The DOI matches its Crossref record; 212 of the 212 references it cites were found in a registry or an index.
Not just amyloid: physiological functions of the amyloid precursor protein family
Abstract
Amyloid precursor protein (APP) gives rise to the amyloid-β peptide and thus has a key role in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP and the closely related APP-like proteins (APLPs) remain less well understood. Studying these physiological functions has been challenging and has required a careful long-term strategy, including the analysis of different App-knockout and Aplp-knockout mice. In this Review, we summarize these findings, focusing on the in vivo roles of APP family members and their processing products for CNS development, synapse formation and function, brain injury and neuroprotection, as well as ageing. In addition, we discuss the implications of APP physiology for therapeutic approaches.
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“A growing body of evidence also suggests a physiological role for APP in synaptic functions [96], potentially through cell adhesion.”
From The new genetic landscape of Alzheimer’s disease: from amyloid cascade to genetically driven synaptic failure hypothesis? (2019) · cites this paper as [96]
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1 retracted
RETRACTED ARTICLE: APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
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RetractedThe precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
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Glia-Derived d-Serine Controls NMDA Receptor Activity and Synaptic Memory
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Knopman, D. S., Amieva, H., Petersen, R. C., Chételat, G., Holtzman, D. M., Hyman, B. T., Nixon, R. A., & Jones, D. T. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-021-00269-y · Cited by 2,606
Hallmarks of neurodegenerative diseases
Wilson, D. M., Cookson, M. R., Van Den Bosch, L., Zetterberg, H., Holtzman, D. M., & Dewachter, I. (2023) · Cell · doi:10.1016/j.cell.2022.12.032 · Cited by 1,789
Alzheimer’s disease: risk factors and potentially protective measures
Silva, M. V. F., Loures, C. D. M. G., Alves, L. C. V., de Souza, L. C., Borges, K. B. G., & Ferriani, M. D. G. C. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0524-y · Cited by 1,031
Practical considerations for choosing a mouse model of Alzheimer’s disease
Jankowsky, J. L., & Zheng, H. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0231-7 · Cited by 449
Molecular mechanisms of ferroptosis and their involvement in brain diseases
Costa, I., Barbosa, D. J., Benfeito, S., Silva, V., Chavarria, D., Borges, F., Remião, F., & Silva, R. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108373 · Cited by 402
Metadata
- Authors
- Müller, U. C., Deller, T., & Korte, M.
- Affiliations
- Heidelberg University (DE)
- Goethe University Frankfurt (DE)
- Corresponding author
- Müller, Ulrike C.
- Venue
- Nature Reviews Neuroscience
- Published
- 2017-03-31
- Volume
- 18
- Issue
- 5
- Pages
- 281-298
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2599851926
- Cited by
- 634
- References
- 212
- Citations by year
- 2026: 49 · 2025: 59 · 2024: 88 · 2023: 69 · 2022: 79 · 2021: 84 · 2020: 62 · 2019: 73 · 2018: 50 · 2017: 21
- FWCI
- 6.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- amyloid precursor protein, amyloid-beta, Alzheimer's disease, central nervous system development, synaptogenesis, synaptic function, brain injury, neuroprotection, aging, APP knockout mice, APP processing, treatment options
- MeSH terms
- Animals, Brain, Humans, Amyloid beta-Protein Precursor, Mice
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