Effects of Aneuploidy on Cellular Physiology and Cell Division in Haploid Yeast
Abstract
Aneuploidy is a condition frequently found in tumor cells, but its effect on cellular physiology is not known. We have characterized one aspect of aneuploidy: the gain of extra chromosomes. We created a collection of haploid yeast strains that each bear an extra copy of one or more of almost all of the yeast chromosomes. Their characterization revealed that aneuploid strains share a number of phenotypes, including defects in cell cycle progression, increased glucose uptake, and increased sensitivity to conditions interfering with protein synthesis and protein folding. These phenotypes were observed only in strains carrying additional yeast genes, which indicates that they reflect the consequences of additional protein production as well as the resulting imbalances in cellular protein composition. We conclude that aneuploidy causes not only a proliferative disadvantage but also a set of phenotypes that is independent of the identity of the individual extra chromosomes.
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Aneuploidy causes a transcriptional response that results in gene expression in chromosomes.
“Torres et al. [91] viewed that aneuploidy causes a transcriptional response that results in gene expression in chromosomes.”
From Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival (2021) · cites this paper as [91]
Cites
Genomic Expression Programs in the Response of Yeast Cells to Environmental Changes
Gasch, A. P., Spellman, P. T., Kao, C. M., Carmel-Harel, O., Eisen, M. B., Storz, G., Botstein, D., & Brown, P. O. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.12.4241 · Cited by 4,815 · see citing works
Why Do Cancers Have High Aerobic Glycolysis?
Gatenby, R. A., & Gillies, R. J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1478 · Cited by 4,784 · see citing works
Genetic instabilities in human cancers
Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1998) · Nature · doi:10.1038/25292 · Cited by 4,168 · see citing works
HSP90 and the chaperoning of cancer
Whitesell, L., & Lindquist, S. L. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1716 · Cited by 2,502 · see citing works
Boyle, E. I., Weng, S., Gollub, J., Jin, H., Botstein, D., Cherry, J. M., & Sherlock, G. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth456 · Cited by 2,067 · see citing works
Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
Schubert, U., Antón, L. C., Gibbs, J. S., Norbury, C. C., Yewdell, J. W., & Bennink, J. R. (2000) · Nature · doi:10.1038/35008096 · Cited by 1,536 · see citing works
Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer
Hughes, T. R., Mao, M., Jones, A. R., Burchard, J., Marton, M. J., Shannon, K. W., Lefkowitz, S. M., Ziman, M., Schelter, J. M., Meyer, M. R., et al. (2001) · Nature Biotechnology · doi:10.1038/86730 · Cited by 1,298 · see citing works
SEGMENTAL ANEUPLOIDY AND THE GENETIC GROSS STRUCTURE OF THE DROSOPHILA GENOME
Lindsley, D. L., Sandler, L., Baker, B. S., Carpenter, A. T. C., Denell, R. E., Hall, J. C., Jacobs, P. A., Miklos, G. L. G., Davis, B. K., Gethmann, R. C., et al. (1972) · Genetics · doi:10.1093/genetics/71.1.157 · Cited by 599 · see citing works
Dunham, M. J., Badrane, H., Ferea, T., Adams, J., Brown, P. O., Rosenzweig, F., & Botstein, D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242624799 · Cited by 564 · see citing works
Self-citationWeaver, B. A. A., & Cleveland, D. W. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.10.002 · Cited by 560 · see citing works
A mutant of Saccharomyces cerevisiae defective for nuclear fusion.
Conde, J., & Fink, G. R. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.10.3651 · Cited by 533 · see citing works
Easton, J. B., & Houghton, P. J. (2006) · Oncogene · doi:10.1038/sj.onc.1209886 · Cited by 460 · see citing works
Wittenberg, C., Sugimoto, K., & Reed, S. I. (1990) · Cell · doi:10.1016/0092-8674(90)90361-h · Cited by 451 · see citing works
Balzi, E., Wang, M., Leterme, S., Van Dyck, L., & Goffeau, A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42155-7 · Cited by 447 · see citing works
CDK Activity Antagonizes Whi5, an Inhibitor of G1/S Transcription in Yeast
Costanzo, M., Nishikawa, J. L., Tang, X., Millman, J. S., Schub, O., Breitkreuz, K. E., Dewar, D., Rupeš, I., Andrews, B., & Tyers, M. (2004) · Cell · doi:10.1016/j.cell.2004.05.024 · Cited by 428 · see citing works
Cln3 Activates G1-Specific Transcription via Phosphorylation of the SBF Bound Repressor Whi5
de Bruin, R. A. M., McDonald, W. H., Kalashnikova, T. I., et al. (2004) · Cell · doi:10.1016/j.cell.2004.05.025 · Cited by 387 · see citing works
Dirick, L., Böhm, T., & Nasmyth, K. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00162.x · Cited by 331 · see citing works
Gunjan, A., & Verreault, A. (2003) · Cell · doi:10.1016/s0092-8674(03)00896-1 · Cited by 325 · see citing works
Regenberg, B., Grotkjær, T., Winther, O., Fausbøll, A., Åkesson, M., Bro, C., Hansen, L. K., Brunak, S., & Nielsen, J. (2006) · Genome biology · doi:10.1186/gb-2006-7-11-r107 · Cited by 238 · see citing works
Bissinger, P. H., & Kuchler, K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41760-1 · Cited by 234 · see citing works
Ubiquitin Depletion as a Key Mediator of Toxicity by Translational Inhibitors
Hanna, J. W., Leggett, D., & Finley, D. J. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.24.9251-9261.2003 · Cited by 210 · see citing works
CLN3, not positive feedback, determines the timing of CLN2 transcription in cycling cells.Preprint
Stuart, D. A., & Wittenberg, C. (1995) · Genes & Development · doi:10.1101/gad.9.22.2780 · Cited by 188 · see citing works
Katz, W. S., Weinstein, B. M., & Solomon, F. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.10.5286 · Cited by 127 · see citing works
Segal, D. J., & McCoy, E. E. (1974) · Journal of Cellular Physiology · doi:10.1002/jcp.1040830112 · Cited by 125 · see citing works
Metabolic cycle, cell cycle, and the finishing kick to Start.
