The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.
Drug resistance in Plasmodium
Open accessAbstract
A marked decrease in malaria-related deaths worldwide has been attributed to the administration of effective antimalarials against Plasmodium falciparum, in particular, artemisinin-based combination therapies (ACTs). Increasingly, ACTs are also used to treat Plasmodium vivax, the second major human malaria parasite. However, resistance to frontline artemisinins and partner drugs is now causing the failure of P. falciparum ACTs in southeast Asia. In this Review, we discuss our current knowledge of markers and mechanisms of resistance to artemisinins and ACTs. In particular, we describe the identification of mutations in the propeller domains of Kelch 13 as the primary marker for artemisinin resistance in P. falciparum and explore two major mechanisms of resistance that have been independently proposed: the activation of the unfolded protein response and proteostatic dysregulation of parasite phosphatidylinositol 3- kinase. We emphasize the continuing challenges and the imminent need to understand mechanisms of resistance to improve parasite detection strategies, develop new combinations to eliminate resistant parasites and prevent their global spread.
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Artemisinin Resistance in Plasmodium falciparum Malaria
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Spread of Artemisinin Resistance in Plasmodium falciparum Malaria
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A molecular marker of artemisinin-resistant Plasmodium falciparum malaria
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Synthesis and Function of 3-Phosphorylated Inositol Lipids
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A Molecular Marker for Chloroquine-Resistant Falciparum Malaria
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CRISPR-Cas Systems in Bacteria and Archaea: Versatile Small RNAs for Adaptive Defense and Regulation
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Cited by
A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites
Birnbaum, J., Scharf, S., Schmidt, S., Jonscher, E., Hoeijmakers, W. A. M., Flemming, S., Toenhake, C. G., Schmitt, M., Sabitzki, R., Bergmann, B., et al. (2020) · Science · doi:10.1126/science.aax4735 · Cited by 419
Plasmodium—a brief introduction to the parasites causing human malaria and their basic biology
Sato, S. (2021) · Journal of Physiological Anthropology · doi:10.1186/s40101-020-00251-9 · Cited by 404
Metadata
- Authors
- Haldar, K., Bhattacharjee, S., & Safeukui, I.
- Venue
- Nature Reviews Microbiology
- Published
- 2018-01-22
- Volume
- 16
- Issue
- 3
- Pages
- 156-170
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W2784798198
- Cited by
- 431
- References
- 126
- FWCI
- 10.55
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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