The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
How antibiotics kill bacteria: from targets to networks
Open accessAbstract
Antibiotic drug–target interactions, and their respective direct effects, are generally well characterized. By contrast, the bacterial responses to antibiotic drug treatments that contribute to cell death are not as well understood and have proven to be complex as they involve many genetic and biochemical pathways. In this Review, we discuss the multilayered effects of drug–target interactions, including the essential cellular processes that are inhibited by bactericidal antibiotics and the associated cellular response mechanisms that contribute to killing. We also discuss new insights into these mechanisms that have been revealed through the study of biological networks, and describe how these insights, together with related developments in synthetic biology, could be exploited to create new antibacterial therapies.
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Cites
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Cited by
A Deep Learning Approach to Antibiotic Discovery
Stokes, J. M., Yang, K., Swanson, K., Jin, W., Cubillos-Ruiz, A., Donghia, N. M., MacNair, C. R., French, S., Carfrae, L. A., Bloom-Ackermann, Z., et al. (2020) · Cell · doi:10.1016/j.cell.2020.01.021 · Cited by 2,463
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Aminov, R. I. (2010) · Frontiers in Microbiology · doi:10.3389/fmicb.2010.00134 · Cited by 1,628
The threat of antimicrobial resistance in developing countries: causes and control strategies
Ayukekbong, J. A., Ntemgwa, M., & Atabe, A. N. (2017) · Antimicrobial Resistance & Infection Control · doi:10.1186/s13756-017-0208-x · Cited by 1,315
The interplay of microbially mediated and abiotic reactions in the biogeochemical Fe cycle
Melton, E. D., Swanner, E. D., Behrens, S., Schmidt, C., & Kappler, A. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3347 · Cited by 899
Prevention of Intravascular Catheter-Related Infections
(2021) · Indian Journal of Continuing Nursing Education · doi:10.4103/2230-7354.320831 · Cited by 855
Metadata
- Authors
- Kohanski, M. A., Dwyer, D. J., & Collins, J. J.
- Venue
- Nature Reviews Microbiology
- Published
- 2010-05-04
- Volume
- 8
- Issue
- 6
- Pages
- 423-435
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W2128912763
- Cited by
- 2,258
- References
- 13
- FWCI
- 6.26
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
