson, V. L., & Dawson, T. M. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.03.004 · Cited by 392 · see citing works

Genome Instability and Aging

Vijg, J., & Suh, Y. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183715 · Cited by 386 · see citing works

Targeting Mitochondrial Dysfunction: Role for PINK1 and Parkin in Mitochondrial Quality Control

Narendra, D. P., & Youle, R. J. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3799 · Cited by 367 · see citing works

Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint

Owusu-Ansah, E., Yavari, A., Mandal, S., & Banerjee, U. K. (2008) · Nature Genetics · doi:10.1038/ng.2007.50 · Cited by 364 · see citing works

Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage

Kennedy, S. R., Salk, J. J., Schmitt, M. W., & Loeb, L. A. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003794 · Cited by 363 · see citing works

Manganese Superoxide Dismutase: Guardian of the Powerhouse

Holley, A. K., Bakthavatchalu, V., Velez-Roman, J. M., & St. Clair, D. K. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12107114 · Cited by 358 · see citing works

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice

Anisimov, V. N., Zabezhinski, M. A., Popovich, I. G., Piskunova, T. S., Semenchenko, A. V., Тындык, М. Л., Yurova, M. N., Rosenfeld, S. V., & Blagosklonny, M. V. (2011) · Cell Cycle · doi:10.4161/cc.10.24.18486 · Cited by 347 · see citing works

Mitochondrial Quality Control Mediated by PINK1 and Parkin: Links to ParkinsonismPreprint

Narendra, D. P., Walker, J. E., & Youle, R. J. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a011338 · Cited by 341 · see citing works

Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age

Elson, J. L., Samuels, D. C., Turnbull, D. M., & Chinnery, P. F. (2001) · The American Journal of Human Genetics · doi:10.1086/318801 · Cited by 340 · see citing works

The functional organization of mitochondrial genomes in human cells

Iborra, F. J., Kimurâ, H., & Cook, P. R. (2004) · BMC Biology · doi:10.1186/1741-7007-2-9 · Cited by 339 · see citing works

Eukaryotic DNA Ligases: Structural and Functional Insights

Ellenberger, T., & Tomkinson, A. E. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061306.123941 · Cited by 337 · see citing works

Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

Suen, D., Narendra, D. P., Tanaka, A., Manfredi, G., & Youle, R. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914569107 · Cited by 335 · see citing works

Precise determination of mitochondrial DNA copy number in human skeletal and cardiac muscle by a PCR-based assay: lack of change of copy number with age

Miller, F. J. (2003) · Nucleic Acids Research · doi:10.1093/nar/gng060 · Cited by 332 · see citing works

Skeletal Muscle Mitochondria and Aging: A Review

Peterson, C. M., Johannsen, D. L., & Ravussin, É. (2012) · Journal of Aging Research · doi:10.1155/2012/194821 · Cited by 318 · see citing works

Oxidative stress response elicited by mitochondrial dysfunction: Implication in the pathophysiology of aging

Wang, C., Wu, S., Wu, Y., & Wei, Y. (2013) · Experimental Biology and Medicine · doi:10.1177/1535370213493069 · Cited by 315 · see citing works

Updating the mitochondrial free radical theory of aging: an integrated view, key aspects, and confounding concepts

Barja, G. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5148 · Cited by 290 · see citing works

Mitochondrial DNA nucleoid structure

Bogenhagen, D. F. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2011.11.005 · Cited by 290 · see citing works

Measurement of DNA oxidation in human cells by chromatographic and enzymic methods

European Standards Committee on Oxidative DNA Damage (ESCODD) (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00041-8 · Cited by 286 · see citing works

The sirtuins, oxidative stress and aging: an emerging link

Merksamer, P. I., Liu, Y., He, W., Hirschey, M. D., Chen, D., & Verdin, E. (2013) · Aging · doi:10.18632/aging.100544 · Cited by 275 · see citing works

Dynamic regulation of macroautophagy by distinctive ubiquitin-like proteins

Klionsky, D. J., & Schulman, B. A. (2014) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2787 · Cited by 274 · see citing works

Germline mitochondrial DNA mutations aggravate ageing and can impair brain development

Ross, J. M., Stewart, J. B., Hagström, E., Brené, S., Mourier, A., Coppotelli, G., Freyer, C., Lagouge, M., Hoffer, B. J., Olson, L., et al. (2013) · Nature · doi:10.1038/nature12474 · Cited by 273 · see citing works

The role of mitochondrial DNA mutations and free radicals in disease and ageing

Lagouge, M., & Larsson, N. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12055 · Cited by 270 · see citing works

Regulation of mitochondrial respiratory chain biogenesis by estrogens/estrogen receptors and physiological, pathological and pharmacological implications

Chen, J., Cammarata, P. R., Baines, C. P., & Yager, J. D. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.06.001 · Cited by 266 · see citing works

When a theory of aging ages badly

Lapointe, J., & Hekimi, S. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0138-8 · Cited by 261 · see citing works

Rheb Regulates Mitophagy Induced by Mitochondrial Energetic Status

Melser, S., Chatelain, É. H., Lavie, J., Mahfouf, W., José, C., Obre, É., Goorden, S. M. I., Priault, M., Elgersma, Y., Rezvani, H. R., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.014 · Cited by 259 · see citing works

Regulation of mitochondrial biogenesis and PGC-1α under cellular stress

Wenz, T. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.01.006 · Cited by 258 · see citing works

Mitochondrial Biogenesis through Activation of Nuclear Signaling ProteinsPreprint

Dominy, J. E., & Puigserver, P. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a015008 · Cited by 255 · see citing works

The key role of growth hormone–insulin–IGF-1 signaling in aging and cancer

Anisimov, V. N., & Bartke, A. (2013) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2013.01.005 · Cited by 222 · see citing works

Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis

He, J.-Y., Cooper, H. M., Reyes, A., Re, M. D., Sembongi, H., Litwin, T., Gao, J., Neuman, K., Fearnley, I., Spinazzola, A., et al. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks266 · Cited by 220 · see citing works

Hydrogen Peroxide as a Signaling Molecule

Veal, E. A., & Day, A. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.3968 · Cited by 217 · see citing works

Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health

Kotiadis, V. N., Duchen, M. R., & Osellame, L. D. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.10.041 · Cited by 212 · see citing works

Loss of autophagy in hypothalamic POMC neurons impairs lipolysis

Kaushik, S., Arias, E., Kwon, H., Lopez, N. M., Athonvarangkul, D., Sahu, S., Schwartz, G. J., Pessin, J. E., & Singh, R. (2012) · The EMBO Reports · doi:10.1038/embor.2011.260 · Cited by 212 · see citing works

The coordination of nuclear and mitochondrial communication during aging and calorie restriction

Finley, L. W. S., & Haigis, M. C. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.03.003 · Cited by 207 · see citing works

Ultra-Deep Sequencing of Mouse Mitochondrial DNA: Mutational Patterns and Their Origins

Ameur, A., Stewart, J. B., Freyer, C., Hagström, E., Ingman, M., Larsson, N., & Gyllensten, U. B. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002028 · Cited by 202 · see citing works

Mitochondria and Aging

Lee, H., & Wei, Y. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-2869-1_14 · Cited by 201 · see citing works

Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics

Marzetti, E., Csiszár, A., Dutta, D., Balagopal, G., Calvani, R., & Leeuwenburgh, C. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00936.2012 · Cited by 197 · see citing works

Is there more to aging than mitochondrial DNA and reactive oxygen species?

ALEXEYEV, M. F. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07269.x · Cited by 194 · see citing works

Mitophagy Selectively Degrades Individual Damaged Mitochondria After Photoirradiation

Kim, I., & Lemasters, J. J. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3768 · Cited by 193 · see citing works

Mitochondria and Ageing

Leeuwenburgh, C., Pamplona, R., & Sanz, A. (2011) · Journal of Aging Research · doi:10.4061/2011/782946 · Cited by 186 · see citing works

Epigenetic silencing mediates mitochondria stress-induced longevity

Schroeder, E. A., Raimundo, N., & Shadel, G. S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.003 · Cited by 186 · see citing works

Regulation of PINK1-Parkin-mediated mitophagy

Springer, W., & Kahle, P. J. (2011) · Autophagy · doi:10.4161/auto.7.3.14348 · Cited by 184 · see citing works

Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging

Kamenisch, Y., Fousteri, M. I., Knoch, J., von Thaler, A., Fehrenbacher, B., Kato, H., Becker, T., Dollé, M. E. T., Kuiper, R., Majora, M., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091834 · Cited by 182 · see citing works

Mitochondrial dysfunction, persistently elevated levels of reactive oxygen species and radiation-induced genomic instability: a review

J.Kim, G., Chandrasekaran, K., & Morgan, W. F. (2006) · Mutagenesis · doi:10.1093/mutage/gel048 · Cited by 181 · see citing works

DNA precursor asymmetries in mammalian tissue mitochondria and possible contribution to mutagenesis through reduced replication fidelity

Song, S., Pursell, Z. F., Copeland, W. C., Longley, M. J., Kunkel, T. A., & Mathews, C. K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500253102 · Cited by 176 · see citing works

Characterization of a histone-like protein extracted from yeast mitochondria.

Caron, F., Jacq, C., & Rouvière‐Yaniv, J. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.9.4265 · Cited by 175 · see citing works

Exercise training attenuates aging-associated mitochondrial dysfunction in rat skeletal muscle: Role of PGC-1α

Kang, C., Chung, E., Diffee, G., & Ji, L. L. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.08.004 · Cited by 174 · see citing works

Oxidative stress is not a major contributor to somatic mitochondrial DNA mutations

Itsara, L. S., Kennedy, S. R., Fox, E. J., Yu, S., Hewitt, J. J., Sanchez-Contreras, M., Cardozo-Pelaez, F., & Pallanck, L. J. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1003974 · Cited by 173 · see citing works

The retrograde response: When mitochondrial quality control is not enough

Jazwinski, S. M. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.02.010 · Cited by 172 · cited 1× · see citing works

Gene therapy for progeny of mito-mice carrying pathogenic mtDNA by nuclear transplantation

Sato, A., Kono, T., Nakada, K., Ishikawa, K., Inoue, S.-I., Yonekawa, H., & Hayashi, J.-I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506197102 · Cited by 171 · see citing works

The AAA⁺ ATPase ATAD3A Controls Mitochondrial Dynamics at the Interface of the Inner and Outer Membranes

Gilquin, B., Taillebourg, E., Cherradi, N., Hubstenberger, A., Gay, O., Merle, N., Assard, N., Fauvarque, M.-O., Tomohiro, S., Kuge, O., et al. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00007-10 · Cited by 171 · see citing works

Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition

Gilkerson, R., de Vries, R. L. A., Lebot, P., Wikström, J. D., Törgyekes, E., Shirihai, O. S., Przedborski, S., & Schon, E. A. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr529 · Cited by 169 · see citing works

Mitochondrial pathology: stress signals from the energy factory

Raimundo, N. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.01.005 · Cited by 164 · see citing works

Mitochondrial Localization of PARP-1 Requires Interaction with Mitofilin and Is Involved in the Maintenance of Mitochondrial DNA Integrity

Rossi, M. N., Carbone, M., Mostocotto, C., Mancone, C., Tripodi, M., Maione, R., & Amati, P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.025882 · Cited by 163 · see citing works

Defects in mitochondrial DNA replication and human disease

Copeland, W. C. (2011) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2011.632763 · Cited by 163 · see citing works

Biology of Mitochondria in Neurodegenerative Diseases

Martin, L. J. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385883-2.00005-9 · Cited by 162 · see citing works

The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes

Terman, A. (2009) · Gerontology · doi:10.1159/000213753 · Cited by 162 · see citing works

Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging.

