The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria
Open accessAbstract
Gram-negative bacteria are responsible for a large proportion of antibiotic-resistant bacterial diseases. These bacteria have a complex cell envelope that comprises an outer membrane and an inner membrane that delimit the periplasm. The outer membrane contains various protein channels, called porins, which are involved in the influx of various compounds, including several classes of antibiotics. Bacterial adaptation to reduce influx through porins is an increasing problem worldwide that contributes, together with efflux systems, to the emergence and dissemination of antibiotic resistance. An exciting challenge is to decipher the genetic and molecular basis of membrane impermeability as a bacterial resistance mechanism. This Review outlines the bacterial response towards antibiotic stress on altered membrane permeability and discusses recent advances in molecular approaches that are improving our knowledge of the physico-chemical parameters that govern the translocation of antibiotics through porin channels.
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“Hydrophilic molecules such as β-lactams, tetracyclines and some fluoroquinolones are particularly affected by changes in permeability of the outer membrane since they often use water-filled diffusion channels known as porins to cross this barrier (37).”
From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [37]
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Molecular Basis of Bacterial Outer Membrane Permeability Revisited
Nikaido, H. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.4.593-656.2003 · Cited by 4,316
A Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics
Kohanski, M. A., Dwyer, D. J., Hayete, B., Lawrence, C. A., & Collins, J. J. (2007) · Cell · doi:10.1016/j.cell.2007.06.049 · Cited by 2,982
Multidrug-resistance efflux pumps ? not just for resistance
Piddock, L. J. V. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1464 · Cited by 1,523
Crystal structures explain functional properties of two E. coli porins
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Structure and function of bacterial outer membrane proteins: barrels in a nutshell
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Efflux-mediated antimicrobial resistance
Poole, K. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki171 · Cited by 1,082
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Li, X.-Z., & Nikaido, H. (2004) · Drugs · doi:10.2165/00003495-200464020-00004 · Cited by 803
Lack of development of new antimicrobial drugs: a potential serious threat to public health
Norrby, S. R., Nord, C. E., & Finch, R. (2005) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(05)01283-1 · Cited by 500
The structure of bacterial outer membrane proteins
Schulz, G. E. (2002) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(02)00577-1 · Cited by 488
Outer membrane barrier as a mechanism of antimicrobial resistance
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- Mena, A. et al. Characterization of a large outbreak by CTX-M-1-producing Klebsiella pneumoniae and mechanisms leading to in vivo carbapenem resistance development. J. Clin. Microbiol. 44, 2831–2837 (2006). · DOI
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Mechanisms of Antibiotic Resistance
Munita, J. M., & Arias, C. A. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.vmbf-0016-2015 · Cited by 2,782
Antimicrobial Resistance in ESKAPE Pathogens
Oliveira, D. M. P. D., Forde, B. M., Kidd, T. J., Harris, P. N. A., Schembri, M. A., Beatson, S. A., Paterson, D. L., & Walker, M. J. (2020) · Clinical Microbiology Reviews · doi:10.1128/cmr.00181-19 · Cited by 2,243
Challenges of Antibacterial Discovery
Silver, L. L. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00030-10 · Cited by 1,432
Comprehensive review of antimicrobial activities of plant flavonoids
Górniak, I., Bartoszewski, R., & Króliczewski, J. (2018) · Phytochemistry Reviews · doi:10.1007/s11101-018-9591-z · Cited by 1,268
Carbapenem resistance in Enterobacteriaceae: here is the storm!
Nordmann, P., Dortet, L., & Poirel, L. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.03.003 · Cited by 1,043
Metadata
- Authors
- Pagès, J.-M., James, C. E., & Winterhalter, M.
- Affiliations
- Aix-Marseille Université (FR)
- Constructor University (DE)
- Corresponding author
- Pagès, Jean-Marie
- Venue
- Nature Reviews Microbiology
- Published
- 2008-11-10
- Volume
- 6
- Issue
- 12
- Pages
- 893-903
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W1996764065
- Cited by
- 939
- References
- 96
- Citations by year
- 2026: 48 · 2025: 59 · 2024: 57 · 2023: 50 · 2022: 75 · 2021: 64 · 2020: 84 · 2019: 67 · 2018: 57 · 2017: 60 · 2016: 60 · 2015: 53 · 2014: 42 · 2013: 32 · 2012: 47
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- green
- usir.salford.ac.uk
- Licence
- Locations
- Nature Reviews Microbiology (publishedVersion)
- PubMed (publishedVersion)
- University of Salford Institutional Repository (University of Salford) (submittedVersion, cc-by)
- Funders
- European Commission
- Topics
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- porin, antibiotic permeation, Gram-negative bacteria, outer membrane, antibiotic resistance, membrane permeability, efflux systems, periplasm, antibiotic translocation, bacterial cell envelope
- MeSH terms
- Animals, Anti-Bacterial Agents, Bacterial Proteins, Cell Membrane Permeability, Diffusion, Gram-Negative Bacteria, Humans, Models, Biological, Models, Molecular, Mutation, Porins, Drug Resistance, Bacterial
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