p14ARF links the tumour suppressors RB and p53

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens

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Cellular senescence: when bad things happen to good cells

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The p53 pathway: positive and negative feedback loops

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The RB and p53 pathways in cancer

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The Rb/E2F pathway: expanding roles and emerging paradigms

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Sibling rivalry in the E2F family

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E2F integrates cell cycle progression with DNA repair, replication, and G ₂ /M checkpoints

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Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53

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Census and evaluation of p53 target genes

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The Regulation of INK4/ARF in Cancer and Aging

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Nucleolar Arf sequesters Mdm2 and activates p53

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Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

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Tumor suppression by Ink4a-Arf: progress and puzzles.

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The ARF/p53 pathway.

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Signaling to p53

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Apaf-1 is a transcriptional target for E2F and p53

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The INK4A/ARF locus and its two gene products.

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twist is a potential oncogene that inhibits apoptosis

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p53 and E2f: partners in life and death

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INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53

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INK4a/ARF: A multifunctional tumor suppressor locus

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Ablation of the Retinoblastoma gene family deregulates G₁ control causing immortalization and increased cell turnover under growth-restricting conditions

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The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

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Tumor suppressors and oncogenes in cellular senescence

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Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse

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DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation

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Opposing Effects of Ras on p53

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Genes involved in senescence and immortalization

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Role of p14^ARF in Replicative and Induced Senescence of Human Fibroblasts

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Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras.

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Genetic and Epigenetic Changes in Human Epithelial Cells Immortalized by Telomerase

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APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death

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The role of ubiquitin modification in the regulation of p53

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TBX-3, the Gene Mutated in Ulnar-Mammary Syndrome, Is a Negative Regulator of p19 and Inhibits Senescence

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Induction of <i>ARF</i> tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1

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Ink4a/Arf links senescence and aging

Sharpless, N. E. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.06.025 · Cited by 142 · see citing works

The Role of UV Induced Lesions in Skin Carcinogenesis: An Overview of Oncogene and Tumor Suppressor Gene Modifications in Xeroderma Pigmentosum Skin Tumors

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E2F transcriptional repressor complexes are critical downstream targets of p19ARF/p53-induced proliferative arrest

Rowland, B. D., Denissov, S. G., Douma, S., Stunnenberg, H. G., Bernards, R., & Peeper, D. S. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00085-5 · Cited by 120 · see citing works

Biallelic Mutations in p16^INK4a Confer Resistance to Ras- and Ets-Induced Senescence in Human Diploid Fibroblasts

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Control of Replicative Life Span in Human Cells: Barriers to Clonal Expansion Intermediate Between M1 Senescence and M2 Crisis

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Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion

Khan, S. H., Moritsugu, J., & Wahl, G. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3266 · Cited by 103 · see citing works

Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of <i>Retinoblastoma</i> and <i>Trp53</i> Tumor Suppressors

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The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis

Evangelou, K., Bartkova, J., Kotsinas, A., Pateras, I. S., Liontos, M., Velimezi, G., Kosar, M., Liloglou, T., Trougakos, I. P., Dyrskjot, L., et al. (2013) · Cell Death &amp; Differentiation · doi:10.1038/cdd.2013.76 · Cited by 59 · see citing works

ΔNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation

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E2F1 is crucial for E2F‐dependent apoptosis

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INVESTIGATING THE ROLE AND REGULATION OF THE SPECIFIC ANDGENERAL PRB-E2F1 INTERACTIONS

Cecchini, M. J., & Dick, F. A. (2008) · Clinical and investigative medicine · doi:10.25011/cim.v31i4.4795

Regulation of the G1/S transition phase in mesangial cells by E2F1

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Characterization of an E2F1-specific binding domain in pRB and its implications for apoptotic regulation

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E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in <i>Rb</i> mutant embryos

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