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Novel Proteinaceous Infectious Particles Cause Scrapie

Prusiner, Stanley B.·1982·Science
DOI 10.1126/science.6801762
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Abstract

After infection and a prolonged incubation period, the scrapie agent causes a degenerative disease of the central nervous system in sheep and goats. Six lines of evidence including sensitivity to proteases demonstrate that this agent contains a protein that is required for infectivity. Although the scrapie agent is irreversibly inactivated by alkali, five procedures with more specificity for modifying nucleic acids failed to cause inactivation. The agent shows heterogeneity with respect to size, apparently a result of its hydrophobicity; the smallest form may have a molecular weight of 50,000 or less. Because the novel properties of the scrapie agent distinguish it from viruses, plasmids, and viroids, a new term "prion" is proposed to denote a small pro teinaceous in fectious particle which is resistant to inactivation by most procedures that modify nucleic acids. Knowledge of the scrapie agent structure may have significance for understanding the causes of several degenerative diseases.

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Cited by

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Metadata

Authors
Prusiner, S. B.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1982-04-09
Volume
216
Issue
4542
Pages
136-144
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.6801762
OpenAlex
W2013679718
Cited by
5,118
References
1
FWCI
17.02
Type
journal article
Language
en
Open access
closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Novel Proteinaceous Infectious Particles Cause Scrapie. https://app.cochat.ai/papers/10.1126/science.6801762
The paper
Prusiner, S. B. (1982). Novel Proteinaceous Infectious Particles Cause Scrapie. Science. https://doi.org/10.1126/science.6801762

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.