Joseph, A.-M., Adhihetty, P. J., Wawrzyniak, N. R., Wohlgemuth, S. E., Picca, A., Kujoth, G. C., Prolla, T. A., & Leeuwenburgh, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069327 · Cited by 161 · see citing works

Role of antioxidant enzymes and small molecular weight antioxidants in the pathogenesis of age-related macular degeneration (AMD)

Tokarz, P., Kaarniranta, K., & Błasiak, J. (2013) · Biogerontology · doi:10.1007/s10522-013-9463-2 · Cited by 160 · see citing works

Mitochondrial-Targeted Plastoquinone Derivatives. Effect on Senescence and Acute Age-Related Pathologies

V. Skulachev, M., N. Antonenko, Y., N. Anisimov, V., V. Chernyak, B., A. Cherepanov, D., A. Chistyakov, V., V. Egorov, M., G. Kolosova, N., A. Korshunova, G., G. Lyamzaev, K., et al. (2011) · Current Drug Targets · doi:10.2174/138945011795528859 · Cited by 156 · see citing works

Mitochondria and autophagy: Critical interplay between the two homeostats

Okamoto, K., & Kondo‐Okamoto, N. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.08.001 · Cited by 154 · see citing works

Mitochondrial function as a determinant of life span

Lanza, I. R., & Nair, K. S. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0724-5 · Cited by 151 · see citing works

Nucleotide excision repair: new tricks with old bricks

Kamileri, I., Karakasilioti, I., & Garinis, G. A. (2012) · Trends in Genetics · doi:10.1016/j.tig.2012.06.004 · Cited by 146 · see citing works

Autophagy and the degradation of mitochondria

Goldman, S. J., Taylor, R., Zhang, Y., & Jin, S. V. (2010) · Mitochondrion · doi:10.1016/j.mito.2010.01.005 · Cited by 145 · see citing works

PGC-1 family coactivators and cell fate: Roles in cancer, neurodegeneration, cardiovascular disease and retrograde mitochondria–nucleus signalling

Jones, A. W. E., Yao, Z., Vicencio, J. M., Karkucińska‐Więckowska, A., & Szabadkai, G. (2011) · Mitochondrion · doi:10.1016/j.mito.2011.09.009 · Cited by 145 · see citing works

Age-Related Changes in the Autophagic Proteolysis of Rat Isolated Liver Cells: Effects of Antiaging Dietary Restrictions

Donati, A., Cavallini, G., Paradiso, C., Vittorini, S., Pollera, M., Gori, Z., & Bergamini, E. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.9.b375 · Cited by 142 · see citing works

Mitochondrial DNA copy number and function decrease with age in the short‐lived fish Nothobranchius furzeri

Hartmann, N., Reichwald, K., Wittig, I., Dröse, S., Schmeisser, S., Lück, C., Hahn, C., Graf, M., Gausmann, U., Tozzini, E. T., et al. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00723.x · Cited by 141 · see citing works

Mitochondrial DNA repair and association with aging – An update

Gredilla, R., Bohr, V. A., & Stevnsner, T. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.01.017 · Cited by 141 · see citing works

Age‐dependent decline of DNA repair activity for oxidative lesions in rat brain mitochondria

Chen, D., Cao, G., Hastings, T. G., Feng, Y., Pei, W., O'Horo, C., & Chen, J. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00916.x · Cited by 139 · see citing works

The interplay of neuronal mitochondrial dynamics and bioenergetics: Implications for Parkinson's disease

Laar, V. S. V., & Berman, S. B. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.05.015 · Cited by 133 · see citing works

Age associated low mitochondrial biogenesis may be explained by lack of response of PGC-1α to exercise training

Derbré, F., Gómez‐Cabrera, M. C., Nascimento, A. L. R., Sanchis‐Gomar, F., Martinez-Bello, V. E., Tresguerres, J. A. F., Fuentes, T., Gratas‐Delamarche, A., Monsalve, M., & Viña, J. (2011) · AGE · doi:10.1007/s11357-011-9264-y · Cited by 129 · see citing works

Autophagy - An Emerging Anti-Aging Mechanism?

Hansen, M. (2012) · Journal of Clinical & Experimental Pathology · doi:10.4172/2161-0681.s4-006 · Cited by 129 · see citing works

mtDNA makes a U-turn for the mitochondrial nucleoid

Kukat, C., & Larsson, N. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.04.009 · Cited by 128 · see citing works

Mammalian Target of Rapamycin: A Signaling Kinase for Every Aspect of Cellular Life

Weichhart, T. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-430-8_1 · Cited by 123 · see citing works

Exercise induces mitochondrial biogenesis after brain ischemia in rats

Zhang, Q., Wu, Y., Zhang, P., Sha, H., Jia, J., Hu, Y., & Zhu, J. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.12.053 · Cited by 121 · see citing works

Current Topics in Ionizing Radiation Research

Nenoi, M. (2012) · InTech eBooks · doi:10.5772/2027 · Cited by 120 · see citing works

ESCODD: European standards committee on oxidative DNA damage

Lunec, J. (1998) · Free Radical Research · doi:10.1080/10715769800300651 · Cited by 118 · see citing works

Comparison of biological effects of DNA damage induced by ionizing radiation and hydrogen peroxide in CHO cells

Dahm-Daphi, C. S. J. (2000) · International Journal of Radiation Biology · doi:10.1080/095530000139023 · Cited by 115 · see citing works

