The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Breaking and joining single-stranded DNA: the HUH endonuclease superfamily
Open accessAbstract
HUH endonucleases are numerous and widespread in all three domains of life. The major function of these enzymes is processing a range of mobile genetic elements by catalysing cleavage and rejoining of single-stranded DNA using an active-site Tyr residue to make a transient 5′-phosphotyrosine bond with the DNA substrate. These enzymes have a key role in rolling-circle replication of plasmids and bacteriophages, in plasmid transfer, in the replication of several eukaryotic viruses and in various types of transposition. They have also been appropriated for cellular processes such as intron homing and the processing of bacterial repeated extragenic palindromes. Here, we provide an overview of these fascinating enzymes and their functions, using well-characterized examples of Rep proteins, relaxases and transposases, and we explore the molecular mechanisms used in their diverse activities.
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Cites
Reassembly of shattered chromosomes in Deinococcus radiodurans
Zahradka, K., Slade, D., Bailone, A., Sommer, S., Averbeck, D., Petranovic, M., Lindner, A. B., & Radman, M. (2006) · Nature · doi:10.1038/nature05160 · Cited by 444
Barabas, O., Ronning, D. R., Guynet, C., Hickman, A. B., Ton-Hoang, B., Chandler, M., & Dyda, F. (2008) · Cell · doi:10.1016/j.cell.2007.12.029 · Cited by 143
Self-citation
Cited by
Mobile Genetic Elements Associated with Antimicrobial Resistance
Partridge, S. R., Kwong, S. M., Firth, N., & Jensen, S. O. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00088-17 · Cited by 2,751
Helitrons , the Eukaryotic Rolling-circle Transposable Elements
Thomas, J., & Pritham, E. J. (2015) · Microbiology Spectrum · doi:10.1128/microbiolspec.mdna3-0049-2014 · Cited by 121
Transposon-encoded nucleases use guide RNAs to promote their selfish spread
Meers, C., Le, H. C., Pesari, S. R., Hoffmann, F. T., Walker, M. W. G., Gezelle, J., Tang, S., & Sternberg, S. H. (2023) · Nature · doi:10.1038/s41586-023-06597-1 · Cited by 60
“IS200/IS605-family trans-posons rely on ssDNA secondary structures for efficient excision 23 , which occur during host replication 37,46 and DSB repair 38 .”
BackgroundMriyaviruses: small relatives of giant viruses
Yutin, N., Mutz, P., Krupovic, M., & Koonin, E. V. (2024) · mBio · doi:10.1128/mbio.01035-24 · Cited by 18
Gaertner, N. F., Maio, F., Arroyo-Mateos, M., Luna, A. P., Sabarit, B., Kwaaitaal, M., Eltschkner, S., Prins, M., Bejarano, E. R., & van den Burg, H. A. (2025) · Journal of Virology · doi:10.1128/jvi.01286-25 · Cited by 1
Metadata
- Authors
- Chandler, M., de la Cruz, F., Dyda, F., Hickman, A. B., Moncalian, G., & Ton-Hoang, B.
- Venue
- Nature Reviews Microbiology
- Published
- 2013-07-08
- Volume
- 11
- Issue
- 8
- Pages
- 525-538
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W1974231532
- Cited by
- 287
- References
- 2
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- green
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