Futcher, B. (2006) · Genome biology · doi:10.1186/gb-2006-7-4-107 · Cited by 76 · see citing works
Growth arrest and chromosome instability in aneuploid yeast
Niwa, O., Tange, Y., & Kurabayashi, A. (2006) · Yeast · doi:10.1002/yea.1411 · Cited by 74 · see citing works
Transfer of chromosome III duringkar mediated cytoduction in yeast
Nilsson‐Tillgren, T., Petersen, J. G. L., Holmberg, S., et al. (1980) · Carlsberg Research Communications · doi:10.1007/bf02906512 · Cited by 69 · see citing works
SEPARATION OF LINKED MARKERS IN CHINESE HAMSTER CELL HYBRIDS: MITOTIC RECOMBINATION IS NOT INVOLVED
Rosenstraus, M., & Chasin, L. A. (1978) · Genetics · doi:10.1093/genetics/90.4.735 · Cited by 64 · see citing works
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Luo, J., Solimini, N. L., & Elledge, S. J. (2009) · Cell · doi:10.1016/j.cell.2009.02.024 · Cited by 1,765 · see citing works
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Holland, A. J., & Cleveland, D. W. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2718 · Cited by 859 · see citing works
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Pavelka, N., Rancati, G., Zhu, J., Bradford, W. D., Saraf, A., Florens, L., Sanderson, B. W., Hattem, G. L., & Li, R. (2010) · Nature · doi:10.1038/nature09529 · Cited by 577 · see citing works
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Dominguez-Brauer, C., Thu, K. L., Mason, J. M., Blaser, H., Bray, M. R., & Mak, T. W. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.11.006 · Cited by 495 · see citing works
Sionov, E., Lee, H., Chang, Y. C., & Kwon-Chung, K. J. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000848 · Cited by 479 · see citing works
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Thompson, S. L., & Compton, D. A. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200905057 · Cited by 494 · see citing works
Gresham, D., Desai, M. M., Tucker, C. M., Jenq, H. T., Pai, D. A., Ward, A., DeSevo, C. G., Botstein, D., & Dunham, M. J. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000303 · Cited by 482 · see citing works
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Yona, A. H., Manor, Y. S., Herbst, R. H., Romano, G. H., Mitchell, A., Kupiec, M., Pilpel, Y., & Dahan, O. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211150109 · Cited by 376 · see citing works
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Geiger, T., Velic, A., Macek, B., Lundberg, E., Kampf, C., Nagaraj, N., Uhlen, M., Cox, J., & Mann, M. (2013) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.024919 · Cited by 235 · see citing works
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Poláková, S., Blume, C., Zárate, J. Á., Mentel, M., Jørck-Ramberg, D., Stenderup, J., & Piškur, J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809793106 · Cited by 206 · see citing works
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Self-citationForche, A., Cromie, G., Gerstein, A. C., Solis, N. V., Pisithkul, T., Srifa, W., Jeffery, E., Abbey, D., Filler, S. G., Dudley, A. M., et al. (2018) · Genetics · doi:10.1534/genetics.118.301019 · Cited by 94 · see citing works
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Rowald, K., Mantovan, M., Passos, J., Buccitelli, C., Mardin, B. R., Korbel, J. O., Jechlinger, M., & Sotillo, R. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.048 · Cited by 84 · see citing works
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- Authors
- Torres, E. M., Sokolsky, T., Tucker, C. M., Chan, L. Y., Boselli, M., Dunham, M. J., & Amon, A.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Sokolsky, Tanya
- Amon, Angelika
- Venue
- Science
- Published
- 2007-08-17
- Volume
- 317
- Issue
- 5840
- Pages
- 916-924
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2006141070
- Cited by
- 935
- References
- 28
- Citations by year
- 2026: 22 · 2025: 42 · 2024: 52 · 2023: 62 · 2022: 52 · 2021: 57 · 2020: 45 · 2019: 50 · 2018: 52 · 2017: 55 · 2016: 52 · 2015: 72 · 2014: 54 · 2013: 46 · 2012: 49
- FWCI
- 17.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Funders
- National Institute of General Medical Sciences (GM071508, GM 56800, P50GM071508)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- aneuploidy, haploid yeast, extra chromosome, cell cycle progression, glucose uptake, protein folding, cancer cells, cell division
- MeSH terms
- Aneuploidy, Cell Division, Genes, Fungal, Glucose, Haploidy, Phenotype, Protein Synthesis Inhibitors, Saccharomyces cerevisiae, Temperature, Transcription, Genetic, Chromosomes, Fungal, Gene Expression Regulation, Fungal, G1 Phase, Saccharomyces cerevisiae Proteins, Cell Proliferation
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