The control of mtDNA replication during differentiation and development

John, J. C. S. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.10.036 · Cited by 113 · see citing works

Formation and repair of oxidative damage in the mitochondrial DNA

Müftüoğlu, M., Mori, M. P., & de Souza-Pinto, N. C. (2014) · Mitochondrion · doi:10.1016/j.mito.2014.03.007 · Cited by 111 · see citing works

Mitochondrial Fusion Proteins and Human Diseases

Ranieri, M., Brajkovic, S., Riboldi, G. M., Ronchi, D., Rizzo, F., Bresolin, N., Corti, S. P., & Comi, G. P. (2013) · Neurology Research International · doi:10.1155/2013/293893 · Cited by 110 · see citing works

Actin and myosin contribute to mammalian mitochondrial DNA maintenance

Reyes, A., He, J., Mao, C., Bailey, L., Re, M. D., Sembongi, H., Kazak, L., Dzionek, K., Holmes, J. B., Cluett, T. J., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr052 · Cited by 107 · see citing works

The Dynamics of the Mitochondrial Organelle as a Potential Therapeutic Target

Stetler, R. A., Leak, R. K., Gao, Y., & Chen, J. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.158 · Cited by 106 · see citing works

Response to the increase of oxidative stress and mutation of mitochondrial DNA in aging

Ma, Y., Wu, S., Lee, W.-Y., Cheng, J.-S., & Wei, Y. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.04.012 · Cited by 105 · see citing works

Proteolytic control of mitochondrial function and morphogenesis

Anand, R., Langer, T., & Baker, M. J. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.06.025 · Cited by 104 · see citing works

Mitochondria in heart failure: the emerging role of mitochondrial dynamics

Marı́n-Garcı́a, J., Akhmedov, A. T., & Moe, G. W. P. L. (2012) · Heart Failure Reviews · doi:10.1007/s10741-012-9330-2 · Cited by 103 · see citing works

Mitochondrial DNA Haplogroup D4a Is a Marker for Extreme Longevity in Japan

Bilal, E., Rabadán, R., Alexe, G., Fuku, N., Ueno, H., Nishigaki, Y., Fujita, Y., Ito, M., Arai, Y., Hirose, N., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002421 · Cited by 103 · see citing works

Lack of age-related increase of mitochondrial DNA amount in brain, skeletal muscle and human heart

Frahm, T., Mohamed, S. A., Bruse, P., Gemünd, C., Oehmichen, M., & Meißner, C. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.06.008 · Cited by 100 · see citing works

Regulation of mitochondrial dynamics: convergences and divergences between yeast and vertebrates

Zhao, J., Lendahl, U., & Nistér, M. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1066-6 · Cited by 99 · see citing works

Branched-chain Amino Acid Metabolon

Islam, M. M., Nautiyal, M., Wynn, R., Mobley, J. A., Chuang, D., & Hutson, S. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.048777 · Cited by 98 · see citing works

Oxidants and not alkylating agents induce rapid mtDNA loss and mitochondrial dysfunction

Furda, A. M., Marrangoni, A., Lokshin, A. E., & Houten, B. V. (2012) · DNA repair · doi:10.1016/j.dnarep.2012.06.002 · Cited by 98 · see citing works

Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse

Dillon, L. M., Williams, S. L., Hida, A., Peacock, J. D., Prolla, T. A., Lincoln, J., & Moraes, C. T. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds049 · Cited by 98 · see citing works

Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1

Burbulla, L. F., Fitzgerald, J. C., Stegen, K., Westermeier, J., Thost, A.-K., Kato, H., Mokranjac, D., Sauerwald, J., Martins, L. M., Woitalla, D., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.103 · Cited by 97 · see citing works

Intracellular trafficking and regulation of mammalian AP-endonuclease 1 (APE1), an essential DNA repair protein

MITRA, S., Izumi, T., Boldogh, I., Bhakat, K. K., Chattopadhyay, R., & Szczęsny, B. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.10.010 · Cited by 96 · see citing works

Quantitative change in mitochondrial DNA content in various mouse tissues during aging

Masuyama, M., Iida, R., Takatsuka, H., Yasuda, T., & Matsuki, T. (2005) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2005.03.001 · Cited by 93 · see citing works

Rapamycin drives selection against a pathogenic heteroplasmic mitochondrial DNA mutation

Dai, Y., Zheng, K., Clark, J., Swerdlow, R. H., Pulst, S. M., Sutton, J. P., Shinobu, L. A., & Simon, D. K. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt450 · Cited by 91 · see citing works

No evidence of mitochondrial respiratory dysfunction in OGG1-null mice deficient in removal of 8-oxodeoxyguanine from mitochondrial DNA

Stuart, J. A., Bourque, B. M., de Souza-Pinto, N. C., & Bohr, V. A. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.12.003 · Cited by 89 · see citing works

Genetic variants and animal models in SNCA and Parkinson disease

Deng, H., & Yuan, L. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.04.002 · Cited by 89 · see citing works

Mitochondrial DNA Replication: What We Know

Clayton, D. A. (2003) · IUBMB Life · doi:10.1080/1521654031000134824 · Cited by 85 · see citing works

UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication

Melber, A., & Haynes, C. M. (2018) · Cell Research · doi:10.1038/cr.2018.16 · Cited by 488 · see citing works

Regulation of SIRT1 in aging: Roles in mitochondrial function and biogenesis

Yuan, Y., Cruzat, V. F., Newsholme, P., Cheng, J., Chen, Y., & Lu, Y. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.02.003 · Cited by 301 · see citing works

Frailty in childhood cancer survivors

Ness, K. K., Armstrong, G. T., Kundu, M., Wilson, C. L., Tchkonia, T., & Kirkland, J. L. (2015) · Cancer · doi:10.1002/cncr.29211 · Cited by 188 · see citing works

