The DOI matches its Crossref record; 277 of the 277 references it cites were found in a registry or an index.
The Regulation of Filamentous Growth in Yeast
Open accessAbstract
Filamentous growth is a nutrient-regulated growth response that occurs in many fungal species. In pathogens, filamentous growth is critical for host–cell attachment, invasion into tissues, and virulence. The budding yeast Saccharomyces cerevisiae undergoes filamentous growth, which provides a genetically tractable system to study the molecular basis of the response. Filamentous growth is regulated by evolutionarily conserved signaling pathways. One of these pathways is a mitogen activated protein kinase (MAPK) pathway. A remarkable feature of the filamentous growth MAPK pathway is that it is composed of factors that also function in other pathways. An intriguing challenge therefore has been to understand how pathways that share components establish and maintain their identity. Other canonical signaling pathways—rat sarcoma/protein kinase A (RAS/PKA), sucrose nonfermentable (SNF), and target of rapamycin (TOR)—also regulate filamentous growth, which raises the question of how signals from multiple pathways become integrated into a coordinated response. Together, these pathways regulate cell differentiation to the filamentous type, which is characterized by changes in cell adhesion, cell polarity, and cell shape. How these changes are accomplished is also discussed. High-throughput genomics approaches have recently uncovered new connections to filamentous growth regulation. These connections suggest that filamentous growth is a more complex and globally regulated behavior than is currently appreciated, which may help to pave the way for future investigations into this eukaryotic cell differentiation behavior.
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Cited by
Sardi, J. C. O., Scorzoni, L., Bernardi, T., Fusco-Almeida, A. M., & Mendes Giannini, M. J. S. (2013) · Journal of Medical Microbiology · doi:10.1099/jmm.0.045054-0 · Cited by 1,184
Bravo Ruiz, G., Ross, Z. K., Gow, N. A. R., & Lorenz, A. (2020) · mSphere · doi:10.1128/msphere.00151-20 · Cited by 101
Lin, C.-J., & Chen, Y.-L. (2018) · Journal of Fungi · doi:10.3390/jof4020068 · Cited by 55
Joshua, I., & Höfken, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040772 · Cited by 40
da Silva, B. M., Braga, M. T., da Silva Passos, J. C., Carvalho, M. L., Rosseti, I. B., de Amorim, L. M. M., da Rocha, J. B. T., Alberto-Silva, C., & Costa, M. S. (2021) · Biofouling · doi:10.1080/08927014.2021.1897110 · Cited by 7
Metadata
- Authors
- Cullen, P. J., & Sprague, G. F.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-01-01
- Volume
- 190
- Issue
- 1
- Pages
- 23-49
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W1986364415
- Cited by
- 278
- References
- 277
- FWCI
- 7.78
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
