Cited by 935Microtubule and mitosis dynamicsFungal and yeast genetics researchCancer-related Molecular Pathways

Effects of Aneuploidy on Cellular Physiology and Cell Division in Haploid Yeast

Torres, Eduardo M., Sokolsky, Tanya, Tucker, Cheryl M., Chan, Leon Y., Boselli, Monica, Dunham, Maitreya J., Amon, Angelika·2007·Science

Abstract

Aneuploidy is a condition frequently found in tumor cells, but its effect on cellular physiology is not known. We have characterized one aspect of aneuploidy: the gain of extra chromosomes. We created a collection of haploid yeast strains that each bear an extra copy of one or more of almost all of the yeast chromosomes. Their characterization revealed that aneuploid strains share a number of phenotypes, including defects in cell cycle progression, increased glucose uptake, and increased sensitivity to conditions interfering with protein synthesis and protein folding. These phenotypes were observed only in strains carrying additional yeast genes, which indicates that they reflect the consequences of additional protein production as well as the resulting imbalances in cellular protein composition. We conclude that aneuploidy causes not only a proliferative disadvantage but also a set of phenotypes that is independent of the identity of the individual extra chromosomes.

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Crossref · 10.1126/science.1142210

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Authors
Torres, E. M., Sokolsky, T., Tucker, C. M., Chan, L. Y., Boselli, M., Dunham, M. J., & Amon, A.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
  • Sokolsky, Tanya
  • Amon, Angelika
Venue
Science
Published
2007-08-17
Volume
317
Issue
5840
Pages
916-924
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2006141070
Cited by
935
References
28
Citations by year
2026: 22 · 2025: 42 · 2024: 52 · 2023: 62 · 2022: 52 · 2021: 57 · 2020: 45 · 2019: 50 · 2018: 52 · 2017: 55 · 2016: 52 · 2015: 72 · 2014: 54 · 2013: 46 · 2012: 49
FWCI
17.79
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
  • ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
Funders
National Institute of General Medical Sciences (GM071508, GM 56800, P50GM071508)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords
aneuploidy, haploid yeast, extra chromosome, cell cycle progression, glucose uptake, protein folding, cancer cells, cell division
MeSH terms
Aneuploidy, Cell Division, Genes, Fungal, Glucose, Haploidy, Phenotype, Protein Synthesis Inhibitors, Saccharomyces cerevisiae, Temperature, Transcription, Genetic, Chromosomes, Fungal, Gene Expression Regulation, Fungal, G1 Phase, Saccharomyces cerevisiae Proteins, Cell Proliferation

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