Mechanisms linking mtDNA damage and aging

Pinto, M., & Moraes, C. T. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.005 · Cited by 179 · see citing works

Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases

DeBalsi, K. L., Hoff, K. E., & Copeland, W. C. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.04.006 · Cited by 180 · see citing works

Parallel damage in mitochondria and lysosomes is an efficient way to photoinduce cell death

Martins, W. K., Santos, N. F., Rocha, C. D. S., Bacellar, I. O. L., Tsubone, T. M., Viotto, A. C., Matsukuma, A. Y., Abrantes, A. B. D. P., Siani, P., Dias, L. G., et al. (2018) · Autophagy · doi:10.1080/15548627.2018.1515609 · Cited by 165 · see citing works

SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy

Lang, A., Anand, R., Altinoluk-Hambüchen, S., Ezzahoini, H., Stefanski, A., Iram, A., Bergmann, L., Urbach, J., Böhler, P., Hänsel, J., et al. (2017) · Aging · doi:10.18632/aging.101307 · Cited by 145 · see citing works

Premature Physiologic Aging as a Paradigm for Understanding Increased Risk of Adverse Health Across the Lifespan of Survivors of Childhood Cancer

Ness, K. K., Kirkland, J. L., Gramatges, M. M., Wang, Z., Kundu, M., McCastlain, K., Li-Harms, X., Zhang, J., Tchkonia, T., Pluijm, S. M. F., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2017.76.7467 · Cited by 140 · see citing works

Mitochondrial and Nuclear DNA Oxidative Damage in Physiological and Pathological Aging

Kowalska, M., Piekut, T., Prendecki, M., Sodel, A., Kozubski, W. P., & Dorszewska, J. (2020) · DNA and Cell Biology · doi:10.1089/dna.2019.5347 · Cited by 112 · see citing works

Cause or casualty: The role of mitochondrial DNA in aging and age-associated disease

Chocrón, E. S., Munkácsy, E., & Pickering, A. M. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.09.035 · Cited by 106 · see citing works

Mitochondrial stress management: a dynamic journey

Valera‐Alberni, M., & Cantó, C. (2018) · Cell Stress · doi:10.15698/cst2018.10.158 · Cited by 90 · see citing works

Recent Advances in Detecting Mitochondrial DNA Heteroplasmic Variations

Duan, M., Tu, J., & Lu, Z. (2018) · Molecules · doi:10.3390/molecules23020323 · Cited by 74 · see citing works

Mitochondrial responsibility in ageing process: innocent, suspect or guilty

López‐Lluch, G., Santos‐Ocaña, C., Sánchez-Alcázar, J. A., Fernández‐Ayala, D. J. M., Asencio, C., Rodríguez‐Aguilera, J. C., & Navas, P. (2015) · Biogerontology · doi:10.1007/s10522-015-9585-9 · Cited by 69 · see citing works

Alzheimer's disease: Innate immunity gone awry?

VanItallie, T. B. (2017) · Metabolism · doi:10.1016/j.metabol.2017.01.014 · Cited by 67 · see citing works

Adverse outcome pathway of fine particulate matter leading to increased cardiovascular morbidity and mortality: An integrated perspective from toxicology and epidemiology

Yu, Y., Sun, Q., Li, T., Ren, X., Lin, L., Sun, M., Duan, J., & Sun, Z. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.128368 · Cited by 67 · see citing works

Multiple Roles of Mitochondria in Aging Processes

CEDIKOVA, M., Pitule, P., Kripnerová, M., MARKOVA, M., & Kuncová, J. (2016) · Physiological Research · doi:10.33549/physiolres.933538 · Cited by 63 · see citing works

Association of particulate matter air pollution with leukocyte mitochondrial DNA copy number

Wang, X., Hart, J. E., Liu, Q., Wu, S., Nan, H., & Laden, F. (2020) · Environment International · doi:10.1016/j.envint.2020.105761 · Cited by 53 · see citing works

Mitochondrial Dysfunction and Diabetic Nephropathy: Nontraditional Therapeutic Opportunities

Zhang, P., Zhou, M. Q., Guo, J., Zheng, H., Tang, J., Zhang, C., Liu, Y., Liu, W. J., & Wang, Y. (2021) · Journal of Diabetes Research · doi:10.1155/2021/1010268 · Cited by 52 · see citing works

Sex Differences in Molecular Mechanisms of Cardiovascular Aging

Justina, V. D., Miguez, J. S., Priviero, F. B. M., Sullivan, J. C., Giachini, F. R. C., & Webb, R. C. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.725884 · Cited by 52 · see citing works

Molecular Machinery and Pathophysiology of Mitochondrial Dynamics

Chiu, Y., Lin, S., Kuo, C.-H., & Li, C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.743892 · Cited by 48 · see citing works

Mitochondrial metabolic failure in telomere attrition-provoked aging of bone marrow mesenchymal stem cells

Sui, B., Hu, C., & Jin, Y. J. (2015) · Biogerontology · doi:10.1007/s10522-015-9609-5 · Cited by 47 · see citing works

Energy and the Alzheimer brain

Mamelak, M. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.02.001 · Cited by 46 · see citing works

The role of mitochondrial dynamics in disease

Wang, Y., Dai, X., Li, H., Jiang, H., Zhou, J.-F., Zhang, S., Guo, J., Shen, L., Yang, H., Lin, J. M., et al. (2023) · MedComm · doi:10.1002/mco2.462 · Cited by 40 · see citing works

Decreased Integrity, Content, and Increased Transcript Level of Mitochondrial DNA Are Associated with Keratoconus

Hao, X., Chen, Z., Qu, M., Zhao, X.-W., Li, S., & Chen, P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165580 · Cited by 39 · see citing works

