DNA N6-methyladenine: a new epigenetic mark in eukaryotes?
Open accessAbstract
DNA N(6)-adenine methylation (N(6)-methyladenine; 6mA) in prokaryotes functions primarily in the host defence system. The prevalence and significance of this modification in eukaryotes had been unclear until recently. Here, we discuss recent publications documenting the presence of 6mA in Chlamydomonas reinhardtii, Drosophila melanogaster and Caenorhabditis elegans; consider possible roles for this DNA modification in regulating transcription, the activity of transposable elements and transgenerational epigenetic inheritance; and propose 6mA as a new epigenetic mark in eukaryotes.
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More chromatin marks and transcription factor families are still being discovered.
“many more chromatin marks and even transcription factor families are still being discovered (Lohse et al., 2010; Luo et al., 2015).”
From The Aging Epigenome (2016) · cites this paper as Luo et al., 2015
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- [43]Jia GF N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO Nature Chemical Biology 7 885 887 2011 22002720 PMC3218240
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Self-citation
- Authors
- Luo, G.-Z., Blanco, M. A., Greer, E. L., He, C., & Shi, Y.
- Affiliations
- Howard Hughes Medical Institute (US)
- Boston Children's Hospital (US)
- Corresponding author
- He, Chuan
- Shi, Yang
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2015-10-28
- Volume
- 16
- Issue
- 12
- Pages
- 705-710
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- PMC
- PMC4763336
- OpenAlex
- W1890391421
- Cited by
- 252
- References
- 73
- Citations by year
- 2026: 12 · 2025: 13 · 2024: 14 · 2023: 21 · 2022: 31 · 2021: 27 · 2020: 30 · 2019: 34 · 2018: 36 · 2017: 21 · 2016: 11
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute on Aging (K99AG043550, R00AG043550, AG043550)
- National Institute of Mental Health (R01MH096066, MH096066)
- National Human Genome Research Institute (R01HG006827, HG006827)
- National Cancer Institute (R01CA118487, CA118487)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- DNA N6-methyladenine, 6mA, DNA methylation, epigenetic modifications, transcriptional regulation, transposable elements, transgenerational epigenetic inheritance, Chlamydomonas reinhardtii, Drosophila melanogaster, Caenorhabditis elegans
- MeSH terms
- Adenine, Animals, DNA, DNA Transposable Elements, Drosophila melanogaster, Genetic Markers, Phylogeny, Transcription, Genetic, Site-Specific DNA-Methyltransferase (Adenine-Specific), Chlamydomonas reinhardtii, Caenorhabditis elegans, DNA Methylation, Epigenesis, Genetic
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