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Oxidative stress activates a positive feedback between the γ‐ and β‐secretase cleavages of the β‐amyloid precursor protein

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Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

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Intramembrane Proteolysis: Theme and Variations

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Reduced Hippocampal Insulin-Degrading Enzyme in Late-Onset Alzheimer's Disease Is Associated with the Apolipoprotein E-ε4 Allele

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Enhanced Ryanodine Receptor Recruitment Contributes to Ca2+Disruptions in Young, Adult, and Aged Alzheimer's Disease Mice

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Causative and susceptibility genes for Alzheimer’s disease: a review

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A focus on the synapse for neuroprotection in Alzheimer disease and other dementias

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Physiological Functions of APP Family ProteinsPreprint

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Tip60 in DNA damage response and growth control: many tricks in one HAT

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Dissection of Amyloid-β Precursor Protein-dependent Transcriptional Transactivation

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Epigenetic codes in cognition and behaviour

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Pathways of the Past: the Imprint of Memory

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Role of Amyloid-β and Tau Proteins in Alzheimer’s Disease: Confuting the Amyloid Cascade

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Amyloid-β peptide levels in brain are inversely correlated with insulysin activity levels <i>in vivo</i>

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Deciphering the Genetic Basis of Alzheimer's Disease

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Proteolytic Processing of Low Density Lipoprotein Receptor-related Protein Mediates Regulated Release of Its Intracellular Domain

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Presenilin-dependent Intramembrane Proteolysis of CD44 Leads to the Liberation of Its Intracellular Domain and the Secretion of an Aβ-like Peptide

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Presenilin-dependent γ-Secretase-like Intramembrane Cleavage of ErbB4

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Cellular functions of TIP60

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Amyloid-Independent Mechanisms in Alzheimer's Disease Pathogenesis

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Insights into the physiological function of the β‐amyloid precursor protein: beyond Alzheimer's disease

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C‐terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase‐3β expression

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The amyloid‐β precursor protein: integrating structure with biological function

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The amyloid precursor protein: A biochemical enigma in brain development, function and disease

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A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP

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The LDL receptor‐related protein (LRP) family: An old family of proteins with new physiological functions

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Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aβ 42 production

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A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt–Oram syndrome

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Epigenetic regulation in the pathophysiology of Alzheimer's disease

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Molecular signatures underlying neurofibrillary tangle susceptibility in Alzheimer’s disease

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The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes

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Modulation of γ-Secretase Reduces β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease

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Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain

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The role of the CD44 transmembrane and cytoplasmic domains in co-ordinating adhesive and signalling events

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The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics—Relevance for Alzheimer's disease

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Back signaling by the Nrg-1 intracellular domain

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Defective Neuromuscular Synapses in Mice Lacking Amyloid Precursor Protein (APP) and APP-Like Protein 2

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Dissection of Amyloid-β Precursor Protein-dependent Transcriptional Transactivation

Cao, X., & Südhof, T. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402248200 · Cited by 309 · see citing works

Fe65 is the sole member of its family that mediates transcription regulated by the amyloid precursor protein

Probst, S., Krüger, M., Kägi, L., Thöni, S., Schuppli, D., Nitsch, R. M., & Konietzko, U. (2020) · Journal of Cell Science · doi:10.1242/jcs.242917 · Cited by 18 · see citing works

A γ-Secretase-independent Mechanism of Signal Transduction by the Amyloid Precursor Protein

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The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor

von Rotz, R. C., Kohli, B. M., Bosset, J., Meier, M. G., Suzuki, T., Nitsch, R. M., & Konietzko, U. (2004) · Journal of Cell Science · doi:10.1242/jcs.01323 · Cited by 348 · see citing works

Contrôle transcriptionnel associé au domaine intracellulaire du précurseur du peptide amyloïd

Huysseune, S. (2010) · Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B))