Peroxisome proliferator‐activated receptor γ coactivator 1α regulates mitochondrial calcium homeostasis, sarcoplasmic reticulum stress, and cell death to mitigate skeletal muscle aging

Gill, J. F., Delezie, J., Santos, G., McGuirk, S., Schnyder, S., Frank, S., Rausch, M., St‐Pierre, J., & Handschin, C. (2019) · Aging Cell · doi:10.1111/acel.12993 · Cited by 39 · see citing works

DNA Methylation of PGC-1α Is Associated With Elevated mtDNA Copy Number and Altered Urinary Metabolites in Autism Spectrum Disorder

Bam, S., Buchanan, E., Mahony, C., & O’Ryan, C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.696428 · Cited by 39 · see citing works

Formoterol attenuated mitochondrial dysfunction in rotenone-induced Parkinson's disease in a rat model: Role of PINK-1/PARKIN and PI3K/Akt/CREB/BDNF/TrKB axis

Khidr, H. Y., Hassan, N. F., Abdelrahman, S. S. M., El‐Ansary, M. R., El-Yamany, M. F., & Rabie, M. A. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111207 · Cited by 37 · see citing works

Targeting the multifaceted roles of mitochondria in intracerebral hemorrhage and therapeutic prospects

Li, Y., Liu, H., Tian, C., An, N., Song, K., Wei, Y., Sun, Y., Xing, Y., & Gao, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112749 · Cited by 35 · see citing works

Biological Aspects of Inflamm-Aging in Childhood Cancer Survivors

Rossi, F., Paola, A. D., Pota, E., Argenziano, M., Pinto, D., Marrapodi, M. M., Leva, C. D., Martino, M. D., & Tortora, C. (2021) · Cancers · doi:10.3390/cancers13194933 · Cited by 34 · see citing works

Testosterone deficiency caused by castration modulates mitochondrial biogenesis through the Ar/Pgc1α/Tfam pathway

Liu, C., Ma, J., Zhang, J., Zhao, H., Zhu, Y., Qi, J., Liu, L., Zhu, L., Jiang, Y., Tang, G., et al. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00505 · Cited by 34 · see citing works

Age-associated decline in Nrf2 signaling and associated mtDNA damage may be involved in the degeneration of the auditory cortex: Implications for central presbycusis

Li, Y., Zhao, X., Hu, Y., Sun, H., He, Z., Yuan, J., Cai, H. “., Sun, Y., Huang, X., Kong, W., et al. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3907 · Cited by 33 · see citing works

Evaluating heteroplasmic variations of the mitochondrial genome from whole genome sequencing data

Duan, M., Chen, L., Ge, Q., Lü, N., Li, J., Pan, X., Qiao, Y., Tu, J., & Lu, Z. (2019) · Gene · doi:10.1016/j.gene.2019.03.016 · Cited by 33 · see citing works

Metabolic Determinants of Mitochondrial Function in Oocytes

Seidler, E. A., & Moley, K. H. (2015) · Seminars in Reproductive Medicine · doi:10.1055/s-0035-1567822 · Cited by 33 · see citing works

Aging and Neurological Diseases

Kowalska, M., Owecki, M. K., Prendecki, M., Wize, K., Nowakowska, J., Kozubski, W. P., Lianeri, M., & Dorszewska, J. (2017) · InTech eBooks · doi:10.5772/intechopen.69499 · Cited by 31 · see citing works

Mitochondrial Dysfunction as the Major Basis of Brain Aging

Bondy, S. C. (2024) · Biomolecules · doi:10.3390/biom14040402 · Cited by 30 · see citing works

Association of Mitochondrial DNA Copy Number and Telomere Length with Prevalent and Incident Cancer and Cancer Mortality in Women: A Prospective Swedish Population-Based Study

Li, Y., Sundquist, K., Wang, X., Zhang, N., Hedelius, A., Sundquist, J., & Memon, A. A. (2021) · Cancers · doi:10.3390/cancers13153842 · Cited by 25 · see citing works

The Age-Sensitive Efficacy of Calorie Restriction on Mitochondrial Biogenesis and mtDNA Damage in Rat Liver

Chimienti, G., Picca, A., Fracasso, F., Russo, F., Orlando, A., Riezzo, G., Leeuwenburgh, C., Pesce, V., & Lezza, A. M. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041665 · Cited by 22 · see citing works

“What makes some rats live so long?” The mitochondrial contribution to longevity through balance of mitochondrial dynamics and mtDNA content

Picca, A., Pesce, V., Sirago, G., Fracasso, F., Leeuwenburgh, C., & Lezza, A. M. S. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.09.010 · Cited by 21 · see citing works

Initial brain aging: heterogeneity of mitochondrial size is associated with decline in complex I-linked respiration in cortex and hippocampus

Thomsen, K., Yokota, T., Hasan‐Olive, M. M., Dreyer, N. S., Fakouri, N. B., Desler, C., Regnell, C. E., Larsen, S., Rasmussen, L. J., Dela, F., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.08.004 · Cited by 20 · see citing works

Key Molecular Mechanisms of Aging, Biomarkers, and Potential Interventions

Proshkina, E., Solovev, I. A., Shaposhnikov, M. V., & Moskalev, A. (2020) · Molecular Biology · doi:10.1134/s0026893320060096 · Cited by 21 · see citing works

Ключевые молекулярные механизмы старения, биомаркеры и потенциальные интервенции

Proshkina, E., Соловьёв, И. А., Shaposhnikov, M. V., & Moskalev, A. A. (2020) · Molecular Biology · doi:10.31857/s0026898420060099 · Cited by 18 · see citing works

