ER-Associated Mitochondrial Division Links the Distribution of Mitochondria and Mitochondrial DNA in Yeast
Open accessAbstract
Mitochondrial division is important for mitochondrial distribution and function. Recent data have demonstrated that ER-mitochondria contacts mark mitochondrial division sites, but the molecular basis and functions of these contacts are not understood. Here we show that in yeast, the ER-mitochondria tethering complex, ERMES, and the highly conserved Miro GTPase, Gem1, are spatially and functionally linked to ER-associated mitochondrial division. Gem1 acts as a negative regulator of ER-mitochondria contacts, an activity required for the spatial resolution and distribution of newly generated mitochondrial tips following division. Previous data have demonstrated that ERMES localizes with a subset of actively replicating mitochondrial nucleoids. We show that mitochondrial division is spatially linked to nucleoids and that a majority of these nucleoids segregate prior to division, resulting in their distribution into newly generated tips in the mitochondrial network. Thus, we postulate that ER-associated division serves to link the distribution of mitochondria and mitochondrial nucleoids in cells. DOI:http://dx.doi.org/10.7554/eLife.00422.001.
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At the fission site of mitochondria, the ERMES complex localizes adjacent to replicating mtDNA and is involved in the distribution of newly replicated mtDNA to the dividing mitochondria.
“At the fission site of mitochondria, the ERMES complex localizes adjacent to replicating mtDNA and is involved in the distribution of newly replicated mtDNA to the dividing mitochondria [33].”
From In Candida glabrata, ERMES Component GEM1 Controls Mitochondrial Morphology, mtROS, and Drug Efflux Pump Expression, Resulting in Azole Susceptibility (2023) · cites this paper as [33]
The Results (Figure 4; page unavailable) place ERMES-linked nucleoids at mitochondrial division sites and report that nucleoids often appear in both newly generated tips. The Introduction identifies the adjacent nucleoids as actively replicating, and the Discussion proposes that ERMES links them to division. The paper does not establish that the mtDNA distributed to the tips was specifically newly replicated. (LLM, conf=0.84)
Experimental — accuracy not yet measuredAfter mitochondrial fission, one of the dividing mitochondria is detached from the ER, a process that requires Gem1 in Saccharomyces cerevisiae.
“After mitochondrial fission, one of the dividing mitochondria is detached from the ER, a process that requires Gem1 in S. cerevisiae [33].”
From In Candida glabrata, ERMES Component GEM1 Controls Mitochondrial Morphology, mtROS, and Drug Efflux Pump Expression, Resulting in Azole Susceptibility (2023) · cites this paper as [33]
The Results report that Gem1 is required for post-division separation of mitochondrial tips, and the Discussion proposes that Gem1 reduces ER–mitochondria contacts after scission. The paper does not establish that one daughter mitochondrion specifically detaches from the ER; it presents the contact-regulation mechanism as an interpretation of the findings. (LLM, conf=0.82)
Experimental — accuracy not yet measuredIn Saccharomyces cerevisiae, mutations leading to decreased GTPase activity, Gem1(S19N) or Gem1(S462N), impair the maintenance of mitochondrial morphology and dissociation of ERMES from the fission site.
“In S. cerevisiae, mutations leading to decreased GTPase activity, Gem1(S19N) or Gem1(S462N), impair the maintenance of mitochondrial morphology and dissociation of ERMES from the fission site [33].”
From In Candida glabrata, ERMES Component GEM1 Controls Mitochondrial Morphology, mtROS, and Drug Efflux Pump Expression, Resulting in Azole Susceptibility (2023) · cites this paper as [33]
The Results (page unavailable) report that Gem1(S19N) and Gem1(S462N) abrogate GTPase activity, fail to fully rescue mitochondrial morphology, and leave stable ERMES-associated constrictions. The paper describes impaired resolution of mitochondrial tips at those sites, not impaired dissociation of ERMES itself from the fission site. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe fission site of mitochondria is wrapped around by ER tubules, where the ERMES complex localizes.
“The fission site of mitochondria is wrapped around by ER tubules [44], where the ERMES complex localizes [33].”
From In Candida glabrata, ERMES Component GEM1 Controls Mitochondrial Morphology, mtROS, and Drug Efflux Pump Expression, Resulting in Azole Susceptibility (2023) · cites this paper as [33]
The ERMES plays an important role in mitochondrial fission.
“As the ERMES plays an important role in mitochondrial fission [33], the impact of each subunit on azole resistance was evaluated.”
From In Candida glabrata, ERMES Component GEM1 Controls Mitochondrial Morphology, mtROS, and Drug Efflux Pump Expression, Resulting in Azole Susceptibility (2023) · cites this paper as [33]
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- Authors
- Murley, A., Lackner, L. L., Osman, C., West, M., Voeltz, G. K., Walter, P., & Nunnari, J.
- Affiliations
- University of California, Davis (US)
- University of California, San Francisco (US)
- University of Colorado Boulder (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Nunnari, Jodi
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2013-05-14
- Volume
- 2
- Pages
- e00422-e00422
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC3654481
- OpenAlex
- W2130893307
- Cited by
- 326
- References
- 55
- Citations by year
- 2026: 7 · 2025: 20 · 2024: 17 · 2023: 16 · 2022: 19 · 2021: 26 · 2020: 34 · 2019: 27 · 2018: 32 · 2017: 26 · 2016: 29 · 2015: 28 · 2014: 31 · 2013: 14
- FWCI
- 15.24
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (5T32GM007377-34, R01GM097432, RO1GM083977)
- Howard Hughes Medical Institute
- Human Frontier Science Program
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- mitochondrial division, ER-mitochondria contact sites, ERMES, mitochondrial nucleoids, mitochondrial DNA segregation, mitochondrial distribution, yeast
- MeSH terms
- DNA, Fungal, DNA, Mitochondrial, Endoplasmic Reticulum, Mitochondria, Saccharomyces cerevisiae, Signal Transduction, Saccharomyces cerevisiae Proteins, Multiprotein Complexes, Mitochondrial Dynamics
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