The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Diversity and selectivity in mRNA translation on the endoplasmic reticulum
Open accessAbstract
Pioneering electron microscopy studies defined two primary populations of ribosomes in eukaryotic cells: one freely dispersed through the cytoplasm and the other bound to the surface of the endoplasmic reticulum (ER). Subsequent investigations revealed a specialized function for each population, with secretory and integral membrane protein-encoding mRNAs translated on ER-bound ribosomes, and cytosolic protein synthesis was widely attributed to free ribosomes. Recent findings have challenged this view, and transcriptome-scale studies of mRNA distribution and translation have now demonstrated that ER-bound ribosomes also function in the translation of a large fraction of mRNAs that encode cytosolic proteins. These studies suggest a far more expansive role for the ER in transcriptome expression, where membrane and secretory protein synthesis represents one element of a multifaceted and dynamic contribution to post-transcriptional gene expression.
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Cites
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
mRNA localization: Gene expression in the spatial dimension
Martin, K. C., & Ephrussi, A. (2009) · Cell · doi:10.1016/j.cell.2009.01.044 · Cited by 1,048
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
Rapoport, T. A. (2007) · Nature · doi:10.1038/nature06384 · Cited by 977
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Schwarz, D. S., & Blower, M. D. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2052-6 · Cited by 1,613
Alternative polyadenylation of mRNA precursors
Tian, B., & Manley, J. L. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.116 · Cited by 1,179
Regulation by 3′-Untranslated Regions
Mayr, C. (2017) · Annual Review of Genetics · doi:10.1146/annurev-genet-120116-024704 · Cited by 588
Heusermann, W., Hean, J., Trojer, D., Steib, E., von Bueren, S., Graff-Meyer, A., Genoud, C., Martin, K., Pizzato, N., Voshol, J., et al. (2016) · Journal of Cell Biology · doi:10.1083/jcb.201506084 · Cited by 447
Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation
Kim, Y.-C., Lee, S. E., Kim, S. K., Jang, H.-D., Hwang, I., Jin, S., Hong, E.-B., Jang, K.-S., & Kim, H.-S. (2019) · Nature Chemical Biology · doi:10.1038/s41589-019-0344-0 · Cited by 184
Metadata
- Authors
- Reid, D. W., & Nicchitta, C. V.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2015-03-04
- Volume
- 16
- Issue
- 4
- Pages
- 221-231
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2023261130
- Cited by
- 273
- References
- 3
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- green
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