Mitochondrial Adaptations in Aged Skeletal Muscle: Effect of Exercise Training

Ziaaldini, M. M., Hosseini, S. R. A., & Fathi, M. (2017) · Physiological Research · doi:10.33549/physiolres.933329 · Cited by 16 · see citing works

p62 Promotes the Mitochondrial Localization of p53 through Its UBA Domain and Participates in Regulating the Sensitivity of Ovarian Cancer Cells to Cisplatin

Kong, Q., Yan, X., Cheng, M., Jiang, X. M., Xu, L., Shen, L., Yu, H., & Sun, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063290 · Cited by 16 · see citing works

Novel role of the SIRT4-OPA1 axis in mitochondrial quality control

Lang, A., & Piekorz, R. P. (2018) · Cell Stress · doi:10.15698/cst2018.01.118 · Cited by 15 · see citing works

Protective Effect of Sirt1 against Radiation-Induced Damage

Qin, H., Zhang, H., Zhang, S., Zhu, S., & Wang, H. (2021) · Radiation Research · doi:10.1667/rade-20-00139.1 · Cited by 13 · see citing works

Small Molecules Targeting Mitochondria: A Mechanistic Approach to Combating Doxorubicin-Induced Cardiotoxicity

Pal, C. (2024) · Cardiovascular Toxicology · doi:10.1007/s12012-024-09941-7 · Cited by 14 · see citing works

Blastocyst mitochondrial DNA (mtDNA) is not affected by oocyte vitrification: a sibling oocyte study

Arnanz, A., Munck, N. D., Bayram, A., El‐Damen, A., Abdalla, A., Elkhatib, I., Melado, L., Lawrenz, B., & Fatemi, H. M. (2020) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-020-01795-6 · Cited by 13 · see citing works

Normal Aging and Dementia

Prendecki, M., Florczak‐Wyspianska, J., Kowalska, M., Lianeri, M., Kozubski, W. P., & Dorszewska, J. (2016) · InTech eBooks · doi:10.5772/64203 · Cited by 12 · see citing works

Increased Systemic Antioxidant Power Ameliorates the Aging-Related Reduction in Oocyte Competence in Mice

Lane, S. L., Parks, J. C., Russ, J. E., Khan, S. A., Schoolcraft, W. B., Yuan, Y., & Katz‐Jaffe, M. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222313019 · Cited by 22 · see citing works

SRT1720 Pretreatment Promotes Mitochondrial Biogenesis of Aged Human Mesenchymal Stem Cells and Improves Their Engraftment in Postinfarct Nonhuman Primate Hearts

Zeng, Z., Yu, K., Hu, W., Cheng, S., Gao, C., Liu, F., Chen, J., Kong, M., Zhang, F., Liu, X., et al. (2021) · Stem Cells and Development · doi:10.1089/scd.2020.0149 · Cited by 9 · see citing works

Disruption of mitochondrial DNA integrity in cardiomyocyte injury upon ischemia/reperfusion

Hu, S., Tang, X., Zhu, F., Chen, L., Wang, S., Wang, H., Li, P., & Li, Y. (2024) · Genes & Diseases · doi:10.1016/j.gendis.2024.101282 · Cited by 7 · see citing works

Whole Mitochondrial Genome Analysis in Non–Small Cell Lung Carcinoma Reveals Unique Tumor-Specific Somatic Mutations

Kim, M., Kim, H.-J., Sung, J.-A., Koh, J., Cho, S., Chung, D. H., Jeon, Y. K., & Lee, S. D. (2023) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2022-0175-oa · Cited by 7 · see citing works

Modelling ageing and age-related disease

Bellantuono, I., & Potter, P. K. (2016) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2017.07.005 · Cited by 7 · see citing works

Identification of two patterns of mitochondrial DNA-copy number variation in postcentral gyrus during aging, influenced by body mass index and type 2 diabetes

Sekiya, F. S., da Silva, C. P. N., Oba‐Shinjo, S. M., Santos‐Bezerra, D. P., Ravagnani, F. G., Pasqualucci, C. A., Gil, S. D. S., Gualano, B., Baptista, M. S., Corrêa‐Giannella, M. L., et al. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111932 · Cited by 6 · see citing works

Hepatic Encephalopathy: Insights Into the Impact of Metabolic Precipitates

Dash, U. K., Tripathi, A., Mazumdar, D., Dusmanta, P., & Singh, S. (2025) · Developmental Neurobiology · doi:10.1002/dneu.22999 · Cited by 5 · see citing works

The Critical Role of Autophagy and Phagocytosis in the Aging Brain

Bondy, S. C., & Wu, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms26010057 · Cited by 5 · see citing works

Biological Aging: From the Boolean Networks to the Geometric Phase

Barragán, J., & Sánchez, S. (2015) · Current Research Journal of Biological Sciences · doi:10.19026/crjbs.7.5207 · Cited by 4 · see citing works

Vimar/RAP1GDS1 promotes acceleration of brain aging after flies and mice reach middle age

Xiong, Y., Cheng, Q., Li, Y., Han, Y., Sun, X., & Liu, L. (2023) · Communications Biology · doi:10.1038/s42003-023-04822-1 · Cited by 4 · see citing works

Alternative Methods for Mitochondrial Transplantation: Efficiency of Unpackaged and Lipid-Packaged PreparationsPreprint

McPhie, D. L., Sargent, L., Babb, S. M., Ben‐Shachar, D., Cataldo, A., & Cohen, B. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/102913 · Cited by 4 · see citing works

Effect Of Atmospheric Particulate Matter On The Functional State Of Mitochondria

Kondratyeva, E. V., & Vitkina, T. (2023) · Russian Open Medical Journal · doi:10.15275/rusomj.2023.0106 · Cited by 3 · see citing works

Exosome miR-152-3p derived from small intestinal epithelium modulates aging process in adipocytes

