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The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria
Open accessAbstract
Gram-negative bacteria are responsible for a large proportion of antibiotic-resistant bacterial diseases. These bacteria have a complex cell envelope that comprises an outer membrane and an inner membrane that delimit the periplasm. The outer membrane contains various protein channels, called porins, which are involved in the influx of various compounds, including several classes of antibiotics. Bacterial adaptation to reduce influx through porins is an increasing problem worldwide that contributes, together with efflux systems, to the emergence and dissemination of antibiotic resistance. An exciting challenge is to decipher the genetic and molecular basis of membrane impermeability as a bacterial resistance mechanism. This Review outlines the bacterial response towards antibiotic stress on altered membrane permeability and discusses recent advances in molecular approaches that are improving our knowledge of the physico-chemical parameters that govern the translocation of antibiotics through porin channels.
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“Hydrophilic molecules such as β-lactams, tetracyclines and some fluoroquinolones are particularly affected by changes in permeability of the outer membrane since they often use water-filled diffusion channels known as porins to cross this barrier (37).”
From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [37]
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Metadata
- Authors
- Pagès, J.-M., James, C. E., & Winterhalter, M.
- Affiliations
- Aix-Marseille Université (FR)
- Constructor University (DE)
- Corresponding author
- Pagès, Jean-Marie
- Venue
- Nature Reviews Microbiology
- Published
- 2008-11-10
- Volume
- 6
- Issue
- 12
- Pages
- 893-903
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W1996764065
- Cited by
- 939
- References
- 96
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- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- green
- usir.salford.ac.uk
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- Nature Reviews Microbiology (publishedVersion)
- PubMed (publishedVersion)
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- Funders
- European Commission
- Topics
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- porin, antibiotic permeation, Gram-negative bacteria, outer membrane, antibiotic resistance, membrane permeability, efflux systems, periplasm, antibiotic translocation, bacterial cell envelope
- MeSH terms
- Animals, Anti-Bacterial Agents, Bacterial Proteins, Cell Membrane Permeability, Diffusion, Gram-Negative Bacteria, Humans, Models, Biological, Models, Molecular, Mutation, Porins, Drug Resistance, Bacterial
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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