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Gastrointestinal Tract as a Major Site of CD4 + T Cell Depletion and Viral Replication in SIV Infection
Abstract
Human and simian immunodeficiency virus (HIV and SIV) replicate optimally in activated memory CD4 + T cells, a cell type that is abundant in the intestine. SIV infection of rhesus monkeys resulted in profound and selective depletion of CD4 + T cells in the intestine within days of infection, before any such changes in peripheral lymphoid tissues. The loss of CD4 + T cells in the intestine occurred coincident with productive infection of large numbers of mononuclear cells at this site. The intestine appears to be a major target for SIV replication and the major site of CD4 + T cell loss in early SIV infection.
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Citations
Cited by
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Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D., et al. (2006) · Nature Medicine · doi:10.1038/nm1511 · Cited by 3,559
. Plasma levels of soluble CD14 independently predict mortality in HIV infection.
Sandler, N. G., Wand, H., Roque, A., Law, M., Nason, M. C., Nixon, D. E., Pedersen, C., Ruxrungtham, K., Lewin, S. R., Emery, S., et al. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiq118 · Cited by 1,106
Sexual Transmission and Propagation of SIV and HIV in Resting and Activated CD4 + T Cells
Zhang, Z.-Q., Schuler, T., Zupancic, M., Wietgrefe, S., Staskus, K. A., Reimann, K. A., Reinhart, T. A., Rogan, M., Cavert, W., Miller, C. J., et al. (1999) · Science · doi:10.1126/science.286.5443.1353 · Cited by 874
Self-citationGuadalupe, M., Reay, E., Sankaran, S., Prindiville, T., Flamm, J., McNeil, A., & Dandekar, S. (2003) · Journal of Virology · doi:10.1128/jvi.77.21.11708-11717.2003 · Cited by 866
Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation
Allers, K., Hütter, G., Hofmann, J., Loddenkemper, C., Rieger, K., Thiel, E., & Schneider, T. (2011) · Blood · doi:10.1182/blood-2010-09-309591 · Cited by 681
Metadata
- Authors
- Veazey, R. S., DeMaria, M., Chalifoux, L. V., Shvetz, D. E., Pauley, D. R., Knight, H. L., Rosenzweig, M., Johnson, R. P., Desrosiers, R. C., & Lackner, A. A.
- Venue
- Science
- Published
- 1998-04-17
- Volume
- 280
- Issue
- 5362
- Pages
- 427-431
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2008994596
- Cited by
- 1,407
- References
- 0
- FWCI
- 11.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Gastrointestinal Tract as a Major Site of CD4 + T Cell Depletion and Viral Replication in SIV Infection. https://app.cochat.ai/papers/10.1126/science.280.5362.427
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- Veazey, R. S., DeMaria, M., Chalifoux, L. V., Shvetz, D. E., Pauley, D. R., Knight, H. L., Rosenzweig, M., Johnson, R. P., Desrosiers, R. C., & Lackner, A. A. (1998). Gastrointestinal Tract as a Major Site of CD4 + T Cell Depletion and Viral Replication in SIV Infection. Science. https://doi.org/10.1126/science.280.5362.427
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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