Di, W., Xue, C., Lin, Y., Zhang, W., & Zhou, Y. (2025) · 3 Biotech · doi:10.1007/s13205-025-04346-x · Cited by 2 · see citing works

Telmisartan ameliorates reproductive dysfunction, oxidative stress, and mitochondrial damages induced by fipronil in male rats via regulation of Nrf2/HO-1/PGC-1α/MNF2/DRP1

Salama, A. R., Aboushouk, A. A., El-Far, A., Ashoura, N. R., Rohiem, A. H., Edres, H. A., & Saad, H. M. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04812-6 · Cited by 2 · see citing works

Redox-Regulated Mitophagy and Lysosomal Dysfunction as a Convergent Mechanism in Female Infertility: Molecular Insights and Therapeutic Perspectives

Voros, C., Chatzinikolaou, F. G., Papadimas, G. K., Karpouzos, A., Papapanagiotou, I., Koulakmanidis, A.-M., Athanasiou, D., Bananis, K., Athanasiou, A. I., Athanasiou, A. V., et al. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48040429 · Cited by 2 · see citing works

Insights into Mechanisms Causing the Maternal Age-Induced Decrease in Oocyte Quality

Boudoures, A. L., & Moley, K. H. (2015) · Springer eBooks · doi:10.1007/978-3-319-17849-3_4 · Cited by 2 · see citing works

CuATSM PET to diagnose age-related diseases: a systematic literature review

Majerníková, N., Yu, J. J., & Maier, A. B. (2020) · Clinical and Translational Imaging · doi:10.1007/s40336-020-00394-w · Cited by 2 · see citing works

Ageing and Longevity

Nagaratnam, N. (2018) · Springer eBooks · doi:10.1007/978-3-319-96998-5_1 · Cited by 2 · see citing works

The aging cardiovascular system

Şener, Y. Z., & Canpolat, U. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-98804-9.00033-5 · Cited by 2 · see citing works

A Study of Mitochondrial DNA Copy Number and Heteroplasmy in Different Rat Brain Regions after Cranial Proton Impact

Abdullaev, S. A., Evdokimovskii, E. V., & Gaziev, A. I. (2020) · Biology Bulletin · doi:10.1134/s1062359020110023 · Cited by 1 · see citing works

Hydrogen-rich water inhibits mitochondrial oxidative stress and inflammation in the skeletal muscle after eccentric exercise

Wang, L., Liu, Z., Hou, Y., & Ge, Y. (2015) · Zhongguo zuzhi gongcheng yanjiu yu linchuang kangfu · Cited by 1 · see citing works

Human Biological Aging: A Vector Model

Barragán, J., & Sánchez, S. (2019) · Current Research Journal of Biological Sciences · doi:10.19026/crjbs.11.6024 · Cited by 1 · see citing works

Experimental Detection of Mitochondrial DNA Insertions in Nuclear Genome of Chicken Embryos Developed from X-Ray Irradiated Eggs

Abdullaev, S. A. (2014) · Journal of Genetics and Genome Research · doi:10.23937/2378-3648/1410008

Atherosclerosis is a side effect of cellular senescence

Леонова, Е. И., Chirinskaite, A. V., & Sopova, J. V. (2022) · Research Results in Pharmacology · doi:10.3897/rrpharmacology.8.81358

CONTEMPORARY APPROACHES TO PROGNOSTICATION AND MANAGEMENT OF PELVIC RADIATION INJURIES IN GYNECOLOGICAL CANCER PATIENTS

Іванкова, В. С., Domina, E. A., Хруленко, Т. В., Барановська, Л. М., & Главін, О. А. (2022) · Проблеми радіаційної медицини та радіобіології = Problems of Radiation Medicine and Radiobiology · doi:10.33145/2304-8336-2022-27-455-473

Determination Mitochondria's Quality Control of Parkinsonism Using Real-Time Reverse-Transcription Polymerase Chain ReactionPreprint

Akram, A.-B. (2024) · Preprints.org · doi:10.20944/preprints202404.1845.v1

BrainBridge Characterizes Key Factors affecting Alzheimer’s Disease and Associated PhenotypesPreprint

Liu, T., Hao, M., Sun, E., Markov, Y., Zhang, L., Zou, J., & Zhao, H. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.03.692255

Mitophagy in age-dependent neurodegeneration

Sukhorukov, V. S., Egorova, A. V., Romanenko, A. S., Ryabova, M. S., & Krasilnikova, A. P. (2025) · Acta Naturae · doi:10.32607/actanaturae.27674

Acteoside ameliorates doxorubicin-induced cardiotoxicity by suppressing ferroptosis through activation of the KEAP1/NRF2 pathway

Wang, M., Wang, C., Liu, Z., Du, X., Tian, L., Li, Q., Zhang, F., Chen, Y., & Lu, C. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.179349

MtDNA mutations, functional decline and turnover of mitochondria in aging

Pang, C. (2008) · Frontiers in bioscience · doi:10.2741/2957 · Cited by 32 · see citing works

Mitochondrial DNA alterations and reduced mitochondrial function in aging

Hebert, S. L., Lanza, I. R., & Nair, K. S. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.03.007 · Cited by 90 · see citing works

Mitochondrial DNA repair and association with aging – An update

Gredilla, R., Bohr, V. A., & Stevnsner, T. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.01.017 · Cited by 141 · see citing works

Mitochondrial DNA damage as driver of cellular outcomes

Nadalutti, C. A., Ayala‐Peña, S., & Santos, J. H. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00389.2021 · Cited by 87 · see citing works

Mitophagy plays a central role in mitochondrial ageing

Diot, A., Morten, K., & Poulton, J. (2016) · Mammalian Genome · doi:10.1007/s00335-016-9651-x · Cited by 109 · see citing works