Integrating mitochondrial translation into the cellular context
Open accessAbstract
Mitochondrial-encoded subunits of the oxidative phosphorylation system assemble with nuclear-encoded subunits into enzymatic complexes. Recent findings showed that mitochondrial translation is linked to other mitochondrial functions, as well as to cellular processes. The supply of mitochondrial-encoded proteins is coordinated by the coupling of mitochondrial protein synthesis with assembly of respiratory chain complexes. MicroRNAs imported from the cytoplasm into mitochondria were, surprisingly, found to act as regulators of mitochondrial translation. In turn, translation in mitochondria controls cellular proliferation, and mitochondrial ribosomal subunits contribute to the cytoplasmic stress response. Thus, translation in mitochondria is apparently integrated into cellular processes.
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COX1 depletion results in defective assembly, and delivery of nuclear-encoded subunits reduces COX1 levels and also disrupts assembly.
“COX1 depletion results in defective assembly, and delivery of nuclear-encoded subunits reduces COX1 levels and also disrupts assembly [82–87].”
From Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function (2019) · cites this paper as [86]
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Murley, A., Lackner, L. L., Osman, C., West, M., Voeltz, G. K., Walter, P., & Nunnari, J. (2013) · eLife · doi:10.7554/elife.00422 · Cited by 326 · see citing works
Organization of mitochondrial gene expression in two distinct ribosome-containing assemblies
Kehrein, K., Schilling, R., Möller-Hergt, B. V., Wurm, C. A., Jakobs, S., Lamkemeyer, T., Langer, T., & Ott, M. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.01.012 · Cited by 112 · see citing works
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Mitonuclear communication in homeostasis and stress
Quirós, P. M., Mottis, A., & Auwerx, J. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.23 · Cited by 787 · see citing works
Mitochondrial protein synthesis adapts to influx of nuclear-encoded protein
Richter-Dennerlein, R., Oeljeklaus, S., Lorenzi, I., Ronsör, C., Bareth, B., Schendzielorz, A. B., Wang, C., Warscheid, B., Rehling, P., & Dennerlein, S. (2016) · Cell · doi:10.1016/j.cell.2016.09.003 · Cited by 232 · see citing works
Self-citationOrr, A. L., Kim, C., Jimenez-Morales, D., Newton, B. W., Johnson, J. R., Krogan, N. J., Swaney, D. L., & Mahley, R. W. (2019) · Journal of Alzheimer's Disease · doi:10.3233/jad-181184 · Cited by 103 · see citing works
Sensing the Stress: A Role for the UPRmt and UPRam in the Quality Control of Mitochondria
Callegari, S., & Dennerlein, S. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00031 · Cited by 58 · see citing works
Self-citation
- Authors
- Richter-Dennerlein, R., Dennerlein, S., & Rehling, P.
- Affiliations
- Max Planck Institute for Biophysical Chemistry (DE)
- Universitätsmedizin Göttingen (DE)
- Corresponding author
- Rehling, Peter
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2015-09-16
- Volume
- 16
- Issue
- 10
- Pages
- 586-592
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2156288061
- Cited by
- 81
- References
- 2
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 8 · 2023: 8 · 2022: 5 · 2021: 9 · 2020: 2 · 2019: 5 · 2018: 8 · 2017: 10 · 2016: 14 · 2015: 1
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Max Planck Digital Library (submittedVersion)
- GRO (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- mitochondrial translation, retrograde signaling, cell proliferation, oxidative phosphorylation
- MeSH terms
- RNA, Mitochondrial, Animals, Biological Transport, Active, Electron Transport, Humans, Mitochondria, RNA, Protein Biosynthesis, Mitochondrial Proteins, MicroRNAs
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