The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.
A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration
Open accessAbstract
There has been an explosion in the number of papers discussing the hypothesis of 'pathogenic spread' in neurodegenerative disease — the idea that abnormal forms of disease-associated proteins, such as tau or α-synuclein, physically move from neuron to neuron to induce disease progression. However, whether inter-neuronal spread of protein aggregates actually occurs in humans and, if so, whether it causes symptom onset remain uncertain. Even if pathogenic spread is proven in humans, it is unclear how much this would alter the specific therapeutic approaches that are in development. A critical appraisal of this increasingly popular hypothesis thus seems both important and timely.
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1 retracted
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Staging of brain pathology related to sporadic Parkinson’s disease
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Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
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Novel Proteinaceous Infectious Particles Cause Scrapie
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Cited by
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases
Soto, C., & Pritzkow, S. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0235-9 · Cited by 1,180
Selective neuronal vulnerability in Parkinson disease
Surmeier, D. J., Obeso, J. A., & Halliday, G. M. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.178 · Cited by 1,116
α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies
Wong, Y. C., & Krainc, D. (2017) · Nature Medicine · doi:10.1038/nm.4269 · Cited by 897
Obeso, J. A., Stamelou, M., Goetz, C. G., Poewe, W., Lang, A. E., Weintraub, D., Burn, D., Halliday, G. M., Bezard, E., Przedborski, S., et al. (2017) · Movement Disorders · doi:10.1002/mds.27115 · Cited by 859
“Although cell-to-cell transmission of alpha-synuclein has been demonstrated in both cell culture and animal models, the exact sequence and molecular mechanisms of propagation of PD’s neuropathology throughout the human brain remain elusive.(157) PARK-LRRK2.”
Propagation of Tau aggregates and neurodegeneration
Goedert, M., Eisenberg, D. S., & Crowther, R. A. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-072116-031153 · Cited by 632
Metadata
- Authors
- Walsh, D. M., & Selkoe, D. J.
- Venue
- Nature Reviews Neuroscience
- Published
- 2016-03-18
- Volume
- 17
- Issue
- 4
- Pages
- 251-260
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2300507818
- Cited by
- 294
- References
- 151
- FWCI
- 7.31
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
