The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Eradicating HIV-1 infection: seeking to clear a persistent pathogen
Open accessAbstract
Effective antiretroviral therapy (ART) blunts viraemia, which enables HIV-1-infected individuals to control infection and live long, productive lives. However, HIV-1 infection remains incurable owing to the persistence of a viral reservoir that harbours integrated provirus within host cellular DNA. This latent infection is unaffected by ART and hidden from the immune system. Recent studies have focused on the development of therapies to disrupt latency. These efforts unmasked residual viral genomes and highlighted the need to enable the clearance of latently infected cells, perhaps via old and new strategies that improve the HIV-1-specific immune response. In this Review, we explore new approaches to eradicate established HIV-1 infection and avoid the burden of lifelong ART.
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Cites
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Vranckx, L. S., Demeulemeester, J., Saleh, S., Boll, A., Vansant, G., Schrijvers, R., Weydert, C., Battivelli, E., Verdin, E., Cereseto, A., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.04.039 · Cited by 113
Engineering virus resistance via CRISPR–Cas systems
Mahas, A., & Mahfouz, M. (2018) · Current Opinion in Virology · doi:10.1016/j.coviro.2018.06.002 · Cited by 74
Activating PKC-ε induces HIV expression with improved tolerability
Irrinki, A. M., Kaur, J., Randhawa, B., McFadden, R., Snyder, C., Truong, H., Soohoo, D., Hu, E., Yu, H., Murray, B. P., et al. (2025) · PLOS Pathogens · doi:10.1371/journal.ppat.1012874 · Cited by 5
Metadata
- Authors
- Archin, N. M., Sung, J. M., Garrido, C., Soriano-Sarabia, N., & Margolis, D. M.
- Venue
- Nature Reviews Microbiology
- Published
- 2014-10-16
- Volume
- 12
- Issue
- 11
- Pages
- 750-764
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W2092524383
- Cited by
- 275
- References
- 10
- FWCI
- 5.87
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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