The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box
Open accessAbstract
Cryptococcus neoformans is generally considered to be an opportunistic fungal pathogen because of its tendency to infect immunocompromised individuals, particularly those infected with HIV. However, this view has been challenged by the recent discovery of specialized interactions between the fungus and its mammalian hosts, and by the emergence of the related species Cryptococcus gattii as a primary pathogen of immunocompetent populations. In this Review, we highlight features of cryptococcal pathogens that reveal their adaptation to the mammalian environment. These features include not only remarkably sophisticated interactions with phagocytic cells to promote intracellular survival, dissemination to the central nervous system and escape, but also surprising morphological and genomic adaptations such as the formation of polyploid giant cells in the lung.
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Cites
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Cited by
Hidden Killers: Human Fungal Infections
Brown, G. D., Denning, D. W., Gow, N. A. R., Levitz, S. M., Netea, M. G., & White, T. C. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004404 · Cited by 4,284
Cryptococcus: from environmental saprophyte to global pathogen
May, R. C., Stone, N. R. H., Wiesner, D. L., Bicanic, T., & Nielsen, K. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2015.6 · Cited by 541
(2014) · doi:10.1128/cmr.00126-13 · Cited by 437
The Spectrum of Fungi That Infects Humans
Kohler, J. R., Casadevall, A., & Perfect, J. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a019273 · Cited by 364
The Regulation of Filamentous Growth in Yeast
Cullen, P. J., & Sprague, G. F. (2012) · Genetics · doi:10.1534/genetics.111.127456 · Cited by 278
Metadata
- Authors
- Kronstad, J. W., Attarian, R., Cadieux, B., Choi, J., D'Souza, C. A., Griffiths, E. J., Geddes, J. M. H., Hu, G., Jung, W. H., Kretschmer, M., Saikia, S., & Wang, J.
- Venue
- Nature Reviews Microbiology
- Published
- 2011-02-16
- Volume
- 9
- Issue
- 3
- Pages
- 193-203
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W2056573634
- Cited by
- 340
- References
- 109
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Kronstad, J. W., Attarian, R., Cadieux, B., Choi, J., D'Souza, C. A., Griffiths, E. J., Geddes, J. M. H., Hu, G., Jung, W. H., Kretschmer, M., Saikia, S., & Wang, J. (2011). Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box. Nature Reviews Microbiology. https://doi.org/10.1038/nrmicro2522
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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