The DOI matches its Crossref record; 190 of the 190 references it cites were found in a registry or an index.
NMD: a multifaceted response to premature translational termination
Open accessAbstract
Although most mRNA molecules derived from protein-coding genes are destined to be translated into functional polypeptides, some are eliminated by cellular quality control pathways that collectively perform the task of mRNA surveillance. In the nonsense-mediated decay (NMD) pathway premature translation termination promotes the recruitment of a set of factors that destabilize a targeted mRNA. The same factors also seem to have key roles in repressing the translation of the mRNA, dissociating its terminating ribosome and messenger ribonucleoproteins (mRNPs), promoting the degradation of its truncated polypeptide product and possibly even feeding back to the site of transcription to interfere with splicing of the primary transcript.
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“Since no exon-exon boundary in the ADNP mRNA is present downstream from any of the mutations, nonsense mediated RNA decay (NMD) is unlikely28-30.”
From A SWI/SNF-related autism syndrome caused by de novo mutations in ADNP (2014) · cites this paper as [30]
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P bodies and the control of mRNA translation and degradation
Parker, R., & Sheth, U. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.02.011 · Cited by 1,335
The highways and byways of mRNA decay
Garneau, N. L., Wilusz, J., & Wilusz, C. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2104 · Cited by 1,294
PTC124 targets genetic disorders caused by nonsense mutations
Welch, E. M., Barton, E. R., Zhuo, J., Tomizawa, Y., Friesen, W. J., Trifillis, P., Paushkin, S. V., Patel, M., Trotta, C. R., Hwang, S., et al. (2007) · Nature · doi:10.1038/nature05756 · Cited by 1,175
Self-citationThe spliceosome deposits multiple proteins 20–24 nucleotides upstream of mRNA exon–exon junctions
Hir, H. L., Izaurralde, E., Maquat, L. E., & Moore, M. J. (2000) · The EMBO Journal · doi:10.1093/emboj/19.24.6860 · Cited by 970
P bodies: at the crossroads of post-transcriptional pathways
Eulálio, A., Behm‐Ansmant, I., & Izaurralde, E. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2080 · Cited by 970
Mendell, J. T., Sharifi, N., Meyers, J. L., Martínez-Murillo, F., & Dietz, H. C. (2004) · Nature Genetics · doi:10.1038/ng1429 · Cited by 880
Hir, H. L., Gatfield, D., Izaurralde, E., & Moore, M. J. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4987 · Cited by 842
Endonucleolytic cleavage of eukaryotic mRNAs with stalls in translation elongation
Doma, M. K., & Parker, R. (2006) · Nature · doi:10.1038/nature04530 · Cited by 789
Kashima, I., Yamashita, A., Izumi, N., Kataoka, N., Morishita, R., Hoshino, S.-I., Ohno, M., Dreyfuss, G., & Ohno, S. (2006) · Genes & Development · doi:10.1101/gad.1389006 · Cited by 664
Translational control in biology and medicine
Mathews, M. B., Sonenberg, N., & Hershey, J. W. B. (2007) · Cited by 661
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Zhang, Y., Zhang, X.-O., Chen, T., Xiang, J.-F., Yin, Q.-F., Xing, Y.-H., Zhu, S., Yang, L., & Chen, L.-L. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.017 · Cited by 2,221
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Metadata
- Authors
- Kervestin, S., & Jacobson, A.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- Jacobson, Allan
- ORCID
- Jacobson, Allan
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2012-10-17
- Volume
- 13
- Issue
- 11
- Pages
- 700-712
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- PMC
- PMC3970730
- OpenAlex
- W2057726003
- Cited by
- 572
- References
- 190
- Citations by year
- 2026: 27 · 2025: 41 · 2024: 20 · 2023: 33 · 2022: 22 · 2021: 20 · 2020: 33 · 2019: 30 · 2018: 45 · 2017: 38 · 2016: 53 · 2015: 63 · 2014: 83 · 2013: 61 · 2012: 2
- FWCI
- 6.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Funders
- National Institute of General Medical Sciences (R37GM027757, R01GM027757)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- nonsense-mediated mRNA decay, mRNA surveillance, mRNA degradation, translation repression, ribonucleoprotein complexes, stop codon
- MeSH terms
- Humans, Peptide Chain Termination, Translational, Peptide Termination Factors, Ribonucleoproteins, Ribosomes, RNA, Messenger, Transcription Factors, Protein Biosynthesis, Trans-Activators, RNA-Binding Proteins, Codon, Nonsense, RNA Helicases, RNA Stability, Nonsense Mediated mRNA Decay
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